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The map label for this gene is dxs

Identifier: 146284018

GI number: 146284018

Start: 4006948

End: 4008846

Strand: Direct

Name: dxs

Synonym: PST_3706

Alternate gene names: 146284018

Gene position: 4006948-4008846 (Clockwise)

Preceding gene: 146284017

Following gene: 146284020

Centisome position: 87.73

GC content: 67.83

Gene sequence:

>1899_bases
ATGCCCAAGACGTTCCATGAGATTCCTCGGGTGCGCCCCGCGACGCCCGTTCTTGACCGAGCGGCGACCCCCGAGCAGCT
GCGCCGACTGGGCGAGGCGGAACTCGAAGAGCTTGCCAACGAACTGCGCCAGGAGCTGCTGTACAGCGTCGGCCGCACCG
GCGGGCACTTCGGCGCCGGCCTCGGCGTGATCGAACTGACCATCGCCCTGCACTACGTCTACGACACACCGGACGACCGG
CTGGTCTGGGACGTGGGCCACCAGGCCTATCCGCACAAGATCCTCACCGGCCGCCGCGAGCGCATGGGCACCCTGCGCCA
GAAGGACGGCCTGGCCGCCTTTCCGCGCCGGGTCGAGAGTGAGTACGACACCTTCGGCGTCGGCCATTCCAGCACCTCGA
TCAGCGCCGCCCTGGGCATGGCGGTCGCCGCGCGTTTGAAAGGCGAACAGCGCAAGTCCATCGCGGTGATCGGTGACGGT
GCGCTGACCGCCGGCATGGCCTTCGAGGCGCTCAACCACGCCCCGGAAGTCGGCGCCAACATGCTGGTGGTGCTCAACGA
CAACGACATGTCGATCTCGCGCAACGTCGGCGGCCTGTCCAACTACCTGGCCAAGATCCTCTCCAGCCGCACCTATTCGA
GCATGCGCGAAGGCAGCAAGAAGATCCTCTCGCGCCTGCCAGGCGCCTGGGAAATCGCCCGCCGCACCGAGGAATACGCC
AAGGGCATGCTGGTGCCCGGCACCCTGTTCGAGGAACTGGGCTGGAACTACATCGGCCCCATCGACGGCCACGACCTGCC
GACCCTGATCGCTACCCTGCGCAATATGCGCGACCTCGACGGCCCGCAGTTCCTCCATGTGGTGACGAAGAAGGGCAAGG
GCTTCGCCCCGGCCGAGGCCGACCCCATCACCTGGCATGCGATCAGCAAACTGGAGCCGGTCGGCGCGCCGCCAGCGCCG
AAGAAGCCCACGGGGCCGAAATACTCCAACGTCTTCGGCCAGTGGCTGTGCGACATGGCCGCCGCCGACCCGCGCCTGAC
CGGCATCACCCCGGCGATGAAGGAAGGCTCCGACCTGGTGGCGTTCAGCGAACGCTATCCGGACCGCTACTTCGACGTCG
CCATCGCCGAGCAGCACGCAGTCACCCTGGCTGCCGGCATGGCCTGCGAAGGCCTGAAGCCGGTGGTGGCGATCTACTCC
ACCTTCCTCCAGCGCGCCTACGATCAGCTGATCCATGACGTCGCGGTGCAGAACCTCGATGTGCTGTTTGCCATCGACCG
CGCCGGCCTGGTCGGCGAGGACGGCCCGACCCATGCCGGCAGCTTCGACCTGTCCTACCTGCGCTGCATCCCCGGCATGC
TGGTGATGACCCCAAGCGACGAGAACGAGATGCGCCGCATGCTCACCACCGGCTACCACTTCGAAGGCCCGGCCGCGGTG
CGCTACCCGCGCGGCAGCGGCCCCAACGCCAGCATCGAGCCGGCCTTGGAACCGCTGGAAATCGGCAAGGCAGTGGTGCG
CCGTCGGGGCAGCAAGGTGGCGCTGCTGGTGTTCGGCGTGCAGCTGCCCGAGGCGCTGCAGGTCGGCGACGCGCTGGACG
CCACGGTGGTCGACATGCGTTTCGTCAAACCGCTGGACGAAGCCCTGCTGCGCGAACTGGCGGGCAGCCACGAGCTGCTG
GTGACGGTCGAGGAGAACAGCATCATGGGCGGTGCCGGCAGTGCGGTGGCCGAGTTCCTCGCTGCCGAAGGCGTGCTGCG
ACCGATCCTGCACCTGGGCCTGCCGGACTACTACGTCGAGCACGCCAAGCCCAGCGAAATGCTCGCCGAATGCGGCCTGG
ATGCAGCCGGCATCGAAGTGGCGGTGCGCAAGCGCCTGGCGGCACTCGGCAAAGCCTGA

Upstream 100 bases:

>100_bases
CCGAAATCGCAGTCAAACCCCTACCGGACCCGGGGCCGTTCTTATCGAGGGGCCCATCGGGTAAACTGCCGCTCTTTTTT
CAACGACAACGATCCGCCTG

Downstream 100 bases:

>100_bases
CGTCGTTTCGCTGGTTGGGTGGAGCGTCATCCACCCTACACTGGCAACTCCGAGTCGCCCCGTTGGCAGACAATCCCGTT
CTCTCAAAAGCAACGGATCT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MPKTFHEIPRVRPATPVLDRAATPEQLRRLGEAELEELANELRQELLYSVGRTGGHFGAGLGVIELTIALHYVYDTPDDR
LVWDVGHQAYPHKILTGRRERMGTLRQKDGLAAFPRRVESEYDTFGVGHSSTSISAALGMAVAARLKGEQRKSIAVIGDG
ALTAGMAFEALNHAPEVGANMLVVLNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKILSRLPGAWEIARRTEEYA
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLDGPQFLHVVTKKGKGFAPAEADPITWHAISKLEPVGAPPAP
KKPTGPKYSNVFGQWLCDMAAADPRLTGITPAMKEGSDLVAFSERYPDRYFDVAIAEQHAVTLAAGMACEGLKPVVAIYS
TFLQRAYDQLIHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENEMRRMLTTGYHFEGPAAV
RYPRGSGPNASIEPALEPLEIGKAVVRRRGSKVALLVFGVQLPEALQVGDALDATVVDMRFVKPLDEALLRELAGSHELL
VTVEENSIMGGAGSAVAEFLAAEGVLRPILHLGLPDYYVEHAKPSEMLAECGLDAAGIEVAVRKRLAALGKA

Sequences:

>Translated_632_residues
MPKTFHEIPRVRPATPVLDRAATPEQLRRLGEAELEELANELRQELLYSVGRTGGHFGAGLGVIELTIALHYVYDTPDDR
LVWDVGHQAYPHKILTGRRERMGTLRQKDGLAAFPRRVESEYDTFGVGHSSTSISAALGMAVAARLKGEQRKSIAVIGDG
ALTAGMAFEALNHAPEVGANMLVVLNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKILSRLPGAWEIARRTEEYA
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLDGPQFLHVVTKKGKGFAPAEADPITWHAISKLEPVGAPPAP
KKPTGPKYSNVFGQWLCDMAAADPRLTGITPAMKEGSDLVAFSERYPDRYFDVAIAEQHAVTLAAGMACEGLKPVVAIYS
TFLQRAYDQLIHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENEMRRMLTTGYHFEGPAAV
RYPRGSGPNASIEPALEPLEIGKAVVRRRGSKVALLVFGVQLPEALQVGDALDATVVDMRFVKPLDEALLRELAGSHELL
VTVEENSIMGGAGSAVAEFLAAEGVLRPILHLGLPDYYVEHAKPSEMLAECGLDAAGIEVAVRKRLAALGKA
>Mature_631_residues
PKTFHEIPRVRPATPVLDRAATPEQLRRLGEAELEELANELRQELLYSVGRTGGHFGAGLGVIELTIALHYVYDTPDDRL
VWDVGHQAYPHKILTGRRERMGTLRQKDGLAAFPRRVESEYDTFGVGHSSTSISAALGMAVAARLKGEQRKSIAVIGDGA
LTAGMAFEALNHAPEVGANMLVVLNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKILSRLPGAWEIARRTEEYAK
GMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLDGPQFLHVVTKKGKGFAPAEADPITWHAISKLEPVGAPPAPK
KPTGPKYSNVFGQWLCDMAAADPRLTGITPAMKEGSDLVAFSERYPDRYFDVAIAEQHAVTLAAGMACEGLKPVVAIYST
FLQRAYDQLIHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENEMRRMLTTGYHFEGPAAVR
YPRGSGPNASIEPALEPLEIGKAVVRRRGSKVALLVFGVQLPEALQVGDALDATVVDMRFVKPLDEALLRELAGSHELLV
TVEENSIMGGAGSAVAEFLAAEGVLRPILHLGLPDYYVEHAKPSEMLAECGLDAAGIEVAVRKRLAALGKA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=658, Percent_Identity=24.468085106383, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4507521, Length=658, Percent_Identity=24.468085106383, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI225637459, Length=430, Percent_Identity=25.5813953488372, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI225637463, Length=430, Percent_Identity=25.5813953488372, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI225637461, Length=430, Percent_Identity=25.5813953488372, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI133778974, Length=423, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1786622, Length=614, Percent_Identity=62.8664495114006, Blast_Score=800, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=636, Percent_Identity=24.8427672955975, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24666278, Length=574, Percent_Identity=26.4808362369338, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45551847, Length=627, Percent_Identity=25.0398724082935, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45550715, Length=627, Percent_Identity=25.0398724082935, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24645119, Length=327, Percent_Identity=29.9694189602446, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_PSEU5 (A4VQS8)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001174171.1
- ProteinModelPortal:   A4VQS8
- SMR:   A4VQS8
- STRING:   A4VQS8
- GeneID:   5096667
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3706
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   A4VQS8
- ProtClustDB:   PRK05444
- BioCyc:   PSTU379731:PST_3706-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68423; Mature: 68292

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTFHEIPRVRPATPVLDRAATPEQLRRLGEAELEELANELRQELLYSVGRTGGHFGAG
CCCCHHHCCCCCCCCCHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LGVIELTIALHYVYDTPDDRLVWDVGHQAYPHKILTGRRERMGTLRQKDGLAAFPRRVES
HHHHHHEEEEEEEEECCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHC
EYDTFGVGHSSTSISAALGMAVAARLKGEQRKSIAVIGDGALTAGMAFEALNHAPEVGAN
CCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCC
MLVVLNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKILSRLPGAWEIARRTEEYA
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLDGPQFLHVVTKKGKGFAPAEA
CCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
DPITWHAISKLEPVGAPPAPKKPTGPKYSNVFGQWLCDMAAADPRLTGITPAMKEGSDLV
CCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEE
AFSERYPDRYFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRAYDQLIHDVAVQNLD
EEHHHCCCHHEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENEMRRMLTTGYHFEGPAAV
EEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEE
RYPRGSGPNASIEPALEPLEIGKAVVRRRGSKVALLVFGVQLPEALQVGDALDATVVDMR
ECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHCCCCCHHHHHHH
FVKPLDEALLRELAGSHELLVTVEENSIMGGAGSAVAEFLAAEGVLRPILHLGLPDYYVE
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HAKPSEMLAECGLDAAGIEVAVRKRLAALGKA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PKTFHEIPRVRPATPVLDRAATPEQLRRLGEAELEELANELRQELLYSVGRTGGHFGAG
CCCHHHCCCCCCCCCHHHCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LGVIELTIALHYVYDTPDDRLVWDVGHQAYPHKILTGRRERMGTLRQKDGLAAFPRRVES
HHHHHHEEEEEEEEECCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHC
EYDTFGVGHSSTSISAALGMAVAARLKGEQRKSIAVIGDGALTAGMAFEALNHAPEVGAN
CCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCC
MLVVLNDNDMSISRNVGGLSNYLAKILSSRTYSSMREGSKKILSRLPGAWEIARRTEEYA
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLDGPQFLHVVTKKGKGFAPAEA
CCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
DPITWHAISKLEPVGAPPAPKKPTGPKYSNVFGQWLCDMAAADPRLTGITPAMKEGSDLV
CCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEE
AFSERYPDRYFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRAYDQLIHDVAVQNLD
EEHHHCCCHHEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VLFAIDRAGLVGEDGPTHAGSFDLSYLRCIPGMLVMTPSDENEMRRMLTTGYHFEGPAAV
EEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCEE
RYPRGSGPNASIEPALEPLEIGKAVVRRRGSKVALLVFGVQLPEALQVGDALDATVVDMR
ECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHCCCCCHHHHHHH
FVKPLDEALLRELAGSHELLVTVEENSIMGGAGSAVAEFLAAEGVLRPILHLGLPDYYVE
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HAKPSEMLAECGLDAAGIEVAVRKRLAALGKA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA