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The map label for this gene is ispA [H]

Identifier: 146284017

GI number: 146284017

Start: 4005953

End: 4006840

Strand: Direct

Name: ispA [H]

Synonym: PST_3705

Alternate gene names: 146284017

Gene position: 4005953-4006840 (Clockwise)

Preceding gene: 146284016

Following gene: 146284018

Centisome position: 87.71

GC content: 68.58

Gene sequence:

>888_bases
ATGATCGGCGACTACCAGAAAGGCTGTCAGCAGCGCGTCGACGGCTGCCTCGAAGCTCTCTTCGTCCCGCCGCTGCCGCA
GCTCGAGCGGCTCTACCAGGCCATGCGCTACAGCGTGATGAACGGTGGCAAGCGCGTCCGCCCGCTGCTGGTCTACGCCG
CCTGCGAAGCACTGAATGGTGACAAGGCCAGCGCCGACGGCGCTGCCTGCGCGGTCGAGCTGATCCATGCCTATTCGCTG
GTGCACGACGATCTGCCGGCCATGGACGACGACGACCTGCGTCGCGGCCAGCCAACCACCCATAAGGCTTTCGACGAGGC
CTGCGCCATCCTTGCCGGCGACGGCCTGCAAAGCCTGGCCTTCGAGGCCATGGCTCAGGAACGCCACAACCCGCAGGATG
CCGCCCTGCGCCTGCGCATGTTCGCCGTGCTGGCGCGCGCCGCCGGGCCTGCGGGGATGGTCGGCGGCCAGGCCATCGAC
CTCGGCTCGGTGGGCCTCAAGCTCGATCGCGATGCCCTCGAGCTGATGCACCGGCACAAGACCGGGGCGCTGATCGAGGC
CAGCGTGCAACTCGGCGCCCTCGCCAGTGGCCGTGCCGATGCCGACAACCTCGCCTCGCTGAGCCAGTATGCACGCGCCA
TCGGCCTGGCCTTCCAGGTCCAGGACGATATCCTCGACGTGGAAAGCGACACCGCCACGCTCGGCAAGCACCAGGGCGCC
GACATCGCCCGGGACAAACCGACCTACCCGGCCCTGCTCGGCATGGACGCGGCCAAGGCCTACGCCCTGGAACTGCGCGA
CCAGGCATTGCACGCCCTGCGGCCTTTCGACTTCGCCGCCGAGCCGCTACGGGAACTGGCGCGCTACATCGTCGAACGGC
GCAATTGA

Upstream 100 bases:

>100_bases
GCCAGGCGGCGCTGAGCCAGGCCGAGCAGAAGGTGCAGATCCTGCTGGAACGCGACGGCAGCCTGCAGGAAGCCCCCTTC
GAGTCGGACCCCGAAGCATG

Downstream 100 bases:

>100_bases
CCTTTCGCCGAAATCGCAGTCAAACCCCTACCGGACCCGGGGCCGTTCTTATCGAGGGGCCCATCGGGTAAACTGCCGCT
CTTTTTTCAACGACAACGAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIGDYQKGCQQRVDGCLEALFVPPLPQLERLYQAMRYSVMNGGKRVRPLLVYAACEALNGDKASADGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLAFEAMAQERHNPQDAALRLRMFAVLARAAGPAGMVGGQAID
LGSVGLKLDRDALELMHRHKTGALIEASVQLGALASGRADADNLASLSQYARAIGLAFQVQDDILDVESDTATLGKHQGA
DIARDKPTYPALLGMDAAKAYALELRDQALHALRPFDFAAEPLRELARYIVERRN

Sequences:

>Translated_295_residues
MIGDYQKGCQQRVDGCLEALFVPPLPQLERLYQAMRYSVMNGGKRVRPLLVYAACEALNGDKASADGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLAFEAMAQERHNPQDAALRLRMFAVLARAAGPAGMVGGQAID
LGSVGLKLDRDALELMHRHKTGALIEASVQLGALASGRADADNLASLSQYARAIGLAFQVQDDILDVESDTATLGKHQGA
DIARDKPTYPALLGMDAAKAYALELRDQALHALRPFDFAAEPLRELARYIVERRN
>Mature_295_residues
MIGDYQKGCQQRVDGCLEALFVPPLPQLERLYQAMRYSVMNGGKRVRPLLVYAACEALNGDKASADGAACAVELIHAYSL
VHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLAFEAMAQERHNPQDAALRLRMFAVLARAAGPAGMVGGQAID
LGSVGLKLDRDALELMHRHKTGALIEASVQLGALASGRADADNLASLSQYARAIGLAFQVQDDILDVESDTATLGKHQGA
DIARDKPTYPALLGMDAAKAYALELRDQALHALRPFDFAAEPLRELARYIVERRN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=232, Percent_Identity=31.4655172413793, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1786623, Length=295, Percent_Identity=49.8305084745763, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1789578, Length=223, Percent_Identity=32.2869955156951, Blast_Score=102, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24651612, Length=222, Percent_Identity=31.5315315315315, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31836; Mature: 31836

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGDYQKGCQQRVDGCLEALFVPPLPQLERLYQAMRYSVMNGGKRVRPLLVYAACEALNG
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
DKASADGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHH
FEAMAQERHNPQDAALRLRMFAVLARAAGPAGMVGGQAIDLGSVGLKLDRDALELMHRHK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEECHHHHHHHHHHC
TGALIEASVQLGALASGRADADNLASLSQYARAIGLAFQVQDDILDVESDTATLGKHQGA
CCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCHHHHCCCCCC
DIARDKPTYPALLGMDAAKAYALELRDQALHALRPFDFAAEPLRELARYIVERRN
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIGDYQKGCQQRVDGCLEALFVPPLPQLERLYQAMRYSVMNGGKRVRPLLVYAACEALNG
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
DKASADGAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTHKAFDEACAILAGDGLQSLA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHH
FEAMAQERHNPQDAALRLRMFAVLARAAGPAGMVGGQAIDLGSVGLKLDRDALELMHRHK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEECHHHHHHHHHHC
TGALIEASVQLGALASGRADADNLASLSQYARAIGLAFQVQDDILDVESDTATLGKHQGA
CCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHCCCCCHHHHCCCCCC
DIARDKPTYPALLGMDAAKAYALELRDQALHALRPFDFAAEPLRELARYIVERRN
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]