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The map label for this gene is lldP [C]

Identifier: 146283654

GI number: 146283654

Start: 3609789

End: 3611483

Strand: Direct

Name: lldP [C]

Synonym: PST_3336

Alternate gene names: 146283654

Gene position: 3609789-3611483 (Clockwise)

Preceding gene: 146283652

Following gene: 146283655

Centisome position: 79.03

GC content: 65.55

Gene sequence:

>1695_bases
ATGTCCAACGGACTGCTCGCACTTTTCGCTTTCACTCCCATTCTGCTCGCGGCCGTGATGCTGATCGGCCTGCGCTGGCC
CGCCAGCCGCGCCATGCCGCTGGTCTACCTGTTCACCGCGGCCATCGGCCTGTTCGTCTGGGACATGAGCTTCAACCGGA
TCATCGCATCCACGCTGCAGGGCCTGGTGATCACGCTCGGTCTGTTGTGGATCATCTTCGGCGCGATCCTGCTGCTGAAC
ACGCTGAAGCACTCCGGCGGCATCACCGCCATCCGCGCCGGCTTCACCACCATCAGCCCCGACCGCCGCATCCAGGCCAT
CATCATCGCCTGGCTATTCGGTTGCTTCATCGAAGGTGCCTCCGGCTTCGGCACCCCGGCGGCAATCGCTGCACCGCTGC
TGGTCGCGGTCGGCTTTCCGGCAATGGCCGCGGTGCTGCTCGGCATGCTGGTACAGAGTACGCCGGTTTCCTTCGGCGCC
GTCGGCACCCCGATCGTGGTGGGCATCAACAGCGGCCTGGACACCGCCACCATCGGCGCGCAACTGACCGCCCAGGGCTC
CAGCTGGAGCATCTTCCTGCAGCAGATCACCAGCAGCGTAGCGATCACCCATGCCATCGTCGGCACCGTCATGCCGCTCG
TCATGGTGCTGATGCTGACGCGCTTCTTCGGTAAGGAGAAAAGCTGGAAAGCCGGTTTCGAAGTGCTGCCGTTCGCGATC
TTCGCCGGTCTGGCCTTCACCCTGCCCTATGCCGCCACCGGCATCTTCCTCGGCCCGGAATTCCCGTCGCTGCTCGGCGG
CCTGGTAGGCCTGGCGATCGTCACCACCGCGGCACGCTTCAAGTTCCTGACGCCGAAGACCACCTGGGACTTCGCCGACG
CCAAGGAATGGCCGGCCGAATGGCTGGGCACCATCGAGATGAAGCTGGACGACATCGCCGCTCGCCCGATGAGCGCGTTC
CGTGCCTGGCTGCCCTACGTACTGGTCGGCGCCCTGCTAGTGATCAGCCGCGTGTTCCCGCAGGTGGGCGCCGCGCTGAA
ATCGGTCTCCGTTGCCTTCGCCAACATCCTCGGCGAGGCCGGCATCAACGCGGGCATCGAGCCGCTGTACCTGCCCGGCG
GCATTCTCGTCGCGGTGGTGCTGATCACCTTCTTCCTGCACGGCATGCGTGCCGCCGAACTCAAGGCAGCGGTGAAGGAG
TCCAGCAGCGTACTGCTGAGCGCCGGATTCGTTCTGCTGTTCACCGTGCCGATGGTGCGCATCCTGATCAACTCCGGCGT
CAACGGCGCCGAACTGGCCAGCATGCCGATCGTCATGGCGCGTTATGTCGCGGACAGCGTAGGCGGTATCTACCCGCTGC
TGGCGCCATCGGTCGGCGCACTGGGCGCCTTCCTGGCCGGCTCCAACACCGTCAGCAACATGATGTTCAGCCAGTTCCAG
TTCGGTGTCGCACAGTCCCTGGGGATTTCCGGCGCGATGGTCGTCGCCACCCAGGCGGTCGGTGCCGCGGCGGGCAACAT
GGTCGCGATCCACAACGTGGTCGCCGCCTCCGCCACCGTCGGCCTGCTCGGCCGCGAAGGCTCCACGTTGCGCAAGACCG
TATGGCCTACGCTGTACTATGTGCTCTTCACCGGGGCGATCGGCCTGATCGCCATCTACGTGCTGGGCGTCACCGACCCG
CTGGTCGGGGTGTAA

Upstream 100 bases:

>100_bases
CAACTAACAATAAGAGGACTCAGCATGAGATCTGTGCACAACAACTATTCCACGGTCCGCTCAGGGCCCCATCTGAATCG
AACCGTAGGGGACGCTTGAC

Downstream 100 bases:

>100_bases
ACGACAGAAACAGACCGTGCCCCCGCTGGGGGCACGGTTGCATTCCAGAAACCGCACTTGACAGTGCTATTGGAAAACGT
AGGCGGGGCAGGCAAGACGA

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSNGLLALFAFTPILLAAVMLIGLRWPASRAMPLVYLFTAAIGLFVWDMSFNRIIASTLQGLVITLGLLWIIFGAILLLN
TLKHSGGITAIRAGFTTISPDRRIQAIIIAWLFGCFIEGASGFGTPAAIAAPLLVAVGFPAMAAVLLGMLVQSTPVSFGA
VGTPIVVGINSGLDTATIGAQLTAQGSSWSIFLQQITSSVAITHAIVGTVMPLVMVLMLTRFFGKEKSWKAGFEVLPFAI
FAGLAFTLPYAATGIFLGPEFPSLLGGLVGLAIVTTAARFKFLTPKTTWDFADAKEWPAEWLGTIEMKLDDIAARPMSAF
RAWLPYVLVGALLVISRVFPQVGAALKSVSVAFANILGEAGINAGIEPLYLPGGILVAVVLITFFLHGMRAAELKAAVKE
SSSVLLSAGFVLLFTVPMVRILINSGVNGAELASMPIVMARYVADSVGGIYPLLAPSVGALGAFLAGSNTVSNMMFSQFQ
FGVAQSLGISGAMVVATQAVGAAAGNMVAIHNVVAASATVGLLGREGSTLRKTVWPTLYYVLFTGAIGLIAIYVLGVTDP
LVGV

Sequences:

>Translated_564_residues
MSNGLLALFAFTPILLAAVMLIGLRWPASRAMPLVYLFTAAIGLFVWDMSFNRIIASTLQGLVITLGLLWIIFGAILLLN
TLKHSGGITAIRAGFTTISPDRRIQAIIIAWLFGCFIEGASGFGTPAAIAAPLLVAVGFPAMAAVLLGMLVQSTPVSFGA
VGTPIVVGINSGLDTATIGAQLTAQGSSWSIFLQQITSSVAITHAIVGTVMPLVMVLMLTRFFGKEKSWKAGFEVLPFAI
FAGLAFTLPYAATGIFLGPEFPSLLGGLVGLAIVTTAARFKFLTPKTTWDFADAKEWPAEWLGTIEMKLDDIAARPMSAF
RAWLPYVLVGALLVISRVFPQVGAALKSVSVAFANILGEAGINAGIEPLYLPGGILVAVVLITFFLHGMRAAELKAAVKE
SSSVLLSAGFVLLFTVPMVRILINSGVNGAELASMPIVMARYVADSVGGIYPLLAPSVGALGAFLAGSNTVSNMMFSQFQ
FGVAQSLGISGAMVVATQAVGAAAGNMVAIHNVVAASATVGLLGREGSTLRKTVWPTLYYVLFTGAIGLIAIYVLGVTDP
LVGV
>Mature_563_residues
SNGLLALFAFTPILLAAVMLIGLRWPASRAMPLVYLFTAAIGLFVWDMSFNRIIASTLQGLVITLGLLWIIFGAILLLNT
LKHSGGITAIRAGFTTISPDRRIQAIIIAWLFGCFIEGASGFGTPAAIAAPLLVAVGFPAMAAVLLGMLVQSTPVSFGAV
GTPIVVGINSGLDTATIGAQLTAQGSSWSIFLQQITSSVAITHAIVGTVMPLVMVLMLTRFFGKEKSWKAGFEVLPFAIF
AGLAFTLPYAATGIFLGPEFPSLLGGLVGLAIVTTAARFKFLTPKTTWDFADAKEWPAEWLGTIEMKLDDIAARPMSAFR
AWLPYVLVGALLVISRVFPQVGAALKSVSVAFANILGEAGINAGIEPLYLPGGILVAVVLITFFLHGMRAAELKAAVKES
SSVLLSAGFVLLFTVPMVRILINSGVNGAELASMPIVMARYVADSVGGIYPLLAPSVGALGAFLAGSNTVSNMMFSQFQF
GVAQSLGISGAMVVATQAVGAAAGNMVAIHNVVAASATVGLLGREGSTLRKTVWPTLYYVLFTGAIGLIAIYVLGVTDPL
VGV

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=577, Percent_Identity=27.0363951473137, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789347, Length=287, Percent_Identity=31.7073170731707, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58820; Mature: 58689

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNGLLALFAFTPILLAAVMLIGLRWPASRAMPLVYLFTAAIGLFVWDMSFNRIIASTLQ
CCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVITLGLLWIIFGAILLLNTLKHSGGITAIRAGFTTISPDRRIQAIIIAWLFGCFIEGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC
SGFGTPAAIAAPLLVAVGFPAMAAVLLGMLVQSTPVSFGAVGTPIVVGINSGLDTATIGA
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHCCC
QLTAQGSSWSIFLQQITSSVAITHAIVGTVMPLVMVLMLTRFFGKEKSWKAGFEVLPFAI
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FAGLAFTLPYAATGIFLGPEFPSLLGGLVGLAIVTTAARFKFLTPKTTWDFADAKEWPAE
HHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHCCHH
WLGTIEMKLDDIAARPMSAFRAWLPYVLVGALLVISRVFPQVGAALKSVSVAFANILGEA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GINAGIEPLYLPGGILVAVVLITFFLHGMRAAELKAAVKESSSVLLSAGFVLLFTVPMVR
CCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ILINSGVNGAELASMPIVMARYVADSVGGIYPLLAPSVGALGAFLAGSNTVSNMMFSQFQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
FGVAQSLGISGAMVVATQAVGAAAGNMVAIHNVVAASATVGLLGREGSTLRKTVWPTLYY
HHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VLFTGAIGLIAIYVLGVTDPLVGV
HHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNGLLALFAFTPILLAAVMLIGLRWPASRAMPLVYLFTAAIGLFVWDMSFNRIIASTLQ
CCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVITLGLLWIIFGAILLLNTLKHSGGITAIRAGFTTISPDRRIQAIIIAWLFGCFIEGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC
SGFGTPAAIAAPLLVAVGFPAMAAVLLGMLVQSTPVSFGAVGTPIVVGINSGLDTATIGA
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHCCC
QLTAQGSSWSIFLQQITSSVAITHAIVGTVMPLVMVLMLTRFFGKEKSWKAGFEVLPFAI
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FAGLAFTLPYAATGIFLGPEFPSLLGGLVGLAIVTTAARFKFLTPKTTWDFADAKEWPAE
HHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHCCHH
WLGTIEMKLDDIAARPMSAFRAWLPYVLVGALLVISRVFPQVGAALKSVSVAFANILGEA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GINAGIEPLYLPGGILVAVVLITFFLHGMRAAELKAAVKESSSVLLSAGFVLLFTVPMVR
CCCCCCCCEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ILINSGVNGAELASMPIVMARYVADSVGGIYPLLAPSVGALGAFLAGSNTVSNMMFSQFQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
FGVAQSLGISGAMVVATQAVGAAAGNMVAIHNVVAASATVGLLGREGSTLRKTVWPTLYY
HHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VLFTGAIGLIAIYVLGVTDPLVGV
HHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]