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The map label for this gene is ipk

Identifier: 146283513

GI number: 146283513

Start: 3433209

End: 3434063

Strand: Direct

Name: ipk

Synonym: PST_3186

Alternate gene names: 146283513

Gene position: 3433209-3434063 (Clockwise)

Preceding gene: 146283512

Following gene: 146283514

Centisome position: 75.17

GC content: 59.3

Gene sequence:

>855_bases
ATGCTGACGCTACCAGCGCCCGCCAAACTCAATCTGATGCTGCACATAGTCGGGCGCCGCGCCGACGGTTACCACGAGTT
GCAGACGCTATTCCAGTTTCTCGACCATGGTGACGAACTCAGCTTCAGCCCGCGTGAAGACGGCGAAATCCGCCTGCATA
CCGAGCTGCCGGGGGTCGATCACGACAGCAACCTGATCGTCCGCGCAGCGCGCCTGCTGCAGCATGAGAGCGGTTGCCCG
CAAGGTGCCGACATTCATCTGCTCAAGCGGCTGCCCATGGGCGGTGGTATTGGCGGTGGCAGCTCCGACGCGGCGACCGC
CCTGCTCGGCCTGAACCACCTGTGGCAGCTGCATCTGGAGGAAGACCAGCTGGCCGAGCTAGGGCTAACCCTGGGCGCCG
ATGTCCCGGTATTCGTTCGCGGCCGGGCAGCCTTTGCCGAGGGGGTTGGCGAGCGTCTGCAACCGGTCGAATTACCCGAA
CCTTGGTTCCTCGTAATCGCGCCGCAAGTCTCTGTTAGTACAGCGGAAATATTTGCCGACCCAGAGTTGACACGTAATAC
CCCGGCCATTACAGTTCGCAGCCTTCTTGCAGGGGGCGGTCATAATGACTGTCAGCCGATCGTCGAGAAGCGTTATCCAG
AAGTTCGTAACGCTTTGAGCTTGTTGAACAAATTCGTTCCGGCAAGCATGACTGGCACTGGAGCTTGTGTGTTTGGGAGC
TTCCCAAACGAAGGCGAGGCTGATAAAGTCCGCCGCCAACTTCCAGACACTTTGCCAAGTTTCGTGGCCCGCGGTCGTAA
CGTTTCGATGTTGCACCGATGCCTTGAAAAACTGGCGCAGGAAGTAAGTGCGTAG

Upstream 100 bases:

>100_bases
CAACGGTTTCGTCCTGCCCGAGCGCATCCGGCTACAAGGGCACGATCTGCAGATCACCCTGGTGATCAAGGACTGGCAAC
CCCGCCAGCTGGGCCGTTGA

Downstream 100 bases:

>100_bases
CACACAGGTTGTACGATACAGGGGCGTCGCCAAGCGGTAAGGCACCAGGTTTTGATCCTGGCATGCGTTGGTTCGAATCC
AGCCGCCCCTGCCATAACCT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLTLPAPAKLNLMLHIVGRRADGYHELQTLFQFLDHGDELSFSPREDGEIRLHTELPGVDHDSNLIVRAARLLQHESGCP
QGADIHLLKRLPMGGGIGGGSSDAATALLGLNHLWQLHLEEDQLAELGLTLGADVPVFVRGRAAFAEGVGERLQPVELPE
PWFLVIAPQVSVSTAEIFADPELTRNTPAITVRSLLAGGGHNDCQPIVEKRYPEVRNALSLLNKFVPASMTGTGACVFGS
FPNEGEADKVRRQLPDTLPSFVARGRNVSMLHRCLEKLAQEVSA

Sequences:

>Translated_284_residues
MLTLPAPAKLNLMLHIVGRRADGYHELQTLFQFLDHGDELSFSPREDGEIRLHTELPGVDHDSNLIVRAARLLQHESGCP
QGADIHLLKRLPMGGGIGGGSSDAATALLGLNHLWQLHLEEDQLAELGLTLGADVPVFVRGRAAFAEGVGERLQPVELPE
PWFLVIAPQVSVSTAEIFADPELTRNTPAITVRSLLAGGGHNDCQPIVEKRYPEVRNALSLLNKFVPASMTGTGACVFGS
FPNEGEADKVRRQLPDTLPSFVARGRNVSMLHRCLEKLAQEVSA
>Mature_284_residues
MLTLPAPAKLNLMLHIVGRRADGYHELQTLFQFLDHGDELSFSPREDGEIRLHTELPGVDHDSNLIVRAARLLQHESGCP
QGADIHLLKRLPMGGGIGGGSSDAATALLGLNHLWQLHLEEDQLAELGLTLGADVPVFVRGRAAFAEGVGERLQPVELPE
PWFLVIAPQVSVSTAEIFADPELTRNTPAITVRSLLAGGGHNDCQPIVEKRYPEVRNALSLLNKFVPASMTGTGACVFGS
FPNEGEADKVRRQLPDTLPSFVARGRNVSMLHRCLEKLAQEVSA

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=277, Percent_Identity=58.8447653429603, Blast_Score=302, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_PSEU5 (A4VPC3)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001173666.1
- ProteinModelPortal:   A4VPC3
- SMR:   A4VPC3
- STRING:   A4VPC3
- GeneID:   5096147
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3186
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- PhylomeDB:   A4VPC3
- ProtClustDB:   PRK00343
- BioCyc:   PSTU379731:PST_3186-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 30803; Mature: 30803

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: ACT_SITE 9-9 ACT_SITE 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLPAPAKLNLMLHIVGRRADGYHELQTLFQFLDHGDELSFSPREDGEIRLHTELPGVD
CCCCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCC
HDSNLIVRAARLLQHESGCPQGADIHLLKRLPMGGGIGGGSSDAATALLGLNHLWQLHLE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHEEECC
EDQLAELGLTLGADVPVFVRGRAAFAEGVGERLQPVELPEPWFLVIAPQVSVSTAEIFAD
HHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCC
PELTRNTPAITVRSLLAGGGHNDCQPIVEKRYPEVRNALSLLNKFVPASMTGTGACVFGS
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECC
FPNEGEADKVRRQLPDTLPSFVARGRNVSMLHRCLEKLAQEVSA
CCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTLPAPAKLNLMLHIVGRRADGYHELQTLFQFLDHGDELSFSPREDGEIRLHTELPGVD
CCCCCCCCHHEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCC
HDSNLIVRAARLLQHESGCPQGADIHLLKRLPMGGGIGGGSSDAATALLGLNHLWQLHLE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHEEECC
EDQLAELGLTLGADVPVFVRGRAAFAEGVGERLQPVELPEPWFLVIAPQVSVSTAEIFAD
HHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHCC
PELTRNTPAITVRSLLAGGGHNDCQPIVEKRYPEVRNALSLLNKFVPASMTGTGACVFGS
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECC
FPNEGEADKVRRQLPDTLPSFVARGRNVSMLHRCLEKLAQEVSA
CCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA