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The map label for this gene is upp

Identifier: 146283502

GI number: 146283502

Start: 3422927

End: 3423565

Strand: Direct

Name: upp

Synonym: PST_3175

Alternate gene names: 146283502

Gene position: 3422927-3423565 (Clockwise)

Preceding gene: 146283497

Following gene: 146283503

Centisome position: 74.94

GC content: 58.84

Gene sequence:

>639_bases
ATGCCCATTCGAGAGATCCGCCATCCGCTGATCCGTCACAAGCTCGGTCTGATGCGCCGCGCCGATATCAGCACCAAGAA
CTTCCGCGAACTGGCTCAGGAAGTGGGCTCGATCCTCACTTATGAGGCGACCTCGGATCTGCCGCTGGAACATTACAACA
TCGACGGCTGGTGCGGCCCGGTGCAAGTGGAGAAGATTTCCGGCAAGAAGATCACCGTCGTACCTATTCTGCGTGCAGGT
ATCGGCATGCTGGACGGCGTTCTCAGCCTCATCCCCGGCGCCAAGGTCAGTGCCGTCGGCATCGCACGCAACGAGGAAAC
CTTCAAGGCACAAACGTACCTGGAAAAGCTGGTACCTGAGATCGAGCAACGTCTGGCGATCATCATTGACCCCATGCTAG
CCACTGGCGGTTCGATGGTCGCCACCATCGACATGCTGAAGAAAGCCGGCTGCAAGGAGATCCGTGCACTGGTTCTGGTG
GCAGCGCCGGAAGGCATTGCCGCAGTGGAAGCAGCTCACCCGGACGTACTCATTCTGACCGCCTCCATCGACGAGCGTCT
CGACGAGCACGGATACATCGTTCCAGGCCTGGGCGATGCAGGCGACAAGATCTTCGGCACCAAACAGAAGGACATCTGA

Upstream 100 bases:

>100_bases
CGTCGGCTGCAGCAAGTCTGCCGACCGAATGACACGCGAATAGCCGCTGACTCGGCGATGCTTTAATCTAAGCCGGTTTA
TTTGCCCGCCGGAGCCCATA

Downstream 100 bases:

>100_bases
GCATGTCGCACACGGATGAGCCGCTTGGCCAACAGGTACTGGCCGGGGCGCAGATGCTATTTGTCGCCTTCGGCGCACTG
GTACTGATGCCGCTGATTAC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGSILTYEATSDLPLEHYNIDGWCGPVQVEKISGKKITVVPILRAG
IGMLDGVLSLIPGAKVSAVGIARNEETFKAQTYLEKLVPEIEQRLAIIIDPMLATGGSMVATIDMLKKAGCKEIRALVLV
AAPEGIAAVEAAHPDVLILTASIDERLDEHGYIVPGLGDAGDKIFGTKQKDI

Sequences:

>Translated_212_residues
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGSILTYEATSDLPLEHYNIDGWCGPVQVEKISGKKITVVPILRAG
IGMLDGVLSLIPGAKVSAVGIARNEETFKAQTYLEKLVPEIEQRLAIIIDPMLATGGSMVATIDMLKKAGCKEIRALVLV
AAPEGIAAVEAAHPDVLILTASIDERLDEHGYIVPGLGDAGDKIFGTKQKDI
>Mature_211_residues
PIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGSILTYEATSDLPLEHYNIDGWCGPVQVEKISGKKITVVPILRAGI
GMLDGVLSLIPGAKVSAVGIARNEETFKAQTYLEKLVPEIEQRLAIIIDPMLATGGSMVATIDMLKKAGCKEIRALVLVA
APEGIAAVEAAHPDVLILTASIDERLDEHGYIVPGLGDAGDKIFGTKQKDI

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=27.7227722772277, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=27.7227722772277, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=68.75, Blast_Score=304, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=26.865671641791, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=26.865671641791, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=203, Percent_Identity=33.9901477832512, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_PSEU5 (A4VPB2)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001173655.1
- ProteinModelPortal:   A4VPB2
- SMR:   A4VPB2
- STRING:   A4VPB2
- GeneID:   5096136
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3175
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   A4VPB2
- ProtClustDB:   PRK00129
- BioCyc:   PSTU379731:PST_3175-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22965; Mature: 22834

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGSILTYEATSDLPLEHYNIDGWCGP
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCEECCCCCCCCC
VQVEKISGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGIARNEETFKAQTYLEKLVPE
EEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
IEQRLAIIIDPMLATGGSMVATIDMLKKAGCKEIRALVLVAAPEGIAAVEAAHPDVLILT
HHHHHHHEECHHHHCCCCHHHHHHHHHHCCHHHHHEEEEEECCCCCEEHCCCCCCEEEEE
ASIDERLDEHGYIVPGLGDAGDKIFGTKQKDI
CCHHHHHHHCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGSILTYEATSDLPLEHYNIDGWCGP
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCEECCCCCCCCC
VQVEKISGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGIARNEETFKAQTYLEKLVPE
EEEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
IEQRLAIIIDPMLATGGSMVATIDMLKKAGCKEIRALVLVAAPEGIAAVEAAHPDVLILT
HHHHHHHEECHHHHCCCCHHHHHHHHHHCCHHHHHEEEEEECCCCCEEHCCCCCCEEEEE
ASIDERLDEHGYIVPGLGDAGDKIFGTKQKDI
CCHHHHHHHCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA