Click here to switch to the map view.

The map label for this gene is xdhB [H]

Identifier: 146283411

GI number: 146283411

Start: 3316170

End: 3318566

Strand: Direct

Name: xdhB [H]

Synonym: PST_3082

Alternate gene names: 146283411

Gene position: 3316170-3318566 (Clockwise)

Preceding gene: 146283410

Following gene: 146283412

Centisome position: 72.6

GC content: 65.25

Gene sequence:

>2397_bases
ATGTCTAACCACGTAACCACCCGCACTCAGGAAGAAATCGCGGCGCTGTTCACGCAGGACCTGGTCACCGGCGTCGGTCG
CAGCGTCAAGCACGACAGCGCGCCCAAGCATGTCTCGGGCGAGGCGGTGTACGTCGACGACCGGCTGGAGTTTCCCAATC
AGCTGCACGTCTATGCCCGCATGAGCGAGCGCGCCCACGCCCGCATCGTCAGCATCGATACCAGCCCCTGCTACCAGATT
CCGGGCGTGGCCATCGCCATCACGGCGAAGGACGTGCCGGGCCAGCTGGACATCGGTGCCGTGATGCCCGGCGACCCGCT
GCTGGCCGACGGCAAGGTCGAGTTCATCGGCCAGCCGGTGATCGCCGTGGCTGCCGACAGCCTGGAAACCGCACGCAAGG
CGGCGATGGCCGCGATCATCGAATACGAGGATCTGGAGCCGGTGCTCGACGTGGTCGAGGCGCTGCACAAGAAGCACTTC
GTGCTCGACAGCCACACCCACAAGCGCGGCGACTCGGCCACCGCCCTGGCCAGCGCGCCGCGTCGGCTGCAGGGTTCGCT
GCACATCGGCGGGCAGGAGCACTTCTACCTGGAGACACAGGTGTCCTCGGTCATGCCCACCGAAGACGGCGGCATGATCG
TCTATACCTCGACACAGAACCCCACCGAGGTGCAGAAGCTGGTGGCCGAAGTGCTCGGCGTACCGATGAACAAGATCGTC
ATCGACATGCGCCGCATGGGCGGCGGCTTCGGCGGCAAGGAAACCCAGGCCGCGGGACCTGCGTGCCTGTGCGCGGTGAT
CGCGCACCTCACCGGTCGGCCGACCAAGATGCGCCTGCCGCGCATGGAAGACATGACCATGACCGGCAAACGCCACCCCT
TCTACGTCGAGTACGACGTCGGCTTCGACGATGACGGTCTGCTGCACGGCATCGAGATCGATCTCGCCGGTAACTGCGGC
TACTCGCCGGACCTTTCCGGCTCGATCGTCGACCGCGCCATGTTCCATTCCGACAACGCCTACTACCTGGGCGACGCCAC
CATCAACGGCCATCGCTGCAAGACCAACCTCGCCTCGAACACCGCCTACCGCGGCTTCGGCGGCCCGCAGGGCATGGTCG
CCATCGAGGAGATCATGGACGCGGTGGCCCGCGAGCTGGGCAAGGACCCGCTCGAGGTGCGCAAGCGCAACTACTACGGC
AAGACCGAGCGCAACGTCACCCACTACTACCAGACCGTTGAGCACAACATGCTCGAGGAGATGACCGCCGAGCTGGAAGC
CAGCAGCGACTATGCAAAGCGACGCGAAGATATCCGCGCGTTCAATGCCAGGAGCCCGATCCTGAAGAAGGGCCTGGCGC
TGACGCCGGTGAAGTTCGGCATCAGCTTCACCGCCAGCTTCCTCAACCAGGCCGGCGCGCTGGTGCACGTCTACACCGAC
GGCAGCATCCACCTGAACCACGGTGGCACCGAGATGGGTCAGGGCCTGAACACCAAGGTCGCGCAGGTGGTGGCCGAGGT
GTTCCAGGTGGATATCGAACGTATCCAGATCACCGCCACCAACACCGACAAGGTGCCCAACACCTCGCCGACGGCAGCCT
CCAGCGGCGCCGACCTCAACGGCAAGGCGGCGCAGAATGCGGCGCAGACCATCAAGCAGCGGCTGGTGGAGTTCGCCGCA
CGCAAGTGGCAGATCTTCGAGGAAGACGTCGAATTCAAGAACGGCCAGGTGCGCCTGCGCGACCACTACATCAGCTTCGA
GGAGCTGATCCAGCAGGCCTATTTCGGCCAGGTCTCGCTGTCCTCCACCGGCTTCTACCGCACGCCGAAGATTTACTACG
ACCGCAGTCAGGCGCGCGGGCGGCCGTTCTACTACTTCGCCTACGGCGCGGCCTGCTCGGAAGTGATCGTCGATACCCTG
ACCGGCGAATACAGGATGCTGCGCAGCGACATCCTGCATGACGTGGGCGCCTCGCTGAACCCGGCCATCGACATCGGCCA
GGTCGAGGGCGGCTTCGTCCAGGGCCTGGGCTGGCTGACCATGGAAGAGCTGGTCTGGAACGACAAGGGCAAGCTGATGA
CCAACGGCCCGGCCAGCTACAAGATCCCGGCGGTGGCGGACATGCCGCTGGATCTTCGGGTCAGGCTGGTGGAGAACCGC
AAGAACCCCGAAGACACCGTGTTCCACTCCAAGGCCGTGGGCGAGCCGCCGTTCATGCTCGGCATCTCGGTCTGGTGCGC
GATCAAGGATGCGGTGGCGAGCCTGGCCGACTACCGGGCGCAGCCGCAGATCGATGCTCCGGCGACCCCCGAGCGCGTGC
TCTGGGGCGTGGAACAGATGCGCAGGTTGAAGCAGGCGGCGAGCAAGTCTGCGACAACGGAGACCACCCCGGCCTGA

Upstream 100 bases:

>100_bases
CGCGCCAGCCGCGAGTATCGCCTGCTGGTCGCACAGAACCTGCTGCGCAAGTGCTTCCTCGAACAACATGCACCGAAGAC
CGAGACGAGGGTGACCGCTT

Downstream 100 bases:

>100_bases
CGCAGGGTGGACAACGCTTTGCTTGTCCACCGTTAGCGCAACACGAACGTCCCGGTGGCGACGCCTTGCACGCGCCACCG
GGCGATACGAAGGACAGAAC

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MSNHVTTRTQEEIAALFTQDLVTGVGRSVKHDSAPKHVSGEAVYVDDRLEFPNQLHVYARMSERAHARIVSIDTSPCYQI
PGVAIAITAKDVPGQLDIGAVMPGDPLLADGKVEFIGQPVIAVAADSLETARKAAMAAIIEYEDLEPVLDVVEALHKKHF
VLDSHTHKRGDSATALASAPRRLQGSLHIGGQEHFYLETQVSSVMPTEDGGMIVYTSTQNPTEVQKLVAEVLGVPMNKIV
IDMRRMGGGFGGKETQAAGPACLCAVIAHLTGRPTKMRLPRMEDMTMTGKRHPFYVEYDVGFDDDGLLHGIEIDLAGNCG
YSPDLSGSIVDRAMFHSDNAYYLGDATINGHRCKTNLASNTAYRGFGGPQGMVAIEEIMDAVARELGKDPLEVRKRNYYG
KTERNVTHYYQTVEHNMLEEMTAELEASSDYAKRREDIRAFNARSPILKKGLALTPVKFGISFTASFLNQAGALVHVYTD
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGADLNGKAAQNAAQTIKQRLVEFAA
RKWQIFEEDVEFKNGQVRLRDHYISFEELIQQAYFGQVSLSSTGFYRTPKIYYDRSQARGRPFYYFAYGAACSEVIVDTL
TGEYRMLRSDILHDVGASLNPAIDIGQVEGGFVQGLGWLTMEELVWNDKGKLMTNGPASYKIPAVADMPLDLRVRLVENR
KNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRAQPQIDAPATPERVLWGVEQMRRLKQAASKSATTETTPA

Sequences:

>Translated_798_residues
MSNHVTTRTQEEIAALFTQDLVTGVGRSVKHDSAPKHVSGEAVYVDDRLEFPNQLHVYARMSERAHARIVSIDTSPCYQI
PGVAIAITAKDVPGQLDIGAVMPGDPLLADGKVEFIGQPVIAVAADSLETARKAAMAAIIEYEDLEPVLDVVEALHKKHF
VLDSHTHKRGDSATALASAPRRLQGSLHIGGQEHFYLETQVSSVMPTEDGGMIVYTSTQNPTEVQKLVAEVLGVPMNKIV
IDMRRMGGGFGGKETQAAGPACLCAVIAHLTGRPTKMRLPRMEDMTMTGKRHPFYVEYDVGFDDDGLLHGIEIDLAGNCG
YSPDLSGSIVDRAMFHSDNAYYLGDATINGHRCKTNLASNTAYRGFGGPQGMVAIEEIMDAVARELGKDPLEVRKRNYYG
KTERNVTHYYQTVEHNMLEEMTAELEASSDYAKRREDIRAFNARSPILKKGLALTPVKFGISFTASFLNQAGALVHVYTD
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGADLNGKAAQNAAQTIKQRLVEFAA
RKWQIFEEDVEFKNGQVRLRDHYISFEELIQQAYFGQVSLSSTGFYRTPKIYYDRSQARGRPFYYFAYGAACSEVIVDTL
TGEYRMLRSDILHDVGASLNPAIDIGQVEGGFVQGLGWLTMEELVWNDKGKLMTNGPASYKIPAVADMPLDLRVRLVENR
KNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRAQPQIDAPATPERVLWGVEQMRRLKQAASKSATTETTPA
>Mature_797_residues
SNHVTTRTQEEIAALFTQDLVTGVGRSVKHDSAPKHVSGEAVYVDDRLEFPNQLHVYARMSERAHARIVSIDTSPCYQIP
GVAIAITAKDVPGQLDIGAVMPGDPLLADGKVEFIGQPVIAVAADSLETARKAAMAAIIEYEDLEPVLDVVEALHKKHFV
LDSHTHKRGDSATALASAPRRLQGSLHIGGQEHFYLETQVSSVMPTEDGGMIVYTSTQNPTEVQKLVAEVLGVPMNKIVI
DMRRMGGGFGGKETQAAGPACLCAVIAHLTGRPTKMRLPRMEDMTMTGKRHPFYVEYDVGFDDDGLLHGIEIDLAGNCGY
SPDLSGSIVDRAMFHSDNAYYLGDATINGHRCKTNLASNTAYRGFGGPQGMVAIEEIMDAVARELGKDPLEVRKRNYYGK
TERNVTHYYQTVEHNMLEEMTAELEASSDYAKRREDIRAFNARSPILKKGLALTPVKFGISFTASFLNQAGALVHVYTDG
SIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGADLNGKAAQNAAQTIKQRLVEFAAR
KWQIFEEDVEFKNGQVRLRDHYISFEELIQQAYFGQVSLSSTGFYRTPKIYYDRSQARGRPFYYFAYGAACSEVIVDTLT
GEYRMLRSDILHDVGASLNPAIDIGQVEGGFVQGLGWLTMEELVWNDKGKLMTNGPASYKIPAVADMPLDLRVRLVENRK
NPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRAQPQIDAPATPERVLWGVEQMRRLKQAASKSATTETTPA

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=756, Percent_Identity=45.5026455026455, Blast_Score=645, Evalue=0.0,
Organism=Homo sapiens, GI71773480, Length=759, Percent_Identity=38.6034255599473, Blast_Score=511, Evalue=1e-144,
Organism=Escherichia coli, GI1789246, Length=848, Percent_Identity=26.6509433962264, Blast_Score=222, Evalue=9e-59,
Organism=Escherichia coli, GI1789230, Length=750, Percent_Identity=27.7333333333333, Blast_Score=219, Evalue=8e-58,
Organism=Escherichia coli, GI1786478, Length=767, Percent_Identity=25.5541069100391, Blast_Score=125, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17540638, Length=771, Percent_Identity=40.7263294422827, Blast_Score=543, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI32566215, Length=716, Percent_Identity=33.7988826815642, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539860, Length=755, Percent_Identity=34.4370860927152, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI17737937, Length=762, Percent_Identity=40.8136482939633, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24647193, Length=761, Percent_Identity=32.0630749014455, Blast_Score=319, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24647199, Length=757, Percent_Identity=30.9114927344782, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI24647201, Length=761, Percent_Identity=29.9605781865966, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24647195, Length=757, Percent_Identity=29.5904887714663, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24647197, Length=757, Percent_Identity=29.5904887714663, Blast_Score=285, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 87538; Mature: 87407

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHVTTRTQEEIAALFTQDLVTGVGRSVKHDSAPKHVSGEAVYVDDRLEFPNQLHVYAR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEE
MSERAHARIVSIDTSPCYQIPGVAIAITAKDVPGQLDIGAVMPGDPLLADGKVEFIGQPV
CCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCEECEECCCCCCEECCEEEECCCCE
IAVAADSLETARKAAMAAIIEYEDLEPVLDVVEALHKKHFVLDSHTHKRGDSATALASAP
EEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHHHCC
RRLQGSLHIGGQEHFYLETQVSSVMPTEDGGMIVYTSTQNPTEVQKLVAEVLGVPMNKIV
HHHCCCEEECCCCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHH
IDMRRMGGGFGGKETQAAGPACLCAVIAHLTGRPTKMRLPRMEDMTMTGKRHPFYVEYDV
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCEECCCCCCEEEEEEC
GFDDDGLLHGIEIDLAGNCGYSPDLSGSIVDRAMFHSDNAYYLGDATINGHRCKTNLASN
CCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEECCEECCCEEECCCCCC
TAYRGFGGPQGMVAIEEIMDAVARELGKDPLEVRKRNYYGKTERNVTHYYQTVEHNMLEE
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MTAELEASSDYAKRREDIRAFNARSPILKKGLALTPVKFGISFTASFLNQAGALVHVYTD
HHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCEECCHHHHHHHHHHHHHCCCCEEEEEEC
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGADLN
CEEEECCCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCC
GKAAQNAAQTIKQRLVEFAARKWQIFEEDVEFKNGQVRLRDHYISFEELIQQAYFGQVSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEE
SSTGFYRTPKIYYDRSQARGRPFYYFAYGAACSEVIVDTLTGEYRMLRSDILHDVGASLN
CCCCCEECCEEEEECHHCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
PAIDIGQVEGGFVQGLGWLTMEELVWNDKGKLMTNGPASYKIPAVADMPLDLRVRLVENR
CCEEECCCCCCHHHCCHHHHHHHHHCCCCCCEEECCCCCEECCEEECCCCCEEEEEECCC
KNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRAQPQIDAPATPERVLWGVEQM
CCCHHHHEEHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RRLKQAASKSATTETTPA
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNHVTTRTQEEIAALFTQDLVTGVGRSVKHDSAPKHVSGEAVYVDDRLEFPNQLHVYAR
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEE
MSERAHARIVSIDTSPCYQIPGVAIAITAKDVPGQLDIGAVMPGDPLLADGKVEFIGQPV
CCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCEECEECCCCCCEECCEEEECCCCE
IAVAADSLETARKAAMAAIIEYEDLEPVLDVVEALHKKHFVLDSHTHKRGDSATALASAP
EEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHHHCC
RRLQGSLHIGGQEHFYLETQVSSVMPTEDGGMIVYTSTQNPTEVQKLVAEVLGVPMNKIV
HHHCCCEEECCCCEEEEEEEHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHH
IDMRRMGGGFGGKETQAAGPACLCAVIAHLTGRPTKMRLPRMEDMTMTGKRHPFYVEYDV
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCEECCCCCCEEEEEEC
GFDDDGLLHGIEIDLAGNCGYSPDLSGSIVDRAMFHSDNAYYLGDATINGHRCKTNLASN
CCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEECCEECCCEEECCCCCC
TAYRGFGGPQGMVAIEEIMDAVARELGKDPLEVRKRNYYGKTERNVTHYYQTVEHNMLEE
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MTAELEASSDYAKRREDIRAFNARSPILKKGLALTPVKFGISFTASFLNQAGALVHVYTD
HHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCEECCHHHHHHHHHHHHHCCCCEEEEEEC
GSIHLNHGGTEMGQGLNTKVAQVVAEVFQVDIERIQITATNTDKVPNTSPTAASSGADLN
CEEEECCCCHHHCCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCC
GKAAQNAAQTIKQRLVEFAARKWQIFEEDVEFKNGQVRLRDHYISFEELIQQAYFGQVSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEE
SSTGFYRTPKIYYDRSQARGRPFYYFAYGAACSEVIVDTLTGEYRMLRSDILHDVGASLN
CCCCCEECCEEEEECHHCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
PAIDIGQVEGGFVQGLGWLTMEELVWNDKGKLMTNGPASYKIPAVADMPLDLRVRLVENR
CCEEECCCCCCHHHCCHHHHHHHHHCCCCCCEEECCCCCEECCEEECCCCCEEEEEECCC
KNPEDTVFHSKAVGEPPFMLGISVWCAIKDAVASLADYRAQPQIDAPATPERVLWGVEQM
CCCHHHHEEHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RRLKQAASKSATTETTPA
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]