Click here to switch to the map view.

The map label for this gene is xdhA [H]

Identifier: 146283410

GI number: 146283410

Start: 3314876

End: 3316177

Strand: Direct

Name: xdhA [H]

Synonym: PST_3081

Alternate gene names: 146283410

Gene position: 3314876-3316177 (Clockwise)

Preceding gene: 146283409

Following gene: 146283411

Centisome position: 72.58

GC content: 66.44

Gene sequence:

>1302_bases
GTGGTCGGCGAACTGGTGGGCGAGCGCCTGCGCTATCGCACCCTCAACTCGTGCCTGACCTTCGTCTCCGCCCTGCACGG
CAAGCAGCTGATCAGCGTCGAAGACCTCAAGGACCAGGGCCGGCTGCACAGCGTCCAGCAGGCGATGGTCGACTGCCACG
GCTCGCAGTGCGGCTTCTGTACCCCCGGATTCGTCATGAGCCTGTTCGCCCTGCAGAAGAACGCCGGCGCGGTCAATGAA
TACGATCCGCACCAGGCCCACGAAGCCCTGGCCGGCAACCTCTGCCGCTGCACCGGCTACCGGCCGATCCTCGAAGCCGC
CGAACAGGCCTGCTGTGCCAAGCAGCCGGACCAGTTCGATGCCCGCGAAGCCGAGACCATCGCCCAGCTCAAGGCCATCG
CCCCGCGTGAAATGGCCGAGCTCAGCGACGGCGAAAAGCGTTGCCTGTCGCCGCTGACCGTCGCCGAACTGGCCGAGGTC
TACGCCGCCAATCCCGATGCACGTCTGCTTGCCGGTGGCACCGACCTGGCCCTGGAGGTCACCCAGTTCCATCGCGAGCT
GCCGGTGATGATCCATGTCGGTCAGATCACCGAGATGAAGCAGGTCCAGACCGCGGACCGCCATATCGAGATTGGTGCAG
CCGCCCCGCTGACCGACTGTTACGCCGCGCTGGCCGCCGAGTACCCGGATTTCGGCGAGCTGCTGCAGCGCTTCGCCTCG
CTGCAGATCCGCAACCAGGGCACGCTCGGTGGCAACATCGGCAACGCCTCGCCGATCGGCGACTCGCCGCCGCTGCTGAT
CGCTCTGGGTGCCGACGTTGTCCTGCGCAAGGGCGTCAACAGCCGCACCCTGCCGCTCGAGGATTACTTCATCGACTACA
AGGTCACCGCGCGCCAGCCCGGGGAATTCATCGAGAAGGTACGAGTGCCGCGCGCCACACCGGATCGCCTGTTCCGCGCC
TACAAGGTTTCCAAGCGACTGGACGACGACATCTCCGCTGTCTGCGCCGCGTTCGACCTGCAGATCACCGATGGCGTGGT
CGCCGATGCCCGGGTCGCCTTTGGCGGCATGGCGGCGATTCCCAAGCGCGCCGCGGCCTGCGAGGCGACCCTGAACGGCG
CGCCCTGGAACCAGCAGACCGTGGAGGCGGCCTGCGATGCACTGGCCGAAGACTTCACGCCGCTGACCGACTTCCGCGCC
AGCCGCGAGTATCGCCTGCTGGTCGCACAGAACCTGCTGCGCAAGTGCTTCCTCGAACAACATGCACCGAAGACCGAGAC
GAGGGTGACCGCTTATGTCTAA

Upstream 100 bases:

>100_bases
CGATCCCAATACCACGGTGCTGCAGTATCTGCGCGAGTATCGTGGCAAGACCGGAACCAAGGAGGGCTGCGCCTCCGGTG
ACTGTGGTGCCTGTACCGTG

Downstream 100 bases:

>100_bases
CCACGTAACCACCCGCACTCAGGAAGAAATCGCGGCGCTGTTCACGCAGGACCTGGTCACCGGCGTCGGTCGCAGCGTCA
AGCACGACAGCGCGCCCAAG

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MVGELVGERLRYRTLNSCLTFVSALHGKQLISVEDLKDQGRLHSVQQAMVDCHGSQCGFCTPGFVMSLFALQKNAGAVNE
YDPHQAHEALAGNLCRCTGYRPILEAAEQACCAKQPDQFDAREAETIAQLKAIAPREMAELSDGEKRCLSPLTVAELAEV
YAANPDARLLAGGTDLALEVTQFHRELPVMIHVGQITEMKQVQTADRHIEIGAAAPLTDCYAALAAEYPDFGELLQRFAS
LQIRNQGTLGGNIGNASPIGDSPPLLIALGADVVLRKGVNSRTLPLEDYFIDYKVTARQPGEFIEKVRVPRATPDRLFRA
YKVSKRLDDDISAVCAAFDLQITDGVVADARVAFGGMAAIPKRAAACEATLNGAPWNQQTVEAACDALAEDFTPLTDFRA
SREYRLLVAQNLLRKCFLEQHAPKTETRVTAYV

Sequences:

>Translated_433_residues
MVGELVGERLRYRTLNSCLTFVSALHGKQLISVEDLKDQGRLHSVQQAMVDCHGSQCGFCTPGFVMSLFALQKNAGAVNE
YDPHQAHEALAGNLCRCTGYRPILEAAEQACCAKQPDQFDAREAETIAQLKAIAPREMAELSDGEKRCLSPLTVAELAEV
YAANPDARLLAGGTDLALEVTQFHRELPVMIHVGQITEMKQVQTADRHIEIGAAAPLTDCYAALAAEYPDFGELLQRFAS
LQIRNQGTLGGNIGNASPIGDSPPLLIALGADVVLRKGVNSRTLPLEDYFIDYKVTARQPGEFIEKVRVPRATPDRLFRA
YKVSKRLDDDISAVCAAFDLQITDGVVADARVAFGGMAAIPKRAAACEATLNGAPWNQQTVEAACDALAEDFTPLTDFRA
SREYRLLVAQNLLRKCFLEQHAPKTETRVTAYV
>Mature_433_residues
MVGELVGERLRYRTLNSCLTFVSALHGKQLISVEDLKDQGRLHSVQQAMVDCHGSQCGFCTPGFVMSLFALQKNAGAVNE
YDPHQAHEALAGNLCRCTGYRPILEAAEQACCAKQPDQFDAREAETIAQLKAIAPREMAELSDGEKRCLSPLTVAELAEV
YAANPDARLLAGGTDLALEVTQFHRELPVMIHVGQITEMKQVQTADRHIEIGAAAPLTDCYAALAAEYPDFGELLQRFAS
LQIRNQGTLGGNIGNASPIGDSPPLLIALGADVVLRKGVNSRTLPLEDYFIDYKVTARQPGEFIEKVRVPRATPDRLFRA
YKVSKRLDDDISAVCAAFDLQITDGVVADARVAFGGMAAIPKRAAACEATLNGAPWNQQTVEAACDALAEDFTPLTDFRA
SREYRLLVAQNLLRKCFLEQHAPKTETRVTAYV

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=434, Percent_Identity=29.0322580645161, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI71773480, Length=474, Percent_Identity=27.4261603375527, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1789231, Length=273, Percent_Identity=28.2051282051282, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789232, Length=93, Percent_Identity=39.7849462365591, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540638, Length=489, Percent_Identity=29.4478527607362, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566215, Length=97, Percent_Identity=45.360824742268, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539860, Length=97, Percent_Identity=44.3298969072165, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737937, Length=436, Percent_Identity=32.3394495412844, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24647197, Length=456, Percent_Identity=30.0438596491228, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24647201, Length=446, Percent_Identity=27.1300448430493, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24647199, Length=455, Percent_Identity=28.3516483516484, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24647195, Length=271, Percent_Identity=31.3653136531365, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24647193, Length=465, Percent_Identity=27.3118279569892, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 47192; Mature: 47192

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGELVGERLRYRTLNSCLTFVSALHGKQLISVEDLKDQGRLHSVQQAMVDCHGSQCGFC
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPGFVMSLFALQKNAGAVNEYDPHQAHEALAGNLCRCTGYRPILEAAEQACCAKQPDQFD
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCCCCC
AREAETIAQLKAIAPREMAELSDGEKRCLSPLTVAELAEVYAANPDARLLAGGTDLALEV
HHHHHHHHHHHHHCHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHH
TQFHRELPVMIHVGQITEMKQVQTADRHIEIGAAAPLTDCYAALAAEYPDFGELLQRFAS
HHHHHCCCEEEEECCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHH
LQIRNQGTLGGNIGNASPIGDSPPLLIALGADVVLRKGVNSRTLPLEDYFIDYKVTARQP
HEECCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHCCCCCCCCCHHHEEEEEEEECCCC
GEFIEKVRVPRATPDRLFRAYKVSKRLDDDISAVCAAFDLQITDGVVADARVAFGGMAAI
HHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEECCCCHHHHHHHHCCHHHC
PKRAAACEATLNGAPWNQQTVEAACDALAEDFTPLTDFRASREYRLLVAQNLLRKCFLEQ
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
HAPKTETRVTAYV
CCCCCCCEEEECC
>Mature Secondary Structure
MVGELVGERLRYRTLNSCLTFVSALHGKQLISVEDLKDQGRLHSVQQAMVDCHGSQCGFC
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPGFVMSLFALQKNAGAVNEYDPHQAHEALAGNLCRCTGYRPILEAAEQACCAKQPDQFD
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCCCCC
AREAETIAQLKAIAPREMAELSDGEKRCLSPLTVAELAEVYAANPDARLLAGGTDLALEV
HHHHHHHHHHHHHCHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHH
TQFHRELPVMIHVGQITEMKQVQTADRHIEIGAAAPLTDCYAALAAEYPDFGELLQRFAS
HHHHHCCCEEEEECCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHH
LQIRNQGTLGGNIGNASPIGDSPPLLIALGADVVLRKGVNSRTLPLEDYFIDYKVTARQP
HEECCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHCCCCCCCCCHHHEEEEEEEECCCC
GEFIEKVRVPRATPDRLFRAYKVSKRLDDDISAVCAAFDLQITDGVVADARVAFGGMAAI
HHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEECCCCHHHHHHHHCCHHHC
PKRAAACEATLNGAPWNQQTVEAACDALAEDFTPLTDFRASREYRLLVAQNLLRKCFLEQ
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
HAPKTETRVTAYV
CCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]