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The map label for this gene is pepA

Identifier: 146283387

GI number: 146283387

Start: 3286777

End: 3288267

Strand: Direct

Name: pepA

Synonym: PST_3058

Alternate gene names: 146283387

Gene position: 3286777-3288267 (Clockwise)

Preceding gene: 146283384

Following gene: 146283388

Centisome position: 71.96

GC content: 66.13

Gene sequence:

>1491_bases
ATGGAATTTGTTGTCAAAAGCGCCAAAGCCTCCACCCAGAAGACCGCCACCCTGATCCTGCCGCTCGGCGAGAACTGCCA
GCTCGGCAGCGTCGCACAGAGCGTGGACAGCGCCAGCGCTGGCGCGCTCAGCACTGCGCTCAAGCGGGGCGACATCCAGG
GCAAGCCGGGACAGACGCTGCTGCTGCACGGCCTGCCGGGGCTCAAGGCCGAGCGGGTACTGCTGGTCGGCACCGGCAAG
GCGGATGAACTCGACAGCCGCCAATGGCGCAAGGTGGTCAATGCAGCGCTGGCGGTCATCAAGAATCTGGGTGGTGGCGA
TGCTGCTTTCGCCATGCAGGACGTGCAGGTCAAGGGGCGCGACAGCTATGCCCGCACACGCCTGCTGGTGGAGATCGTTG
CCGACGGCCAGTACGTGTTCGACCAATTCAAGAGCAAGAAGGCCGAACCGCGTGCACTGCAGAAGATCATCCTGCTCTGC
GACAAGGCCGAACAGGCCGGCGTCGAGCGTGCCGCCCGCGAGGCCTCGGCGATCGCCACCGGCATGGCCTTCACCCGCGA
CCTGGGCAACCTGCCGCCGAACGTCTGCCACCCGACCTTCCTCGCCGATCAGGCCCGGCAGCTGAGCAAGGCCTACAAGG
GTGTCAAGCTCGATGTGCTGGACGAGAAGAAACTGCGCGAACTCGGCGCCGGCGCGTTCCTCGCGGTATCCCAGGGCAGC
GACCAGCCGGGCTGCATCATCGTTCTGCAGTACAACGGCGGCAAAAAGGGCGACAAGCCCTACGCACTGGTCGGCAAGGG
CATTACCTTCGATACCGGCGGCATCAGCCTCAAGCCGGGCCTGGGCATGGACGAGATGAAGTACGACATGGGCGGCGGCG
CCAGCGTGCTCGGTACGCTCAAGGCCGTGCTCGAACTGCAGTTGCCGATCAACCTGGTCTGCCTGCTGGCCTGCGCCGAG
AACATGCCCAGCGGCGGCGCGACTCGCCCGGGTGACATCGTCACCACCATGAGCGGCCAGACCGTTGAGATCCTCAACAC
CGACGCCGAAGGCCGACTGGTGCTGTGCGACACCCTGACCTACGCCGAGCGCTTCGAGCCGCGAGCCGTGGTCGACGTGG
CCACCCTGACCGGCGCCTGCATCGTCGCGCTGGGCAGCAATACCTCGGGCCTGCTCGGCAACAACGACGAGCTCATCCAG
CAGCTGCTGCAGGCCGGCGAAAGCGCCGCCGACCGCGCCTGGCAATTGCCGCTGTTCGACGAGTATCAGGAGCAGCTGGA
CAGCCCCTTCGCCGACATCGCCAATATCGGCGGGCCCAAGGCCGGCACCATCACTGCCGCCTGCTTCCTCTCGCGCTTCA
CCAAGAAGTACCCCTGGGCCCACCTGGACATCGCCGGCACCGCCTGGACCAGTGGCGGCAAGGAAAAAGGCGCGACTGGC
CGTCCCGTGCCCCTGCTGACCCAGTATCTGCTGGACCGGATCAACGGATGA

Upstream 100 bases:

>100_bases
CTAGCGCAGTCGTCAAGTAACGACCGAACAGGCGAACCACCGGAAAATAAGCCCGGCATTATCCTGCAAACCCGACTCTT
TGTCTTGGGGACACCACGTC

Downstream 100 bases:

>100_bases
GCCCGATCACCGCGCGTGACAGCGGCCGACACGGCCCCGCGCCCGCCGGGCCGGCGGGCGCACGTCCATGACACGCATCG
AGTTCTACGTGCTGCCGGAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MEFVVKSAKASTQKTATLILPLGENCQLGSVAQSVDSASAGALSTALKRGDIQGKPGQTLLLHGLPGLKAERVLLVGTGK
ADELDSRQWRKVVNAALAVIKNLGGGDAAFAMQDVQVKGRDSYARTRLLVEIVADGQYVFDQFKSKKAEPRALQKIILLC
DKAEQAGVERAAREASAIATGMAFTRDLGNLPPNVCHPTFLADQARQLSKAYKGVKLDVLDEKKLRELGAGAFLAVSQGS
DQPGCIIVLQYNGGKKGDKPYALVGKGITFDTGGISLKPGLGMDEMKYDMGGGASVLGTLKAVLELQLPINLVCLLACAE
NMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFEPRAVVDVATLTGACIVALGSNTSGLLGNNDELIQ
QLLQAGESAADRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKKYPWAHLDIAGTAWTSGGKEKGATG
RPVPLLTQYLLDRING

Sequences:

>Translated_496_residues
MEFVVKSAKASTQKTATLILPLGENCQLGSVAQSVDSASAGALSTALKRGDIQGKPGQTLLLHGLPGLKAERVLLVGTGK
ADELDSRQWRKVVNAALAVIKNLGGGDAAFAMQDVQVKGRDSYARTRLLVEIVADGQYVFDQFKSKKAEPRALQKIILLC
DKAEQAGVERAAREASAIATGMAFTRDLGNLPPNVCHPTFLADQARQLSKAYKGVKLDVLDEKKLRELGAGAFLAVSQGS
DQPGCIIVLQYNGGKKGDKPYALVGKGITFDTGGISLKPGLGMDEMKYDMGGGASVLGTLKAVLELQLPINLVCLLACAE
NMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFEPRAVVDVATLTGACIVALGSNTSGLLGNNDELIQ
QLLQAGESAADRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKKYPWAHLDIAGTAWTSGGKEKGATG
RPVPLLTQYLLDRING
>Mature_496_residues
MEFVVKSAKASTQKTATLILPLGENCQLGSVAQSVDSASAGALSTALKRGDIQGKPGQTLLLHGLPGLKAERVLLVGTGK
ADELDSRQWRKVVNAALAVIKNLGGGDAAFAMQDVQVKGRDSYARTRLLVEIVADGQYVFDQFKSKKAEPRALQKIILLC
DKAEQAGVERAAREASAIATGMAFTRDLGNLPPNVCHPTFLADQARQLSKAYKGVKLDVLDEKKLRELGAGAFLAVSQGS
DQPGCIIVLQYNGGKKGDKPYALVGKGITFDTGGISLKPGLGMDEMKYDMGGGASVLGTLKAVLELQLPINLVCLLACAE
NMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFEPRAVVDVATLTGACIVALGSNTSGLLGNNDELIQ
QLLQAGESAADRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKKYPWAHLDIAGTAWTSGGKEKGATG
RPVPLLTQYLLDRING

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=482, Percent_Identity=35.6846473029046, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI47155554, Length=259, Percent_Identity=35.1351351351351, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1790710, Length=497, Percent_Identity=53.7223340040241, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI87082123, Length=292, Percent_Identity=40.0684931506849, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=341, Percent_Identity=32.5513196480938, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=215, Percent_Identity=33.0232558139535, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI20129969, Length=361, Percent_Identity=33.5180055401662, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI161077148, Length=474, Percent_Identity=29.535864978903, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI20130057, Length=474, Percent_Identity=29.535864978903, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24662227, Length=354, Percent_Identity=33.0508474576271, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21355725, Length=498, Percent_Identity=28.9156626506024, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24661038, Length=323, Percent_Identity=33.7461300309598, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21355645, Length=323, Percent_Identity=32.5077399380805, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24662223, Length=323, Percent_Identity=32.5077399380805, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19922386, Length=316, Percent_Identity=33.8607594936709, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI20129963, Length=322, Percent_Identity=32.6086956521739, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21357381, Length=275, Percent_Identity=38.1818181818182, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379063, Length=275, Percent_Identity=38.1818181818182, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221379062, Length=275, Percent_Identity=38.1818181818182, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646701, Length=235, Percent_Identity=29.3617021276596, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646703, Length=235, Percent_Identity=29.3617021276596, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358201, Length=235, Percent_Identity=29.3617021276596, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_PSEU5 (A4VNZ7)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001173540.1
- ProteinModelPortal:   A4VNZ7
- SMR:   A4VNZ7
- STRING:   A4VNZ7
- MEROPS:   M17.003
- GeneID:   5096020
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3058
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHNSG
- PhylomeDB:   A4VNZ7
- ProtClustDB:   PRK00913
- BioCyc:   PSTU379731:PST_3058-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52392; Mature: 52392

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 278-278 ACT_SITE 352-352

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFVVKSAKASTQKTATLILPLGENCQLGSVAQSVDSASAGALSTALKRGDIQGKPGQTL
CCCEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEE
LLHGLPGLKAERVLLVGTGKADELDSRQWRKVVNAALAVIKNLGGGDAAFAMQDVQVKGR
EEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEEECCC
DSYARTRLLVEIVADGQYVFDQFKSKKAEPRALQKIILLCDKAEQAGVERAAREASAIAT
CHHHHHHEEEHHECCCHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GMAFTRDLGNLPPNVCHPTFLADQARQLSKAYKGVKLDVLDEKKLRELGAGAFLAVSQGS
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCEEEEEECCC
DQPGCIIVLQYNGGKKGDKPYALVGKGITFDTGGISLKPGLGMDEMKYDMGGGASVLGTL
CCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCHHHHHHH
KAVLELQLPINLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLT
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEECHH
YAERFEPRAVVDVATLTGACIVALGSNTSGLLGNNDELIQQLLQAGESAADRAWQLPLFD
HHHHCCCCCEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHCEECCCCHH
EYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKKYPWAHLDIAGTAWTSGGKEKGATG
HHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCCCCC
RPVPLLTQYLLDRING
CCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFVVKSAKASTQKTATLILPLGENCQLGSVAQSVDSASAGALSTALKRGDIQGKPGQTL
CCCEECCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEE
LLHGLPGLKAERVLLVGTGKADELDSRQWRKVVNAALAVIKNLGGGDAAFAMQDVQVKGR
EEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEEECCC
DSYARTRLLVEIVADGQYVFDQFKSKKAEPRALQKIILLCDKAEQAGVERAAREASAIAT
CHHHHHHEEEHHECCCHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GMAFTRDLGNLPPNVCHPTFLADQARQLSKAYKGVKLDVLDEKKLRELGAGAFLAVSQGS
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHCCCEEEEEECCC
DQPGCIIVLQYNGGKKGDKPYALVGKGITFDTGGISLKPGLGMDEMKYDMGGGASVLGTL
CCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCHHHHHHH
KAVLELQLPINLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLT
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEECHH
YAERFEPRAVVDVATLTGACIVALGSNTSGLLGNNDELIQQLLQAGESAADRAWQLPLFD
HHHHCCCCCEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHCEECCCCHH
EYQEQLDSPFADIANIGGPKAGTITAACFLSRFTKKYPWAHLDIAGTAWTSGGKEKGATG
HHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCCCCC
RPVPLLTQYLLDRING
CCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA