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The map label for this gene is yahK [H]

Identifier: 146283347

GI number: 146283347

Start: 3250003

End: 3251058

Strand: Direct

Name: yahK [H]

Synonym: PST_3017

Alternate gene names: 146283347

Gene position: 3250003-3251058 (Clockwise)

Preceding gene: 146283346

Following gene: 146283348

Centisome position: 71.16

GC content: 64.3

Gene sequence:

>1056_bases
ATGAGCCAGACCCTCGGTTACGCCGCCCTCGACCCGAACAGCCCGCTCGCACCCTATTCGTTTTCGCGCCGCGAGGTGGG
CCCGAATGACGTGAAGATCGACATCCTCTACTGCGGTGTCTGCCATTCGGACCTGCATACCGCACGCAACGAGTGGAACA
ACACGCTCTACCCATCCGTGCCCGGCCACGAGATCGTCGGCCGTGTGACGGCAGTCGGTTCAGCCGTGAGCGCATTCAAG
GTCGGCGACGTCGCCGGCGTCGGCTGCCTGGTCGACAGCTGCCGCACGTGCTCGTCCTGTGGCGAAGGGCTGGAGCAGTA
TTGCGAGAACGGTTTCGTCGGCACCTACAACGGTCCGGCGTTCGGCGGCGGCGAAAACACCCTCGGCGGCTACTCGGACA
ACATCGTGGTGGACGAGAAGTACGTGCTACGCATCAGCCACACCGACAACCTGGCCGCGGTCGCGCCGCTGCTCTGTGCC
GGCATCACCACCTACTCGCCGCTGCGCCAATGGAAGGTCGGCCCGGGACAGAAGGTCGGCGTGGTCGGCCTTGGCGGACT
CGGCCATATGGCGGTGAAGATCGCCAATGCCATGGGCGCGAAGGTCGTGCTGTTCACCACCTCGCCGGACAAGCGGGAAG
ATGCCCTGCGCCTCGGCGCCGCCGAAGTGGTGGTATCGAAGAACAAGGAGGAGATGGCGGCGCACGTCAACAGTTTCGAC
TTCATCCTCAACACCGTTGCCGCGCCGCATAACCTCGATGCGTTCGTGAACCTGCTCAAGCGCGACGCCACCATGACGCT
GGTCGGAGCACCAGCCGCGCCGCATCCGTCGCCCAGCGTGTTCGGCCTGATCTTCAAGCGCCGCCGCATCGCCGGCTCGT
TGATTGGCGGCATCGCCGAGACCCAGGAGATGCTCGACTTCTGCGCCGAGCACGGCATCGTCTCGGACATCGAGATGATC
CGCATGCAGGACATCAACGAAGCCTACGAGCGCATGCTCAAGAGCGACGTGAAGTACCGTTTCGTCATCGACATGGCCAC
CCTGAAGGCGGCCTGA

Upstream 100 bases:

>100_bases
CAGCAGAAACACGTAAGCCATCGGCAGGATTGTGCAAACGATGCCGATGCGCTCGCCATTAGGCTTGCGCTGTGCAACCC
CGATCATCAAAGGAGCCGTC

Downstream 100 bases:

>100_bases
TCGTTCGGCTGGCGAGCCCGCAGGCGCGCCAGCCCTTCCCTCTTTCATGCGCAGCCGCTAAGGTCGCCCGCCTTCGTCGT
GGAGGCGGCATGCGCTATCT

Product: oxidoreductase, zinc-binding

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSQTLGYAALDPNSPLAPYSFSRREVGPNDVKIDILYCGVCHSDLHTARNEWNNTLYPSVPGHEIVGRVTAVGSAVSAFK
VGDVAGVGCLVDSCRTCSSCGEGLEQYCENGFVGTYNGPAFGGGENTLGGYSDNIVVDEKYVLRISHTDNLAAVAPLLCA
GITTYSPLRQWKVGPGQKVGVVGLGGLGHMAVKIANAMGAKVVLFTTSPDKREDALRLGAAEVVVSKNKEEMAAHVNSFD
FILNTVAAPHNLDAFVNLLKRDATMTLVGAPAAPHPSPSVFGLIFKRRRIAGSLIGGIAETQEMLDFCAEHGIVSDIEMI
RMQDINEAYERMLKSDVKYRFVIDMATLKAA

Sequences:

>Translated_351_residues
MSQTLGYAALDPNSPLAPYSFSRREVGPNDVKIDILYCGVCHSDLHTARNEWNNTLYPSVPGHEIVGRVTAVGSAVSAFK
VGDVAGVGCLVDSCRTCSSCGEGLEQYCENGFVGTYNGPAFGGGENTLGGYSDNIVVDEKYVLRISHTDNLAAVAPLLCA
GITTYSPLRQWKVGPGQKVGVVGLGGLGHMAVKIANAMGAKVVLFTTSPDKREDALRLGAAEVVVSKNKEEMAAHVNSFD
FILNTVAAPHNLDAFVNLLKRDATMTLVGAPAAPHPSPSVFGLIFKRRRIAGSLIGGIAETQEMLDFCAEHGIVSDIEMI
RMQDINEAYERMLKSDVKYRFVIDMATLKAA
>Mature_350_residues
SQTLGYAALDPNSPLAPYSFSRREVGPNDVKIDILYCGVCHSDLHTARNEWNNTLYPSVPGHEIVGRVTAVGSAVSAFKV
GDVAGVGCLVDSCRTCSSCGEGLEQYCENGFVGTYNGPAFGGGENTLGGYSDNIVVDEKYVLRISHTDNLAAVAPLLCAG
ITTYSPLRQWKVGPGQKVGVVGLGGLGHMAVKIANAMGAKVVLFTTSPDKREDALRLGAAEVVVSKNKEEMAAHVNSFDF
ILNTVAAPHNLDAFVNLLKRDATMTLVGAPAAPHPSPSVFGLIFKRRRIAGSLIGGIAETQEMLDFCAEHGIVSDIEMIR
MQDINEAYERMLKSDVKYRFVIDMATLKAA

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI71743840, Length=355, Percent_Identity=24.2253521126761, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI34577061, Length=362, Percent_Identity=26.5193370165746, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=24.2253521126761, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501939, Length=350, Percent_Identity=24.8571428571429, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI156523966, Length=350, Percent_Identity=24.8571428571429, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=25.0696378830084, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786518, Length=341, Percent_Identity=69.7947214076246, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI87082401, Length=345, Percent_Identity=33.9130434782609, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=27.7955271565495, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=286, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI226510992, Length=260, Percent_Identity=28.0769230769231, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788407, Length=278, Percent_Identity=26.6187050359712, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=28.5294117647059, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71988145, Length=322, Percent_Identity=27.639751552795, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=341, Percent_Identity=26.9794721407625, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI25146526, Length=234, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=236, Percent_Identity=30.9322033898305, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=212, Percent_Identity=31.1320754716981, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=321, Percent_Identity=36.4485981308411, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323961, Length=327, Percent_Identity=33.6391437308869, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=33.2326283987915, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=33.134328358209, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=31.437125748503, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324486, Length=326, Percent_Identity=32.2085889570552, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=25.6, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319258, Length=320, Percent_Identity=24.6875, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319257, Length=221, Percent_Identity=26.6968325791855, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=24.7282608695652, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37486; Mature: 37355

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTLGYAALDPNSPLAPYSFSRREVGPNDVKIDILYCGVCHSDLHTARNEWNNTLYPSV
CCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCCC
PGHEIVGRVTAVGSAVSAFKVGDVAGVGCLVDSCRTCSSCGEGLEQYCENGFVGTYNGPA
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
FGGGENTLGGYSDNIVVDEKYVLRISHTDNLAAVAPLLCAGITTYSPLRQWKVGPGQKVG
CCCCCCCCCCCCCCEEECCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEE
VVGLGGLGHMAVKIANAMGAKVVLFTTSPDKREDALRLGAAEVVVSKNKEEMAAHVNSFD
EEEECCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCHHHHEEECCHHHHHHHHHHHH
FILNTVAAPHNLDAFVNLLKRDATMTLVGAPAAPHPSPSVFGLIFKRRRIAGSLIGGIAE
HHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCAEHGIVSDIEMIRMQDINEAYERMLKSDVKYRFVIDMATLKAA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCC
>Mature Secondary Structure 
SQTLGYAALDPNSPLAPYSFSRREVGPNDVKIDILYCGVCHSDLHTARNEWNNTLYPSV
CCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCCC
PGHEIVGRVTAVGSAVSAFKVGDVAGVGCLVDSCRTCSSCGEGLEQYCENGFVGTYNGPA
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCC
FGGGENTLGGYSDNIVVDEKYVLRISHTDNLAAVAPLLCAGITTYSPLRQWKVGPGQKVG
CCCCCCCCCCCCCCEEECCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCEEE
VVGLGGLGHMAVKIANAMGAKVVLFTTSPDKREDALRLGAAEVVVSKNKEEMAAHVNSFD
EEEECCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCHHHHEEECCHHHHHHHHHHHH
FILNTVAAPHNLDAFVNLLKRDATMTLVGAPAAPHPSPSVFGLIFKRRRIAGSLIGGIAE
HHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCAEHGIVSDIEMIRMQDINEAYERMLKSDVKYRFVIDMATLKAA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]