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The map label for this gene is rnz [H]

Identifier: 146283279

GI number: 146283279

Start: 3169531

End: 3170544

Strand: Direct

Name: rnz [H]

Synonym: PST_2944

Alternate gene names: 146283279

Gene position: 3169531-3170544 (Clockwise)

Preceding gene: 146283278

Following gene: 146283280

Centisome position: 69.39

GC content: 69.33

Gene sequence:

>1014_bases
ATGCCCGTGGACCTGCTCTTTCTCGGTACCTCGTCCGGCACCCCGACCCGCGCGCGCAACGTCAGCGCGCTGGCACTGCT
GGAAGAGACCGGCAAGGCCTGGTACCTGATCGACTGCGGCGAGGGCACCCAGCATCGCCTGCTGCGCACGCCGCTGTCGC
TGCACGACCTGCGCGCGATCTGCATCACCCATGTGCATGGCGACCACTGCTACGGCCTGCCCGGCCTGCTGGCCAGCGCA
GGCATGATGGGGCGCAAGGCACCGCTGACGATCATCGCCCCGCAGGGCATCGAGACCTGGGTACGCGCCACCCTGAGCAT
GAGTCAGAGCTGGCTGAGCTACGAGCTGGACTTCCATGCGGTCGAGACATTGGACGAATGGCGCAGCCCGAACATGCGCA
TCGAGGCGACCGAGCTGTCCCATCGCGTGCCCTGCTACGGCTACAGCTTCAGCGAGGCGCGCCCCGATCCGCGGCTTGAC
ATCGAACGTCTGGAACATGACGGTGTGCCGCGCGGCCCGCTCTGGGGCCAGCTGGCGCGCGGCTTCGACATCGAGCACGA
GGGGCGCGTGCTGCGCAGCCACGACTACCTGAGCTTCAGCCGCAGCCCGCGGCGCATCGTCGTCGGGGGCGACAACGACC
GTCCCGACCTGCTGGCCGAAGCCTGCCGCGATGCCCAGCTGCTGGTGCACGAGGCGACCTACACCGAGGCCGTGGCCAAC
GACGCCCGCAACGACTTCGGCCACAGCACGGCCGCCACCGTGGCGCGCTTCGCCCAGGCGGTCGGTTTGCCCAACCTGGT
GCTGACCCACTTCAGCGCGCGCTATCAGAAGCACGTCGGCCGCGGCCATTCGATCGAGGACCTGCGCGCCGAAGCCGCTG
CGCTCTACGCCGGCCAGCTGCTGCTCGCCGAGGATTACCTGCGCCTGCATCTGGGCAAGGATGGTCTGCTGACGGTCGTC
GAACCGCCGTCCACTTCGCGCCCGCCGCGCCGCGACGGCGAATCCAGGGCCTGA

Upstream 100 bases:

>100_bases
CCGCTTCATCGACGAGCAGCTCGCCCGCAGCGCCTGAGGACGCAACCCCGGGACCGCTCCCCCGGTCGTACGGCATACTA
GCCAGCCCCCTCTGGAGAAC

Downstream 100 bases:

>100_bases
ACCGGTAAATCGTCAGCAACCGCACCGGTGCTGACATGGCTGTCTCCGCCCTGCCATCTTTCGCCCCACCGAAGGAGCCG
CCGATGGAACGTCTGACTGC

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MPVDLLFLGTSSGTPTRARNVSALALLEETGKAWYLIDCGEGTQHRLLRTPLSLHDLRAICITHVHGDHCYGLPGLLASA
GMMGRKAPLTIIAPQGIETWVRATLSMSQSWLSYELDFHAVETLDEWRSPNMRIEATELSHRVPCYGYSFSEARPDPRLD
IERLEHDGVPRGPLWGQLARGFDIEHEGRVLRSHDYLSFSRSPRRIVVGGDNDRPDLLAEACRDAQLLVHEATYTEAVAN
DARNDFGHSTAATVARFAQAVGLPNLVLTHFSARYQKHVGRGHSIEDLRAEAAALYAGQLLLAEDYLRLHLGKDGLLTVV
EPPSTSRPPRRDGESRA

Sequences:

>Translated_337_residues
MPVDLLFLGTSSGTPTRARNVSALALLEETGKAWYLIDCGEGTQHRLLRTPLSLHDLRAICITHVHGDHCYGLPGLLASA
GMMGRKAPLTIIAPQGIETWVRATLSMSQSWLSYELDFHAVETLDEWRSPNMRIEATELSHRVPCYGYSFSEARPDPRLD
IERLEHDGVPRGPLWGQLARGFDIEHEGRVLRSHDYLSFSRSPRRIVVGGDNDRPDLLAEACRDAQLLVHEATYTEAVAN
DARNDFGHSTAATVARFAQAVGLPNLVLTHFSARYQKHVGRGHSIEDLRAEAAALYAGQLLLAEDYLRLHLGKDGLLTVV
EPPSTSRPPRRDGESRA
>Mature_336_residues
PVDLLFLGTSSGTPTRARNVSALALLEETGKAWYLIDCGEGTQHRLLRTPLSLHDLRAICITHVHGDHCYGLPGLLASAG
MMGRKAPLTIIAPQGIETWVRATLSMSQSWLSYELDFHAVETLDEWRSPNMRIEATELSHRVPCYGYSFSEARPDPRLDI
ERLEHDGVPRGPLWGQLARGFDIEHEGRVLRSHDYLSFSRSPRRIVVGGDNDRPDLLAEACRDAQLLVHEATYTEAVAND
ARNDFGHSTAATVARFAQAVGLPNLVLTHFSARYQKHVGRGHSIEDLRAEAAALYAGQLLLAEDYLRLHLGKDGLLTVVE
PPSTSRPPRRDGESRA

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=362, Percent_Identity=31.767955801105, Blast_Score=161, Evalue=8e-40,
Organism=Escherichia coli, GI87082078, Length=279, Percent_Identity=39.7849462365591, Blast_Score=182, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24652403, Length=308, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 37337; Mature: 37205

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVDLLFLGTSSGTPTRARNVSALALLEETGKAWYLIDCGEGTQHRLLRTPLSLHDLRAI
CCEEEEEEECCCCCCCCCCCCHHEEEEHHCCCEEEEEECCCCCHHHHHHCCCCHHHHHEE
CITHVHGDHCYGLPGLLASAGMMGRKAPLTIIAPQGIETWVRATLSMSQSWLSYELDFHA
EEEEECCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHEEECCHHH
VETLDEWRSPNMRIEATELSHRVPCYGYSFSEARPDPRLDIERLEHDGVPRGPLWGQLAR
HHHHHHHCCCCCEEEEHHHCCCCCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHC
GFDIEHEGRVLRSHDYLSFSRSPRRIVVGGDNDRPDLLAEACRDAQLLVHEATYTEAVAN
CCCCCCCCCEEECCCCEEECCCCCEEEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHH
DARNDFGHSTAATVARFAQAVGLPNLVLTHFSARYQKHVGRGHSIEDLRAEAAALYAGQL
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LLAEDYLRLHLGKDGLLTVVEPPSTSRPPRRDGESRA
HHHHHHHHEEECCCCCEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVDLLFLGTSSGTPTRARNVSALALLEETGKAWYLIDCGEGTQHRLLRTPLSLHDLRAI
CEEEEEEECCCCCCCCCCCCHHEEEEHHCCCEEEEEECCCCCHHHHHHCCCCHHHHHEE
CITHVHGDHCYGLPGLLASAGMMGRKAPLTIIAPQGIETWVRATLSMSQSWLSYELDFHA
EEEEECCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHEEECCHHH
VETLDEWRSPNMRIEATELSHRVPCYGYSFSEARPDPRLDIERLEHDGVPRGPLWGQLAR
HHHHHHHCCCCCEEEEHHHCCCCCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHC
GFDIEHEGRVLRSHDYLSFSRSPRRIVVGGDNDRPDLLAEACRDAQLLVHEATYTEAVAN
CCCCCCCCCEEECCCCEEECCCCCEEEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHH
DARNDFGHSTAATVARFAQAVGLPNLVLTHFSARYQKHVGRGHSIEDLRAEAAALYAGQL
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LLAEDYLRLHLGKDGLLTVVEPPSTSRPPRRDGESRA
HHHHHHHHEEECCCCCEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA