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The map label for this gene is purM [H]

Identifier: 146283165

GI number: 146283165

Start: 3051904

End: 3052878

Strand: Direct

Name: purM [H]

Synonym: PST_2830

Alternate gene names: 146283165

Gene position: 3051904-3052878 (Clockwise)

Preceding gene: 146283162

Following gene: 146283166

Centisome position: 66.82

GC content: 64.92

Gene sequence:

>975_bases
GTGGCCAAACGCACCGCACGACCTGAGGTGATGGGTGGCCTGGGCGGCTTCGGCGCCCTGTGCGAAATCCCGGCGGGCTA
CAAGCAGCCGGTGCTGGTCTCCGGCACAGACGGCGTCGGTACCAAACTGCGTCTGGCGCTGAACCTGAACAAGCATGACA
GCATTGGTCAGGATCTGGTCGCCATGTGCGTCAACGACCTGGTGGTCTGTGGCGCCGAGCCGCTGTTCTTCCTCGACTAC
TACGCCACCGGCAAGCTCAACGTCGACGTGGCCGCCACCGTGGTCACCGGCATCGGCGCCGGTTGCGAACTGGCCGGCTG
CTCCCTGGTGGGTGGCGAAACCGCCGAGATGCCGGGCATGTACGAAGGCGAGGATTACGACCTGGCCGGCTTCTGCGTCG
GCGTGGTGGAGAAGAGCGAGATCATTGATGGCTCCAAGGTGCAGGCCGGTGATGCCCTCATCGCGCTGCCCTCCTCCGGC
CCGCACTCCAACGGTTATTCGCTGATCCGCAAGATCATCGAGGTGGCCGGTGCCGATATCGAGAACACCCAGCTGGCCGG
CAAGCCGCTCACCGAGTTGCTGATGGCACCGACCCGCATCTACGTCAAGCCGCTGCTCAAGCTGATCAAGGATACCGGGG
CGGTCAAGGCCATGGCCCACATCACCGGCGGCGGCCTGCTCGACAACATCCCGCGCGTGCTGCCCGAAGGTGCCCAGGCG
GTGATCGATGTCGCCAGCTGGACTCGCCCGGCGGTGTTCGACTGGTTGCAGGAAAAGGGCAACGTCGACGAACACGAGAT
GCACCGCGTGCTCAACTGCGGCGTCGGCATGGTTATCTGCGTGGCTCAGGAGCAGGTCGAGTCCGTCCTGGCCAACCTGC
GCGCATCCGGTGAGGCACCGTGGGTCATCGGCCAGATCGCCACTGCAGCGCAGGGCGCGGAACGCGTCGTACTGAACAAC
CTGAAACAGCATTGA

Upstream 100 bases:

>100_bases
CACAGGCCCGGATTCTATGAGCAAGCAACCCTCCCTCAGCTACAAGGACGCAGGCGTCGATATCGATGCAGGCGAAGCGC
TGGTCGAACGCATCAAGGGC

Downstream 100 bases:

>100_bases
TGGGCACGACCTGCAACGTAGTGGTGCTGATTTCGGGTTCCGGCAGCAACCTGCAGGCACTGATCGATAGCCAGCACGAA
GGCAACCCGGCGCGCATTCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDY
YATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKSEIIDGSKVQAGDALIALPSSG
PHSNGYSLIRKIIEVAGADIENTQLAGKPLTELLMAPTRIYVKPLLKLIKDTGAVKAMAHITGGGLLDNIPRVLPEGAQA
VIDVASWTRPAVFDWLQEKGNVDEHEMHRVLNCGVGMVICVAQEQVESVLANLRASGEAPWVIGQIATAAQGAERVVLNN
LKQH

Sequences:

>Translated_324_residues
MAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDY
YATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKSEIIDGSKVQAGDALIALPSSG
PHSNGYSLIRKIIEVAGADIENTQLAGKPLTELLMAPTRIYVKPLLKLIKDTGAVKAMAHITGGGLLDNIPRVLPEGAQA
VIDVASWTRPAVFDWLQEKGNVDEHEMHRVLNCGVGMVICVAQEQVESVLANLRASGEAPWVIGQIATAAQGAERVVLNN
LKQH
>Mature_323_residues
AKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDYY
ATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKSEIIDGSKVQAGDALIALPSSGP
HSNGYSLIRKIIEVAGADIENTQLAGKPLTELLMAPTRIYVKPLLKLIKDTGAVKAMAHITGGGLLDNIPRVLPEGAQAV
IDVASWTRPAVFDWLQEKGNVDEHEMHRVLNCGVGMVICVAQEQVESVLANLRASGEAPWVIGQIATAAQGAERVVLNNL
KQH

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=326, Percent_Identity=50.3067484662577, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI209869995, Length=326, Percent_Identity=50.3067484662577, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI209869993, Length=326, Percent_Identity=50.3067484662577, Blast_Score=324, Evalue=7e-89,
Organism=Escherichia coli, GI1788845, Length=318, Percent_Identity=67.9245283018868, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17567511, Length=337, Percent_Identity=42.1364985163205, Blast_Score=233, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6321203, Length=327, Percent_Identity=46.177370030581, Blast_Score=272, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24582400, Length=306, Percent_Identity=43.1372549019608, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 33959; Mature: 33827

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLV
CCCCCCCCHHHCCCCCCCHHHCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCHHHHHH
AMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGM
HHHHHHHHHHCCCCEEEEEEEECCEECCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCC
YEGEDYDLAGFCVGVVEKSEIIDGSKVQAGDALIALPSSGPHSNGYSLIRKIIEVAGADI
CCCCCCCHHHHHHHHHHHHHCCCCCCEECCCEEEECCCCCCCCCHHHHHHHHHHHHCCCC
ENTQLAGKPLTELLMAPTRIYVKPLLKLIKDTGAVKAMAHITGGGLLDNIPRVLPEGAQA
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCCHHH
VIDVASWTRPAVFDWLQEKGNVDEHEMHRVLNCGVGMVICVAQEQVESVLANLRASGEAP
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCC
WVIGQIATAAQGAERVVLNNLKQH
EEHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
AKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLV
CCCCCCCHHHCCCCCCCHHHCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCHHHHHH
AMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGM
HHHHHHHHHHCCCCEEEEEEEECCEECCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCC
YEGEDYDLAGFCVGVVEKSEIIDGSKVQAGDALIALPSSGPHSNGYSLIRKIIEVAGADI
CCCCCCCHHHHHHHHHHHHHCCCCCCEECCCEEEECCCCCCCCCHHHHHHHHHHHHCCCC
ENTQLAGKPLTELLMAPTRIYVKPLLKLIKDTGAVKAMAHITGGGLLDNIPRVLPEGAQA
CCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCCHHH
VIDVASWTRPAVFDWLQEKGNVDEHEMHRVLNCGVGMVICVAQEQVESVLANLRASGEAP
HHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCC
WVIGQIATAAQGAERVVLNNLKQH
EEHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA