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The map label for this gene is macA [H]

Identifier: 146282860

GI number: 146282860

Start: 2749986

End: 2751170

Strand: Direct

Name: macA [H]

Synonym: PST_2519

Alternate gene names: 146282860

Gene position: 2749986-2751170 (Clockwise)

Preceding gene: 146282858

Following gene: 146282861

Centisome position: 60.21

GC content: 69.03

Gene sequence:

>1185_bases
GTGCCTGCCGTAAGATCCATCCGCCGTCTAGTTATCCTGGCCATTGCGCTACTGGCGCTTGGCGGCTGGCTGATCTGGCG
TCAGCTGCAGGGCCCGGAACTGCCGGCCTACCGCCTGGAAGCTCGCCCACTGGTGCAGCGCGTGGTGGCCAGTGGTGAAG
TGGACAGCCAGTCGCTGGCGCAGGTCGGCAGCGAAATCACCGGCGTGGTTGCTGCACGCCATGTGCGGGAAGGCGACGCG
GTGAACGCCGGTGATCTGCTGCTGGAACTGCGCGACGACGAACAGCGCGCGCGCCTGCGCGAGGCCGAAGCGGCGCTGCA
GCAGCTCATCGATTCCACTCGACCGCAGGCGCAGGCCACCCTGCGCGAGGCACAACACAATCTGGAACAGGCCAGCCGCG
AGCTGCAGCGCCGCGAAACGCTGTTCGAGCGCAAGCTGCTGGCTTCCGAGCCGCTGGAGCAGGCGCGCCGCGCGGAGCTG
ACCGCACGCGTAGTGCGTGATCGCGCCCGCTTCGCCGCCGCAGCGCTGGCCGAAGGTGGCAGCGAGGAACAGGTCCTGCG
GCAGCGTCTGGAGGTCGCCCGTGCGAACCTGGCACGAACCCGTATTCACGCCCAGGTCGATGGCATCGTGCAGTCGCGCG
ACGTCGAGCCGGGCGACCTGGTTCAGCCGGGCCGCACACTGCTGACCATTGCCCGCTCCGGCAGCAGCGAAATCCTCTTG
CCCCTCGACGAGAAGAGCCTGGCACCGATCGAGCACGGGCAGAGCGCCCGGATCATCGCCGACGCCTATCCGGACCGCGT
GCTGACGGCGAAGGTGAGCTTCATCGCACCGAGCGTGGATACGGCGCGCGGCACCATCGATGTCCATCTGGACCTGCAGG
AGCCGGCCGTCTTTCTCCGCCAGGGCATGACGGTATCGGTGAACATCGAGACAGGCCGGCGCGAGCAGGCACTGGTGCTG
CCCAATGATGCGCTGCGCGCCCGCGACGGGTCGCGCGCCCAGGTGCTACGGGTGCGCGATGGCGTGGTCGAGCGCGTCGG
TGTGCGACTGGGAATGCTGGGCACGGCGCTCAGCGAGATCAGCGAGGGGCTGGAGGCCGGCGATCTGGTGCTGATCGGCG
ACGCCGAAGAAGGCCAGCGCGTGCGGCCGCGCGTACAACCCATCCCCAGCGGCAGCCAGGACTGA

Upstream 100 bases:

>100_bases
ATCGTGTCGCTTGCAGCGCGCGTTGTAAGCACGCCGAGGATGTCCGTAAGCTTGCACCGTTTCGATGGCCGTCACGGGCC
GTATCAGGGAGTGGTCCGTC

Downstream 100 bases:

>100_bases
GCGCATGCGCCTGGCCGATTCGCTGTGGACCGAATGGAAGATCGCCCTACGCTTCCTGCTGGACAACCGCATGCAGACGC
TGCTGATCACCTTCGGCATC

Product: membrane fusion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MPAVRSIRRLVILAIALLALGGWLIWRQLQGPELPAYRLEARPLVQRVVASGEVDSQSLAQVGSEITGVVAARHVREGDA
VNAGDLLLELRDDEQRARLREAEAALQQLIDSTRPQAQATLREAQHNLEQASRELQRRETLFERKLLASEPLEQARRAEL
TARVVRDRARFAAAALAEGGSEEQVLRQRLEVARANLARTRIHAQVDGIVQSRDVEPGDLVQPGRTLLTIARSGSSEILL
PLDEKSLAPIEHGQSARIIADAYPDRVLTAKVSFIAPSVDTARGTIDVHLDLQEPAVFLRQGMTVSVNIETGRREQALVL
PNDALRARDGSRAQVLRVRDGVVERVGVRLGMLGTALSEISEGLEAGDLVLIGDAEEGQRVRPRVQPIPSGSQD

Sequences:

>Translated_394_residues
MPAVRSIRRLVILAIALLALGGWLIWRQLQGPELPAYRLEARPLVQRVVASGEVDSQSLAQVGSEITGVVAARHVREGDA
VNAGDLLLELRDDEQRARLREAEAALQQLIDSTRPQAQATLREAQHNLEQASRELQRRETLFERKLLASEPLEQARRAEL
TARVVRDRARFAAAALAEGGSEEQVLRQRLEVARANLARTRIHAQVDGIVQSRDVEPGDLVQPGRTLLTIARSGSSEILL
PLDEKSLAPIEHGQSARIIADAYPDRVLTAKVSFIAPSVDTARGTIDVHLDLQEPAVFLRQGMTVSVNIETGRREQALVL
PNDALRARDGSRAQVLRVRDGVVERVGVRLGMLGTALSEISEGLEAGDLVLIGDAEEGQRVRPRVQPIPSGSQD
>Mature_393_residues
PAVRSIRRLVILAIALLALGGWLIWRQLQGPELPAYRLEARPLVQRVVASGEVDSQSLAQVGSEITGVVAARHVREGDAV
NAGDLLLELRDDEQRARLREAEAALQQLIDSTRPQAQATLREAQHNLEQASRELQRRETLFERKLLASEPLEQARRAELT
ARVVRDRARFAAAALAEGGSEEQVLRQRLEVARANLARTRIHAQVDGIVQSRDVEPGDLVQPGRTLLTIARSGSSEILLP
LDEKSLAPIEHGQSARIIADAYPDRVLTAKVSFIAPSVDTARGTIDVHLDLQEPAVFLRQGMTVSVNIETGRREQALVLP
NDALRARDGSRAQVLRVRDGVVERVGVRLGMLGTALSEISEGLEAGDLVLIGDAEEGQRVRPRVQPIPSGSQD

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=389, Percent_Identity=25.9640102827763, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082036, Length=334, Percent_Identity=25.748502994012, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787013, Length=296, Percent_Identity=23.9864864864865, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43086; Mature: 42954

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVRSIRRLVILAIALLALGGWLIWRQLQGPELPAYRLEARPLVQRVVASGEVDSQSLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
QVGSEITGVVAARHVREGDAVNAGDLLLELRDDEQRARLREAEAALQQLIDSTRPQAQAT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
LREAQHNLEQASRELQRRETLFERKLLASEPLEQARRAELTARVVRDRARFAAAALAEGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SEEQVLRQRLEVARANLARTRIHAQVDGIVQSRDVEPGDLVQPGRTLLTIARSGSSEILL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEE
PLDEKSLAPIEHGQSARIIADAYPDRVLTAKVSFIAPSVDTARGTIDVHLDLQEPAVFLR
ECCCCCCCCCCCCCCCEEEECCCCCCEEEEEHHHCCCCCCCCCCEEEEEEECCCHHHHHH
QGMTVSVNIETGRREQALVLPNDALRARDGSRAQVLRVRDGVVERVGVRLGMLGTALSEI
CCCEEEEEECCCCCCCEEECCCHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHH
SEGLEAGDLVLIGDAEEGQRVRPRVQPIPSGSQD
HCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAVRSIRRLVILAIALLALGGWLIWRQLQGPELPAYRLEARPLVQRVVASGEVDSQSLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
QVGSEITGVVAARHVREGDAVNAGDLLLELRDDEQRARLREAEAALQQLIDSTRPQAQAT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
LREAQHNLEQASRELQRRETLFERKLLASEPLEQARRAELTARVVRDRARFAAAALAEGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SEEQVLRQRLEVARANLARTRIHAQVDGIVQSRDVEPGDLVQPGRTLLTIARSGSSEILL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEE
PLDEKSLAPIEHGQSARIIADAYPDRVLTAKVSFIAPSVDTARGTIDVHLDLQEPAVFLR
ECCCCCCCCCCCCCCCEEEECCCCCCEEEEEHHHCCCCCCCCCCEEEEEEECCCHHHHHH
QGMTVSVNIETGRREQALVLPNDALRARDGSRAQVLRVRDGVVERVGVRLGMLGTALSEI
CCCEEEEEECCCCCCCEEECCCHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHH
SEGLEAGDLVLIGDAEEGQRVRPRVQPIPSGSQD
HCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]