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The map label for this gene is yciK [H]

Identifier: 146282669

GI number: 146282669

Start: 2539445

End: 2540185

Strand: Direct

Name: yciK [H]

Synonym: PST_2325

Alternate gene names: 146282669

Gene position: 2539445-2540185 (Clockwise)

Preceding gene: 146282668

Following gene: 146282675

Centisome position: 55.6

GC content: 62.08

Gene sequence:

>741_bases
ATGTTCGAGTATTCCGCCCGCCCCGACCTGCTCGCAGGGCGCATCATCCTGGTCACCGGCGCTGGCCGGGGCATCGGTGA
AGCTGCTGCCAAGGCCTACGCGGCCCACGGAGCTACCGTGCTGTTACTGGGCAAGAATGAAGACAATCTGAATCGGGTGT
ACGACGAAATCGAAGCAGCAGGCCATCCGCGCCCCGCTGTCATCCCGTTCAACCTGGAGACAGCCCTGCCGCATCAGTAC
GACGAGCTGGCAGCCATGATCGAGCGGGAATTCGGACACCTGGACGGATTGCTGCACAACGCTGCGATCGTTGGCCCTCG
CACGCCGATCGAGCAGTTGTCCGGCGACAATTTCATGCGAGTCATGCAGATCAACGTGAATGCCATGTTCATGCTGACCA
GCACCTTGCTACCGCTGCTCAAGCTCTCCAAAGACGCCTCGGTGATCTTCACCTCCAGCAGCGTCGGACGCAAAGGCCGC
GCCTACTGGGGTGCCTACGCCGTATCGAAGTTCGCCACGGAAGGACTGATGCAGGTTCTGGCCGACGAGCTGGACGATAC
CGCGCCGGTGCGTGCCAACAGCATCAACCCGGGCGCTACTCGGACCGACATGCGCGCCAAGGCGTACCCGGGCGAGAACC
CGCTCGTCAATCCATTGCCGGAAGAAATCATGCCGGTCTATCTGTACCTGATGGGCCCGGATAGCGCCGGCATCAACGGC
CAGGCGCTGGACGCGCAATGA

Upstream 100 bases:

>100_bases
CCTGTGCAGTTGCTGAAACAGCCATAGGGTCACCACCACAGCATCATCACTCGGCAGTAATTGCCGAAGCACCCATCACT
TTCGATTTACGAGGCATCCG

Downstream 100 bases:

>100_bases
AGTCCGCGCAGCGCAGTCATCCACTGCGCTGCGCTGCAGACCGCTCAGGGACGCTTGCTGCGCTCGCGCCCGAAGCCGGG
CCGCTGACCTTCTCCGGCCG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MFEYSARPDLLAGRIILVTGAGRGIGEAAAKAYAAHGATVLLLGKNEDNLNRVYDEIEAAGHPRPAVIPFNLETALPHQY
DELAAMIEREFGHLDGLLHNAAIVGPRTPIEQLSGDNFMRVMQINVNAMFMLTSTLLPLLKLSKDASVIFTSSSVGRKGR
AYWGAYAVSKFATEGLMQVLADELDDTAPVRANSINPGATRTDMRAKAYPGENPLVNPLPEEIMPVYLYLMGPDSAGING
QALDAQ

Sequences:

>Translated_246_residues
MFEYSARPDLLAGRIILVTGAGRGIGEAAAKAYAAHGATVLLLGKNEDNLNRVYDEIEAAGHPRPAVIPFNLETALPHQY
DELAAMIEREFGHLDGLLHNAAIVGPRTPIEQLSGDNFMRVMQINVNAMFMLTSTLLPLLKLSKDASVIFTSSSVGRKGR
AYWGAYAVSKFATEGLMQVLADELDDTAPVRANSINPGATRTDMRAKAYPGENPLVNPLPEEIMPVYLYLMGPDSAGING
QALDAQ
>Mature_246_residues
MFEYSARPDLLAGRIILVTGAGRGIGEAAAKAYAAHGATVLLLGKNEDNLNRVYDEIEAAGHPRPAVIPFNLETALPHQY
DELAAMIEREFGHLDGLLHNAAIVGPRTPIEQLSGDNFMRVMQINVNAMFMLTSTLLPLLKLSKDASVIFTSSSVGRKGR
AYWGAYAVSKFATEGLMQVLADELDDTAPVRANSINPGATRTDMRAKAYPGENPLVNPLPEEIMPVYLYLMGPDSAGING
QALDAQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=27.0916334661355, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=29.1457286432161, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI33667109, Length=203, Percent_Identity=29.064039408867, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4504505, Length=234, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=25.7028112449799, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787526, Length=245, Percent_Identity=51.0204081632653, Blast_Score=224, Evalue=3e-60,
Organism=Escherichia coli, GI87082100, Length=208, Percent_Identity=31.25, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=26.7782426778243, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=29.8387096774194, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=28.5123966942149, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=25.8196721311475, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=241, Percent_Identity=26.1410788381743, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=196, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=27.5303643724696, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=31.8181818181818, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=25.6916996047431, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=212, Percent_Identity=26.4150943396226, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=210, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=196, Percent_Identity=30.1020408163265, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=244, Percent_Identity=25.4098360655738, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=24.7104247104247, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=205, Percent_Identity=25.8536585365854, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=196, Percent_Identity=30.1020408163265, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=192, Percent_Identity=29.6875, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=30.5, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=203, Percent_Identity=23.6453201970443, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=205, Percent_Identity=27.8048780487805, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=200, Percent_Identity=24.5, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=226, Percent_Identity=28.7610619469027, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322227, Length=200, Percent_Identity=28.5, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=234, Percent_Identity=25.2136752136752, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24644339, Length=197, Percent_Identity=32.48730964467, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=31.8367346938775, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=29.2, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571526, Length=198, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=32.6530612244898, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640492, Length=192, Percent_Identity=28.6458333333333, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281364892, Length=198, Percent_Identity=31.3131313131313, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=196, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355631, Length=223, Percent_Identity=26.457399103139, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21358495, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26509; Mature: 26509

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEYSARPDLLAGRIILVTGAGRGIGEAAAKAYAAHGATVLLLGKNEDNLNRVYDEIEAA
CCCCCCCCCCEECEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHC
GHPRPAVIPFNLETALPHQYDELAAMIEREFGHLDGLLHNAAIVGPRTPIEQLSGDNFMR
CCCCCEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHCCCCEEE
VMQINVNAMFMLTSTLLPLLKLSKDASVIFTSSSVGRKGRAYWGAYAVSKFATEGLMQVL
EEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ADELDDTAPVRANSINPGATRTDMRAKAYPGENPLVNPLPEEIMPVYLYLMGPDSAGING
HHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCC
QALDAQ
CCCCCC
>Mature Secondary Structure
MFEYSARPDLLAGRIILVTGAGRGIGEAAAKAYAAHGATVLLLGKNEDNLNRVYDEIEAA
CCCCCCCCCCEECEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHC
GHPRPAVIPFNLETALPHQYDELAAMIEREFGHLDGLLHNAAIVGPRTPIEQLSGDNFMR
CCCCCEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHCCCCEEE
VMQINVNAMFMLTSTLLPLLKLSKDASVIFTSSSVGRKGRAYWGAYAVSKFATEGLMQVL
EEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ADELDDTAPVRANSINPGATRTDMRAKAYPGENPLVNPLPEEIMPVYLYLMGPDSAGING
HHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCC
QALDAQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]