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The map label for this gene is mtaD [H]

Identifier: 146282666

GI number: 146282666

Start: 2536375

End: 2537862

Strand: Direct

Name: mtaD [H]

Synonym: PST_2322

Alternate gene names: 146282666

Gene position: 2536375-2537862 (Clockwise)

Preceding gene: 146282663

Following gene: 146282667

Centisome position: 55.53

GC content: 59.74

Gene sequence:

>1488_bases
TTGCCCTCTCCTATATATAGGCAGTGCAGCGCTACATATAGGCAGTGCAGCGCTACCAGGACGCCTGCTGCAACCAGCGT
TACGGCTTCCTTCAATCCAGCGTCCCCAGCCATTACACTAGTCGACCTTCTCATCCAGTCACGGCTCCCCATGTCCCGGC
AAAGCCTCACTCCGCTAGATCTGCTTCTATTTCCGACCTGGCTGGTTCCGGTCGAGCCAGCGGGAGTAGTGCTCAAGGGG
CATGGATTGGGCATCCGTGATGGACGCATCATACTCATCGCACCGCGTGAGGAAGCACTCAAGCATCCGGCGCAGGAGAA
GCTCGAACTCGAAGGAATGATGTTGGCTCCCGGCCTGATCAATACTCACGGACACGCGGCGATGACGCTGTTTCGTGGGC
TGGCCGATGATCTACCGCTGCAACGCTGGCTGCGCGACCACATCTGGCCGGCCGAAGCACGCTGGGTCGACGAAGACTTC
GTGCGCTGCGGCACCGAACTGGCCATCGCCGAGCAGCTCAAAGGCGGCATCACCTGCTTCTCTGACATGTATTTCCACCC
CGCTGTAGTAAGCGAACTGGTACATAAGCATGGCGTACGAGCACAGATTGCCGTCCCTGTGCTCGATTTCCCCGTACCCG
GCGCACGCGACGCGGACGAGGCGCTACGCAATGGCGTGGCGTTGTTCGATGATCTCAAGCATCACCCGCGTATCTCGATC
GCATTCGGGCCCCACGCGCCTTATTCGGTTGCGGATGACAAACTCGAAAACATCAGAATTCTGGTCGCCGAGATGGACGC
CTGCATTCATATGCACGTCCATGAAACCGCGCACGAGATCCAAGAGGCGCTGCACAAGCATGGCGAACGCCCCTTGGCCA
GGCTCGCGCGACTCCAGTTGCTCGGCCCTCGGTTCCAGGCTGTGCATATGACCCAGGTCGACGAAGAAGACATCGCGTTG
CTCACCGAGCATAACTGCAGTGTCATTCATTGCCCCGAATCGAACTTGAAGCTCGCCAGCGGCTTCTGTCCTGTAGAGCG
CCTGTGGGAAGCCGGAGTCAATGTTGCCATTGGCACCGATGGCGCCGCGAGCAACAACGATCTGGACCTGCTTGGCGAAA
CCCGTACCGCCGCGTTGCTGGCCAAGGCGGTCGCCGGTTCAGCGACCGCCCTGGATGCACATCGCGCATTGCGCATGGCT
ACGCTCAATGGTGCACGGGCGTTGGGGATCGATGATCACACTGGCTCGCTGGAGATCGGAAAATTCGCCGACCTGGTCGC
CGTCGATCTCTCCGGTTTGGCTCAGCAACCAATATACGATCCGGTTTCTCAGCTGATCTATTCCACAGGGCGAGACGCCG
TCCGGCATGCCTGGGTAGGAGGAAAACAGTTGTTGAACAACGGCAAGCTGACCCGGATGGACGAGCAGCGTGTCATCGCG
AATGCCCGCCAATGGGGCGCCCGGATTGCCAGCACGGACAGCCAGTGA

Upstream 100 bases:

>100_bases
TTACAAGAGGTTTTGCTTGAGGACTGCGCCGGAAGTGGTGCGCATTATAGGCACCTGAAAACAGCCGTCAACCGTTTATT
TCGGTTTTCATCCATGGCAT

Downstream 100 bases:

>100_bases
CGAAGGCGAGTAGATATGCAGGACCCCCGCGACCGAATGACCTATGCGCCCTCGCCGCTATCCGAAGCTGGCAACATGAG
CGATTGCAGCTCAAGCTTCT

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MPSPIYRQCSATYRQCSATRTPAATSVTASFNPASPAITLVDLLIQSRLPMSRQSLTPLDLLLFPTWLVPVEPAGVVLKG
HGLGIRDGRIILIAPREEALKHPAQEKLELEGMMLAPGLINTHGHAAMTLFRGLADDLPLQRWLRDHIWPAEARWVDEDF
VRCGTELAIAEQLKGGITCFSDMYFHPAVVSELVHKHGVRAQIAVPVLDFPVPGARDADEALRNGVALFDDLKHHPRISI
AFGPHAPYSVADDKLENIRILVAEMDACIHMHVHETAHEIQEALHKHGERPLARLARLQLLGPRFQAVHMTQVDEEDIAL
LTEHNCSVIHCPESNLKLASGFCPVERLWEAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVAGSATALDAHRALRMA
TLNGARALGIDDHTGSLEIGKFADLVAVDLSGLAQQPIYDPVSQLIYSTGRDAVRHAWVGGKQLLNNGKLTRMDEQRVIA
NARQWGARIASTDSQ

Sequences:

>Translated_495_residues
MPSPIYRQCSATYRQCSATRTPAATSVTASFNPASPAITLVDLLIQSRLPMSRQSLTPLDLLLFPTWLVPVEPAGVVLKG
HGLGIRDGRIILIAPREEALKHPAQEKLELEGMMLAPGLINTHGHAAMTLFRGLADDLPLQRWLRDHIWPAEARWVDEDF
VRCGTELAIAEQLKGGITCFSDMYFHPAVVSELVHKHGVRAQIAVPVLDFPVPGARDADEALRNGVALFDDLKHHPRISI
AFGPHAPYSVADDKLENIRILVAEMDACIHMHVHETAHEIQEALHKHGERPLARLARLQLLGPRFQAVHMTQVDEEDIAL
LTEHNCSVIHCPESNLKLASGFCPVERLWEAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVAGSATALDAHRALRMA
TLNGARALGIDDHTGSLEIGKFADLVAVDLSGLAQQPIYDPVSQLIYSTGRDAVRHAWVGGKQLLNNGKLTRMDEQRVIA
NARQWGARIASTDSQ
>Mature_494_residues
PSPIYRQCSATYRQCSATRTPAATSVTASFNPASPAITLVDLLIQSRLPMSRQSLTPLDLLLFPTWLVPVEPAGVVLKGH
GLGIRDGRIILIAPREEALKHPAQEKLELEGMMLAPGLINTHGHAAMTLFRGLADDLPLQRWLRDHIWPAEARWVDEDFV
RCGTELAIAEQLKGGITCFSDMYFHPAVVSELVHKHGVRAQIAVPVLDFPVPGARDADEALRNGVALFDDLKHHPRISIA
FGPHAPYSVADDKLENIRILVAEMDACIHMHVHETAHEIQEALHKHGERPLARLARLQLLGPRFQAVHMTQVDEEDIALL
TEHNCSVIHCPESNLKLASGFCPVERLWEAGVNVAIGTDGAASNNDLDLLGETRTAALLAKAVAGSATALDAHRALRMAT
LNGARALGIDDHTGSLEIGKFADLVAVDLSGLAQQPIYDPVSQLIYSTGRDAVRHAWVGGKQLLNNGKLTRMDEQRVIAN
ARQWGARIASTDSQ

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=441, Percent_Identity=26.0770975056689, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1789249, Length=393, Percent_Identity=26.972010178117, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082177, Length=448, Percent_Identity=24.3303571428571, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17540282, Length=395, Percent_Identity=24.8101265822785, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319963, Length=329, Percent_Identity=23.1003039513678, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24643849, Length=382, Percent_Identity=25.9162303664921, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 53952; Mature: 53821

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPIYRQCSATYRQCSATRTPAATSVTASFNPASPAITLVDLLIQSRLPMSRQSLTPLD
CCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
LLLFPTWLVPVEPAGVVLKGHGLGIRDGRIILIAPREEALKHPAQEKLELEGMMLAPGLI
HHHHCHHEEEECCCCEEEECCCCCCCCCEEEEEECCHHHHHCCHHHHHCCCCEEECCCCC
NTHGHAAMTLFRGLADDLPLQRWLRDHIWPAEARWVDEDFVRCGTELAIAEQLKGGITCF
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHCCCCHHHHHCCCHHHHHHHHCCCCEEH
SDMYFHPAVVSELVHKHGVRAQIAVPVLDFPVPGARDADEALRNGVALFDDLKHHPRISI
HHHCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHCCHHHHHHHCCCCEEEE
AFGPHAPYSVADDKLENIRILVAEMDACIHMHVHETAHEIQEALHKHGERPLARLARLQL
EECCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LGPRFQAVHMTQVDEEDIALLTEHNCSVIHCPESNLKLASGFCPVERLWEAGVNVAIGTD
CCCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCEEECCCCCHHHHHHCCCEEEEECC
GAASNNDLDLLGETRTAALLAKAVAGSATALDAHRALRMATLNGARALGIDDHTGSLEIG
CCCCCCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCEECC
KFADLVAVDLSGLAQQPIYDPVSQLIYSTGRDAVRHAWVGGKQLLNNGKLTRMDEQRVIA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCEEEHHHHHHH
NARQWGARIASTDSQ
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
PSPIYRQCSATYRQCSATRTPAATSVTASFNPASPAITLVDLLIQSRLPMSRQSLTPLD
CCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCHH
LLLFPTWLVPVEPAGVVLKGHGLGIRDGRIILIAPREEALKHPAQEKLELEGMMLAPGLI
HHHHCHHEEEECCCCEEEECCCCCCCCCEEEEEECCHHHHHCCHHHHHCCCCEEECCCCC
NTHGHAAMTLFRGLADDLPLQRWLRDHIWPAEARWVDEDFVRCGTELAIAEQLKGGITCF
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHCCCCHHHHHCCCHHHHHHHHCCCCEEH
SDMYFHPAVVSELVHKHGVRAQIAVPVLDFPVPGARDADEALRNGVALFDDLKHHPRISI
HHHCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHCCHHHHHHHCCCCEEEE
AFGPHAPYSVADDKLENIRILVAEMDACIHMHVHETAHEIQEALHKHGERPLARLARLQL
EECCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LGPRFQAVHMTQVDEEDIALLTEHNCSVIHCPESNLKLASGFCPVERLWEAGVNVAIGTD
CCCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCEEECCCCCHHHHHHCCCEEEEECC
GAASNNDLDLLGETRTAALLAKAVAGSATALDAHRALRMATLNGARALGIDDHTGSLEIG
CCCCCCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCEECC
KFADLVAVDLSGLAQQPIYDPVSQLIYSTGRDAVRHAWVGGKQLLNNGKLTRMDEQRVIA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHCCCCCEEEHHHHHHH
NARQWGARIASTDSQ
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA