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The map label for this gene is hdc [H]

Identifier: 145301202

GI number: 145301202

Start: 4694773

End: 4695936

Strand: Direct

Name: hdc [H]

Synonym: ASA_4380

Alternate gene names: 145301202

Gene position: 4694773-4695936 (Clockwise)

Preceding gene: 145301201

Following gene: NA

Centisome position: 99.84

GC content: 46.31

Gene sequence:

>1164_bases
ATGATAATGGGTTTGTCATCAGAAGATGCCGGGAAAATAGAGTCGTTTTGGCGGTATTGTGTGCAGCATCAATATTTCAA
TATCGGTTATCCAGAGGCGGCTGACTTTGACTACTCCGCTTTAAACCGTTTTCTAAACTTCTCTATCAATAACTGTGGTG
ATTGGAGCCAGCAGAGCAACTACCTTCTCAACTCCTTTGATTTTGAAAGAGAGGTGATGCAATTCTTTGCAACCCTGTTC
TGCATTCCTTTTGAGCAAAGTTGGGGTTATGTGACCAACGGTGGTACTGAGGGGAATATGTTCGGATGCTATCTGGCCCG
CGAGTTATTTCCTGAGGCAACATTATATTACTCAAAAGATACACATTATTCGGTTGCAAAGATCATCCGACTATTGAGAG
TAAAGTCATGTATGGTCGATTCACTGCCTAATGGCGAGATGAATTATGATGACCTGATCAATCGAATTCGACTGGATGGA
GAGCGTCACCCTATTATATTTGCCAACATAGGGACGACGATGACAGGGGCGACAGACAATATTGCCACCATTCAAAGACG
CTTGAAAAAAATAGGAATCACCAAGGGGGACTATTACCTGCATGCCGATGCTGCATTGAGTGGCATGATCTTGCCCTTCA
TCGACAACCCTCAACCTTTCTCTTTTGCCGATGGCGTCGACTCGATAAGTGTATCGGGTCATAAAATGATCGGTTCTCCC
ATTCCCTGCGGGATTGTCCTGGCCAGACGCAAGCATGTCGAGCATGTCTCGGTTGAAATAGATTATATCTCGGCATGTGA
TCAGACAATCAGTGGCTCGCGCAATGGCTACACCCCGCTACTGCTATGGATGGCAATAAAAAGCCGATCATTTTCAGACT
GGCGTCAGCGAACGCAGCACTGTCTTGATATGGCCCAATATGTCATCGAGCGTTTTCACGCCAAAGGTATTCATGCCTGG
CGCAATCCAAATTCGATCACTGTGGTTTTCCCAAAGCCTGCTGACCATATATGGAAAAAGCACTGTCTGGCCACATCAGG
AAAAATATCACATATCATCACCATGCCTCATCACACCGGGAAGGAAACCCTGGACAGGGTGATCAATGACATTGCTCTGG
ATAGAGAACCTGGCCGCGGTTTGGCGCATGCGTTGACTGTCTGA

Upstream 100 bases:

>100_bases
CCCTTACGATTAATCATCGGCAACTTGATAAATCAAGGTGCGGATTGCCAAACTACACCACCAAATGTGCAGGCATGCCT
GCATAGCGCTAGCCATGGGT

Downstream 100 bases:

>100_bases
TAGCACCAGAGTCGACGGCCTTGCCATGGTGGATGCGGTTGCAGGGCGAAAGCCAGCTCTCGCCCTGTTTTCTTGCGTTA
CTCTGGCTGCTTCTCGCTAG

Product: histidine decarboxylase

Products: NA

Alternate protein names: HDC [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MIMGLSSEDAGKIESFWRYCVQHQYFNIGYPEAADFDYSALNRFLNFSINNCGDWSQQSNYLLNSFDFEREVMQFFATLF
CIPFEQSWGYVTNGGTEGNMFGCYLARELFPEATLYYSKDTHYSVAKIIRLLRVKSCMVDSLPNGEMNYDDLINRIRLDG
ERHPIIFANIGTTMTGATDNIATIQRRLKKIGITKGDYYLHADAALSGMILPFIDNPQPFSFADGVDSISVSGHKMIGSP
IPCGIVLARRKHVEHVSVEIDYISACDQTISGSRNGYTPLLLWMAIKSRSFSDWRQRTQHCLDMAQYVIERFHAKGIHAW
RNPNSITVVFPKPADHIWKKHCLATSGKISHIITMPHHTGKETLDRVINDIALDREPGRGLAHALTV

Sequences:

>Translated_387_residues
MIMGLSSEDAGKIESFWRYCVQHQYFNIGYPEAADFDYSALNRFLNFSINNCGDWSQQSNYLLNSFDFEREVMQFFATLF
CIPFEQSWGYVTNGGTEGNMFGCYLARELFPEATLYYSKDTHYSVAKIIRLLRVKSCMVDSLPNGEMNYDDLINRIRLDG
ERHPIIFANIGTTMTGATDNIATIQRRLKKIGITKGDYYLHADAALSGMILPFIDNPQPFSFADGVDSISVSGHKMIGSP
IPCGIVLARRKHVEHVSVEIDYISACDQTISGSRNGYTPLLLWMAIKSRSFSDWRQRTQHCLDMAQYVIERFHAKGIHAW
RNPNSITVVFPKPADHIWKKHCLATSGKISHIITMPHHTGKETLDRVINDIALDREPGRGLAHALTV
>Mature_387_residues
MIMGLSSEDAGKIESFWRYCVQHQYFNIGYPEAADFDYSALNRFLNFSINNCGDWSQQSNYLLNSFDFEREVMQFFATLF
CIPFEQSWGYVTNGGTEGNMFGCYLARELFPEATLYYSKDTHYSVAKIIRLLRVKSCMVDSLPNGEMNYDDLINRIRLDG
ERHPIIFANIGTTMTGATDNIATIQRRLKKIGITKGDYYLHADAALSGMILPFIDNPQPFSFADGVDSISVSGHKMIGSP
IPCGIVLARRKHVEHVSVEIDYISACDQTISGSRNGYTPLLLWMAIKSRSFSDWRQRTQHCLDMAQYVIERFHAKGIHAW
RNPNSITVVFPKPADHIWKKHCLATSGKISHIITMPHHTGKETLDRVINDIALDREPGRGLAHALTV

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Drosophila melanogaster, GI21356415, Length=264, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.22 [H]

Molecular weight: Translated: 43898; Mature: 43898

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMGLSSEDAGKIESFWRYCVQHQYFNIGYPEAADFDYSALNRFLNFSINNCGDWSQQSN
CEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHCC
YLLNSFDFEREVMQFFATLFCIPFEQSWGYVTNGGTEGNMFGCYLARELFPEATLYYSKD
CHHHCCCHHHHHHHHHHHHHEECCCCCCCEEECCCCCCCCHHHHHHHHHCCCCEEEECCC
THYSVAKIIRLLRVKSCMVDSLPNGEMNYDDLINRIRLDGERHPIIFANIGTTMTGATDN
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCEECCCCCH
IATIQRRLKKIGITKGDYYLHADAALSGMILPFIDNPQPFSFADGVDSISVSGHKMIGSP
HHHHHHHHHHHCCCCCCEEEEECCHHCCEEEEECCCCCCCCHHCCCCCEECCCCEECCCC
IPCGIVLARRKHVEHVSVEIDYISACDQTISGSRNGYTPLLLWMAIKSRSFSDWRQRTQH
CCHHHHHHHHHCCEEEEEEEEEHHHCCHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
CLDMAQYVIERFHAKGIHAWRNPNSITVVFPKPADHIWKKHCLATSGKISHIITMPHHTG
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCC
KETLDRVINDIALDREPGRGLAHALTV
HHHHHHHHHHHHCCCCCCCCHHHHHCC
>Mature Secondary Structure
MIMGLSSEDAGKIESFWRYCVQHQYFNIGYPEAADFDYSALNRFLNFSINNCGDWSQQSN
CEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHCC
YLLNSFDFEREVMQFFATLFCIPFEQSWGYVTNGGTEGNMFGCYLARELFPEATLYYSKD
CHHHCCCHHHHHHHHHHHHHEECCCCCCCEEECCCCCCCCHHHHHHHHHCCCCEEEECCC
THYSVAKIIRLLRVKSCMVDSLPNGEMNYDDLINRIRLDGERHPIIFANIGTTMTGATDN
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCEECCCCCH
IATIQRRLKKIGITKGDYYLHADAALSGMILPFIDNPQPFSFADGVDSISVSGHKMIGSP
HHHHHHHHHHHCCCCCCEEEEECCHHCCEEEEECCCCCCCCHHCCCCCEECCCCEECCCC
IPCGIVLARRKHVEHVSVEIDYISACDQTISGSRNGYTPLLLWMAIKSRSFSDWRQRTQH
CCHHHHHHHHHCCEEEEEEEEEHHHCCHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
CLDMAQYVIERFHAKGIHAWRNPNSITVVFPKPADHIWKKHCLATSGKISHIITMPHHTG
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCC
KETLDRVINDIALDREPGRGLAHALTV
HHHHHHHHHHHHCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2033044; 12089029 [H]