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The map label for this gene is yeiG [H]

Identifier: 145301026

GI number: 145301026

Start: 4475765

End: 4476601

Strand: Direct

Name: yeiG [H]

Synonym: ASA_4181

Alternate gene names: 145301026

Gene position: 4475765-4476601 (Clockwise)

Preceding gene: 145301025

Following gene: 145301028

Centisome position: 95.18

GC content: 65.47

Gene sequence:

>837_bases
ATGAATCTGGACATTATCAGCAGCAACAAGAGCTTCGATGGCTGGCACAAGCGCTACAGCCACAGCTCCAGCGTGCTCGG
CTGCGAGATGCGCTTCGCTATCTATCTGCCGCCCCAGGCCCTCACCGGCCAGAAGGTGCCTGTGCTCTACTGGCTCTCCG
GCCTCACCTGCACCGATGAAAACTTCATGCAGAAGGCGGGGGCGCACCGCATCGCCGCCGAGCTCGGCATCGCCCTGGTG
GCACCGGACACCAGCCCCCGCGGCGAAGGAGTGGCGGACGATCCCGCTTACGATCTCGGCATGGGGGCAGGCTTTTACGT
CAACGCCAGCCAGAACCCCTGGCGTGATCACTACCAGATGTATGATTACGTCACCCGCGAGCTGCCTGACCTGATAGAGA
CCCACTTCCCGGTCTCGACCCGCCGCGCCATCAGCGGCCACTCCATGGGGGGTCACGGCGCCCTGATCGCCGCCCTGCGC
GAGCCCGGTCGCTACCGATCCGTGTCGGCCTTCAGCCCCATCAGCCACCCGAGCCGCTGCCCCTGGGGGCAGAAGGCGCT
CGGCGCCTACCTCGGCAACAATCCCCTGCTGTGGCAGGAGTGGGATGCCTGCCAGCTGCTGCGCCACCACCCGGTAACAC
CGCTGCCGACCCTGGTGGATGTGGGGCTGGACGATCCCTTCCTCGCCGAGCAGCTGCACATCGATGCCCTGGCGGATATT
GCCGCCAGCAAGGCCTGGCCGCTGGAGCTCAATCGCCACCCCGGCTATGACCACAGCTACTACTTTGTGGCGAGCTTTAT
CGAGGCACACCTGCGCTTCCACGCCCGCCATCTCTGA

Upstream 100 bases:

>100_bases
TCGAGCTGATGCACGAAGGCAAGAGCATCCGCACCGTCATTCACTACTGAGCATGATCACCCCGCCCGTCCCTCGACGGG
CGGGGTGCAGGAGTTCCTCG

Downstream 100 bases:

>100_bases
TCAAAACAGGCCCATGAAGGGCCTGTTTTTTTCTATCTTCGATTATCTGCTTGCGGTCAGGCTTCAGCTGCCCTGGCGGG
TCACGTCCCCCGAGCCTGCG

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNLDIISSNKSFDGWHKRYSHSSSVLGCEMRFAIYLPPQALTGQKVPVLYWLSGLTCTDENFMQKAGAHRIAAELGIALV
APDTSPRGEGVADDPAYDLGMGAGFYVNASQNPWRDHYQMYDYVTRELPDLIETHFPVSTRRAISGHSMGGHGALIAALR
EPGRYRSVSAFSPISHPSRCPWGQKALGAYLGNNPLLWQEWDACQLLRHHPVTPLPTLVDVGLDDPFLAEQLHIDALADI
AASKAWPLELNRHPGYDHSYYFVASFIEAHLRFHARHL

Sequences:

>Translated_278_residues
MNLDIISSNKSFDGWHKRYSHSSSVLGCEMRFAIYLPPQALTGQKVPVLYWLSGLTCTDENFMQKAGAHRIAAELGIALV
APDTSPRGEGVADDPAYDLGMGAGFYVNASQNPWRDHYQMYDYVTRELPDLIETHFPVSTRRAISGHSMGGHGALIAALR
EPGRYRSVSAFSPISHPSRCPWGQKALGAYLGNNPLLWQEWDACQLLRHHPVTPLPTLVDVGLDDPFLAEQLHIDALADI
AASKAWPLELNRHPGYDHSYYFVASFIEAHLRFHARHL
>Mature_278_residues
MNLDIISSNKSFDGWHKRYSHSSSVLGCEMRFAIYLPPQALTGQKVPVLYWLSGLTCTDENFMQKAGAHRIAAELGIALV
APDTSPRGEGVADDPAYDLGMGAGFYVNASQNPWRDHYQMYDYVTRELPDLIETHFPVSTRRAISGHSMGGHGALIAALR
EPGRYRSVSAFSPISHPSRCPWGQKALGAYLGNNPLLWQEWDACQLLRHHPVTPLPTLVDVGLDDPFLAEQLHIDALADI
AASKAWPLELNRHPGYDHSYYFVASFIEAHLRFHARHL

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=52.3131672597865, Blast_Score=306, Evalue=9e-84,
Organism=Escherichia coli, GI1788477, Length=277, Percent_Identity=58.4837545126354, Blast_Score=334, Evalue=4e-93,
Organism=Escherichia coli, GI1786551, Length=276, Percent_Identity=52.536231884058, Blast_Score=298, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17510185, Length=282, Percent_Identity=42.5531914893617, Blast_Score=227, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6322393, Length=281, Percent_Identity=42.3487544483986, Blast_Score=224, Evalue=9e-60,
Organism=Drosophila melanogaster, GI45551932, Length=279, Percent_Identity=49.1039426523297, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=48.936170212766, Blast_Score=281, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31001; Mature: 31001

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDIISSNKSFDGWHKRYSHSSSVLGCEMRFAIYLPPQALTGQKVPVLYWLSGLTCTDE
CCCEEECCCCCCCHHHHHHCCCCCEEEEEEEEEEEECCHHCCCCCCEEEEEECCCEECCH
NFMQKAGAHRIAAELGIALVAPDTSPRGEGVADDPAYDLGMGAGFYVNASQNPWRDHYQM
HHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCHHHHHH
YDYVTRELPDLIETHFPVSTRRAISGHSMGGHGALIAALREPGRYRSVSAFSPISHPSRC
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHEHHCCCCCCCCCCCCCCCCCCCC
PWGQKALGAYLGNNPLLWQEWDACQLLRHHPVTPLPTLVDVGLDDPFLAEQLHIDALADI
CCCHHHHHHHHCCCCCEECCCHHHHHHHHCCCCCCCHHEECCCCCCHHHHHHHHHHHHHH
AASKAWPLELNRHPGYDHSYYFVASFIEAHLRFHARHL
HHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLDIISSNKSFDGWHKRYSHSSSVLGCEMRFAIYLPPQALTGQKVPVLYWLSGLTCTDE
CCCEEECCCCCCCHHHHHHCCCCCEEEEEEEEEEEECCHHCCCCCCEEEEEECCCEECCH
NFMQKAGAHRIAAELGIALVAPDTSPRGEGVADDPAYDLGMGAGFYVNASQNPWRDHYQM
HHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCHHHHHH
YDYVTRELPDLIETHFPVSTRRAISGHSMGGHGALIAALREPGRYRSVSAFSPISHPSRC
HHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHEHHCCCCCCCCCCCCCCCCCCCC
PWGQKALGAYLGNNPLLWQEWDACQLLRHHPVTPLPTLVDVGLDDPFLAEQLHIDALADI
CCCHHHHHHHHCCCCCEECCCHHHHHHHHCCCCCCCHHEECCCCCCHHHHHHHHHHHHHH
AASKAWPLELNRHPGYDHSYYFVASFIEAHLRFHARHL
HHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA