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The map label for this gene is adhC [H]

Identifier: 145301025

GI number: 145301025

Start: 4474587

End: 4475714

Strand: Direct

Name: adhC [H]

Synonym: ASA_4180

Alternate gene names: 145301025

Gene position: 4474587-4475714 (Clockwise)

Preceding gene: 145301023

Following gene: 145301026

Centisome position: 95.16

GC content: 62.77

Gene sequence:

>1128_bases
ATGGCACAGGTTCAAAGCATCAAGTGTAAAGCCGCCATCGCCTGGGGACCGGGCCAGCCCCTCTCCATCGAAGAGGTGGA
GGTCATGCCACCCCAGGCCGGTGAAGTGCGGGTGCGGATCGTCGCCACCGGCGTCTGCCACACAGATGCCTTCACGCTAT
CCGGCGAAGATCCGGAAGGGGTCTTCCCCTGCATCCTGGGCCATGAAGGCGGCGGCATCGTCGAGTCAATCGGGGAAGGC
GTCACCAGCGTCAAGGTGGGTGATCACGTGATCCCGCTCTACACCCCGGAGTGCGGCGAGTGCAAGTTCTGCAGATCCGG
CAAGACCAACCTGTGCCAGAAGATCCGCGCCACCCAGGGCAAGGGGCTGATGCCGGACGGCACCACCCGTTTCTCCAAGG
ATGGTCAGCCCATCTATCACTACATGGGCACCTCCACCTTCAGTGAGTACACAGTCCTGCCCGAAATCTCCATCGCCAAA
GTGGACCCGGCCGCCCCGCTGGAAGAGGTATGCCTGCTCGGCTGCGGCGTCACCACCGGCATAGGCGCCGTGATGAACAC
CGCCAAGGTGAAGGAAGGTGAGAGCGTCGCCATCTTCGGGCTGGGTGGCATTGGTCTCTCCGCCGTGATCGGCGCCCGCC
TCGCCAAGGCCGGTCGCATCATCGCCATCGACATCAACGAGAGCAAGTTCGAGCTGGCCCGCAAGCTGGGCGCCACCGAC
TGTATCAACCCGAACGATTTCGACAAGCCCATCCAGGAGGTTATCGTCGAGATGACCGACGGCGGCGTCGACTTCTCGTT
CGAGTGCATCGGCAACGTCAAAGTGATGCGCGCGGCGCTGGAGTGTTGTCACAAGGGCTGGGGCGAGTCGGTCATTATCG
GCGTCGCAGGAGCTGGCCAGGAGATCAGCACACGTCCGTTCCAGCTGGTCACCGGCCGGGTCTGGCGCGGCAGTGCCTTC
GGTGGCGTGCGCGGTCGCAGCGAACTGCCGAGCTATGTGCAGCGCTACATGCAGGGGGAGTTCAAGCTGGACGACTTCAT
CACCCATACCATGCCGCTGGAGCAAATCAACGAGGCGTTCGAGCTGATGCACGAAGGCAAGAGCATCCGCACCGTCATTC
ACTACTGA

Upstream 100 bases:

>100_bases
ATTTGATATTTAGCCTTATTATCACCAAATCGAAGGGGAAACTACACTGCATACCTGAGTTCATCTCTGTTCACCTACCG
CAACAAGAAGGATGTCATTC

Downstream 100 bases:

>100_bases
GCATGATCACCCCGCCCGTCCCTCGACGGGCGGGGTGCAGGAGTTCCTCGATGAATCTGGACATTATCAGCAGCAACAAG
AGCTTCGATGGCTGGCACAA

Product: Zn-dependent alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MAQVQSIKCKAAIAWGPGQPLSIEEVEVMPPQAGEVRVRIVATGVCHTDAFTLSGEDPEGVFPCILGHEGGGIVESIGEG
VTSVKVGDHVIPLYTPECGECKFCRSGKTNLCQKIRATQGKGLMPDGTTRFSKDGQPIYHYMGTSTFSEYTVLPEISIAK
VDPAAPLEEVCLLGCGVTTGIGAVMNTAKVKEGESVAIFGLGGIGLSAVIGARLAKAGRIIAIDINESKFELARKLGATD
CINPNDFDKPIQEVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAF
GGVRGRSELPSYVQRYMQGEFKLDDFITHTMPLEQINEAFELMHEGKSIRTVIHY

Sequences:

>Translated_375_residues
MAQVQSIKCKAAIAWGPGQPLSIEEVEVMPPQAGEVRVRIVATGVCHTDAFTLSGEDPEGVFPCILGHEGGGIVESIGEG
VTSVKVGDHVIPLYTPECGECKFCRSGKTNLCQKIRATQGKGLMPDGTTRFSKDGQPIYHYMGTSTFSEYTVLPEISIAK
VDPAAPLEEVCLLGCGVTTGIGAVMNTAKVKEGESVAIFGLGGIGLSAVIGARLAKAGRIIAIDINESKFELARKLGATD
CINPNDFDKPIQEVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAF
GGVRGRSELPSYVQRYMQGEFKLDDFITHTMPLEQINEAFELMHEGKSIRTVIHY
>Mature_374_residues
AQVQSIKCKAAIAWGPGQPLSIEEVEVMPPQAGEVRVRIVATGVCHTDAFTLSGEDPEGVFPCILGHEGGGIVESIGEGV
TSVKVGDHVIPLYTPECGECKFCRSGKTNLCQKIRATQGKGLMPDGTTRFSKDGQPIYHYMGTSTFSEYTVLPEISIAKV
DPAAPLEEVCLLGCGVTTGIGAVMNTAKVKEGESVAIFGLGGIGLSAVIGARLAKAGRIIAIDINESKFELARKLGATDC
INPNDFDKPIQEVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFG
GVRGRSELPSYVQRYMQGEFKLDDFITHTMPLEQINEAFELMHEGKSIRTVIHY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=67.479674796748, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=55.2845528455285, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=53.6388140161725, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=53.6585365853659, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=54.1554959785523, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=52.3035230352303, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=52.6170798898072, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=51.219512195122, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=51.219512195122, Blast_Score=399, Evalue=1e-111,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=71.5447154471545, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI87082125, Length=374, Percent_Identity=25.1336898395722, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787863, Length=361, Percent_Identity=25.4847645429363, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=26.0989010989011, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786825, Length=363, Percent_Identity=25.8953168044077, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788073, Length=366, Percent_Identity=26.5027322404372, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081918, Length=340, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=228, Percent_Identity=27.6315789473684, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=360, Percent_Identity=23.6111111111111, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786518, Length=372, Percent_Identity=26.3440860215054, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790718, Length=329, Percent_Identity=24.6200607902736, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=58.4, Blast_Score=480, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=58.0901856763926, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=57.0588235294118, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17562584, Length=364, Percent_Identity=28.8461538461538, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=26.6129032258064, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=362, Percent_Identity=26.7955801104972, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=60.857908847185, Blast_Score=492, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6319621, Length=375, Percent_Identity=29.0666666666667, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=360, Percent_Identity=30, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=359, Percent_Identity=28.6908077994429, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=359, Percent_Identity=26.7409470752089, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=368, Percent_Identity=26.9021739130435, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=27.3480662983425, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=27.3480662983425, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=64.1509433962264, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17137530, Length=348, Percent_Identity=27.0114942528736, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737897, Length=376, Percent_Identity=23.6702127659574, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40160; Mature: 40028

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVQSIKCKAAIAWGPGQPLSIEEVEVMPPQAGEVRVRIVATGVCHTDAFTLSGEDPEG
CCCCCCEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEEEEEEECCEEEECCCCCCC
VFPCILGHEGGGIVESIGEGVTSVKVGDHVIPLYTPECGECKFCRSGKTNLCQKIRATQG
CEEEEEECCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
KGLMPDGTTRFSKDGQPIYHYMGTSTFSEYTVLPEISIAKVDPAAPLEEVCLLGCGVTTG
CCCCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHCCHHHH
IGAVMNTAKVKEGESVAIFGLGGIGLSAVIGARLAKAGRIIAIDINESKFELARKLGATD
HHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCC
CINPNDFDKPIQEVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQ
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
EISTRPFQLVTGRVWRGSAFGGVRGRSELPSYVQRYMQGEFKLDDFITHTMPLEQINEAF
CCCCCCEEEEECEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
ELMHEGKSIRTVIHY
HHHHCCCCEEEEECC
>Mature Secondary Structure 
AQVQSIKCKAAIAWGPGQPLSIEEVEVMPPQAGEVRVRIVATGVCHTDAFTLSGEDPEG
CCCCCEEEEEEEEECCCCCCCCCEEEECCCCCCCEEEEEEEEEEEECCEEEECCCCCCC
VFPCILGHEGGGIVESIGEGVTSVKVGDHVIPLYTPECGECKFCRSGKTNLCQKIRATQG
CEEEEEECCCCCHHHHHCCCCEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
KGLMPDGTTRFSKDGQPIYHYMGTSTFSEYTVLPEISIAKVDPAAPLEEVCLLGCGVTTG
CCCCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHCCHHHH
IGAVMNTAKVKEGESVAIFGLGGIGLSAVIGARLAKAGRIIAIDINESKFELARKLGATD
HHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCC
CINPNDFDKPIQEVIVEMTDGGVDFSFECIGNVKVMRAALECCHKGWGESVIIGVAGAGQ
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCC
EISTRPFQLVTGRVWRGSAFGGVRGRSELPSYVQRYMQGEFKLDDFITHTMPLEQINEAF
CCCCCCEEEEECEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
ELMHEGKSIRTVIHY
HHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]