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The map label for this gene is hutC [H]

Identifier: 145300222

GI number: 145300222

Start: 3607933

End: 3608964

Strand: Direct

Name: hutC [H]

Synonym: ASA_3335

Alternate gene names: 145300222

Gene position: 3607933-3608964 (Clockwise)

Preceding gene: 145300221

Following gene: 145300223

Centisome position: 76.73

GC content: 69.09

Gene sequence:

>1032_bases
ATGATGCGCCTGCCTCTGCCCTGGCTTTTCGCGCTCACCGGCGGAGCGCTGGCGCTGCTGCTGGTCGGGTCGCTGGCGAC
CGGCCCCATGGCGCTCTCCCTCGGCGAGAGCCTGCGTGCCCTGGTCGCCGGGCAGGAGAGCGGGATTGCGGCCCACAAGC
TCTTGATCGTGCAGGAGATCCGCCTGCCACGTACCCTGCTCTGCATCGCCGTGGGAGGCATACTCGGCCTCTGTGGCGCC
GTCATGCAGGGGCTGTTTCGCAATCCGCTGGCCGACCCCGGCATCATAGGGGTCTCCGGTGGGGCTGCGCTCGGCGCCGC
GCTGGCCATAGTGCTGCTGGCGCCCCTCGGCCAGCAGTGGCAAAGCCTGCTCGGCATAGGTCTGCTGCCCCTGCTCGCCT
TCCTCGGCGGGGCGCTTACCACCACGCTGGTATATTTGCTGGGCACCCGGGAAGGGGGTACCTCCGTCACCGTCATGTTG
CTGGCGGGGGTGGCCATCACGGCACTGTCCGGCGCCGTGATAGGGCTGCTCACCTACCTGGCCGACGACCAGATGCTGCG
CAACCTGAGCCTGTGGCAGATGGGCACCTTGGCGGCGGGCAAGCCGGTGGACGTGGCGCTGGCGCTGGCCACCCTGGTCG
TTCTGCTGCTGTTGTTCATGCGCGATGCCAATCCCCTCAACGCCCTGTTGCTGGGGGAAGGGGAGGCCCGTCATCTGGGG
GTCAATGTGCAATCTCTCAAGCGGCGCCTGATCCTGCTCACCGCCGCCGGGGTCGGCGTGGCCGTCGCCGTGGCGGGCAT
GATCGGCTTCGTCGGTCTGGTGGTGCCCCATCTGGTGCGGCTGCTGGCCGGCCCCAACCATGTCAGGTTGCTGCCGCTTT
CGGCCTTGCTCGGCGCAGCCCTGCTGCTGGGCGCCGACATGCTGGCCCGCACTCTGCTGGCGCCGGCCGAGCTGCCGGTC
GGCATCATCACGGCCCTGCTGGGCGCCCCCTTCTTCATCTGGCTGCTGGTCAAGGGCCGTCGGACGCTTTAA

Upstream 100 bases:

>100_bases
GGGCCATCCACGCCATCGACGGCCACGCCCTGCAAGGGGGCCTCAGCCTCACCTCGTTGCACCAGGCAAACCAGATCGCC
AAGTGGATCAAGCTGGGTTC

Downstream 100 bases:

>100_bases
CCGGAGGTCTATCTTGCCTGCATCAACGCCCCTGCTGCGCTGTCACCAGCTCAGCCTCACCCGTGGTGGCCGCCCCATCC
TGGACAGGCTCGACCTCAGC

Product: ABC-type hemin transporter, permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MMRLPLPWLFALTGGALALLLVGSLATGPMALSLGESLRALVAGQESGIAAHKLLIVQEIRLPRTLLCIAVGGILGLCGA
VMQGLFRNPLADPGIIGVSGGAALGAALAIVLLAPLGQQWQSLLGIGLLPLLAFLGGALTTTLVYLLGTREGGTSVTVML
LAGVAITALSGAVIGLLTYLADDQMLRNLSLWQMGTLAAGKPVDVALALATLVVLLLLFMRDANPLNALLLGEGEARHLG
VNVQSLKRRLILLTAAGVGVAVAVAGMIGFVGLVVPHLVRLLAGPNHVRLLPLSALLGAALLLGADMLARTLLAPAELPV
GIITALLGAPFFIWLLVKGRRTL

Sequences:

>Translated_343_residues
MMRLPLPWLFALTGGALALLLVGSLATGPMALSLGESLRALVAGQESGIAAHKLLIVQEIRLPRTLLCIAVGGILGLCGA
VMQGLFRNPLADPGIIGVSGGAALGAALAIVLLAPLGQQWQSLLGIGLLPLLAFLGGALTTTLVYLLGTREGGTSVTVML
LAGVAITALSGAVIGLLTYLADDQMLRNLSLWQMGTLAAGKPVDVALALATLVVLLLLFMRDANPLNALLLGEGEARHLG
VNVQSLKRRLILLTAAGVGVAVAVAGMIGFVGLVVPHLVRLLAGPNHVRLLPLSALLGAALLLGADMLARTLLAPAELPV
GIITALLGAPFFIWLLVKGRRTL
>Mature_343_residues
MMRLPLPWLFALTGGALALLLVGSLATGPMALSLGESLRALVAGQESGIAAHKLLIVQEIRLPRTLLCIAVGGILGLCGA
VMQGLFRNPLADPGIIGVSGGAALGAALAIVLLAPLGQQWQSLLGIGLLPLLAFLGGALTTTLVYLLGTREGGTSVTVML
LAGVAITALSGAVIGLLTYLADDQMLRNLSLWQMGTLAAGKPVDVALALATLVVLLLLFMRDANPLNALLLGEGEARHLG
VNVQSLKRRLILLTAAGVGVAVAVAGMIGFVGLVVPHLVRLLAGPNHVRLLPLSALLGAALLLGADMLARTLLAPAELPV
GIITALLGAPFFIWLLVKGRRTL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=291, Percent_Identity=44.6735395189003, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790740, Length=302, Percent_Identity=39.0728476821192, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790741, Length=307, Percent_Identity=35.8306188925081, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786805, Length=295, Percent_Identity=38.3050847457627, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786347, Length=332, Percent_Identity=31.6265060240964, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786804, Length=287, Percent_Identity=31.7073170731707, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35087; Mature: 35087

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRLPLPWLFALTGGALALLLVGSLATGPMALSLGESLRALVAGQESGIAAHKLLIVQEI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RLPRTLLCIAVGGILGLCGAVMQGLFRNPLADPGIIGVSGGAALGAALAIVLLAPLGQQW
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCHHH
QSLLGIGLLPLLAFLGGALTTTLVYLLGTREGGTSVTVMLLAGVAITALSGAVIGLLTYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADDQMLRNLSLWQMGTLAAGKPVDVALALATLVVLLLLFMRDANPLNALLLGEGEARHLG
HHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEC
VNVQSLKRRLILLTAAGVGVAVAVAGMIGFVGLVVPHLVRLLAGPNHVRLLPLSALLGAA
CCHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
LLLGADMLARTLLAPAELPVGIITALLGAPFFIWLLVKGRRTL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMRLPLPWLFALTGGALALLLVGSLATGPMALSLGESLRALVAGQESGIAAHKLLIVQEI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
RLPRTLLCIAVGGILGLCGAVMQGLFRNPLADPGIIGVSGGAALGAALAIVLLAPLGQQW
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCHHH
QSLLGIGLLPLLAFLGGALTTTLVYLLGTREGGTSVTVMLLAGVAITALSGAVIGLLTYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADDQMLRNLSLWQMGTLAAGKPVDVALALATLVVLLLLFMRDANPLNALLLGEGEARHLG
HHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEC
VNVQSLKRRLILLTAAGVGVAVAVAGMIGFVGLVVPHLVRLLAGPNHVRLLPLSALLGAA
CCHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
LLLGADMLARTLLAPAELPVGIITALLGAPFFIWLLVKGRRTL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]