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The map label for this gene is ppiC [H]

Identifier: 145299728

GI number: 145299728

Start: 3008036

End: 3008314

Strand: Direct

Name: ppiC [H]

Synonym: ASA_2805

Alternate gene names: 145299728

Gene position: 3008036-3008314 (Clockwise)

Preceding gene: 145299727

Following gene: 145299730

Centisome position: 63.97

GC content: 56.63

Gene sequence:

>279_bases
ATGAAGAAAGCCTGTGCCCAGCACATCCTGGTCAAGACCGAGAAGCAGTGTCTGGAGATCAAGGAGAAACTTGCCAAGGG
AGCCGACTTTGGCCAGATGGCCAAGCGCTTCTCCACCTGCGCCTCATCCAAGCGCTCGGGGGATCTGGGGGAGTTTTCGA
AGGGTGACATGGTCAAGCCGTTTGACGATGCCGTGTTCAAGGGTGAGTTGCTGACCGTACTCGGCCCTGTGCGCACCAAG
TTCGGCTTTCACCTCATCAAGGTGCTATACCGCAACTGA

Upstream 100 bases:

>100_bases
GACGGCTCACCTGCGTGGCTAATGCCAGAGTCCGGCTGACGTGTGCGATGAATTGGGGTAATCTTGCGCCCCGATTTGCC
ATCCGCCGAGGAGCACCCGA

Downstream 100 bases:

>100_bases
TTGCTCATAAACGGATGGCTCAGAGCTCGGGTGACAACACCAGGGGCCAACCGCCGCACCGGCGGGCATAGAAGCCAAAG
CGCCAGGGATGGCGTTGTGC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase C; Parvulin; Rotamase C [H]

Number of amino acids: Translated: 92; Mature: 92

Protein sequence:

>92_residues
MKKACAQHILVKTEKQCLEIKEKLAKGADFGQMAKRFSTCASSKRSGDLGEFSKGDMVKPFDDAVFKGELLTVLGPVRTK
FGFHLIKVLYRN

Sequences:

>Translated_92_residues
MKKACAQHILVKTEKQCLEIKEKLAKGADFGQMAKRFSTCASSKRSGDLGEFSKGDMVKPFDDAVFKGELLTVLGPVRTK
FGFHLIKVLYRN
>Mature_92_residues
MKKACAQHILVKTEKQCLEIKEKLAKGADFGQMAKRFSTCASSKRSGDLGEFSKGDMVKPFDDAVFKGELLTVLGPVRTK
FGFHLIKVLYRN

Specific function: PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=85, Percent_Identity=41.1764705882353, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790211, Length=91, Percent_Identity=56.043956043956, Blast_Score=107, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 10268; Mature: 10268

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKACAQHILVKTEKQCLEIKEKLAKGADFGQMAKRFSTCASSKRSGDLGEFSKGDMVKP
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
FDDAVFKGELLTVLGPVRTKFGFHLIKVLYRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKACAQHILVKTEKQCLEIKEKLAKGADFGQMAKRFSTCASSKRSGDLGEFSKGDMVKP
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
FDDAVFKGELLTVLGPVRTKFGFHLIKVLYRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]