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The map label for this gene is guaD [H]

Identifier: 145299654

GI number: 145299654

Start: 2924565

End: 2925083

Strand: Direct

Name: guaD [H]

Synonym: ASA_2728

Alternate gene names: 145299654

Gene position: 2924565-2925083 (Clockwise)

Preceding gene: 145299652

Following gene: 145299655

Centisome position: 62.19

GC content: 63.2

Gene sequence:

>519_bases
ATGTCTCATCCACCTGTCGACCCCGCTGGCTCTCGCCTGATCCAGTCGCTGACCGCTAACCCCAGCCATCAGGAGTGGCT
GGAGCAGGCGCTGCAACTGGCCCTGCAGAATCGGCAGCGAGGAGGTCGCCCCTTCGCAGCCCTGCTGGTGCAAAATGACC
GACTGGTAGCAGGCGCCGTCAATGCCATGCATCTGGAGGGTGACCCCACCCGCCATGCGGAGCTGGAAGCCCTGCGCCAG
GCCAGCCAATCCGGGCCGCTGGCGGGGGCCATCATCTATGCCAGCGGCCACCCCTGCCCCATGTGCCTGAGTGCGCTGGT
GATGAACGGCATCCGCGCCGTCTATTACGCCTTTGATAACCATGATGCAGCCCCCTTCGGCTTTGACAGCACATCGAGCT
ATGACAAGCTGCGACTGCCCCTTAACCCGCCACCTCTGCCCCTCATCAAACTACCAGTCTCCCTCGGCGCCACCGCGCTC
TATGGAGACAACTCAGAGGCGGAACTAGCCCATGAGTAA

Upstream 100 bases:

>100_bases
ATTTACAAAATTACTGGATGTCATTCTATCATTTAATTTCCAAATGATTGATGGCGCCACTAGGCTGATCTGCTCCCCTC
ATTGGCTTAAGGTCTCTCTC

Downstream 100 bases:

>100_bases
GGACCTGCCCGCCAGCACTCTGCACCACAGCAAGCAGGATCTGGCCCTGCTGGTGCTGGTGATCCTGATTGGCCTCAATC
TGCGTCCCTTTCTCACCGCC

Product: cytidine/deoxycytidylate deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MSHPPVDPAGSRLIQSLTANPSHQEWLEQALQLALQNRQRGGRPFAALLVQNDRLVAGAVNAMHLEGDPTRHAELEALRQ
ASQSGPLAGAIIYASGHPCPMCLSALVMNGIRAVYYAFDNHDAAPFGFDSTSSYDKLRLPLNPPPLPLIKLPVSLGATAL
YGDNSEAELAHE

Sequences:

>Translated_172_residues
MSHPPVDPAGSRLIQSLTANPSHQEWLEQALQLALQNRQRGGRPFAALLVQNDRLVAGAVNAMHLEGDPTRHAELEALRQ
ASQSGPLAGAIIYASGHPCPMCLSALVMNGIRAVYYAFDNHDAAPFGFDSTSSYDKLRLPLNPPPLPLIKLPVSLGATAL
YGDNSEAELAHE
>Mature_171_residues
SHPPVDPAGSRLIQSLTANPSHQEWLEQALQLALQNRQRGGRPFAALLVQNDRLVAGAVNAMHLEGDPTRHAELEALRQA
SQSGPLAGAIIYASGHPCPMCLSALVMNGIRAVYYAFDNHDAAPFGFDSTSSYDKLRLPLNPPPLPLIKLPVSLGATALY
GDNSEAELAHE

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17555996, Length=125, Percent_Identity=35.2, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554608, Length=134, Percent_Identity=29.8507462686567, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 18438; Mature: 18307

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPPVDPAGSRLIQSLTANPSHQEWLEQALQLALQNRQRGGRPFAALLVQNDRLVAGAV
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECC
NAMHLEGDPTRHAELEALRQASQSGPLAGAIIYASGHPCPMCLSALVMNGIRAVYYAFDN
EEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEEECC
HDAAPFGFDSTSSYDKLRLPLNPPPLPLIKLPVSLGATALYGDNSEAELAHE
CCCCCCCCCCCCCCCEEECCCCCCCCCEEEECHHHCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
SHPPVDPAGSRLIQSLTANPSHQEWLEQALQLALQNRQRGGRPFAALLVQNDRLVAGAV
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEECC
NAMHLEGDPTRHAELEALRQASQSGPLAGAIIYASGHPCPMCLSALVMNGIRAVYYAFDN
EEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEEECC
HDAAPFGFDSTSSYDKLRLPLNPPPLPLIKLPVSLGATALYGDNSEAELAHE
CCCCCCCCCCCCCCCEEECCCCCCCCCEEEECHHHCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]