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The map label for this gene is aroP [H]

Identifier: 145299483

GI number: 145299483

Start: 2722071

End: 2723447

Strand: Direct

Name: aroP [H]

Synonym: ASA_2547

Alternate gene names: 145299483

Gene position: 2722071-2723447 (Clockwise)

Preceding gene: 145299481

Following gene: 145299484

Centisome position: 57.89

GC content: 58.9

Gene sequence:

>1377_bases
ATGGATCTTCAACAAGACGGCGAGGAGCTGAAGCGCGGCCTGAAAAACCGCCATATCCAGCTCATCGCATTGGGCTGTGC
CATAGGTACCGGCCTGTTTCTCGGCATTGCCCAGACCATCAAGATGGCGGGCCCCTCAGTGCTGCTCGGCTATGCCATCG
GCGGCTTTATTGCCTTTCTCATCATGCGCCAGTTGGGTGAGATGGTGGTGGAAGAGCCGGTAGCGGGCTCCTTCAGCCAC
TTTGCCTACAAATACTGGGGTGACTTCGCCGGTTTCGCCTCCGGCTGGAACTACTGGGTACTCTACGTGCTGGTGAGCAT
GGCCGAGCTGACGGCGGTCGGCATCTATGTCCAGTACTGGTGGCCCGAGATCCCGACCTGGATGTCGGCTGCCGTCTTCT
TCGTGCTGATCAACGCCATCAACCTCTCCAACGTCAAGGCGTTCGGCGAGATGGAATTCTGGTTTGCCATCATCAAGGTG
GTCGCCATCGTCGGCATGATTGGCTTTGGCGGCTACCTGCTCGCCAGCGGCAACGGCGGACCGGATGCCAGCATCACCAA
TCTGTGGGACCAGGGCGGTTTCTTCCCCAACGGCATCAGCGGTCTGGTGATGGCGATGGCGGTGATCATGTTCTCGTTTG
GCGGCCTTGAGCTGGTAGGGATCACGGCCGCAGAGGCGGATGACCCCGATAAGAGCATTCCCAAGGCCACCAATCAGGTG
ATCTACCGTATCCTGATTTTCTACATTGGCGCCCTGGCCGTGCTAATGTCCCTCTATCCCTGGGGCAAGGTGGTGGAAGG
CGGCAGTCCCTTCGTGATGATCTTCCACGCGCTGGATAGCAACCTGGTGGCAACCGTGCTCAACATGGTGGTGCTGACCG
CTGCATTGTCGGTCTACAACAGCTGTGTCTACTGCAACAGCCGCATGCTGTTCGGTCTGGCCAAGCAGGGCAACGGCCCG
CGCAGCCTGCTCAAAACCAGCAAGAGCGGTGTGCCCGTAGTGGCTATCTCCGTCTCCGCAGCGGCAACCCTCTTGTGCGT
GCTGATCAACTACCTGATGCCGGGCAAGGCGTTCGAGTTGCTGATGGCACTGGTGGTCTCGGCCCTGGTCATCAACTGGG
CCATGATAAGCCTTGCGCACCTGAAGTTTCGCAAGAGCAAACAGGCCGAAGGGGTTGAGCCCAAGTTCAAGGCATTCTGG
TACCCGTTCGGTAACTACCTCTGCCTTGCCTTCATGGCCGGTATCCTGGTCATCATGTACCTGACTCCGGGCATCCAGAT
CTCGGTGCTGCTCATCCCGGTCTGGATCGTCGTGCTGGCCATCGGTTATCAACTCAAGCTGAAACGTCAGGGACGTCTTG
CCGCCGACCTTGGCTGA

Upstream 100 bases:

>100_bases
GTCACGTTTCAAGCACGCTTTGCCGTGCAAGGTCACATGAGTGACTCGACGGGCGAGATGACAGACGAGTGACATCAGAG
ACGTAAGGAAGGAAGGAAGA

Downstream 100 bases:

>100_bases
TTTTTCCGACGCTCGTTATTCAAATGCCGGTCACTGACCGGCATTTTTCTATCCATCTTCTATCTGCTGCCAGATGCTGA
GCACAGGGATGCAAGCCATC

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MDLQQDGEELKRGLKNRHIQLIALGCAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFASGWNYWVLYVLVSMAELTAVGIYVQYWWPEIPTWMSAAVFFVLINAINLSNVKAFGEMEFWFAIIKV
VAIVGMIGFGGYLLASGNGGPDASITNLWDQGGFFPNGISGLVMAMAVIMFSFGGLELVGITAAEADDPDKSIPKATNQV
IYRILIFYIGALAVLMSLYPWGKVVEGGSPFVMIFHALDSNLVATVLNMVVLTAALSVYNSCVYCNSRMLFGLAKQGNGP
RSLLKTSKSGVPVVAISVSAAATLLCVLINYLMPGKAFELLMALVVSALVINWAMISLAHLKFRKSKQAEGVEPKFKAFW
YPFGNYLCLAFMAGILVIMYLTPGIQISVLLIPVWIVVLAIGYQLKLKRQGRLAADLG

Sequences:

>Translated_458_residues
MDLQQDGEELKRGLKNRHIQLIALGCAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFASGWNYWVLYVLVSMAELTAVGIYVQYWWPEIPTWMSAAVFFVLINAINLSNVKAFGEMEFWFAIIKV
VAIVGMIGFGGYLLASGNGGPDASITNLWDQGGFFPNGISGLVMAMAVIMFSFGGLELVGITAAEADDPDKSIPKATNQV
IYRILIFYIGALAVLMSLYPWGKVVEGGSPFVMIFHALDSNLVATVLNMVVLTAALSVYNSCVYCNSRMLFGLAKQGNGP
RSLLKTSKSGVPVVAISVSAAATLLCVLINYLMPGKAFELLMALVVSALVINWAMISLAHLKFRKSKQAEGVEPKFKAFW
YPFGNYLCLAFMAGILVIMYLTPGIQISVLLIPVWIVVLAIGYQLKLKRQGRLAADLG
>Mature_458_residues
MDLQQDGEELKRGLKNRHIQLIALGCAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFASGWNYWVLYVLVSMAELTAVGIYVQYWWPEIPTWMSAAVFFVLINAINLSNVKAFGEMEFWFAIIKV
VAIVGMIGFGGYLLASGNGGPDASITNLWDQGGFFPNGISGLVMAMAVIMFSFGGLELVGITAAEADDPDKSIPKATNQV
IYRILIFYIGALAVLMSLYPWGKVVEGGSPFVMIFHALDSNLVATVLNMVVLTAALSVYNSCVYCNSRMLFGLAKQGNGP
RSLLKTSKSGVPVVAISVSAAATLLCVLINYLMPGKAFELLMALVVSALVINWAMISLAHLKFRKSKQAEGVEPKFKAFW
YPFGNYLCLAFMAGILVIMYLTPGIQISVLLIPVWIVVLAIGYQLKLKRQGRLAADLG

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=399, Percent_Identity=21.8045112781955, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=74.780701754386, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=65.3333333333333, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=46.2882096069869, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=40.6593406593407, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790653, Length=459, Percent_Identity=40.5228758169935, Blast_Score=342, Evalue=4e-95,
Organism=Escherichia coli, GI87081915, Length=453, Percent_Identity=36.2030905077263, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1789017, Length=432, Percent_Identity=36.5740740740741, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI87081708, Length=427, Percent_Identity=35.3629976580796, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1788480, Length=466, Percent_Identity=32.8326180257511, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082023, Length=369, Percent_Identity=22.7642276422764, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=25.4335260115607, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=373, Percent_Identity=24.3967828418231, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=444, Percent_Identity=35.5855855855856, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6324061, Length=445, Percent_Identity=33.2584269662921, Blast_Score=226, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6324924, Length=450, Percent_Identity=32.2222222222222, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322892, Length=444, Percent_Identity=33.5585585585586, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324553, Length=401, Percent_Identity=33.4164588528678, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=440, Percent_Identity=33.8636363636364, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6319824, Length=403, Percent_Identity=30.0248138957816, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=493, Percent_Identity=30.4259634888438, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=429, Percent_Identity=30.3030303030303, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=28.992628992629, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322967, Length=399, Percent_Identity=30.3258145363409, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320251, Length=403, Percent_Identity=28.7841191066998, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319608, Length=438, Percent_Identity=27.3972602739726, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=407, Percent_Identity=28.2555282555283, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=400, Percent_Identity=28, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=398, Percent_Identity=28.1407035175879, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=28.3208020050125, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=492, Percent_Identity=25.4065040650407, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667468, Length=280, Percent_Identity=25.7142857142857, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668806, Length=378, Percent_Identity=24.0740740740741, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356285, Length=378, Percent_Identity=24.0740740740741, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668802, Length=378, Percent_Identity=24.0740740740741, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221512776, Length=338, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24666159, Length=338, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49681; Mature: 49681

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQQDGEELKRGLKNRHIQLIALGCAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFASGWNYWVLYVLVSMAELTAVGIYVQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEE
WPEIPTWMSAAVFFVLINAINLSNVKAFGEMEFWFAIIKVVAIVGMIGFGGYLLASGNGG
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PDASITNLWDQGGFFPNGISGLVMAMAVIMFSFGGLELVGITAAEADDPDKSIPKATNQV
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHH
IYRILIFYIGALAVLMSLYPWGKVVEGGSPFVMIFHALDSNLVATVLNMVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAKQGNGPRSLLKTSKSGVPVVAISVSAAATLLCVLINYLMPGKAFEL
HHHHCCCHHHEEECCCCCCHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHH
LMALVVSALVINWAMISLAHLKFRKSKQAEGVEPKFKAFWYPFGNYLCLAFMAGILVIMY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHHH
LTPGIQISVLLIPVWIVVLAIGYQLKLKRQGRLAADLG
HCCCCEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MDLQQDGEELKRGLKNRHIQLIALGCAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFASGWNYWVLYVLVSMAELTAVGIYVQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEE
WPEIPTWMSAAVFFVLINAINLSNVKAFGEMEFWFAIIKVVAIVGMIGFGGYLLASGNGG
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PDASITNLWDQGGFFPNGISGLVMAMAVIMFSFGGLELVGITAAEADDPDKSIPKATNQV
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHH
IYRILIFYIGALAVLMSLYPWGKVVEGGSPFVMIFHALDSNLVATVLNMVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAKQGNGPRSLLKTSKSGVPVVAISVSAAATLLCVLINYLMPGKAFEL
HHHHCCCHHHEEECCCCCCHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHH
LMALVVSALVINWAMISLAHLKFRKSKQAEGVEPKFKAFWYPFGNYLCLAFMAGILVIMY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCHHHHHHHHHHHHHHHHHH
LTPGIQISVLLIPVWIVVLAIGYQLKLKRQGRLAADLG
HCCCCEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]