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The map label for this gene is hpt [H]

Identifier: 145296693

GI number: 145296693

Start: 2869913

End: 2870497

Strand: Reverse

Name: hpt [H]

Synonym: cgR_2598

Alternate gene names: 145296693

Gene position: 2870497-2869913 (Counterclockwise)

Preceding gene: 145296694

Following gene: 145296692

Centisome position: 86.61

GC content: 54.19

Gene sequence:

>585_bases
ATGGCCGACCACAAAGATCTCAATGTTCCAGCCAACCCATACGGCACCGACATTGAATCAGTATTGATCAGCGAAGAGAA
GCTCAAGCAGCGCATCGCCGAAATGGCCAAGCGCGTCTCCGAAGAGTTCAAAGACGCCGAAGAAGACCTCATCCTGGTGT
GCGTGCTCAAGGGCGCGTTCTACTTCCTGGCAGATTTCTCCCGCATGCTCGACATCCCCACCCAGTCCGAGTTCATGGCG
GTGTCCTCTTACGGAAACTCCACCTCCTCTTCAGGCGTGGTGCGCATCCTCAAGGACCTGGACAAGGAAATTGAAGGCCG
CGACGTTTTGATCGTGGAAGACATTATCGATTCCGGACTGACCTTGTCCTGGCTGATGCGCAACCTGAAAAACCGCAACC
CTAAGTCCCTCAACGTGATCACCTTGCTGCGTAAGCCAGAGCGCCTGACCACCAGCATCGACATGTTCGACATTGGATTT
GATATTCCAAATGAGTTTGTTGTGGGCTACGGACTTGATTTCGCAGAACGCTACCGCGACCTGCCATATGTGGGCACCCT
CGAGCCTCACGTGTACTCCGACTAG

Upstream 100 bases:

>100_bases
AAGGTTGGAAGTGGTGCGGCAAAGTGGCAAGCTTAAGATCACTGATTGACACCTGAATCTACAACACAAGGGGAACGCGA
CGATGAGTAACAACGTAGAA

Downstream 100 bases:

>100_bases
TAATCAAAAGTGCGAAAGAGGGAACGTTTTGGCCCTCAACTTCGTTTGATTAGTTGTCTAGTAGATCCCTTTTATTCGAT
TCCGAGAAAGGCACGGGCAA

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAFYFLADFSRMLDIPTQSEFMA
VSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTSIDMFDIGF
DIPNEFVVGYGLDFAERYRDLPYVGTLEPHVYSD

Sequences:

>Translated_194_residues
MADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAFYFLADFSRMLDIPTQSEFMA
VSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTSIDMFDIGF
DIPNEFVVGYGLDFAERYRDLPYVGTLEPHVYSD
>Mature_193_residues
ADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAFYFLADFSRMLDIPTQSEFMAV
SSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGLTLSWLMRNLKNRNPKSLNVITLLRKPERLTTSIDMFDIGFD
IPNEFVVGYGLDFAERYRDLPYVGTLEPHVYSD

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=193, Percent_Identity=35.2331606217617, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI9910262, Length=197, Percent_Identity=32.994923857868, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI87081689, Length=167, Percent_Identity=50.8982035928144, Blast_Score=176, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17510817, Length=186, Percent_Identity=31.7204301075269, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 22020; Mature: 21889

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEHHHHHHHH
YFLADFSRMLDIPTQSEFMAVSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGL
HHHHHHHHHHCCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
TLSWLMRNLKNRNPKSLNVITLLRKPERLTTSIDMFDIGFDIPNEFVVGYGLDFAERYRD
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHEEEEEECCCCCCCCEEEECCCCHHHHHCC
LPYVGTLEPHVYSD
CCCCCCCCCCCCCC
>Mature Secondary Structure 
ADHKDLNVPANPYGTDIESVLISEEKLKQRIAEMAKRVSEEFKDAEEDLILVCVLKGAF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEHHHHHHHH
YFLADFSRMLDIPTQSEFMAVSSYGNSTSSSGVVRILKDLDKEIEGRDVLIVEDIIDSGL
HHHHHHHHHHCCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
TLSWLMRNLKNRNPKSLNVITLLRKPERLTTSIDMFDIGFDIPNEFVVGYGLDFAERYRD
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHEEEEEECCCCCCCCEEEECCCCHHHHHCC
LPYVGTLEPHVYSD
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA