Click here to switch to the map view.

The map label for this gene is folP1 [H]

Identifier: 145296690

GI number: 145296690

Start: 2865781

End: 2866635

Strand: Reverse

Name: folP1 [H]

Synonym: cgR_2595

Alternate gene names: 145296690

Gene position: 2866635-2865781 (Counterclockwise)

Preceding gene: 145296691

Following gene: 145296689

Centisome position: 86.5

GC content: 58.95

Gene sequence:

>855_bases
ATGAACGTATCCTCTTTGACCATCCCGGGACGCTGTTTGGTCATGGGAATTGTCAATGTCACTGAGGATTCCTTTTCGGA
CGGTGGCAAGTACATTGACGTTGATCAGGCGATCGCGCATGCCAAGGAATTGGTGGCTGCTGGCGCCGACATGATTGATG
TCGGCGGCGAGTCCACCCGGCCTGGGGCAGTGCGCGTCGACGCGTCCGTGGAACGGGACCGGGTTGTGCCGGTCATTAAG
GCGCTTCACGACGCCGGCATCCACACTTCCGTAGACACCATGCGGGCCTCCGTGGCGCAGGCTGCCGCGGGCGCTGGCGT
CTCCATGATCAACGACGTCTCTGGCGGTTTGGCTGATCCTGAGATGTTTTCTGTCATGGCGGAAGCGCAAATTCCCGTCT
GTTTGATGCACTGGCGCACCCTCCAATTCGGTGATGCCGCAGGTCAGGCAGATCACGGTGGAGACGTTGTAGCCGATGTG
CACGCAGTGCTTGATGATCTTGTCGCCCGCGCCACCGCTGCTGGTGTGGCCGAAAACCAGATCGTGCTTGATCCAGGTTT
GGGTTTTGCCAAATCACGTGAAGACAACTGGCGTTTGCTGCAAGCACTGCCCGAGTTTATTTCTGGACCTTTCCCCATCC
TGGTGGGAGCATCCCGGAAGCGATTCCTGGCTGGCGTGCGCAAAGACCGTGGCCTAGATGTCACCCCCATTGATGCCGAC
CCAGCAACCGCAGCGGTGACCGCAGTTTCTGCACATATGGGAGCATGGGGTGTGCGCGTGCACGATGTCCCAGTATCAAG
GGACGCTGTTGATGTTGCCGCATTGTGGCGAAGTGGAGGAACTCACCATGGCTGA

Upstream 100 bases:

>100_bases
TAAGCCTGGCGCTGTGACCACGACGTCTGCGGTGCGCGGCGGCTTTAAGAACAATGCTGCCTCCCGTGCTGAGGTGTTCT
CCCTGATTCGGGGGCACTAA

Downstream 100 bases:

>100_bases
TCGTATTGAACTTAAAGGCCTTGAATGCTTCGGACACCACGGTGTGTTCGACTTTGAAAAAGAGCAAGGCCAGCCCTTCA
TTGTGGATGTCACCTGCTGG

Product: hypothetical protein

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNVSSLTIPGRCLVMGIVNVTEDSFSDGGKYIDVDQAIAHAKELVAAGADMIDVGGESTRPGAVRVDASVERDRVVPVIK
ALHDAGIHTSVDTMRASVAQAAAGAGVSMINDVSGGLADPEMFSVMAEAQIPVCLMHWRTLQFGDAAGQADHGGDVVADV
HAVLDDLVARATAAGVAENQIVLDPGLGFAKSREDNWRLLQALPEFISGPFPILVGASRKRFLAGVRKDRGLDVTPIDAD
PATAAVTAVSAHMGAWGVRVHDVPVSRDAVDVAALWRSGGTHHG

Sequences:

>Translated_284_residues
MNVSSLTIPGRCLVMGIVNVTEDSFSDGGKYIDVDQAIAHAKELVAAGADMIDVGGESTRPGAVRVDASVERDRVVPVIK
ALHDAGIHTSVDTMRASVAQAAAGAGVSMINDVSGGLADPEMFSVMAEAQIPVCLMHWRTLQFGDAAGQADHGGDVVADV
HAVLDDLVARATAAGVAENQIVLDPGLGFAKSREDNWRLLQALPEFISGPFPILVGASRKRFLAGVRKDRGLDVTPIDAD
PATAAVTAVSAHMGAWGVRVHDVPVSRDAVDVAALWRSGGTHHG
>Mature_284_residues
MNVSSLTIPGRCLVMGIVNVTEDSFSDGGKYIDVDQAIAHAKELVAAGADMIDVGGESTRPGAVRVDASVERDRVVPVIK
ALHDAGIHTSVDTMRASVAQAAAGAGVSMINDVSGGLADPEMFSVMAEAQIPVCLMHWRTLQFGDAAGQADHGGDVVADV
HAVLDDLVARATAAGVAENQIVLDPGLGFAKSREDNWRLLQALPEFISGPFPILVGASRKRFLAGVRKDRGLDVTPIDAD
PATAAVTAVSAHMGAWGVRVHDVPVSRDAVDVAALWRSGGTHHG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=264, Percent_Identity=39.7727272727273, Blast_Score=174, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=31.3291139240506, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29521; Mature: 29521

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSSLTIPGRCLVMGIVNVTEDSFSDGGKYIDVDQAIAHAKELVAAGADMIDVGGESTR
CCCCCCCCCCCEEEEEEHHCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCC
PGAVRVDASVERDRVVPVIKALHDAGIHTSVDTMRASVAQAAAGAGVSMINDVSGGLADP
CCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCH
EMFSVMAEAQIPVCLMHWRTLQFGDAAGQADHGGDVVADVHAVLDDLVARATAAGVAENQ
HHHHHHHHCCCCEEEEHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
IVLDPGLGFAKSREDNWRLLQALPEFISGPFPILVGASRKRFLAGVRKDRGLDVTPIDAD
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCEEECCCC
PATAAVTAVSAHMGAWGVRVHDVPVSRDAVDVAALWRSGGTHHG
CHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNVSSLTIPGRCLVMGIVNVTEDSFSDGGKYIDVDQAIAHAKELVAAGADMIDVGGESTR
CCCCCCCCCCCEEEEEEHHCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCC
PGAVRVDASVERDRVVPVIKALHDAGIHTSVDTMRASVAQAAAGAGVSMINDVSGGLADP
CCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCH
EMFSVMAEAQIPVCLMHWRTLQFGDAAGQADHGGDVVADVHAVLDDLVARATAAGVAENQ
HHHHHHHHCCCCEEEEHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
IVLDPGLGFAKSREDNWRLLQALPEFISGPFPILVGASRKRFLAGVRKDRGLDVTPIDAD
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCEEECCCC
PATAAVTAVSAHMGAWGVRVHDVPVSRDAVDVAALWRSGGTHHG
CHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]