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The map label for this gene is guaB [C]

Identifier: 145296676

GI number: 145296676

Start: 2849555

End: 2850988

Strand: Direct

Name: guaB [C]

Synonym: cgR_2581

Alternate gene names: 145296676

Gene position: 2849555-2850988 (Clockwise)

Preceding gene: 145296672

Following gene: 145296678

Centisome position: 85.98

GC content: 60.04

Gene sequence:

>1434_bases
ATGCGTTTTCTTAACAATTCCAATCCGCCCTATGAGCTGACCTACTCGGACGTGTTTATGGTTCCTTCACGTTCCGATGT
GGGCTCCCGCATGTCTGTGGATCTGCGCACCAATGACGGAACTGGAACAACCATCCCGCTCGTTGTGGCAAACATGACTG
CTGTTGCTGGCCGACGCATGGCTGAGACCATTGCGCGCCGCGGTGGCATGGCGATTCTTCCGCAGGATGTGCCCGCCGAT
ATTGCTGCGGAGACTATCGCGAACGTGAAGAAAGCCGACCTGGTTTTCGATACCCCGATTACCGTAAAACCGCACCACAC
CGTAGGTTATGCACGCAACTTGATCCACAAGCGCGCGCACGGTGCCGCCATTGTTTTGGAAGGCGACAAGCCGGTCGGCA
TCGTCACCGACAAGGACCTCGAGGGCGCAGACAACTTCACCCAAGTGGGCACCCTCATGTCCACTTCTCTGCTGACGCTA
CCTGAGGATATTTCCCCCGAAGATGCCTTCGGAATCCTCCACGAACACAGTCGCAAACTCGCCCCCGTTGTGGCGGCTGA
TGGTTCACTCCGCGGCATCCTCACCCGCACCGGCGCCCTGCGCGCCACCATGTACAAGCCGGCTATCGACGCCAACGGCC
GCCTTCGAGTCGGCGCCGCCATCGGCATCAACGGCGACATCGAAGGACGCACCAAAACGCTTCTCGACGCCGGCGCCGAC
GTTTTAGTCGTCGACACAGCACACGGCCACCAATCCACCATGATCAGCGCCCTCAAACGCATCCGCGCACTCGACGTCAA
CGTCCCCATCGTTGCCGGCAACGTGGTCACCGCCGATGGTGTCCGCGACCTCGTTGAAGCAGGCGCAAACATCATCAAGG
TAGGCGTTGGACCAGGCGCGATGTGCACCACCCGCATGCAAACCGGCGTTGGCCGACCACAGTTCTCCGCAGTGCTGGAA
TGCGCAGCCGAAGCCCGCAAACTCGGCGCACACGTATGGGCAGACGGCGGAGTCCGCGACCCCCGCGACGTCGCCCTCGC
ACTCGCAGCTGGCGCCTCCAACGTGATGGTCGGATCCTGGTTCTCCGGAACCTACGAATCCCCCGGCGACCTCCGCTTCG
AATCCGACGGACGCATGTACAAAGAATCCTTCGGCATGGCATCCCGGCGCGCCGTGGAAAGCCGAAACCAAAAGGTCGAA
GCTTTCGAAAAAGCACGCCGCGCAATGTTCGAAGAAGGCATCTCCACTGCCCGCATCTACATTGACAAACGCCACGGCGG
AGTTGAAGACCTGGTAGATCAAATCATCTCCGGTGTCCGCTCCTCATTCACCTACGCAGGCGCCGATTCGATTGAAACCT
TCTTCGAACGCGCCACCGTCGGAGTTCAATCCACCGAAGGCTACGCAGAAGGAAAGCCACGTGCTTCGCGTTAA

Upstream 100 bases:

>100_bases
GTAGCGAACACCGGGTTTGAGCGTCGAAAAGCAGCTGGAAAGCGCAATTGAGGTACCCTTGCCGTGTTCAGGGATAACTG
ATTAATCAACTAGGAGACCC

Downstream 100 bases:

>100_bases
GTGTTGTTGGTGGTTGCGCCGGGAGCCGTAGGGTTCCCGGCGTTTTTCTACGTTTTGGAGCAACAACATGCTTTTCAAAT
TAGTCTCAAGCTCATGGAAT

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MRFLNNSNPPYELTYSDVFMVPSRSDVGSRMSVDLRTNDGTGTTIPLVVANMTAVAGRRMAETIARRGGMAILPQDVPAD
IAAETIANVKKADLVFDTPITVKPHHTVGYARNLIHKRAHGAAIVLEGDKPVGIVTDKDLEGADNFTQVGTLMSTSLLTL
PEDISPEDAFGILHEHSRKLAPVVAADGSLRGILTRTGALRATMYKPAIDANGRLRVGAAIGINGDIEGRTKTLLDAGAD
VLVVDTAHGHQSTMISALKRIRALDVNVPIVAGNVVTADGVRDLVEAGANIIKVGVGPGAMCTTRMQTGVGRPQFSAVLE
CAAEARKLGAHVWADGGVRDPRDVALALAAGASNVMVGSWFSGTYESPGDLRFESDGRMYKESFGMASRRAVESRNQKVE
AFEKARRAMFEEGISTARIYIDKRHGGVEDLVDQIISGVRSSFTYAGADSIETFFERATVGVQSTEGYAEGKPRASR

Sequences:

>Translated_477_residues
MRFLNNSNPPYELTYSDVFMVPSRSDVGSRMSVDLRTNDGTGTTIPLVVANMTAVAGRRMAETIARRGGMAILPQDVPAD
IAAETIANVKKADLVFDTPITVKPHHTVGYARNLIHKRAHGAAIVLEGDKPVGIVTDKDLEGADNFTQVGTLMSTSLLTL
PEDISPEDAFGILHEHSRKLAPVVAADGSLRGILTRTGALRATMYKPAIDANGRLRVGAAIGINGDIEGRTKTLLDAGAD
VLVVDTAHGHQSTMISALKRIRALDVNVPIVAGNVVTADGVRDLVEAGANIIKVGVGPGAMCTTRMQTGVGRPQFSAVLE
CAAEARKLGAHVWADGGVRDPRDVALALAAGASNVMVGSWFSGTYESPGDLRFESDGRMYKESFGMASRRAVESRNQKVE
AFEKARRAMFEEGISTARIYIDKRHGGVEDLVDQIISGVRSSFTYAGADSIETFFERATVGVQSTEGYAEGKPRASR
>Mature_477_residues
MRFLNNSNPPYELTYSDVFMVPSRSDVGSRMSVDLRTNDGTGTTIPLVVANMTAVAGRRMAETIARRGGMAILPQDVPAD
IAAETIANVKKADLVFDTPITVKPHHTVGYARNLIHKRAHGAAIVLEGDKPVGIVTDKDLEGADNFTQVGTLMSTSLLTL
PEDISPEDAFGILHEHSRKLAPVVAADGSLRGILTRTGALRATMYKPAIDANGRLRVGAAIGINGDIEGRTKTLLDAGAD
VLVVDTAHGHQSTMISALKRIRALDVNVPIVAGNVVTADGVRDLVEAGANIIKVGVGPGAMCTTRMQTGVGRPQFSAVLE
CAAEARKLGAHVWADGGVRDPRDVALALAAGASNVMVGSWFSGTYESPGDLRFESDGRMYKESFGMASRRAVESRNQKVE
AFEKARRAMFEEGISTARIYIDKRHGGVEDLVDQIISGVRSSFTYAGADSIETFFERATVGVQSTEGYAEGKPRASR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=478, Percent_Identity=31.1715481171548, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI217035146, Length=475, Percent_Identity=30.5263157894737, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI156616279, Length=475, Percent_Identity=30.5263157894737, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI34328930, Length=475, Percent_Identity=30.5263157894737, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI34328928, Length=475, Percent_Identity=30.5263157894737, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI217035152, Length=472, Percent_Identity=30.7203389830508, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI217035148, Length=474, Percent_Identity=29.957805907173, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI217035150, Length=474, Percent_Identity=29.1139240506329, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI156104880, Length=236, Percent_Identity=41.1016949152542, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI50541956, Length=218, Percent_Identity=39.4495412844037, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI50541954, Length=218, Percent_Identity=39.4495412844037, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI50541952, Length=218, Percent_Identity=39.4495412844037, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI50541948, Length=218, Percent_Identity=39.4495412844037, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1788855, Length=461, Percent_Identity=34.70715835141, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786293, Length=246, Percent_Identity=36.5853658536585, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=490, Percent_Identity=29.5918367346939, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17560440, Length=218, Percent_Identity=40.3669724770642, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71994389, Length=417, Percent_Identity=31.4148681055156, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6322012, Length=453, Percent_Identity=29.3598233995585, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323585, Length=467, Percent_Identity=29.3361884368308, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=29.3103448275862, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319352, Length=363, Percent_Identity=28.099173553719, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24641071, Length=457, Percent_Identity=31.2910284463895, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24641073, Length=457, Percent_Identity=31.2910284463895, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI28571163, Length=416, Percent_Identity=31.25, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR018529
- InterPro:   IPR001093
- InterPro:   IPR005991 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 50819; Mature: 50819

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLNNSNPPYELTYSDVFMVPSRSDVGSRMSVDLRTNDGTGTTIPLVVANMTAVAGRRM
CCCCCCCCCCEEEEECEEEEECCCCCCCCEEEEEEEECCCCCCEEEHEEHHHHHHHHHHH
AETIARRGGMAILPQDVPADIAAETIANVKKADLVFDTPITVKPHHTVGYARNLIHKRAH
HHHHHHCCCEEEECCCCCHHHHHHHHHCCHHCCEEECCCEEECCCCHHHHHHHHHHHHCC
GAAIVLEGDKPVGIVTDKDLEGADNFTQVGTLMSTSLLTLPEDISPEDAFGILHEHSRKL
CCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
APVVAADGSLRGILTRTGALRATMYKPAIDANGRLRVGAAIGINGDIEGRTKTLLDAGAD
CEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCC
VLVVDTAHGHQSTMISALKRIRALDVNVPIVAGNVVTADGVRDLVEAGANIIKVGVGPGA
EEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCEEEHHHHHHHHHCCCCEEEEECCCCC
MCTTRMQTGVGRPQFSAVLECAAEARKLGAHVWADGGVRDPRDVALALAAGASNVMVGSW
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHEEEEECCCCCEEEEEC
FSGTYESPGDLRFESDGRMYKESFGMASRRAVESRNQKVEAFEKARRAMFEEGISTARIY
CCCCCCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IDKRHGGVEDLVDQIISGVRSSFTYAGADSIETFFERATVGVQSTEGYAEGKPRASR
EECCCCCHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFLNNSNPPYELTYSDVFMVPSRSDVGSRMSVDLRTNDGTGTTIPLVVANMTAVAGRRM
CCCCCCCCCCEEEEECEEEEECCCCCCCCEEEEEEEECCCCCCEEEHEEHHHHHHHHHHH
AETIARRGGMAILPQDVPADIAAETIANVKKADLVFDTPITVKPHHTVGYARNLIHKRAH
HHHHHHCCCEEEECCCCCHHHHHHHHHCCHHCCEEECCCEEECCCCHHHHHHHHHHHHCC
GAAIVLEGDKPVGIVTDKDLEGADNFTQVGTLMSTSLLTLPEDISPEDAFGILHEHSRKL
CCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
APVVAADGSLRGILTRTGALRATMYKPAIDANGRLRVGAAIGINGDIEGRTKTLLDAGAD
CEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCC
VLVVDTAHGHQSTMISALKRIRALDVNVPIVAGNVVTADGVRDLVEAGANIIKVGVGPGA
EEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCEEEHHHHHHHHHCCCCEEEEECCCCC
MCTTRMQTGVGRPQFSAVLECAAEARKLGAHVWADGGVRDPRDVALALAAGASNVMVGSW
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHEEEEECCCCCEEEEEC
FSGTYESPGDLRFESDGRMYKESFGMASRRAVESRNQKVEAFEKARRAMFEEGISTARIY
CCCCCCCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IDKRHGGVEDLVDQIISGVRSSFTYAGADSIETFFERATVGVQSTEGYAEGKPRASR
EECCCCCHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]