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The map label for this gene is qacA [H]

Identifier: 145296607

GI number: 145296607

Start: 2778012

End: 2779496

Strand: Direct

Name: qacA [H]

Synonym: cgR_2515

Alternate gene names: 145296607

Gene position: 2778012-2779496 (Clockwise)

Preceding gene: 145296601

Following gene: 145296608

Centisome position: 83.82

GC content: 53.06

Gene sequence:

>1485_bases
ATGACTTCAGAAACTTTACAGGCGCAAGCGCCTACGAAAACCCAACGTTGGGCTTTCCTCGCCGTTATCAGCGGTGGTCT
CTTTCTGATCGGTGTAGACAACTCGATTCTCTACACCGCACTCCCTCTGCTGCGTGAACAGCTCGCAGCCACTGAAACCC
AAGCGTTGTGGATCATCAACGCATATCCCCTGCTCATGGCGGGTCTTCTTTTGGGTACCGGCACTTTGGGTGACAAAATC
GGCCACCGCCGGATGTTCCTCATGGGCTTGAGCATTTTCGGAATCGCTTCACTTGGTGCTGCGTTTGCTCCAACTGCGTG
GGCTCTTGTTGCTGCGAGAGCTTTCCTTGGCATCGGTGCGGCGACGATGATGCCCGCAACTTTGGCTCTGATCCGCATTA
CGTTTGAGGATGAGCGTGAGCGCAACACTGCAATTGGTATTTGGGGTTCTGTGGCAATTCTTGGCGCGGCGGCAGGTCCG
ATCATTGGTGGTGCGCTGTTGGAATTCTTCTGGTGGGGTTCGGTTTTCCTGATTAATGTTCCGGTGGCTGTTATCGCGTT
GATCGCTACACTTTTTGTGGCGCCGGCCAATATCGCGAATCCGTCTAAGCATTGGGATTTCTTGTCGTCGTTCTATGCGC
TGCTCACACTTGCTGGGTTGATCATCACGATCAAGGAATCTGTGAATACTGCACGCCATATGCCTCTTCTTTTGGGTGCA
GTCATCATGTTGATCATTGGTGCGGTGTTGTTTAGCAGTCGTCAGAAGAAGATCGAGGAGCCACTTCTAGATCTGTCGTT
GTTCCGTAATCGCCTTTTCTTAGGCGGTGTGGTTGCTGCGGGCATGGCGATGTTTACTGTGTCCGGTTTGGAAATGACTA
CCTCGCAGCGTTTCCAGTTGTCTGTGGGATTCACTCCACTTGAGGCGGGTTTTCTCATGATCCCTGCTGCGTTGGGTAGC
TTCCCGATGTCTATTATCGGTGGTGCAAACTTGCATCGTTGGGGCTTCAAACCGCTGATCAGTGGTGGTTTCTTTGCCAC
GGCAGTCGGCATCGCCCTGTGTATTTGGGGCGCGACTCATACTGATGGTTTGCCGTTTTTCATCGCGGGTCTGTTCTTCA
TGGGCGCGGGTGCCGGTTCGGTAATGTCTGTGTCTTCCACTGCGATTATCGGTTCCGCTCCAGTGCGTAAAGCTGGAATG
GCGTCGTCGATTGAAGAGGTCTCCTATGAGTTCGGCACGCTGTTGTCTGTAGCGATTTTGGGTAGCTTGTTCCCATTCTT
CTACTCGCTGCATGCGCCAGCAGAGGTTGCGGATAACTTCTCGGCGGGTGTTCACCACGCGATTTATGGCGATGCGGCGC
GTGCATCTTTGGACGTCGCATACATTAACGTGTTGATCATTGCCCTAGTATGCGCAGTAGCGGCTGCTCTGATCAGCAGT
TACCTTTTCCGCGGAAATCCGAAGGGAGCCAATAATGCGCACTAG

Upstream 100 bases:

>100_bases
CCTACGATTTCCGACGCCTTAAATCGCCACACAGCGCCGTGGCCTAAAACACCAACAAAAGAGTTGTAACTGTACCGACC
ATTCGTTACAGTTACGATCC

Downstream 100 bases:

>100_bases
TAAAAAAGAGATGATCCTGCGCACGGCCATCGATTATATCGGCGAGCACAGCCTCGAGACGCTGAGTTACGATTCGCTCG
CCGAGGCAACCGGTCTGTCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTSETLQAQAPTKTQRWAFLAVISGGLFLIGVDNSILYTALPLLREQLAATETQALWIINAYPLLMAGLLLGTGTLGDKI
GHRRMFLMGLSIFGIASLGAAFAPTAWALVAARAFLGIGAATMMPATLALIRITFEDERERNTAIGIWGSVAILGAAAGP
IIGGALLEFFWWGSVFLINVPVAVIALIATLFVAPANIANPSKHWDFLSSFYALLTLAGLIITIKESVNTARHMPLLLGA
VIMLIIGAVLFSSRQKKIEEPLLDLSLFRNRLFLGGVVAAGMAMFTVSGLEMTTSQRFQLSVGFTPLEAGFLMIPAALGS
FPMSIIGGANLHRWGFKPLISGGFFATAVGIALCIWGATHTDGLPFFIAGLFFMGAGAGSVMSVSSTAIIGSAPVRKAGM
ASSIEEVSYEFGTLLSVAILGSLFPFFYSLHAPAEVADNFSAGVHHAIYGDAARASLDVAYINVLIIALVCAVAAALISS
YLFRGNPKGANNAH

Sequences:

>Translated_494_residues
MTSETLQAQAPTKTQRWAFLAVISGGLFLIGVDNSILYTALPLLREQLAATETQALWIINAYPLLMAGLLLGTGTLGDKI
GHRRMFLMGLSIFGIASLGAAFAPTAWALVAARAFLGIGAATMMPATLALIRITFEDERERNTAIGIWGSVAILGAAAGP
IIGGALLEFFWWGSVFLINVPVAVIALIATLFVAPANIANPSKHWDFLSSFYALLTLAGLIITIKESVNTARHMPLLLGA
VIMLIIGAVLFSSRQKKIEEPLLDLSLFRNRLFLGGVVAAGMAMFTVSGLEMTTSQRFQLSVGFTPLEAGFLMIPAALGS
FPMSIIGGANLHRWGFKPLISGGFFATAVGIALCIWGATHTDGLPFFIAGLFFMGAGAGSVMSVSSTAIIGSAPVRKAGM
ASSIEEVSYEFGTLLSVAILGSLFPFFYSLHAPAEVADNFSAGVHHAIYGDAARASLDVAYINVLIIALVCAVAAALISS
YLFRGNPKGANNAH
>Mature_493_residues
TSETLQAQAPTKTQRWAFLAVISGGLFLIGVDNSILYTALPLLREQLAATETQALWIINAYPLLMAGLLLGTGTLGDKIG
HRRMFLMGLSIFGIASLGAAFAPTAWALVAARAFLGIGAATMMPATLALIRITFEDERERNTAIGIWGSVAILGAAAGPI
IGGALLEFFWWGSVFLINVPVAVIALIATLFVAPANIANPSKHWDFLSSFYALLTLAGLIITIKESVNTARHMPLLLGAV
IMLIIGAVLFSSRQKKIEEPLLDLSLFRNRLFLGGVVAAGMAMFTVSGLEMTTSQRFQLSVGFTPLEAGFLMIPAALGSF
PMSIIGGANLHRWGFKPLISGGFFATAVGIALCIWGATHTDGLPFFIAGLFFMGAGAGSVMSVSSTAIIGSAPVRKAGMA
SSIEEVSYEFGTLLSVAILGSLFPFFYSLHAPAEVADNFSAGVHHAIYGDAARASLDVAYINVLIIALVCAVAAALISSY
LFRGNPKGANNAH

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=400, Percent_Identity=30.25, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788392, Length=432, Percent_Identity=29.3981481481481, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788710, Length=474, Percent_Identity=24.8945147679325, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1790195, Length=429, Percent_Identity=26.1072261072261, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789042, Length=444, Percent_Identity=22.5225225225225, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324954, Length=290, Percent_Identity=26.8965517241379, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51977; Mature: 51846

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSETLQAQAPTKTQRWAFLAVISGGLFLIGVDNSILYTALPLLREQLAATETQALWIIN
CCCCCCCCCCCCCHHHHEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEE
AYPLLMAGLLLGTGTLGDKIGHRRMFLMGLSIFGIASLGAAFAPTAWALVAARAFLGIGA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ATMMPATLALIRITFEDERERNTAIGIWGSVAILGAAAGPIIGGALLEFFWWGSVFLINV
HHHHHHHHHHEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHH
PVAVIALIATLFVAPANIANPSKHWDFLSSFYALLTLAGLIITIKESVNTARHMPLLLGA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIMLIIGAVLFSSRQKKIEEPLLDLSLFRNRLFLGGVVAAGMAMFTVSGLEMTTSQRFQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEE
SVGFTPLEAGFLMIPAALGSFPMSIIGGANLHRWGFKPLISGGFFATAVGIALCIWGATH
EECCCCHHCCHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCC
TDGLPFFIAGLFFMGAGAGSVMSVSSTAIIGSAPVRKAGMASSIEEVSYEFGTLLSVAIL
CCCHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCHHCHHHHHHHHHHHHHHHHHHHHH
GSLFPFFYSLHAPAEVADNFSAGVHHAIYGDAARASLDVAYINVLIIALVCAVAAALISS
HHHHHHHHHHCCCHHHHCCHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFRGNPKGANNAH
HHHCCCCCCCCCCC
>Mature Secondary Structure 
TSETLQAQAPTKTQRWAFLAVISGGLFLIGVDNSILYTALPLLREQLAATETQALWIIN
CCCCCCCCCCCCHHHHEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEE
AYPLLMAGLLLGTGTLGDKIGHRRMFLMGLSIFGIASLGAAFAPTAWALVAARAFLGIGA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ATMMPATLALIRITFEDERERNTAIGIWGSVAILGAAAGPIIGGALLEFFWWGSVFLINV
HHHHHHHHHHEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHH
PVAVIALIATLFVAPANIANPSKHWDFLSSFYALLTLAGLIITIKESVNTARHMPLLLGA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIMLIIGAVLFSSRQKKIEEPLLDLSLFRNRLFLGGVVAAGMAMFTVSGLEMTTSQRFQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEE
SVGFTPLEAGFLMIPAALGSFPMSIIGGANLHRWGFKPLISGGFFATAVGIALCIWGATH
EECCCCHHCCHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCC
TDGLPFFIAGLFFMGAGAGSVMSVSSTAIIGSAPVRKAGMASSIEEVSYEFGTLLSVAIL
CCCHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCHHCHHHHHHHHHHHHHHHHHHHHH
GSLFPFFYSLHAPAEVADNFSAGVHHAIYGDAARASLDVAYINVLIIALVCAVAAALISS
HHHHHHHHHHCCCHHHHCCHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFRGNPKGANNAH
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]