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The map label for this gene is fabG [C]

Identifier: 145296432

GI number: 145296432

Start: 2582723

End: 2583433

Strand: Reverse

Name: fabG [C]

Synonym: cgR_2346

Alternate gene names: 145296432

Gene position: 2583433-2582723 (Counterclockwise)

Preceding gene: 145296434

Following gene: 145296427

Centisome position: 77.95

GC content: 59.49

Gene sequence:

>711_bases
ATGAAAAAGAAGATTGCGGTCGTTACCGGAGCGACCGGAGGCATGGGAATTGAGATCGTCAAAGACCTCTCCCGCGACCA
CATTGTCTACGCCTTGGGCCGAAATCCAGAGCATCTGGCAGCTCTCGCAGAGATCGAGGGAGTAGAGCCTATCGAGTCCG
ATATCGTGAAGGAAGTGTTGGAAGAGGGAGGCGTCGACAAGCTAAAAAACCTCGACCACGTGGATACGCTGGTGCACGCC
GCGGCGGTGGCGCGTGACACGACCATCGAAGCCGGCAGTGTGGCCGAATGGCACGCACACCTTGATCTCAACGTCATTGT
CCCGGCCGAGTTGAGTCGCCAACTCTTGCCCGCCCTCCGCGCCGCATCCGGCTGCGTCATCTACATCAACTCCGGCGCCG
GCAACGGACCACACCCCGGCAACACCATCTACGCCGCCAGCAAACACGCCCTCCGCGGACTCGCCGACGCCTTCCGCAAA
GAAGAAGCCAACAACGGCATCCGCGTCAGCACCGTCAGCCCCGGCCCCACCAACACCCCCATGCTGAAAGGCCTCATGGA
CTCACAAGGCACCAACTTCCGCCCAGAGATCTACATCGAACCAAAAGAAATCGCCAACGCAATCAGATTCGTGATTGACG
CTGGCGAAACCACCCAGATCACCAACGTGGACGTACGACCACGCATCGAACTGGCTGACCGGAAAGACTAG

Upstream 100 bases:

>100_bases
AACCAGCGTTTTCAGCGAGATACTGGACATATCAACTAAAATCCCTGAATAAAACATCTAACATGGGTTTTATACAGAAA
ATTCATACGAAAGGTTGATC

Downstream 100 bases:

>100_bases
TTTTTAGGGGCTTCCTGAGGTTCTAGTGGGGCTGTTTGGGTTTCGGTGTTGATAGGCTCGGTGTTGGTTTGTTTGCGGCC
ATCTGCGAGCTTGCGGGCCA

Product: short chain dehydrogenase

Products: 3-oxoacyl-CoA; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKKKIAVVTGATGGMGIEIVKDLSRDHIVYALGRNPEHLAALAEIEGVEPIESDIVKEVLEEGGVDKLKNLDHVDTLVHA
AAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLLPALRAASGCVIYINSGAGNGPHPGNTIYAASKHALRGLADAFRK
EEANNGIRVSTVSPGPTNTPMLKGLMDSQGTNFRPEIYIEPKEIANAIRFVIDAGETTQITNVDVRPRIELADRKD

Sequences:

>Translated_236_residues
MKKKIAVVTGATGGMGIEIVKDLSRDHIVYALGRNPEHLAALAEIEGVEPIESDIVKEVLEEGGVDKLKNLDHVDTLVHA
AAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLLPALRAASGCVIYINSGAGNGPHPGNTIYAASKHALRGLADAFRK
EEANNGIRVSTVSPGPTNTPMLKGLMDSQGTNFRPEIYIEPKEIANAIRFVIDAGETTQITNVDVRPRIELADRKD
>Mature_236_residues
MKKKIAVVTGATGGMGIEIVKDLSRDHIVYALGRNPEHLAALAEIEGVEPIESDIVKEVLEEGGVDKLKNLDHVDTLVHA
AAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLLPALRAASGCVIYINSGAGNGPHPGNTIYAASKHALRGLADAFRK
EEANNGIRVSTVSPGPTNTPMLKGLMDSQGTNFRPEIYIEPKEIANAIRFVIDAGETTQITNVDVRPRIELADRKD

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI5031737, Length=204, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI33667109, Length=191, Percent_Identity=34.0314136125654, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI32483357, Length=236, Percent_Identity=26.6949152542373, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787335, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786812, Length=159, Percent_Identity=31.4465408805031, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787820, Length=234, Percent_Identity=24.7863247863248, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=28.8770053475936, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=174, Percent_Identity=32.7586206896552, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322227, Length=201, Percent_Identity=25.3731343283582, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643142, Length=182, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007236, Length=242, Percent_Identity=26.0330578512397, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=182, Percent_Identity=29.6703296703297, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24663911, Length=255, Percent_Identity=27.0588235294118, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641388, Length=247, Percent_Identity=25.9109311740891, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281364494, Length=257, Percent_Identity=26.0700389105058, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.36

Molecular weight: Translated: 25288; Mature: 25288

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIAVVTGATGGMGIEIVKDLSRDHIVYALGRNPEHLAALAEIEGVEPIESDIVKEVL
CCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHH
EEGGVDKLKNLDHVDTLVHAAAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLLPALR
HCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEECHHHHHHHHHHHH
AASGCVIYINSGAGNGPHPGNTIYAASKHALRGLADAFRKEEANNGIRVSTVSPGPTNTP
HCCCEEEEEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCH
MLKGLMDSQGTNFRPEIYIEPKEIANAIRFVIDAGETTQITNVDVRPRIELADRKD
HHHHHHHCCCCCCCCEEEECHHHHHHHHHHEEECCCCEEEEECCCCCCEECCCCCC
>Mature Secondary Structure
MKKKIAVVTGATGGMGIEIVKDLSRDHIVYALGRNPEHLAALAEIEGVEPIESDIVKEVL
CCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHH
EEGGVDKLKNLDHVDTLVHAAAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLLPALR
HCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEECHHHHHHHHHHHH
AASGCVIYINSGAGNGPHPGNTIYAASKHALRGLADAFRKEEANNGIRVSTVSPGPTNTP
HCCCEEEEEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCH
MLKGLMDSQGTNFRPEIYIEPKEIANAIRFVIDAGETTQITNVDVRPRIELADRKD
HHHHHHHCCCCCCCCEEEECHHHHHHHHHHEEECCCCEEEEECCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-3-hydroxyacyl-CoA; NADP+

Specific reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]