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The map label for this gene is hsaA [H]

Identifier: 145296379

GI number: 145296379

Start: 2527230

End: 2528399

Strand: Direct

Name: hsaA [H]

Synonym: cgR_2293

Alternate gene names: 145296379

Gene position: 2527230-2528399 (Clockwise)

Preceding gene: 145296377

Following gene: 145296380

Centisome position: 76.26

GC content: 53.85

Gene sequence:

>1170_bases
TTGTTCGACAGAGTCGATCTCACAGTTACCGCCGAACCTCCCGGTGCGCCCAGACAAGACGCATTTGAACATGCCCTCGA
AGTACTACGCGAACGCCGAGACGAATTCAAACAACTCGGATACGTTCCAAAAGACTACATAGCGCTTCTGAAGAAGGCAG
GAATCTACAGAGCCTCAACTCCAGCAACCTTTGGTGGGGAACCACAGGCTCCTGCTGATTTCTTGGAACTGATTGAACAA
ATCTCCACCATTGACCCAGCTACAGGCTGGGTGGCTAGCTTCGGATCTGCACTTACCTACTTCTCCGCGCTTCCTTACGA
GACGCAGCAAGAGCTATATGGAAAAGGTCTTGACCTAGCTTTCGCCGGTGGCATGTTCCCAATGGTCGAAGCTGAAAAGG
TCGAAGGCGGATACATCGCTAGCGGAACTTGGATGTTCGCCAGCGGATGTGCTGGAGCTGACATTCTTGGAATTGGTCTC
CGCGGTGGTCCTGAGACCGAAGGAAAGCCAGTCACTGCACTCGTACATCCAGACGACGTGACGATCGTAGAAAACTGGAA
TGTCTCGGGCATGCGCTCCACTGGATCCAACAATGTGGTGGTAAAAGACCTCTTCATCCCTGAAGAGCACACCTTCATCC
GAGGCGGTCAGCCCACGATCGAAGAACCACTCACCCGTTATCCAGCTTTGGCCTATGCGGCGCAAGTCCTTGCAGTCACC
GCGCTGGGTGCAGGCCGAGGCGCGCTCGACTTCGTTCGAGACCAAGGCGCTGGAGCAAAATCAGTCACCGGAGGAGCCGC
AAAAGGCAACCGCGGTGTTTATAAATTAGGACTTGCACACGCTGAAGCTGAACTTCGCTCCGCGAGATCCTACTTTTACG
AAACCACCCGGGAAGTCTGGCAAAAAGCCGTAGACGATTCCCCAATTACAGTTGAGGACACCGTCTACCTGCGCATTGCT
GCAACTCATGCCGCCCAAGCAGGAAGAAAAGCCGTACTTGCAGCCTTTGATCTTGCTGGAACAGGCGCTATTTACAACAC
CCATCCCTTACAACGCTTCCTTCAAGACGGTCTTGTTCCAGCTCAGCACGCCATGCTCCAAGAAAACACTTTCGAGGCCA
GTGGCGCGCTGCTGATGGGCTTTGATGCTGGTATTCCAAGCTTCCCCTGA

Upstream 100 bases:

>100_bases
GCAGGTTTCTCCCATATCGCCGATGTGAGAAGAGACATAATCTCGTTTTATGTCCACAACCACAAAAGAAACCAGCCACA
CAAACACAGGAGGGGACTTG

Downstream 100 bases:

>100_bases
TCACCACACTCTCAAGGAGATCCCCAATGTCTGAAACCCCATTAAGAACACTGTTCTGTCTGGGAAATAACCAGAACTTC
TTTGATCTGCCAAAGGCCGA

Product: hypothetical protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MFDRVDLTVTAEPPGAPRQDAFEHALEVLRERRDEFKQLGYVPKDYIALLKKAGIYRASTPATFGGEPQAPADFLELIEQ
ISTIDPATGWVASFGSALTYFSALPYETQQELYGKGLDLAFAGGMFPMVEAEKVEGGYIASGTWMFASGCAGADILGIGL
RGGPETEGKPVTALVHPDDVTIVENWNVSGMRSTGSNNVVVKDLFIPEEHTFIRGGQPTIEEPLTRYPALAYAAQVLAVT
ALGAGRGALDFVRDQGAGAKSVTGGAAKGNRGVYKLGLAHAEAELRSARSYFYETTREVWQKAVDDSPITVEDTVYLRIA
ATHAAQAGRKAVLAAFDLAGTGAIYNTHPLQRFLQDGLVPAQHAMLQENTFEASGALLMGFDAGIPSFP

Sequences:

>Translated_389_residues
MFDRVDLTVTAEPPGAPRQDAFEHALEVLRERRDEFKQLGYVPKDYIALLKKAGIYRASTPATFGGEPQAPADFLELIEQ
ISTIDPATGWVASFGSALTYFSALPYETQQELYGKGLDLAFAGGMFPMVEAEKVEGGYIASGTWMFASGCAGADILGIGL
RGGPETEGKPVTALVHPDDVTIVENWNVSGMRSTGSNNVVVKDLFIPEEHTFIRGGQPTIEEPLTRYPALAYAAQVLAVT
ALGAGRGALDFVRDQGAGAKSVTGGAAKGNRGVYKLGLAHAEAELRSARSYFYETTREVWQKAVDDSPITVEDTVYLRIA
ATHAAQAGRKAVLAAFDLAGTGAIYNTHPLQRFLQDGLVPAQHAMLQENTFEASGALLMGFDAGIPSFP
>Mature_389_residues
MFDRVDLTVTAEPPGAPRQDAFEHALEVLRERRDEFKQLGYVPKDYIALLKKAGIYRASTPATFGGEPQAPADFLELIEQ
ISTIDPATGWVASFGSALTYFSALPYETQQELYGKGLDLAFAGGMFPMVEAEKVEGGYIASGTWMFASGCAGADILGIGL
RGGPETEGKPVTALVHPDDVTIVENWNVSGMRSTGSNNVVVKDLFIPEEHTFIRGGQPTIEEPLTRYPALAYAAQVLAVT
ALGAGRGALDFVRDQGAGAKSVTGGAAKGNRGVYKLGLAHAEAELRSARSYFYETTREVWQKAVDDSPITVEDTVYLRIA
ATHAAQAGRKAVLAAFDLAGTGAIYNTHPLQRFLQDGLVPAQHAMLQENTFEASGALLMGFDAGIPSFP

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 41596; Mature: 41596

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRVDLTVTAEPPGAPRQDAFEHALEVLRERRDEFKQLGYVPKDYIALLKKAGIYRAST
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEECCC
PATFGGEPQAPADFLELIEQISTIDPATGWVASFGSALTYFSALPYETQQELYGKGLDLA
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEE
FAGGMFPMVEAEKVEGGYIASGTWMFASGCAGADILGIGLRGGPETEGKPVTALVHPDDV
ECCCCCCCCCCEECCCCEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCEEEEECCCCE
TIVENWNVSGMRSTGSNNVVVKDLFIPEEHTFIRGGQPTIEEPLTRYPALAYAAQVLAVT
EEEECCCCCCCCCCCCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ALGAGRGALDFVRDQGAGAKSVTGGAAKGNRGVYKLGLAHAEAELRSARSYFYETTREVW
HHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
QKAVDDSPITVEDTVYLRIAATHAAQAGRKAVLAAFDLAGTGAIYNTHPLQRFLQDGLVP
HHHCCCCCCEEECEEEEEEEEHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCH
AQHAMLQENTFEASGALLMGFDAGIPSFP
HHHHHHHCCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MFDRVDLTVTAEPPGAPRQDAFEHALEVLRERRDEFKQLGYVPKDYIALLKKAGIYRAST
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEECCC
PATFGGEPQAPADFLELIEQISTIDPATGWVASFGSALTYFSALPYETQQELYGKGLDLA
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEE
FAGGMFPMVEAEKVEGGYIASGTWMFASGCAGADILGIGLRGGPETEGKPVTALVHPDDV
ECCCCCCCCCCEECCCCEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCEEEEECCCCE
TIVENWNVSGMRSTGSNNVVVKDLFIPEEHTFIRGGQPTIEEPLTRYPALAYAAQVLAVT
EEEECCCCCCCCCCCCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ALGAGRGALDFVRDQGAGAKSVTGGAAKGNRGVYKLGLAHAEAELRSARSYFYETTREVW
HHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
QKAVDDSPITVEDTVYLRIAATHAAQAGRKAVLAAFDLAGTGAIYNTHPLQRFLQDGLVP
HHHCCCCCCEEECEEEEEEEEHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCH
AQHAMLQENTFEASGALLMGFDAGIPSFP
HHHHHHHCCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA