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The map label for this gene is murC

Identifier: 145296119

GI number: 145296119

Start: 2245155

End: 2246615

Strand: Reverse

Name: murC

Synonym: cgR_2039

Alternate gene names: 145296119

Gene position: 2246615-2245155 (Counterclockwise)

Preceding gene: 145296120

Following gene: 145296118

Centisome position: 67.79

GC content: 56.33

Gene sequence:

>1461_bases
GTGACCACTCCACACTTGGATTCTGCACAAGATATTGATCTGTCCCGCGTCCACCTCATCGGTATTGGCGGAGCCGGAAT
GTCTGGCGTTGCCCGAATCCTGCTTGCCCGCGGTAAGACAGTCACTGGTTCCGATGCCAAAGATTCCCGCACCTTGCTTC
CACTCCGCGCCGTGGGAGCCACCATCGCAGTGGGACACGCCGCGGAAAACCTTGAGCTTTCCGGCGAACTTCCCACCGTC
GTGGTGACCTCTTTTGCCGCCATTCCGCAAGACAACCCGGAACTTGTTCGTGCACGTGAAGAAGGCATTCCGGTTATTCG
TCGCTCCGATCTGTTGGGCGAATTGCTGGAAGGCTCCACCCAGGTCTTGATCGCGGGTACCCACGGTAAGACCTCCACCA
CCTCTATGTCTGTGGTAGCTATGCAGGCAGCGGGCATGGATCCAAGCTTTGCTATCGGCGGACAGCTCAACAAGGCTGGC
ACCAATGCGCACCATGGAACTGGTGAGGTCTTTATCGCTGAAGCAGATGAATCTGACGCATCGCTGCTGCGCTACAAGCC
AAATGTTGCAGTGGTCACCAATGTGGAACCAGACCACCTGGACTTCTTTAAAACCCCTGAAGCCTACTTCCAAGTGTTCG
ACGATTTCGCAGGACGCATCACCCCGAACGGCAAGCTGGTTGTGTGCCTGAACGATCCTCACGCAGCGGAGCTGGGGGAG
AGGTCTGTCCGCAAGGGTATCAAGACTGTTGGTTATGGTACCGCTGACGCAGTACAGGCACACCCTGAGGTTCCAGCGAT
GGCTACCATCGTGGATTCCCAAGTTGTCGCAGAAGGCACCCGCGCCACCATCAACATCGATGGACAGGAAGTATCTGTGA
TTCTTCAAATCCCTGGTGATCACATGGTACTCAACGGTGCAGCCGCCCTGCTGGCCGGATACCTGGTGGGTGGGGACGTC
GACAAGCTTGTTGAAGGCTTGTCGGATTTCTCCGGCGTGCGACGCCGCTTTGAGTTCCACGGTGCTATCGAGGGCGGCAA
ATTTAATGGCGCGGCTATTTATGATGATTACGCACACCACCCAACGGAAGTAACTGCAGTGCTCAGCGCTGCGCGCACCC
GGGTGAAGGCCGCTGGAAAGGGCCGTGTCATCGTCGCGTTCCAACCACATTTGTACTCACGCACCATGGAATTCCAAAAG
GAGTTCGCGGAGGCACTGTCACTGGCAGACGCTGCCGTGGTGCTCGAGATTTACGGAGCGCGCGAACAACCGGTGGATGG
CGTGTCCTCGGAAATCATCACCGATGCGATGACCATTCCAGTGGTGTACGAACCTAATTTCTCTGCAGTCCCAGAACGCA
TTGCAGAAATCGCAGGACCTAATGACATCGTGCTCACCATGGGTGCAGGTTCCGTGACCATGCTTGCTCCAGAAATCCTG
GATCAGCTGCAAAACAATTAG

Upstream 100 bases:

>100_bases
GCAGGTAACGCGTCCACGGTGATTGCAGACATGATTGCTGCAACTATCAAAAGCCAACACAACTAAAACGACCAGCTCAA
CGCAAAGGAATAGTTTAAAG

Downstream 100 bases:

>100_bases
GACGTAAGTGAACAAGGCAGGACTAGCGTGAACAAAAAAGTCATCGCCATTGTTGTGGGTGTGGTTGTTGTCCTCGTGGC
AATCCTGGGCGTTGTTGCCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGATIAVGHAAENLELSGELPTV
VVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAG
TNAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDV
DKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHHPTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTMEFQK
EFAEALSLADAAVVLEIYGAREQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
DQLQNN

Sequences:

>Translated_486_residues
MTTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGATIAVGHAAENLELSGELPTV
VVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAG
TNAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDV
DKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHHPTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTMEFQK
EFAEALSLADAAVVLEIYGAREQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
DQLQNN
>Mature_485_residues
TTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGATIAVGHAAENLELSGELPTVV
VTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAGT
NAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGER
SVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDVD
KLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHHPTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTMEFQKE
FAEALSLADAAVVLEIYGAREQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEILD
QLQNN

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=470, Percent_Identity=37.2340425531915, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1790680, Length=484, Percent_Identity=28.3057851239669, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CORGB (A4QFM2)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138940.1
- ProteinModelPortal:   A4QFM2
- SMR:   A4QFM2
- STRING:   A4QFM2
- GeneID:   4994415
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2039
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   EPNFSAV
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51200; Mature: 51068

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGA
CCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEHHHCCC
TIAVGHAAENLELSGELPTVVVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGST
EEEECCCCCCCEECCCCCCCEEHHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCC
QVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAGTNAHHGTGEVFIAEADESDA
EEEEEECCCCCCCCEEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCC
SLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
EEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCEECCCCEEEEEECCCCHHHHHH
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGD
HHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHCCHHHCCCCEEEEEECCCEEEEEEEECCC
HMVLNGAAALLAGYLVGGDVDKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHH
EEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEECCCCCC
PTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTMEFQKEFAEALSLADAAVVLEIYGA
CHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
REQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
CCCCCCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHH
DQLQNN
HHHHCC
>Mature Secondary Structure 
TTPHLDSAQDIDLSRVHLIGIGGAGMSGVARILLARGKTVTGSDAKDSRTLLPLRAVGA
CCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCEEEEHHHCCC
TIAVGHAAENLELSGELPTVVVTSFAAIPQDNPELVRAREEGIPVIRRSDLLGELLEGST
EEEECCCCCCCEECCCCCCCEEHHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCC
QVLIAGTHGKTSTTSMSVVAMQAAGMDPSFAIGGQLNKAGTNAHHGTGEVFIAEADESDA
EEEEEECCCCCCCCEEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCC
SLLRYKPNVAVVTNVEPDHLDFFKTPEAYFQVFDDFAGRITPNGKLVVCLNDPHAAELGE
EEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCEECCCCEEEEEECCCCHHHHHH
RSVRKGIKTVGYGTADAVQAHPEVPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGD
HHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHCCHHHCCCCEEEEEECCCEEEEEEEECCC
HMVLNGAAALLAGYLVGGDVDKLVEGLSDFSGVRRRFEFHGAIEGGKFNGAAIYDDYAHH
EEEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEECCCCCC
PTEVTAVLSAARTRVKAAGKGRVIVAFQPHLYSRTMEFQKEFAEALSLADAAVVLEIYGA
CHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
REQPVDGVSSEIITDAMTIPVVYEPNFSAVPERIAEIAGPNDIVLTMGAGSVTMLAPEIL
CCCCCCCCHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHH
DQLQNN
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA