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The map label for this gene is lexA

Identifier: 145295835

GI number: 145295835

Start: 1955829

End: 1956590

Strand: Direct

Name: lexA

Synonym: cgR_1760

Alternate gene names: 145295835

Gene position: 1955829-1956590 (Clockwise)

Preceding gene: 145295832

Following gene: 145295836

Centisome position: 59.01

GC content: 54.33

Gene sequence:

>762_bases
ATGGCAATCGAAAAGAAGCCAGCAGGTGCACGAGGCAGTCGCGGTAGCCGCACAGTTAAGACCTTGCCCAACGGAAAACC
AGATCCAGCAAGTTTGTCAGATAGGCAGCGCAGGATTTTAGAGGTTATCCGAGATGCTGTGGTTTTGAGGGGTTATCCAC
CAAGCATTAGGGAAATTGGTGATGCTGCAGGACTTCAATCCACTTCTTCCGTTGCTTACCAGCTTAAAGAGCTAGAGAAG
AAGGGCTTCCTGCGCAGGGACCCTAATAAGCCTCGCGCGGTGGATGTTCGCCACCTTCCAGAAACTGAAAGCCGCTCCTC
CAAGGCTGCTACACAGGCAAAGAGCAAGGCCCCTCAGGCCGGGGCCCATGATCCTGAGTTAGCTGGCCAGACCTCATTTG
TCCCAGTGGTGGGCAAAATTGCCGCTGGTAGCCCGATCACCGCTGAGCAGAACATCGAAGAGTACTACCCACTCCCCGCA
GAAATCGTCGGAGACGGTGACTTGTTCATGCTCCAGGTTGTTGGCGAGTCCATGAGGGATGCTGGCATCCTTACCGGCGA
CTGGGTTGTTGTTCGTTCCCAGCCGGTAGCTGAGCAGGGCGAGTTCGTCGCGGCAATGATTGACGGTGAAGCCACCGTGA
AGGAATTCCACAAGGATTCATCTGGCATCTGGCTCCTGCCACACAACGATACGTTTGCCCCAATTCCTGCTGAGAATGCA
GAAATCATGGGCAAGGTTGTTTCCGTGATGCGCAAGCTTTAA

Upstream 100 bases:

>100_bases
AGAAGTTCACACTGGATGAACCCTCATCAAGAGTGAACATGGAAGCGAACAGAGTTTTTAGTGCTTTAACGGGCACACAA
TGAGAGGAAGGGAACGGAAG

Downstream 100 bases:

>100_bases
GTCGCTTTTCAGGTTCCCGCCACAGTATGTGTTCTCACATATCGTGGCGGGTTTTGCTTTATATAGCCACATTCGGGGGT
AATCGGGCAAATAAGTTTTT

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MAIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIGDAAGLQSTSSVAYQLKELEK
KGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQAGAHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPA
EIVGDGDLFMLQVVGESMRDAGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
EIMGKVVSVMRKL

Sequences:

>Translated_253_residues
MAIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIGDAAGLQSTSSVAYQLKELEK
KGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQAGAHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPA
EIVGDGDLFMLQVVGESMRDAGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
EIMGKVVSVMRKL
>Mature_252_residues
AIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIGDAAGLQSTSSVAYQLKELEKK
GFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQAGAHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPAE
IVGDGDLFMLQVVGESMRDAGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENAE
IMGKVVSVMRKL

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_CORGB (A4QET8)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138656.1
- ProteinModelPortal:   A4QET8
- SMR:   A4QET8
- STRING:   A4QET8
- GeneID:   4993148
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1760
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- ProtClustDB:   PRK00215
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 27272; Mature: 27141

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: ACT_SITE 177-177 ACT_SITE 214-214

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIG
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
DAAGLQSTSSVAYQLKELEKKGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCC
GAHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPAEIVGDGDLFMLQVVGESMRD
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCHHEECCCCEEEHHHHHHHHHH
AGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
CCCEECCEEEEECCCCCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
EIMGKVVSVMRKL
HHHHHHHHHHHCC
>Mature Secondary Structure 
AIEKKPAGARGSRGSRTVKTLPNGKPDPASLSDRQRRILEVIRDAVVLRGYPPSIREIG
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
DAAGLQSTSSVAYQLKELEKKGFLRRDPNKPRAVDVRHLPETESRSSKAATQAKSKAPQA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCC
GAHDPELAGQTSFVPVVGKIAAGSPITAEQNIEEYYPLPAEIVGDGDLFMLQVVGESMRD
CCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCHHEECCCCEEEHHHHHHHHHH
AGILTGDWVVVRSQPVAEQGEFVAAMIDGEATVKEFHKDSSGIWLLPHNDTFAPIPAENA
CCCEECCEEEEECCCCCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCH
EIMGKVVSVMRKL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA