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The map label for this gene is apt

Identifier: 145295775

GI number: 145295775

Start: 1893364

End: 1893921

Strand: Reverse

Name: apt

Synonym: cgR_1700

Alternate gene names: 145295775

Gene position: 1893921-1893364 (Counterclockwise)

Preceding gene: 145295776

Following gene: 145295774

Centisome position: 57.15

GC content: 54.12

Gene sequence:

>558_bases
GTGAGCGATCAAGCTCTAAGCACCTTCGACAGGGCACGTGAGGCCCTAGACAAGAAAACCCGATATGTGCAGGATTTCCC
AGAAAAGGGTGTGCTTTTTGAAGACCTCACCCCGGTCTTGGGCGATGCAGAATCATTTGCGGCCGTGGTGGACGCCATGG
CTGAAGCTGCAGAAAAACTGAATGCAGAAATCATCGGTGGCTTAGATGCGCGCGGATTCCTCCTCGGATCCGCTGTTGCC
TACAAACTCGGTCTGGGTGTGCTGGCGATCCGCAAGAAGGGAAAGCTCCCCCCACCTGTGGTGACCCAGGAGTATGAACT
TGAATACGGCACTGCAGCACTCGAGCTGCCCAGTGAAGGAATCGACATTGCTGGTAAAAACATCGTTTTGATCGACGATG
TGCTGGCAACCGGTGGCACCTTGGGCGCTGCACGTAAACTAATTGAATCGTGTGACGGACATGTTTCCGGATATGTTCTT
GCCATTGAGGTCCCAGGCCTCGGCGGTAGGGATAATCTTGGTGCTAGGCCCGTCATTGTGGTCAGAGATCCTCAGTAG

Upstream 100 bases:

>100_bases
GTTTGTGATAGATCGCACAGTCGGTAACGTTGTTGTTAATACAGACCTAGCCGGTATCGGTTGGAACATGGACCGTTGGT
CCAGAAGTGAGGAATAAGTA

Downstream 100 bases:

>100_bases
AAGGATCGAAAGAAAGGCGGCAGGAAAATGAGTCTGGAGCGCAACACGCAAAAATCTTCCATGGGTGTGCGAAGCATGTC
AGCCAGGCTTGCCCGCAGCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MSDQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFAAVVDAMAEAAEKLNAEIIGGLDARGFLLGSAVA
YKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEGIDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVL
AIEVPGLGGRDNLGARPVIVVRDPQ

Sequences:

>Translated_185_residues
MSDQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFAAVVDAMAEAAEKLNAEIIGGLDARGFLLGSAVA
YKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEGIDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVL
AIEVPGLGGRDNLGARPVIVVRDPQ
>Mature_184_residues
SDQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFAAVVDAMAEAAEKLNAEIIGGLDARGFLLGSAVAY
KLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEGIDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVLA
IEVPGLGGRDNLGARPVIVVRDPQ

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=173, Percent_Identity=39.3063583815029, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI71773201, Length=132, Percent_Identity=41.6666666666667, Blast_Score=107, Evalue=6e-24,
Organism=Escherichia coli, GI1786675, Length=160, Percent_Identity=38.75, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=38.0116959064327, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323619, Length=165, Percent_Identity=36.969696969697, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320649, Length=165, Percent_Identity=33.9393939393939, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136334, Length=156, Percent_Identity=42.9487179487179, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CORGB (A4QEM8)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138596.1
- ProteinModelPortal:   A4QEM8
- SMR:   A4QEM8
- STRING:   A4QEM8
- GeneID:   4992068
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1700
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   ELCAING
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19478; Mature: 19346

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFAAVVDAMAEAAEKL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHHHC
NAEIIGGLDARGFLLGSAVAYKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEG
CHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEECCCCCEEEECCCCC
IDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVLAIEVPGLGGRDNLGARPVIV
CCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEE
VRDPQ
EECCC
>Mature Secondary Structure 
SDQALSTFDRAREALDKKTRYVQDFPEKGVLFEDLTPVLGDAESFAAVVDAMAEAAEKL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHHHC
NAEIIGGLDARGFLLGSAVAYKLGLGVLAIRKKGKLPPPVVTQEYELEYGTAALELPSEG
CHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEECCCCCEEEECCCCC
IDIAGKNIVLIDDVLATGGTLGAARKLIESCDGHVSGYVLAIEVPGLGGRDNLGARPVIV
CCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEE
VRDPQ
EECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA