Click here to switch to the map view.

The map label for this gene is relA

Identifier: 145295774

GI number: 145295774

Start: 1891054

End: 1893336

Strand: Reverse

Name: relA

Synonym: cgR_1699

Alternate gene names: 145295774

Gene position: 1893336-1891054 (Counterclockwise)

Preceding gene: 145295775

Following gene: 145295769

Centisome position: 57.13

GC content: 55.28

Gene sequence:

>2283_bases
ATGAGTCTGGAGCGCAACACGCAAAAATCTTCCATGGGTGTGCGAAGCATGTCAGCCAGGCTTGCCCGCAGCCTCACAGG
AAACCGCGTTCGCACCAACCCTGTGCTGGATCCGCTGCTGAGCATCCACCGGCAATTTCACCCACGCGCCGACGTACAAG
TGTTGGAACGTGCATATGACACCGCGGAACGTCTTCATGATGGTGTGATTCGAAAATCGGGCGATCCGTATATTACCCAC
CCGTTGGCTGTCGCCACCATCGCTGCGGAAATCGGCATGGACACCACCACGCTCGTCGCAGCCTTGTTGCATGACACGGT
GGAAGACACCGACTACTCTTTGGACGATCTCACCCGAGATTTCGGAGAAGAAGTTGCCAGGCTTGTCGACGGTGTCACCA
AGCTCGACAAAGTCGCACTAGGTGCTGCCGCGGAGGCCGAAACGATTCGCAAAATGATCGTCGCCATGAGCCAGGACCCC
CGCGTGCTGGTGATTAAAGTGGCCGACCGTTTGCACAATATGCGCACCATGCGGTTCCTGCCGCCGGAAAAGCAAGCTAA
AAAAGCACGCCAAACCCTTGAAGTGATTGCTCCTTTGGCACACCGCCTGGGCATGGCCAGCGTGAAATGGGAATTGGAAG
ATCTATCCTTTGCCATTTTGTACCCCAAGAAGTACGAAGAGATCGTGCGTCTTGTTGCCGACCGCGCGCCCTCTAGAGAC
CGGTACCTCAAAGAAATTATTGATCAAGTCACCGGTGGCTTGCGCGAAAACAACATCGCGGCAGAAGTGCTTGGTCGACC
AAAGCACTACTGGTCTATCTATCAAAAGATGATCGTTCGCGGTCGTGATTTTGACGATATTTTTGATCTTGTTGGCATCC
GCATCCTGGTAGACAACGTGAACAACTGTTACGCCGCCATCGGTGTCGTGCACTCCCTGTTCAATGCTCTGCCTGGCCGA
TTCAAAGACTATATTTCAGCCCCGCGCTTCGGTGTCTACCAATCCCTGCACACCACCGTGATGGGACCTGGCGGTAAGCC
TCTGGAAGTTCAGGCACGTACCCACGACATGCACTACAACGCCGAATTCGGCATTGCAGCGCACTGGCGATACAAAGAAA
CCAAAGGCAGCCACAGTGGCGAGCAAGCCGAAGTGGATCAAATGGCGTGGATGCGCCAACTCCTGGACTGGCAAAAAGAA
GCAGCCGACCCCAACGAGTTCCTGGACAGCCTGCGCTACGATCTGACTTCCAAGCAGATCTTCGTGTTCACACCCAAAGG
TGATGTGGTCAACCTGCCGGTGAACTCCACCCCGGTGGACTTCGCCTACGCGGTGCACACCGAAGTGGGGCACCGCTGCA
TCGGCGCCAAAATCAACGGCAAACTGGTCGCTTTGGAAACGAAACTCAAATCCGGCGATCGTGTTGAAGTCTTTACCTCC
AAGGACCAAAACGCTGGCCCAAGTAGGGGATGGCAAGAATTTGTTGTCTCACCTCGTGCAAAGGCCAAGATTCGCCAGTG
GTTTGCCAAGGAACGACGCGAAGAATACCTAGAAGCCGGACGCGATGCGCTGGCAGCAGTTATTCAGCGTGGCGGTCTGC
CAATGCACCGCTTGTTCACCGCGTCCTCCATGAAGACGGTGGCAACAGAGCTGCACTACCCAGATGTAGATGCGCTCTAC
ACAGCCATCGGCTCCGGTTCCGTTTCTGCGCAACACGTAGTCAACCGTCTCATGGCCATCTTTGGTGACGAAGAAGATGC
CGAAGACGCATTGGTTGCACGCACCCCATTCAGCGAGCTGGTCAATTCCCGTGCCACCACGGAAAGCAGCACCGGCATCC
TGGTCGAAGGCAGCCCAGATGTCATGGCTAAGCTCGCTAAATGCTGTATGCCAGTGCCAGGAGATGAAATCTTTGGATTC
GTCACCCGTGGTGGCGGTGTCTCCGTACACCGAACAGACTGCACGAATGTGGAAAAGCTCAAAGAAGAGCCAGAACGCAT
TGTCTCCGTCTCCTGGGCTTCGGAAGGTCAAGGTTCAGTATTCTCTGCCACACTGCAGCTTGAAGCACTTGATCGCGCAG
GCCTGCTCTTTGAGCTCACCCGCGTAATCAACGAACAAAAGGTCTCCGTTACCGCAATGAACTCCCATTGCTCAGAAGAC
CGCGTAGCCACCGTGCGCTTCACCTTTGCGGTCTCTGACACCAAGCAGTTGGGATCCCTGATGACACAGCTGCGCAATGC
CGAAGGAGTGTTTGATGTCTACCGAGTGACCTCGGGTGGCTAG

Upstream 100 bases:

>100_bases
TGAGGTCCCAGGCCTCGGCGGTAGGGATAATCTTGGTGCTAGGCCCGTCATTGTGGTCAGAGATCCTCAGTAGAAGGATC
GAAAGAAAGGCGGCAGGAAA

Downstream 100 bases:

>100_bases
AGGCCTTTAGATTGTGAAAAAGCCTTGGGCTTCAACCACCGTGTGGTTGAAGCCCAAGGCTTTGGTGATTAACCCTGAAA
TTTACTGCAATGAACGCTGG

Product: hypothetical protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MSLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYDTAERLHDGVIRKSGDPYITH
PLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRDFGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDP
RVLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
RYLKEIIDQVTGGLRENNIAAEVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGR
FKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKE
AADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALY
TAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGF
VTRGGGVSVHRTDCTNVEKLKEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG

Sequences:

>Translated_760_residues
MSLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYDTAERLHDGVIRKSGDPYITH
PLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRDFGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDP
RVLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
RYLKEIIDQVTGGLRENNIAAEVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGR
FKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKE
AADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALY
TAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGF
VTRGGGVSVHRTDCTNVEKLKEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG
>Mature_759_residues
SLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYDTAERLHDGVIRKSGDPYITHP
LAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRDFGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPR
VLVIKVADRLHNMRTMRFLPPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRDR
YLKEIIDQVTGGLRENNIAAEVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNVNNCYAAIGVVHSLFNALPGRF
KDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYNAEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEA
ADPNEFLDSLRYDLTSKQIFVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTSK
DQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFTASSMKTVATELHYPDVDALYT
AIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSELVNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGFV
TRGGGVSVHRTDCTNVEKLKEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSEDR
VATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain

Homologues:

Organism=Homo sapiens, GI38348360, Length=135, Percent_Identity=42.2222222222222, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790082, Length=723, Percent_Identity=38.3125864453665, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1789147, Length=688, Percent_Identity=36.6279069767442, Blast_Score=496, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RELA_CORGL (O87331)

Other databases:

- EMBL:   AF038651
- EMBL:   BA000036
- EMBL:   BX927153
- RefSeq:   NP_600866.1
- RefSeq:   YP_225937.1
- ProteinModelPortal:   O87331
- SMR:   O87331
- GeneID:   1019621
- GeneID:   3343569
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1861
- KEGG:   cgl:NCgl1590
- HOGENOM:   HBG594146
- OMA:   LMNAETM
- PhylomeDB:   O87331
- ProtClustDB:   CLSK811437
- BioCyc:   CGLU196627:CG1861-MONOMER
- BRENDA:   2.7.6.5
- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676
- Gene3D:   G3DSA:3.10.20.30
- SMART:   SM00471
- SMART:   SM00954
- TIGRFAMs:   TIGR00691

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS; SSF81271 TGS-like

EC number: =2.7.6.5

Molecular weight: Translated: 84448; Mature: 84317

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHH
TAERLHDGVIRKSGDPYITHPLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRD
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
FGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPRVLVIKVADRLHNMRTMRFL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEECC
PPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
CCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
RYLKEIIDQVTGGLRENNIAAEVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNV
HHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECC
NNCYAAIGVVHSLFNALPGRFKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYN
CHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHEECCCCCCEEEEEEECCEEEC
AEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEAADPNEFLDSLRYDLTSKQI
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
EEECCCCCEEECCCCCCCCCEEEEEHHHHCCEEECEEECCEEEEEEEECCCCCEEEEEEC
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFT
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ASSMKTVATELHYPDVDALYTAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSEL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHH
VNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGFVTRGGGVSVHRTDCTNVEKL
HCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECCCCCHHHH
KEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
HHCHHHEEEEEECCCCCCCEEEEEEEEEHHHHCHHHHHHHHHHCHHHEEEEEECCCCCCC
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG
CEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure 
SLERNTQKSSMGVRSMSARLARSLTGNRVRTNPVLDPLLSIHRQFHPRADVQVLERAYD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHH
TAERLHDGVIRKSGDPYITHPLAVATIAAEIGMDTTTLVAALLHDTVEDTDYSLDDLTRD
HHHHHHHHHHHCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
FGEEVARLVDGVTKLDKVALGAAAEAETIRKMIVAMSQDPRVLVIKVADRLHNMRTMRFL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEECC
PPEKQAKKARQTLEVIAPLAHRLGMASVKWELEDLSFAILYPKKYEEIVRLVADRAPSRD
CCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHCCCCHH
RYLKEIIDQVTGGLRENNIAAEVLGRPKHYWSIYQKMIVRGRDFDDIFDLVGIRILVDNV
HHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECC
NNCYAAIGVVHSLFNALPGRFKDYISAPRFGVYQSLHTTVMGPGGKPLEVQARTHDMHYN
CHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHEECCCCCCEEEEEEECCEEEC
AEFGIAAHWRYKETKGSHSGEQAEVDQMAWMRQLLDWQKEAADPNEFLDSLRYDLTSKQI
CCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FVFTPKGDVVNLPVNSTPVDFAYAVHTEVGHRCIGAKINGKLVALETKLKSGDRVEVFTS
EEECCCCCEEECCCCCCCCCEEEEEHHHHCCEEECEEECCEEEEEEEECCCCCEEEEEEC
KDQNAGPSRGWQEFVVSPRAKAKIRQWFAKERREEYLEAGRDALAAVIQRGGLPMHRLFT
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ASSMKTVATELHYPDVDALYTAIGSGSVSAQHVVNRLMAIFGDEEDAEDALVARTPFSEL
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHH
VNSRATTESSTGILVEGSPDVMAKLAKCCMPVPGDEIFGFVTRGGGVSVHRTDCTNVEKL
HCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHEEEEECCCCEEEEECCCCCHHHH
KEEPERIVSVSWASEGQGSVFSATLQLEALDRAGLLFELTRVINEQKVSVTAMNSHCSED
HHCHHHEEEEEECCCCCCCEEEEEEEEEHHHHCHHHHHHHHHHCHHHEEEEEECCCCCCC
RVATVRFTFAVSDTKQLGSLMTQLRNAEGVFDVYRVTSGG
CEEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9695918; 12948626