| Definition | Corynebacterium glutamicum R chromosome, complete genome. |
|---|---|
| Accession | NC_009342 |
| Length | 3,314,179 |
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The map label for this gene is tyrS [H]
Identifier: 145295540
GI number: 145295540
Start: 1620927
End: 1622189
Strand: Direct
Name: tyrS [H]
Synonym: cgR_1468
Alternate gene names: 145295540
Gene position: 1620927-1622189 (Clockwise)
Preceding gene: 145295539
Following gene: 145295543
Centisome position: 48.91
GC content: 57.32
Gene sequence:
>1263_bases ATGAACATCATTGACGAACTCTCCTGGCGCGGACTCATCAACCAGTCCACCGACCTTGAGGCCCTTCGCGAGGAAGCTTC AACCCCCATCACCTTGTACTGCGGATTCGACCCAACCGGTCCATCCCTCCACGCAGGACACCTCGTTCCACTGCTCATGC TGCGCCGTTTCCAGCAAGCAGGACACAACCCAATCGTGCTTGCAGGTGGCGCAACCGGCATGATCGGCGACCCCCGCGAT GTCGGCGAGCGCACCATGAACTCCGCAGACACCGTCTCTGTTTGGGCAGAACGCATCTCCGGTCAGCTCAGCCGCTTCGT TGATTTCGACGGCGAGCACGCAGCCCGTCTGGTCAACAACGCCGAGTGGACCAACGAAATGTCCGTAGTGACCTTTCTCC GTGATGTAGGAAAGCACTTCTCCCTCAACACCATGCTCGCTCGCGACACCGTCAAGCGTCGCCTCGAGTCCGACGGCATT TCCTACACCGAGTTCTCCTACATGCTGCTGCAGGCCAACGACTACGTTGAACTGAACAAGCGCTTCGGCTGCACCCTGCA GGTAGGTGGCGGTGACCAGTGGGGCAACATCGTTTCTGGCGTTGACCTCAACCGTCGCGTCAACGGCACCTCTGTCCACG CAGTGACCGTACCTTTGGTTACCGATTCCGACGGCAAGAAGTTCGGCAAGTCCACCGGCGGCGGAAGTCTCTGGTTGGAT CCGGAAATGACCAGCCCATACGCTTGGTACCAGTACTTCATCAACGCATCCGACGCTGACGTGATCCGTTACCTCCGCTG GTTCACCTTCCTCACCCAGGAAGAACTTGCTGAGTTGGAAGTTGAAGTTGCAGAGCGCCCATTCAAGCGCGAAGCACAGC GTCGTCTTGCACGCGAAATGACCAACTTGGTTCACGGAACCGAAGCAACCGAAGCAGTCGAGCTTGCTGCTCAAGCACTG TTCGGCCGCGCAGAACTCCGCGACTTAGACGAAAAAACTCTCGCTGCATCCGTTTCTGAAACTGCAGTTGCAGAAATCAA GGCAGGGGAGCCACGCACCATCATAGATCTGTTGGTGGCCAGCGGACTTGCTGATTCCAAGGGCGCAGCAAAGCGTGCAG TCAAGGAAGGCGGTGCGTACGTAAACAACGAACGTATCGAATCGGATGATTGGGAGCCTTCCGCTGAAGACCTTCTTCAC GGTTCATGGCTAGTACTGCGCCGTGGCAAGAAGAACTTCGCAGGAGTTCAGATCCTCGGCTAA
Upstream 100 bases:
>100_bases GGCCTATCGCATTGACGACGGAATTCCGGTGCTTCTCATCGACGAAGCCACCGAGTGGACCCCCAACAACTAGAAGTACA TCAAGGACATTTTTAACACC
Downstream 100 bases:
>100_bases TAATCGCTGAACTGATTGCGGTTTTTCATTTGTCTGACTTCTGGAAAACCAAAAGGAGGGGTGAGCACCAAATTCTGGTG CCCACCCCTCCTTTTAGCAA
Product: tyrosyl-tRNA synthetase
Products: NA
Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]
Number of amino acids: Translated: 420; Mature: 420
Protein sequence:
>420_residues MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQAGHNPIVLAGGATGMIGDPRD VGERTMNSADTVSVWAERISGQLSRFVDFDGEHAARLVNNAEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGI SYTEFSYMLLQANDYVELNKRFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREMTNLVHGTEATEAVELAAQAL FGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVASGLADSKGAAKRAVKEGGAYVNNERIESDDWEPSAEDLLH GSWLVLRRGKKNFAGVQILG
Sequences:
>Translated_420_residues MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQAGHNPIVLAGGATGMIGDPRD VGERTMNSADTVSVWAERISGQLSRFVDFDGEHAARLVNNAEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGI SYTEFSYMLLQANDYVELNKRFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREMTNLVHGTEATEAVELAAQAL FGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVASGLADSKGAAKRAVKEGGAYVNNERIESDDWEPSAEDLLH GSWLVLRRGKKNFAGVQILG >Mature_420_residues MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQAGHNPIVLAGGATGMIGDPRD VGERTMNSADTVSVWAERISGQLSRFVDFDGEHAARLVNNAEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGI SYTEFSYMLLQANDYVELNKRFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREMTNLVHGTEATEAVELAAQAL FGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVASGLADSKGAAKRAVKEGGAYVNNERIESDDWEPSAEDLLH GSWLVLRRGKKNFAGVQILG
Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]
COG id: COG0162
COG function: function code J; Tyrosyl-tRNA synthetase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 S4 RNA-binding domain [H]
Homologues:
Organism=Homo sapiens, GI94681057, Length=410, Percent_Identity=35.3658536585366, Blast_Score=232, Evalue=4e-61, Organism=Escherichia coli, GI1787925, Length=418, Percent_Identity=47.8468899521531, Blast_Score=389, Evalue=1e-109, Organism=Caenorhabditis elegans, GI25145802, Length=422, Percent_Identity=33.8862559241706, Blast_Score=196, Evalue=2e-50, Organism=Caenorhabditis elegans, GI25145805, Length=296, Percent_Identity=34.4594594594595, Blast_Score=150, Evalue=1e-36, Organism=Saccharomyces cerevisiae, GI6325160, Length=448, Percent_Identity=34.1517857142857, Blast_Score=250, Evalue=4e-67, Organism=Drosophila melanogaster, GI20130383, Length=405, Percent_Identity=35.5555555555556, Blast_Score=244, Evalue=1e-64,
Paralogues:
None
Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001412 - InterPro: IPR002305 - InterPro: IPR014729 - InterPro: IPR002942 - InterPro: IPR002307 [H]
Pfam domain/function: PF00579 tRNA-synt_1b [H]
EC number: =6.1.1.1 [H]
Molecular weight: Translated: 46370; Mature: 46370
Theoretical pI: Translated: 4.83; Mature: 4.83
Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I ; PS00430 TONB_DEPENDENT_REC_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQA CCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC GHNPIVLAGGATGMIGDPRDVGERTMNSADTVSVWAERISGQLSRFVDFDGEHAARLVNN CCCCEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC AEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGISYTEFSYMLLQANDYVELNK CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHEEEEEEECCCCEEECC RFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD CCCCEEEECCCCCCCCHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCCCCEEEC PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREM CCCCCCCEEHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH TNLVHGTEATEAVELAAQALFGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVA HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH SGLADSKGAAKRAVKEGGAYVNNERIESDDWEPSAEDLLHGSWLVLRRGKKNFAGVQILG CCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHCCCEEEEECCCCCCCCEEEEC >Mature Secondary Structure MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQA CCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC GHNPIVLAGGATGMIGDPRDVGERTMNSADTVSVWAERISGQLSRFVDFDGEHAARLVNN CCCCEEEECCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC AEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGISYTEFSYMLLQANDYVELNK CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHEEEEEEECCCCEEECC RFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD CCCCEEEECCCCCCCCHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCCCCEEEC PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREM CCCCCCCEEHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH TNLVHGTEATEAVELAAQALFGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVA HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH SGLADSKGAAKRAVKEGGAYVNNERIESDDWEPSAEDLLHGSWLVLRRGKKNFAGVQILG CCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHCCCEEEEECCCCCCCCEEEEC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12948626 [H]