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The map label for this gene is tpx

Identifier: 145295228

GI number: 145295228

Start: 1277028

End: 1277525

Strand: Direct

Name: tpx

Synonym: cgR_1169

Alternate gene names: 145295228

Gene position: 1277028-1277525 (Clockwise)

Preceding gene: 145295225

Following gene: 145295231

Centisome position: 38.53

GC content: 54.82

Gene sequence:

>498_bases
ATGGCTAAAACACATTTTCAAGGCAACGAAACTGCTACCTCCGGCGAACTGCCACAGGTCGGCGACAACCTCGCAGAGTT
CAACCTCGTCAACACCGAACTGGGCGAGGTCTCCTCAAAGGACTTCCAGGGCCGCAAGCTTGTCCTGAACATCTTCCCAT
CCGTTGACACCGGCGTTTGTGCAACATCAGTCCGCAAGTTCAACGAGGCAGCAGCAAGCCTGGAAAACACCACCGTGCTG
TGCATCTCCAAGGATCTTCCATTCGCACTGGGCCGTTTCTGCTCCGCAGAAGGCATCGAGAACGTCACCCCAGTATCCGC
ATTCCGTTCCACCTTCGGTGAAGACAACGGCATCGTGCTCGAAGGCTCACCACTTAAGGGGCTTCTTGCACGCAGCGTCA
TCGTCGTCGATGAAAACGGCAAGGTTGCTTACACCCAGTTGGTTGATGAGATCTCCACTGAACCTGATTACGACGCTGCA
CTTGCTGCGCTGAACTAA

Upstream 100 bases:

>100_bases
AGCTTTTTGCATGTGTCATATCGTACCGTTTGCATAAGCCTGTTCGCGCTTGGTGAACCTTTTCTAGCACCAAAACAAAA
CTCTCCCTAGTATGGGGTCC

Downstream 100 bases:

>100_bases
TTTACTTCGCTCACGGTAATTTCTGATGAAGCTTCGGTGGTCTCCACCGGAGCTTCAGTTGTTTCGGGTTCAGTTTCGGG
GGTGGTCGACGGAGCTAAGA

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MAKTHFQGNETATSGELPQVGDNLAEFNLVNTELGEVSSKDFQGRKLVLNIFPSVDTGVCATSVRKFNEAAASLENTTVL
CISKDLPFALGRFCSAEGIENVTPVSAFRSTFGEDNGIVLEGSPLKGLLARSVIVVDENGKVAYTQLVDEISTEPDYDAA
LAALN

Sequences:

>Translated_165_residues
MAKTHFQGNETATSGELPQVGDNLAEFNLVNTELGEVSSKDFQGRKLVLNIFPSVDTGVCATSVRKFNEAAASLENTTVL
CISKDLPFALGRFCSAEGIENVTPVSAFRSTFGEDNGIVLEGSPLKGLLARSVIVVDENGKVAYTQLVDEISTEPDYDAA
LAALN
>Mature_164_residues
AKTHFQGNETATSGELPQVGDNLAEFNLVNTELGEVSSKDFQGRKLVLNIFPSVDTGVCATSVRKFNEAAASLENTTVLC
ISKDLPFALGRFCSAEGIENVTPVSAFRSTFGEDNGIVLEGSPLKGLLARSVIVVDENGKVAYTQLVDEISTEPDYDAAL
AALN

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2)

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1787584, Length=166, Percent_Identity=54.8192771084337, Blast_Score=187, Evalue=3e-49,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPX_CORGL (Q8NRG3)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927151
- RefSeq:   NP_600314.1
- RefSeq:   YP_225377.1
- ProteinModelPortal:   Q8NRG3
- SMR:   Q8NRG3
- World-2DPAGE:   0001:Q8NRG3
- GeneID:   1019071
- GeneID:   3343397
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1236
- KEGG:   cgl:NCgl1041
- HOGENOM:   HBG493509
- OMA:   VRKFNAQ
- PhylomeDB:   Q8NRG3
- ProtClustDB:   PRK00522
- BioCyc:   CGLU196627:CG1236-MONOMER
- HAMAP:   MF_00269
- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10681:SF3

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17532; Mature: 17401

Theoretical pI: Translated: 4.15; Mature: 4.15

Prosite motif: PS51352 THIOREDOXIN_2; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTHFQGNETATSGELPQVGDNLAEFNLVNTELGEVSSKDFQGRKLVLNIFPSVDTGVC
CCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
ATSVRKFNEAAASLENTTVLCISKDLPFALGRFCSAEGIENVTPVSAFRSTFGEDNGIVL
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEE
EGSPLKGLLARSVIVVDENGKVAYTQLVDEISTEPDYDAALAALN
ECCCCHHHHHCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHEECC
>Mature Secondary Structure 
AKTHFQGNETATSGELPQVGDNLAEFNLVNTELGEVSSKDFQGRKLVLNIFPSVDTGVC
CCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
ATSVRKFNEAAASLENTTVLCISKDLPFALGRFCSAEGIENVTPVSAFRSTFGEDNGIVL
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEE
EGSPLKGLLARSVIVVDENGKVAYTQLVDEISTEPDYDAALAALN
ECCCCHHHHHCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626