Click here to switch to the map view.

The map label for this gene is ydgK [H]

Identifier: 145295190

GI number: 145295190

Start: 1242031

End: 1243335

Strand: Reverse

Name: ydgK [H]

Synonym: cgR_1132

Alternate gene names: 145295190

Gene position: 1243335-1242031 (Counterclockwise)

Preceding gene: 145295194

Following gene: 145295186

Centisome position: 37.52

GC content: 50.88

Gene sequence:

>1305_bases
TTGACCGATAACAAACCCGTGGTGCAGGAAAACAAAACGGAAACAGCTCCTCACATTGGCAAGAGCAGTTCAAACACGAT
TGGTTTGGCAACGCTTTTCACCCTGGCGATCCTTTCCGCAGTAGCACCATTTAGCATCGACTTGTACCTTCCAGCATTCC
CTGCAATGACTGAGGACCTCCACACCACTGCAACCGGAGTGCAGCTTTCCCTCACCGCGTTCCTTATCGGCGCCGGTGTT
GGCCAGGTTGTTTTCGGACCTCTTTCAGATCGCATTGGTCGGCTTATTCCGCTGTACATTGGCCTAGTTCTATTTCTAGT
AGCTAGCATCGTCACCGTTTTCGCCAGCAACGTCGAAATCCTCGTCGCTGCGCGCCTTGCTCAAGGTCTCGGTGGTGCGT
CCGGCATGGTTATTGGTCGCGCAATGGTTCTAGATAAAGAAAAAGGTGCAGCTGCTGCCAAAGCGTTGAGCATCATGATG
GTCATCGGTGGAATCGCACCTGTTGTTGCACCATTAGCGGGCAGTCTGCTGGCAGATCTCATTGGATGGCGTGGCCTTCT
TGCCATCGTCGCAGGTATTGGTGTTGTAGGCATCGCATCTACTGTTTTCTTTATCCGGGAGACTCTACCTAAATCACAGC
GTTCCCACTCCGCTCAAGCATCAACATCTAAGCCCATTAAGGCTCTTGCTTTCCGTGGCTACATCGGTAACGTCGTCGCT
TTTGCATTCGCAATGGCCATTTTGATGTCCTACATTTCAGCATCGCCATTTGTCTACCAAAACATGATCGGCTTAGATGC
TGTCGGATACGGCTTTGCTTTTGCCGTCAACGCAATCGGCATTACGGTCCTCACCGGAATTTCTGCACGTTTGACCGGTC
GCGTTACAACTTTCGCGCTCACCTTAATTGGGCTTTCTACCAGCTTTATTGCAATTGTCGTTATCTCAATCCTCACGTTT
AGCAGTGCACCAGCTAGCTGGCTCATGGTTCCACTATTTTGCGCTATCGCACCTTTGGGACTTGTCCTTGGTAACGCTAC
TGCCCTTGCACTTTCTGCTGTTCCACAAACTGCTACCGGCACTGGTTCAGCGATCTTGGGCCTCATTCAATTTCTACTTG
CAGGTATCGTCGCCGGCTTAGTTGGTATCGCTGGTGAAGACACCACGGTACCGCTAGCTCTGACCATGGTCGCAGCAGTA
CTCATTGCCCTCAGCGGACTTGCACTTGGACGCACTGAAAAACATGCAACCGTTGTTGAGTCCACAGAACCCGTTGGTGA
AACAAGTAAAGCTACTGCTAAATAA

Upstream 100 bases:

>100_bases
TCTCAGACAATGTGTACTCCCTCACTTCCCAAATTGGATAAGTCTGAGTATAGTTTCCACATTGATACTTATGTTTTCAT
AACTAGATTGGTGGATTTCT

Downstream 100 bases:

>100_bases
CCTGGATCTCGCTAAAACATTGACTGACTTTCACCGCAAAGCTTCGCAAATCCAGCCTTCTGGCATAGTACCGCCGGCAA
GCAAGTCACGAACCTTATCC

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTDNKPVVQENKTETAPHIGKSSSNTIGLATLFTLAILSAVAPFSIDLYLPAFPAMTEDLHTTATGVQLSLTAFLIGAGV
GQVVFGPLSDRIGRLIPLYIGLVLFLVASIVTVFASNVEILVAARLAQGLGGASGMVIGRAMVLDKEKGAAAAKALSIMM
VIGGIAPVVAPLAGSLLADLIGWRGLLAIVAGIGVVGIASTVFFIRETLPKSQRSHSAQASTSKPIKALAFRGYIGNVVA
FAFAMAILMSYISASPFVYQNMIGLDAVGYGFAFAVNAIGITVLTGISARLTGRVTTFALTLIGLSTSFIAIVVISILTF
SSAPASWLMVPLFCAIAPLGLVLGNATALALSAVPQTATGTGSAILGLIQFLLAGIVAGLVGIAGEDTTVPLALTMVAAV
LIALSGLALGRTEKHATVVESTEPVGETSKATAK

Sequences:

>Translated_434_residues
MTDNKPVVQENKTETAPHIGKSSSNTIGLATLFTLAILSAVAPFSIDLYLPAFPAMTEDLHTTATGVQLSLTAFLIGAGV
GQVVFGPLSDRIGRLIPLYIGLVLFLVASIVTVFASNVEILVAARLAQGLGGASGMVIGRAMVLDKEKGAAAAKALSIMM
VIGGIAPVVAPLAGSLLADLIGWRGLLAIVAGIGVVGIASTVFFIRETLPKSQRSHSAQASTSKPIKALAFRGYIGNVVA
FAFAMAILMSYISASPFVYQNMIGLDAVGYGFAFAVNAIGITVLTGISARLTGRVTTFALTLIGLSTSFIAIVVISILTF
SSAPASWLMVPLFCAIAPLGLVLGNATALALSAVPQTATGTGSAILGLIQFLLAGIVAGLVGIAGEDTTVPLALTMVAAV
LIALSGLALGRTEKHATVVESTEPVGETSKATAK
>Mature_433_residues
TDNKPVVQENKTETAPHIGKSSSNTIGLATLFTLAILSAVAPFSIDLYLPAFPAMTEDLHTTATGVQLSLTAFLIGAGVG
QVVFGPLSDRIGRLIPLYIGLVLFLVASIVTVFASNVEILVAARLAQGLGGASGMVIGRAMVLDKEKGAAAAKALSIMMV
IGGIAPVVAPLAGSLLADLIGWRGLLAIVAGIGVVGIASTVFFIRETLPKSQRSHSAQASTSKPIKALAFRGYIGNVVAF
AFAMAILMSYISASPFVYQNMIGLDAVGYGFAFAVNAIGITVLTGISARLTGRVTTFALTLIGLSTSFIAIVVISILTFS
SAPASWLMVPLFCAIAPLGLVLGNATALALSAVPQTATGTGSAILGLIQFLLAGIVAGLVGIAGEDTTVPLALTMVAAVL
IALSGLALGRTEKHATVVESTEPVGETSKATAK

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=371, Percent_Identity=29.1105121293801, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI48994889, Length=400, Percent_Identity=31, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790146, Length=240, Percent_Identity=27.5, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787065, Length=375, Percent_Identity=25.8666666666667, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082312, Length=150, Percent_Identity=34, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790794, Length=230, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319480, Length=324, Percent_Identity=21.6049382716049, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44121; Mature: 43990

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNKPVVQENKTETAPHIGKSSSNTIGLATLFTLAILSAVAPFSIDLYLPAFPAMTEDL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
HTTATGVQLSLTAFLIGAGVGQVVFGPLSDRIGRLIPLYIGLVLFLVASIVTVFASNVEI
HHHHCCHHHHHHHHHHHCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LVAARLAQGLGGASGMVIGRAMVLDKEKGAAAAKALSIMMVIGGIAPVVAPLAGSLLADL
HHHHHHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGWRGLLAIVAGIGVVGIASTVFFIRETLPKSQRSHSAQASTSKPIKALAFRGYIGNVVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
FAFAMAILMSYISASPFVYQNMIGLDAVGYGFAFAVNAIGITVLTGISARLTGRVTTFAL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TLIGLSTSFIAIVVISILTFSSAPASWLMVPLFCAIAPLGLVLGNATALALSAVPQTATG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
TGSAILGLIQFLLAGIVAGLVGIAGEDTTVPLALTMVAAVLIALSGLALGRTEKHATVVE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
STEPVGETSKATAK
CCCCCCCCCCCCCC
>Mature Secondary Structure 
TDNKPVVQENKTETAPHIGKSSSNTIGLATLFTLAILSAVAPFSIDLYLPAFPAMTEDL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
HTTATGVQLSLTAFLIGAGVGQVVFGPLSDRIGRLIPLYIGLVLFLVASIVTVFASNVEI
HHHHCCHHHHHHHHHHHCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LVAARLAQGLGGASGMVIGRAMVLDKEKGAAAAKALSIMMVIGGIAPVVAPLAGSLLADL
HHHHHHHHHCCCCCHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGWRGLLAIVAGIGVVGIASTVFFIRETLPKSQRSHSAQASTSKPIKALAFRGYIGNVVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
FAFAMAILMSYISASPFVYQNMIGLDAVGYGFAFAVNAIGITVLTGISARLTGRVTTFAL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TLIGLSTSFIAIVVISILTFSSAPASWLMVPLFCAIAPLGLVLGNATALALSAVPQTATG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
TGSAILGLIQFLLAGIVAGLVGIAGEDTTVPLALTMVAAVLIALSGLALGRTEKHATVVE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
STEPVGETSKATAK
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]