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The map label for this gene is manB [C]

Identifier: 145294859

GI number: 145294859

Start: 888947

End: 890674

Strand: Reverse

Name: manB [C]

Synonym: cgR_0806

Alternate gene names: 145294859

Gene position: 890674-888947 (Counterclockwise)

Preceding gene: 145294865

Following gene: 145294856

Centisome position: 26.87

GC content: 54.34

Gene sequence:

>1728_bases
ATGAGGCAACCTGCGCACCAATTTCCATCACGTGAAATACCTTTCTGTTTTGTCCGCAGGCGTATCAGGAAAACCTGCAG
CGCGGTAGAGTCGAGTCTAATAGTGATCCCACGAAAACAAAGGATCGGGGTGTTCATGGACGAGTCTCGTCAGCTTAGTT
TCGGCACAGCAGGGTTGCGTGCACCAGTTGGCCCGGCGCGCCATCAGATGAATGTTTTGCAGGTAACCAGAACTACAGCA
GGTGTTGCTAGTTGGTTGGCAGAACGTGCGGCACTAAATCCAGTGCCGCATTTGGTTCCTGAGGATGAAACAGGAATCGG
CAGGGCGTTGTATCCCCAAGATGGTCCGTTGCGGGTCGTTGTGGGGTATGACGCTCGCTATGGTTCGCATACTTTTGCTG
CAACCACTGCGGAGGTGTTCGCGGGTGCTGGTTTTGAGGTGACGTTGCTCCCCACGCCTAGCCCTACGCCGTTGATTCCG
TGGTTGGTGAACAAGCATGGGTTGGATGCGGGCGTTCAGATCACGGCTTCGCATAATGGTGCGGCGGACAATGGCTACAA
GGTGTTTTTGTCTAATGGTCGCCAGCTTTATTCTGAACTGGAGCCTGAGCTTGAGGCGCATATCAATGCTGTGGAAGATC
CGATTCGGGTTCCTCGGGTGACGGTGCGCCCCACTGCTGATCAGCTGCGTAGATATGTTGATGAGATGGTGTCGTTGGTG
ACTCCTGATCAGGCTGATTTGTTGCGGGTGAATTCTGAGCGGGGCAATCTTCGCGTGGTGTATACCGCTCTGCATGGTGT
GGGTGGCCGCGCGATGGCCAATGCTTTCCAATTTGCTGGTTTTCCCCATACTCATGGCGTGAAGGCTCAGCAGTATCCTG
ATCCCACCTTCCCCACTGTGGCGTTCCCCAATCCGGAAGAGCCTTCTGCGATTGAGTTGTTGTTGGAACGCGCAAAGGAA
AAGAACGCTGACATTTTGTTTGCGCTTGATCCTGATGCCGATCGTTGTGCTGTGGGTATTCGTACCGCTGATGGCGGCCA
CCGAATGCTCTCTGGCGATGAGGTGGGCACACTTTTGGCTACTCGTTTGGTTCCGGAGTATTCCGGTGAAGGCCCACGTC
CCGTGGTTGCCACCACGGTGGTTTCTTCGCAGCTTCTGGGTATCATCGCCGAGGATAAAGGGTGGGATTATTCCGAGACA
CTGACGGGATTCAAAAACCTGTCGAGGGCTGCCGATGGTCTCGACGGACCGCTTGCTTTCGCTTATGAGGAAGCTGTGGG
CACCTGCCCGGTTCCAGATGTCGTGCCGGATAAGGACGGCATCTCTACAGCGTTGTTCATGGCGTCGTGGGCTGCCGAAC
TGAAGGCTCAGGGCGCAAGCCTGCAGCAAAAACTCAATGAGTTGTATCGCCGATATGGGTATTTTGCGTCCTCGCAAATT
GCTGTGCGCACGAGCAGTCCACGCGAGTTAGTTGATCACTGGATTGCGCATCCTCAGCAAGAACTCATTGGAGTGTCTGC
CACCCCACATATTCTTCCTGAAAAACAGGGCATTGCTTTGCATGGCGAGGTGGGGCATGTGCATATCCGCGCTATTGGTC
GAGTCTCTGGCACTGAGGCAAAAGCCAAGCTCTATTTGGAAGTTGGTCAGGCCAGCTCCCATGATGAGGCGGCTCAGTTG
CTTCATCAGTTAGAGGATGAAGTCCAAAGCTGGTTGAGCAAGCTTTAG

Upstream 100 bases:

>100_bases
GCCAAATACTCAGTCGTGCGGTATTCCATGTGGGAGAGCTCAGGATGGCTGTGCAAATGCCTGCGCCACTTAATGACCTC
GTCATGGTGGCGGTCCATCC

Downstream 100 bases:

>100_bases
TTTCCTGGCTGCTCGCGGTTGCGGGTGAGCCGGAGGTCTGCGTCGAAAAGCAATGGATCTTTTTCTGAAGGCCACCGCAC
GTCAATGGCGGCGGTTTCGT

Product: hypothetical protein

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MRQPAHQFPSREIPFCFVRRRIRKTCSAVESSLIVIPRKQRIGVFMDESRQLSFGTAGLRAPVGPARHQMNVLQVTRTTA
GVASWLAERAALNPVPHLVPEDETGIGRALYPQDGPLRVVVGYDARYGSHTFAATTAEVFAGAGFEVTLLPTPSPTPLIP
WLVNKHGLDAGVQITASHNGAADNGYKVFLSNGRQLYSELEPELEAHINAVEDPIRVPRVTVRPTADQLRRYVDEMVSLV
TPDQADLLRVNSERGNLRVVYTALHGVGGRAMANAFQFAGFPHTHGVKAQQYPDPTFPTVAFPNPEEPSAIELLLERAKE
KNADILFALDPDADRCAVGIRTADGGHRMLSGDEVGTLLATRLVPEYSGEGPRPVVATTVVSSQLLGIIAEDKGWDYSET
LTGFKNLSRAADGLDGPLAFAYEEAVGTCPVPDVVPDKDGISTALFMASWAAELKAQGASLQQKLNELYRRYGYFASSQI
AVRTSSPRELVDHWIAHPQQELIGVSATPHILPEKQGIALHGEVGHVHIRAIGRVSGTEAKAKLYLEVGQASSHDEAAQL
LHQLEDEVQSWLSKL

Sequences:

>Translated_575_residues
MRQPAHQFPSREIPFCFVRRRIRKTCSAVESSLIVIPRKQRIGVFMDESRQLSFGTAGLRAPVGPARHQMNVLQVTRTTA
GVASWLAERAALNPVPHLVPEDETGIGRALYPQDGPLRVVVGYDARYGSHTFAATTAEVFAGAGFEVTLLPTPSPTPLIP
WLVNKHGLDAGVQITASHNGAADNGYKVFLSNGRQLYSELEPELEAHINAVEDPIRVPRVTVRPTADQLRRYVDEMVSLV
TPDQADLLRVNSERGNLRVVYTALHGVGGRAMANAFQFAGFPHTHGVKAQQYPDPTFPTVAFPNPEEPSAIELLLERAKE
KNADILFALDPDADRCAVGIRTADGGHRMLSGDEVGTLLATRLVPEYSGEGPRPVVATTVVSSQLLGIIAEDKGWDYSET
LTGFKNLSRAADGLDGPLAFAYEEAVGTCPVPDVVPDKDGISTALFMASWAAELKAQGASLQQKLNELYRRYGYFASSQI
AVRTSSPRELVDHWIAHPQQELIGVSATPHILPEKQGIALHGEVGHVHIRAIGRVSGTEAKAKLYLEVGQASSHDEAAQL
LHQLEDEVQSWLSKL
>Mature_575_residues
MRQPAHQFPSREIPFCFVRRRIRKTCSAVESSLIVIPRKQRIGVFMDESRQLSFGTAGLRAPVGPARHQMNVLQVTRTTA
GVASWLAERAALNPVPHLVPEDETGIGRALYPQDGPLRVVVGYDARYGSHTFAATTAEVFAGAGFEVTLLPTPSPTPLIP
WLVNKHGLDAGVQITASHNGAADNGYKVFLSNGRQLYSELEPELEAHINAVEDPIRVPRVTVRPTADQLRRYVDEMVSLV
TPDQADLLRVNSERGNLRVVYTALHGVGGRAMANAFQFAGFPHTHGVKAQQYPDPTFPTVAFPNPEEPSAIELLLERAKE
KNADILFALDPDADRCAVGIRTADGGHRMLSGDEVGTLLATRLVPEYSGEGPRPVVATTVVSSQLLGIIAEDKGWDYSET
LTGFKNLSRAADGLDGPLAFAYEEAVGTCPVPDVVPDKDGISTALFMASWAAELKAQGASLQQKLNELYRRYGYFASSQI
AVRTSSPRELVDHWIAHPQQELIGVSATPHILPEKQGIALHGEVGHVHIRAIGRVSGTEAKAKLYLEVGQASSHDEAAQL
LHQLEDEVQSWLSKL

Specific function: Involved In The Biosynthesis Of The Capsular Polysaccharide Colanic Acid. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=567, Percent_Identity=31.3932980599647, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI63055049, Length=449, Percent_Identity=33.630289532294, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71993870, Length=439, Percent_Identity=33.4851936218679, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI71993878, Length=295, Percent_Identity=32.5423728813559, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323934, Length=584, Percent_Identity=29.2808219178082, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24651977, Length=455, Percent_Identity=34.0659340659341, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI20129809, Length=455, Percent_Identity=34.0659340659341, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24653722, Length=475, Percent_Identity=30.9473684210526, Blast_Score=189, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 62554; Mature: 62554

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQPAHQFPSREIPFCFVRRRIRKTCSAVESSLIVIPRKQRIGVFMDESRQLSFGTAGLR
CCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCEEECCCCCCC
APVGPARHQMNVLQVTRTTAGVASWLAERAALNPVPHLVPEDETGIGRALYPQDGPLRVV
CCCCHHHHHCCHHEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEE
VGYDARYGSHTFAATTAEVFAGAGFEVTLLPTPSPTPLIPWLVNKHGLDAGVQITASHNG
EECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEEECCCC
AADNGYKVFLSNGRQLYSELEPELEAHINAVEDPIRVPRVTVRPTADQLRRYVDEMVSLV
CCCCCEEEEECCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHC
TPDQADLLRVNSERGNLRVVYTALHGVGGRAMANAFQFAGFPHTHGVKAQQYPDPTFPTV
CCCCHHEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
AFPNPEEPSAIELLLERAKEKNADILFALDPDADRCAVGIRTADGGHRMLSGDEVGTLLA
ECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCEEECCCHHHHHHH
TRLVPEYSGEGPRPVVATTVVSSQLLGIIAEDKGWDYSETLTGFKNLSRAADGLDGPLAF
HHHCCCCCCCCCCCEEEHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
AYEEAVGTCPVPDVVPDKDGISTALFMASWAAELKAQGASLQQKLNELYRRYGYFASSQI
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEE
AVRTSSPRELVDHWIAHPQQELIGVSATPHILPEKQGIALHGEVGHVHIRAIGRVSGTEA
EEECCCHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCC
KAKLYLEVGQASSHDEAAQLLHQLEDEVQSWLSKL
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQPAHQFPSREIPFCFVRRRIRKTCSAVESSLIVIPRKQRIGVFMDESRQLSFGTAGLR
CCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCEEECCCCCCC
APVGPARHQMNVLQVTRTTAGVASWLAERAALNPVPHLVPEDETGIGRALYPQDGPLRVV
CCCCHHHHHCCHHEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEE
VGYDARYGSHTFAATTAEVFAGAGFEVTLLPTPSPTPLIPWLVNKHGLDAGVQITASHNG
EECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCEEEEECCCC
AADNGYKVFLSNGRQLYSELEPELEAHINAVEDPIRVPRVTVRPTADQLRRYVDEMVSLV
CCCCCEEEEECCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHC
TPDQADLLRVNSERGNLRVVYTALHGVGGRAMANAFQFAGFPHTHGVKAQQYPDPTFPTV
CCCCHHEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
AFPNPEEPSAIELLLERAKEKNADILFALDPDADRCAVGIRTADGGHRMLSGDEVGTLLA
ECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCCEEECCCHHHHHHH
TRLVPEYSGEGPRPVVATTVVSSQLLGIIAEDKGWDYSETLTGFKNLSRAADGLDGPLAF
HHHCCCCCCCCCCCEEEHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
AYEEAVGTCPVPDVVPDKDGISTALFMASWAAELKAQGASLQQKLNELYRRYGYFASSQI
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEE
AVRTSSPRELVDHWIAHPQQELIGVSATPHILPEKQGIALHGEVGHVHIRAIGRVSGTEA
EEECCCHHHHHHHHHCCCHHHHEECCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCC
KAKLYLEVGQASSHDEAAQLLHQLEDEVQSWLSKL
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]