Click here to switch to the map view.

The map label for this gene is phr [H]

Identifier: 145294801

GI number: 145294801

Start: 823495

End: 824943

Strand: Reverse

Name: phr [H]

Synonym: cgR_0748

Alternate gene names: 145294801

Gene position: 824943-823495 (Counterclockwise)

Preceding gene: 145294802

Following gene: 145294798

Centisome position: 24.89

GC content: 46.58

Gene sequence:

>1449_bases
ATGAATGCAAACGTAAGGGTGTTTATTTTAAACTCATTAGCTATGAATGATCCACACCGGCCTCCCACCCTTCTATGGTT
CCGCGATGACCTCCGACTAAGTGATAATGCTGCTTTAAAATGGGCTGCTGATCATGGCCCCGTTATTGGACTCTTCATTG
ATGAAACGATCAATCGCAGCATTGGGGCCGCAGCACGATGGTGGCGGGAACAAAGCCTTAATGCTTTAGCCCAAGATCTT
TCTTTTTACGGAGTACCTTTACTACGACGTACCGGTAATCCGCTTGAAATACTGCCGAAAATAGTCTCTGAGATGGAAGT
CAAAGCCGTCACATGGAATCGACGCTATCATCAACCGTTATGTGAAGTGGATGCCACTCTCAAAAAAAATCTCCGCGATC
AAGGGATTGAAGTGCATAGCCACCCAGGTTTTTTACTCACTGAACCCTGGGAAGTCAGTACCGCTACCGGAACTCCCTAC
AAGGTATTTACCCCTTTTTCTAAAGCCGCATGGGAAGTAGCCAGAGGACATGCATATGAAACTGTTAAAAACAATGTGAC
TGTCCCCTCTCACCTAACAGGACCAGAGGGTGTAGAGCTGCCCATTCCAGAAATGGAGCAACCTTTTTGGGCAACAACGT
TAGTTAAGGAGTGTGCTCCCGGTGAAAAAAATGCTTCGGAAAAACTCTTTGATTTTTTGGAACATCTACAGGACTACCCG
CAAGCTCGAGACAGCTTAGCCCGATCCGCTACAAGTAAATTATCTGCTCATCTAAGGTTTGGTGAGATCAGCATCCACCG
CGTGTGGGCAGAGACTGCAGCAATAGACTCTGAAGGAACTGAGTTATTTCTTAAAGAACTTCTGTGGAGAGATTTTGCGT
GGCATCGACTTTATGCCCTGCCACACATGGACACGCAAAACGTTCGTATGCAATTTAATCGTTTCGGATGGTCCTGGGAC
CCGAGTGAAAAAGATAAACTTAACACTCCATCCACCCCTCTTATCCCCACCAAAGCTGACCAATTCCATGAGGATTTAGC
AGCATGGCGTGCAGGAAAAACAGGAATTCCGCTGGTCGATGCAGGTATGCGAGAATTATGGGCCACCGGGTCAATGCACA
ATCGCGTCAGAATGGTAGTAGCTAGTTTTTTAACCAAGAATCTCCAGATCCATTGGCGTCATGGCGAAGAATGGTTTTGG
GAAACTCTCGTAGATGCTGATCCAGCTTCTAATGCTTTCAACTGGCAATGGGCTGCGGGTAGCGGAGATGACGCTTCGCC
TTATTTCCGTATTTTTAATCCGGTCACCCAAGCGAAAAAATTTGATCCAGATGAAACTTATATTCGTCGCTGGGTACCCG
AATATGGAACACCATCATATCCGGATCCCATCGTCGATCTGAAGGAATCCCGTCAAATTGCTTTAGACGCCTACTCTGCG
ATTAAGTGA

Upstream 100 bases:

>100_bases
AGCACTGTTCTAGAAGTACTGCATCATTTAGACATGGAATTACGATACTGATACTGCGTTGGATTGAGGTTGTCATAAAT
CTGGCTTTCTCCACGGTTGA

Downstream 100 bases:

>100_bases
GTTTACGCGCAGCTTTTAAAATATTCGAACGCATATAAGGAAAAATAATCGCATGGAACGGTGAAACAACCCACCAATAG
AGATAACCGGGCAAACCCTT

Product: hypothetical protein

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNANVRVFILNSLAMNDPHRPPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRSIGAAARWWREQSLNALAQDL
SFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPLCEVDATLKKNLRDQGIEVHSHPGFLLTEPWEVSTATGTPY
KVFTPFSKAAWEVARGHAYETVKNNVTVPSHLTGPEGVELPIPEMEQPFWATTLVKECAPGEKNASEKLFDFLEHLQDYP
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYALPHMDTQNVRMQFNRFGWSWD
PSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVDAGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFW
ETLVDADPASNAFNWQWAAGSGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
IK

Sequences:

>Translated_482_residues
MNANVRVFILNSLAMNDPHRPPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRSIGAAARWWREQSLNALAQDL
SFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPLCEVDATLKKNLRDQGIEVHSHPGFLLTEPWEVSTATGTPY
KVFTPFSKAAWEVARGHAYETVKNNVTVPSHLTGPEGVELPIPEMEQPFWATTLVKECAPGEKNASEKLFDFLEHLQDYP
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYALPHMDTQNVRMQFNRFGWSWD
PSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVDAGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFW
ETLVDADPASNAFNWQWAAGSGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
IK
>Mature_482_residues
MNANVRVFILNSLAMNDPHRPPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRSIGAAARWWREQSLNALAQDL
SFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPLCEVDATLKKNLRDQGIEVHSHPGFLLTEPWEVSTATGTPY
KVFTPFSKAAWEVARGHAYETVKNNVTVPSHLTGPEGVELPIPEMEQPFWATTLVKECAPGEKNASEKLFDFLEHLQDYP
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYALPHMDTQNVRMQFNRFGWSWD
PSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVDAGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFW
ETLVDADPASNAFNWQWAAGSGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
IK

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=465, Percent_Identity=28.3870967741935, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI4758072, Length=455, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI188536103, Length=424, Percent_Identity=27.5943396226415, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786926, Length=507, Percent_Identity=34.3195266272189, Blast_Score=219, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324962, Length=522, Percent_Identity=29.8850574712644, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17137248, Length=479, Percent_Identity=28.39248434238, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24585455, Length=479, Percent_Identity=28.39248434238, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24648152, Length=495, Percent_Identity=27.4747474747475, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 55097; Mature: 55097

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANVRVFILNSLAMNDPHRPPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRS
CCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEEECHHHCHH
IGAAARWWREQSLNALAQDLSFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHEEEEEEECCHHCCCH
CEVDATLKKNLRDQGIEVHSHPGFLLTEPWEVSTATGTPYKVFTPFSKAAWEVARGHAYE
HHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHH
TVKNNVTVPSHLTGPEGVELPIPEMEQPFWATTLVKECAPGEKNASEKLFDFLEHLQDYP
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYAL
HHHHHHHHHHHHHHHHHEEECCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEC
PHMDTQNVRMQFNRFGWSWDPSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVD
CCCCCCHHHEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
AGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFWETLVDADPASNAFNWQWAAG
HHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEECCC
SGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
CCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHCCCEEEEHHHHH
IK
CC
>Mature Secondary Structure
MNANVRVFILNSLAMNDPHRPPTLLWFRDDLRLSDNAALKWAADHGPVIGLFIDETINRS
CCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEEECHHHCHH
IGAAARWWREQSLNALAQDLSFYGVPLLRRTGNPLEILPKIVSEMEVKAVTWNRRYHQPL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHEEEEEEECCHHCCCH
CEVDATLKKNLRDQGIEVHSHPGFLLTEPWEVSTATGTPYKVFTPFSKAAWEVARGHAYE
HHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHCCHHH
TVKNNVTVPSHLTGPEGVELPIPEMEQPFWATTLVKECAPGEKNASEKLFDFLEHLQDYP
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
QARDSLARSATSKLSAHLRFGEISIHRVWAETAAIDSEGTELFLKELLWRDFAWHRLYAL
HHHHHHHHHHHHHHHHHEEECCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEC
PHMDTQNVRMQFNRFGWSWDPSEKDKLNTPSTPLIPTKADQFHEDLAAWRAGKTGIPLVD
CCCCCCHHHEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHH
AGMRELWATGSMHNRVRMVVASFLTKNLQIHWRHGEEWFWETLVDADPASNAFNWQWAAG
HHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEECCC
SGDDASPYFRIFNPVTQAKKFDPDETYIRRWVPEYGTPSYPDPIVDLKESRQIALDAYSA
CCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHCCCEEEEHHHHH
IK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]