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The map label for this gene is cutR [H]

Identifier: 145294590

GI number: 145294590

Start: 600802

End: 601476

Strand: Reverse

Name: cutR [H]

Synonym: cgR_0541

Alternate gene names: 145294590

Gene position: 601476-600802 (Counterclockwise)

Preceding gene: 145294594

Following gene: 145294589

Centisome position: 18.15

GC content: 65.63

Gene sequence:

>675_bases
ATGACAATCCGCGTTCTCGTCGTCGACGACGAAAGCTACCTCGCCGACGCCATTTGCACTGCGCTGAACAGCGCACACAT
GCAGGCCACTACGGTCTACGACGGTGCCACCGCGCGCTCGTCGATCGACGATATCCGGCCCGACGTCGTCGTCCTGGACC
GCGACCTTCCGGGCATCCACGGCGACGACATCTGCCGCTGGGTGGTCGATACCCACCCGGCGACGAGGGTGATCATGCTG
ACCGCCTCGGGGGCGCTCGACGACCGCCTGGCTGGGTTCGACCTCGGCGCGGATGATTACCTGCCCAAGCCCTTCGAAGT
CTCGGAGCTCATCGCGCGGGTTAATGCGCTGGCCAAGCGAAACCTGCCGGTACGCGGCGAAGTCTACCGGTGTGGCGACG
TGCGGCTGGACACCTTCCGCCGTGAGGTCACCCGGGGTGGAGTGGCGGTGCCCTTGAGCCCGAAGGAGTTTGCCGTGCTA
GAGGTCCTCATGGAGGCAGCCGGTGGGGTGTTTTCCGCCGAGGATCTGCTCGCGGAGGCGTGGGACGAGAATGCTGATCC
CTTCACGAATTCCCCGCGCGTGACGGTCTCCCATCTGCGCAAGAAGCTGGGCGAGCCGCGGATCGTGCATACCGTGGCAG
GTGCCGGTTACTATGTGGCGGAGGTGCCGCGATGA

Upstream 100 bases:

>100_bases
GATACCAACGTTTCGGTTCTGCATAGCTGGGACGGTACGCAGGCCGATGTTGCGGGGACGTTAACGCGGGCACAACACCC
GTGCCGTTACGATCGGTGCC

Downstream 100 bases:

>100_bases
AGTTGAGTTTGCGGGCACGGATCACCGTGGTGTTCTTGGGCACCGTCCTGGGCGTGGGGTTGGCGCTGATTGGGCTGGTG
TACGCCTATTTGAAGCTCAC

Product: hypothetical protein

Products: NA

Alternate protein names: Defective melC1 suppressor protein [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MTIRVLVVDDESYLADAICTALNSAHMQATTVYDGATARSSIDDIRPDVVVLDRDLPGIHGDDICRWVVDTHPATRVIML
TASGALDDRLAGFDLGADDYLPKPFEVSELIARVNALAKRNLPVRGEVYRCGDVRLDTFRREVTRGGVAVPLSPKEFAVL
EVLMEAAGGVFSAEDLLAEAWDENADPFTNSPRVTVSHLRKKLGEPRIVHTVAGAGYYVAEVPR

Sequences:

>Translated_224_residues
MTIRVLVVDDESYLADAICTALNSAHMQATTVYDGATARSSIDDIRPDVVVLDRDLPGIHGDDICRWVVDTHPATRVIML
TASGALDDRLAGFDLGADDYLPKPFEVSELIARVNALAKRNLPVRGEVYRCGDVRLDTFRREVTRGGVAVPLSPKEFAVL
EVLMEAAGGVFSAEDLLAEAWDENADPFTNSPRVTVSHLRKKLGEPRIVHTVAGAGYYVAEVPR
>Mature_223_residues
TIRVLVVDDESYLADAICTALNSAHMQATTVYDGATARSSIDDIRPDVVVLDRDLPGIHGDDICRWVVDTHPATRVIMLT
ASGALDDRLAGFDLGADDYLPKPFEVSELIARVNALAKRNLPVRGEVYRCGDVRLDTFRREVTRGGVAVPLSPKEFAVLE
VLMEAAGGVFSAEDLLAEAWDENADPFTNSPRVTVSHLRKKLGEPRIVHTVAGAGYYVAEVPR

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=38.2882882882883, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=34.2222222222222, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=34.375, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=31.1111111111111, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=33.6283185840708, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=31.0502283105023, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.8888888888889, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=31.0810810810811, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=27.5229357798165, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=31.7391304347826, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=26.3392857142857, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=36.036036036036, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=24.7826086956522, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=27.7777777777778, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24416; Mature: 24285

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRVLVVDDESYLADAICTALNSAHMQATTVYDGATARSSIDDIRPDVVVLDRDLPGIH
CEEEEEEECCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCC
GDDICRWVVDTHPATRVIMLTASGALDDRLAGFDLGADDYLPKPFEVSELIARVNALAKR
CCHHHHHEECCCCCEEEEEEEECCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
NLPVRGEVYRCGDVRLDTFRREVTRGGVAVPLSPKEFAVLEVLMEAAGGVFSAEDLLAEA
CCCCCCCEEECCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
WDENADPFTNSPRVTVSHLRKKLGEPRIVHTVAGAGYYVAEVPR
HCCCCCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCEEEEECCC
>Mature Secondary Structure 
TIRVLVVDDESYLADAICTALNSAHMQATTVYDGATARSSIDDIRPDVVVLDRDLPGIH
EEEEEEECCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCC
GDDICRWVVDTHPATRVIMLTASGALDDRLAGFDLGADDYLPKPFEVSELIARVNALAKR
CCHHHHHEECCCCCEEEEEEEECCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
NLPVRGEVYRCGDVRLDTFRREVTRGGVAVPLSPKEFAVLEVLMEAAGGVFSAEDLLAEA
CCCCCCCEEECCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
WDENADPFTNSPRVTVSHLRKKLGEPRIVHTVAGAGYYVAEVPR
HCCCCCCCCCCCCEEHHHHHHHHCCCEEEEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]