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The map label for this gene is cutS [H]

Identifier: 145294589

GI number: 145294589

Start: 599771

End: 600805

Strand: Reverse

Name: cutS [H]

Synonym: cgR_0540

Alternate gene names: 145294589

Gene position: 600805-599771 (Counterclockwise)

Preceding gene: 145294590

Following gene: 145294587

Centisome position: 18.13

GC content: 66.38

Gene sequence:

>1035_bases
ATGAAGTTGAGTTTGCGGGCACGGATCACCGTGGTGTTCTTGGGCACCGTCCTGGGCGTGGGGTTGGCGCTGATTGGGCT
GGTGTACGCCTATTTGAAGCTCACGCCGGTGCCTTTCATGGCGCAGATCCCAACCCCGGATGAGGGGCTGGTCATCGACG
GTGCGGTGCCGATCGCCGATGAGGTTTTGCGCCGCGTGTTGGTGGCTTCCCTGACCGTATTGGCATTGCTCACCGCGGTC
GCTGGGGTGATCGGTTGGTTCGTGGCTGGGCTCGTGATTAAGCCGCTTCGGGATTTTGCGGACGACGCCGCGACCGTCAC
CCGGGGTGATTTGAGTGCCCGCATCAGCCACCAGGGCCCTGATGACGAGGTGGGCGAGCTGGCAGATGCGCTGAATGCAA
TGCTCGACGAGCTGGCGGATGGCCTCGAGCGGCAACGCCGCTTCGCGTCGAACGCCTCCCACGAGCTGAAAACTCCGATC
GCGACGATCCAGACGATGGCTGATGTGGCGCTGGCCAGCGGTGATGAGCAGATACTGCGGGAGACGCTGGGACGAGTGCG
CGAGGTCAACGCGCGCGCTGCCGATACCGTGGCTGCCCTGCTGCAGCTGGCGAACGTGGACGTCCGGGATCGCCAGGAGG
TGGATCTGGCCGCGCTGTGCCGTGACATCGGTTGTGGGCAGGGTGTGCCGGTGACGGCGGAAGCGCTCACGGTGGCTGCC
TCCCCCACTCTGGTGCGTCAGGCAGTGGAGAACATGGTGTGCAACGGGCTCACCCACGGCGAAGATCCGTCCGTGACGGT
GGCACAGGCGGGTCGGAACGCAGAGATCACCGTAGAGTCAGGTGGGCCGCAGCTGGACGCGGCGGAGGTCCGCACGTGGG
TGGAGCCCTTCGCACGGGCGCAGCGGACCGCGGGGGCAGGCCAAGGCCTGGGGCTGGCGATCGTCGATGCAATTGCGAAA
GCCCACGGCGGTTCGGTGGAACTCAGGCCGCGGGCTCAAGGTGGGCTCGCCGTGACGCTGCGCCTGCCTGCTTAG

Upstream 100 bases:

>100_bases
CCCCGCGCGTGACGGTCTCCCATCTGCGCAAGAAGCTGGGCGAGCCGCGGATCGTGCATACCGTGGCAGGTGCCGGTTAC
TATGTGGCGGAGGTGCCGCG

Downstream 100 bases:

>100_bases
AGGGCTAGCGCAGCTGAGGAGTGCTTCTTCGGCTTCGAGCATGTAACGCAGGATCTCGACGACCTGGTCGGTGGTGGTGC
ACCCCGCCTGCGCGGCGGCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKLSLRARITVVFLGTVLGVGLALIGLVYAYLKLTPVPFMAQIPTPDEGLVIDGAVPIADEVLRRVLVASLTVLALLTAV
AGVIGWFVAGLVIKPLRDFADDAATVTRGDLSARISHQGPDDEVGELADALNAMLDELADGLERQRRFASNASHELKTPI
ATIQTMADVALASGDEQILRETLGRVREVNARAADTVAALLQLANVDVRDRQEVDLAALCRDIGCGQGVPVTAEALTVAA
SPTLVRQAVENMVCNGLTHGEDPSVTVAQAGRNAEITVESGGPQLDAAEVRTWVEPFARAQRTAGAGQGLGLAIVDAIAK
AHGGSVELRPRAQGGLAVTLRLPA

Sequences:

>Translated_344_residues
MKLSLRARITVVFLGTVLGVGLALIGLVYAYLKLTPVPFMAQIPTPDEGLVIDGAVPIADEVLRRVLVASLTVLALLTAV
AGVIGWFVAGLVIKPLRDFADDAATVTRGDLSARISHQGPDDEVGELADALNAMLDELADGLERQRRFASNASHELKTPI
ATIQTMADVALASGDEQILRETLGRVREVNARAADTVAALLQLANVDVRDRQEVDLAALCRDIGCGQGVPVTAEALTVAA
SPTLVRQAVENMVCNGLTHGEDPSVTVAQAGRNAEITVESGGPQLDAAEVRTWVEPFARAQRTAGAGQGLGLAIVDAIAK
AHGGSVELRPRAQGGLAVTLRLPA
>Mature_344_residues
MKLSLRARITVVFLGTVLGVGLALIGLVYAYLKLTPVPFMAQIPTPDEGLVIDGAVPIADEVLRRVLVASLTVLALLTAV
AGVIGWFVAGLVIKPLRDFADDAATVTRGDLSARISHQGPDDEVGELADALNAMLDELADGLERQRRFASNASHELKTPI
ATIQTMADVALASGDEQILRETLGRVREVNARAADTVAALLQLANVDVRDRQEVDLAALCRDIGCGQGVPVTAEALTVAA
SPTLVRQAVENMVCNGLTHGEDPSVTVAQAGRNAEITVESGGPQLDAAEVRTWVEPFARAQRTAGAGQGLGLAIVDAIAK
AHGGSVELRPRAQGGLAVTLRLPA

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=300, Percent_Identity=26.3333333333333, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790861, Length=310, Percent_Identity=26.7741935483871, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=24.2647058823529, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=27.1477663230241, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1789403, Length=231, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 35913; Mature: 35913

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSLRARITVVFLGTVLGVGLALIGLVYAYLKLTPVPFMAQIPTPDEGLVIDGAVPIAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCHHH
EVLRRVLVASLTVLALLTAVAGVIGWFVAGLVIKPLRDFADDAATVTRGDLSARISHQGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCC
DDEVGELADALNAMLDELADGLERQRRFASNASHELKTPIATIQTMADVALASGDEQILR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
ETLGRVREVNARAADTVAALLQLANVDVRDRQEVDLAALCRDIGCGQGVPVTAEALTVAA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHC
SPTLVRQAVENMVCNGLTHGEDPSVTVAQAGRNAEITVESGGPQLDAAEVRTWVEPFARA
CHHHHHHHHHHHHHCCCCCCCCCCEEHEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
QRTAGAGQGLGLAIVDAIAKAHGGSVELRPRAQGGLAVTLRLPA
HHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCC
>Mature Secondary Structure
MKLSLRARITVVFLGTVLGVGLALIGLVYAYLKLTPVPFMAQIPTPDEGLVIDGAVPIAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCHHH
EVLRRVLVASLTVLALLTAVAGVIGWFVAGLVIKPLRDFADDAATVTRGDLSARISHQGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCC
DDEVGELADALNAMLDELADGLERQRRFASNASHELKTPIATIQTMADVALASGDEQILR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
ETLGRVREVNARAADTVAALLQLANVDVRDRQEVDLAALCRDIGCGQGVPVTAEALTVAA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHC
SPTLVRQAVENMVCNGLTHGEDPSVTVAQAGRNAEITVESGGPQLDAAEVRTWVEPFARA
CHHHHHHHHHHHHHCCCCCCCCCCEEHEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
QRTAGAGQGLGLAIVDAIAKAHGGSVELRPRAQGGLAVTLRLPA
HHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]