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The map label for this gene is dapA [C]

Identifier: 145294575

GI number: 145294575

Start: 585996

End: 586946

Strand: Reverse

Name: dapA [C]

Synonym: cgR_0526

Alternate gene names: 145294575

Gene position: 586946-585996 (Counterclockwise)

Preceding gene: 145294576

Following gene: 145294574

Centisome position: 17.71

GC content: 55.52

Gene sequence:

>951_bases
ATGGCACGCTTTTCACCACAAGATCTCGCAGACCACCTCAAGGATGGACTGCTCTCTTTCCCAGCAACTGCTTTCCAAGA
TGACCTCGAAGTAGATGAAGTTGCGTATGTCGAGCACATTGAATGGCAGTCCAGCTACCCAGTAGCTGGCCTCTTCGCAG
CTGGCGGTACTGGCGAAGGATTCAGCCTTACCGTTGAGGAAAACCACCGTGTCACTCAACTTGCAGTTCAGGCATCCAGT
CCGGAGGTTCCGGTGCTGGGATCGGCTACTGGTTCAACCAAATCTGCCATCGCCAACGCGCAAGGCGCAGAGGCCGCAGG
CGCGGAAGGTGTTCTCCTGCTTCCTCCCTACCTCACCGAATGCGATGCAGAAGGCTTGTACAATCACGCAGCCGCAGTCT
GTGAATCCACCTCCCTTGGTGTCATCGTGTACAACCGCGCAAACGCCATCTACTCCCCTGAGGTTATTGCCCGACTCTCT
GAGCGCTACCCCAACTTCATCGGATTCAAAGATGGCACCGGAAACATCGAGCACCTAGCAAAGATCACGACATTGTGCGG
TGACCGCCTGTTCTACCTGGGTGGACTGCCAACCGCAGAAACCTTTGCACTTCCGCTGCTTCAGATGGGCATGAGCACCT
ACTCCTCTGCAATGTTCAACTTCATTCCTGATTTCGCACTGAGCTTCTACGCTGATGTTCGTGCGCAGGACAGCGCAGCA
GTAAAGCAGAAGCTGAGCGATTTTGTGCTCCCCTACTTGGATATCCGCGATCGCGCACAAGGCTACGGTGTCTCCATTGT
TAAGGGCGGACTCAAGGCTGTTGGCCGCAACGCTGGCGGCGTTCGCCCACCACTGCGTAACCTCTCCGAACAAGACATTG
CAGATCTCTCCGACTTGCTCGCCACCTCTGGCGCAGGTTCTTACCGCCTTCCAGTTGAGGTGAAAGCATGA

Upstream 100 bases:

>100_bases
CTTTTAGGCATTTCAGCATGCCAAACTAATCTTGGACAGGTATCACTGGCTCCTCTTAGACTCCAAAGTGTCTTTGAAAA
CACTCACCCAAGGAGCCCTC

Downstream 100 bases:

>100_bases
TTACCGCAACCGCACTGCATGGGTGTTCACTGATTGATGGCGAGTGGGTCGCTGGAAAAAATGGTGAGATTACAGGATTC
GATCCGCGCACCAATGCGAG

Product: 5-dehydro-4-deoxyglucarate dehydratase

Products: NA

Alternate protein names: 5-keto-4-deoxy-glucarate dehydratase; KDGDH

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MARFSPQDLADHLKDGLLSFPATAFQDDLEVDEVAYVEHIEWQSSYPVAGLFAAGGTGEGFSLTVEENHRVTQLAVQASS
PEVPVLGSATGSTKSAIANAQGAEAAGAEGVLLLPPYLTECDAEGLYNHAAAVCESTSLGVIVYNRANAIYSPEVIARLS
ERYPNFIGFKDGTGNIEHLAKITTLCGDRLFYLGGLPTAETFALPLLQMGMSTYSSAMFNFIPDFALSFYADVRAQDSAA
VKQKLSDFVLPYLDIRDRAQGYGVSIVKGGLKAVGRNAGGVRPPLRNLSEQDIADLSDLLATSGAGSYRLPVEVKA

Sequences:

>Translated_316_residues
MARFSPQDLADHLKDGLLSFPATAFQDDLEVDEVAYVEHIEWQSSYPVAGLFAAGGTGEGFSLTVEENHRVTQLAVQASS
PEVPVLGSATGSTKSAIANAQGAEAAGAEGVLLLPPYLTECDAEGLYNHAAAVCESTSLGVIVYNRANAIYSPEVIARLS
ERYPNFIGFKDGTGNIEHLAKITTLCGDRLFYLGGLPTAETFALPLLQMGMSTYSSAMFNFIPDFALSFYADVRAQDSAA
VKQKLSDFVLPYLDIRDRAQGYGVSIVKGGLKAVGRNAGGVRPPLRNLSEQDIADLSDLLATSGAGSYRLPVEVKA
>Mature_315_residues
ARFSPQDLADHLKDGLLSFPATAFQDDLEVDEVAYVEHIEWQSSYPVAGLFAAGGTGEGFSLTVEENHRVTQLAVQASSP
EVPVLGSATGSTKSAIANAQGAEAAGAEGVLLLPPYLTECDAEGLYNHAAAVCESTSLGVIVYNRANAIYSPEVIARLSE
RYPNFIGFKDGTGNIEHLAKITTLCGDRLFYLGGLPTAETFALPLLQMGMSTYSSAMFNFIPDFALSFYADVRAQDSAAV
KQKLSDFVLPYLDIRDRAQGYGVSIVKGGLKAVGRNAGGVRPPLRNLSEQDIADLSDLLATSGAGSYRLPVEVKA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Escherichia coli, GI1788823, Length=175, Percent_Identity=30.2857142857143, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082415, Length=304, Percent_Identity=25.9868421052632, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786463, Length=200, Percent_Identity=28.5, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): KDGD_CORGB (A4QB97)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001137396.1
- ProteinModelPortal:   A4QB97
- STRING:   A4QB97
- GeneID:   4991661
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_0526
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   RNRKKGY
- ProtClustDB:   PRK03620
- HAMAP:   MF_00694
- InterPro:   IPR013785
- InterPro:   IPR017655
- InterPro:   IPR002220
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.41

Molecular weight: Translated: 33580; Mature: 33449

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFSPQDLADHLKDGLLSFPATAFQDDLEVDEVAYVEHIEWQSSYPVAGLFAAGGTGEG
CCCCCHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
FSLTVEENHRVTQLAVQASSPEVPVLGSATGSTKSAIANAQGAEAAGAEGVLLLPPYLTE
EEEEEECCCCEEEEEEECCCCCCCEEECCCCCHHHHHHCCCCCCCCCCCCEEECCCCHHH
CDAEGLYNHAAAVCESTSLGVIVYNRANAIYSPEVIARLSERYPNFIGFKDGTGNIEHLA
CCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHH
KITTLCGDRLFYLGGLPTAETFALPLLQMGMSTYSSAMFNFIPDFALSFYADVRAQDSAA
HHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VKQKLSDFVLPYLDIRDRAQGYGVSIVKGGLKAVGRNAGGVRPPLRNLSEQDIADLSDLL
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHH
ATSGAGSYRLPVEVKA
HHCCCCCEEECEEECC
>Mature Secondary Structure 
ARFSPQDLADHLKDGLLSFPATAFQDDLEVDEVAYVEHIEWQSSYPVAGLFAAGGTGEG
CCCCHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
FSLTVEENHRVTQLAVQASSPEVPVLGSATGSTKSAIANAQGAEAAGAEGVLLLPPYLTE
EEEEEECCCCEEEEEEECCCCCCCEEECCCCCHHHHHHCCCCCCCCCCCCEEECCCCHHH
CDAEGLYNHAAAVCESTSLGVIVYNRANAIYSPEVIARLSERYPNFIGFKDGTGNIEHLA
CCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHH
KITTLCGDRLFYLGGLPTAETFALPLLQMGMSTYSSAMFNFIPDFALSFYADVRAQDSAA
HHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VKQKLSDFVLPYLDIRDRAQGYGVSIVKGGLKAVGRNAGGVRPPLRNLSEQDIADLSDLL
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHH
ATSGAGSYRLPVEVKA
HHCCCCCEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA