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The map label for this gene is menA [H]

Identifier: 145294570

GI number: 145294570

Start: 580863

End: 581759

Strand: Reverse

Name: menA [H]

Synonym: cgR_0521

Alternate gene names: 145294570

Gene position: 581759-580863 (Counterclockwise)

Preceding gene: 145294572

Following gene: 145294568

Centisome position: 17.55

GC content: 58.64

Gene sequence:

>897_bases
ATGTCTCACACGGAACCCCAGCCGAATTCTGTAACTTTGTCCGATTGGATTCAGGGCGCACGCCCGCATACCTGGGCAAA
TGCGTTCGCGCCTGTCATTGCCGGTTCAGGTGTCGCCGCTTTTCATGATGGTTTTGTGTGGTGGAAGGCCTTGCTGGCGC
TTGTCGTGGCGTGGGCTTTGATCATCGGTGTGAATTACGCCAATGATTACTCTGATGGCATTCGTGGCACCGATGAAGAC
CGCACCGGTCCTCTGCGACTCACTGGTTCTGGGTTGGCTGAGCCGAAGAAAGTGAAAGCTGCGGCGTTTATTTCTTTCGG
TATCGCAGGTGTCGCCGGCACCGCGCTGAGCCTGTTGAGCGCGTGGTGGCTGATCCTCATCGGCATCCTGTGTGTGCTGG
GCGCGTGGTTCTACACCGGTGGTAAAAATCCTTATGGTTACCGCGGGCTCGGCGAGATTGCTGTGTTCATCTTCTTCGGC
CTCGTCGCGGTCATGGGAACGCAGTTCACCCAAACCGGTTCCGTCAGCTGGGCCGGTTTGGCCGCCGCAGTTGGCGTGGG
TTCGATGTCTGCTGGCGTGAACTTGGCCAACAATATTCGCGATATTCCAACCGATAGCAAGACCGGAAAAATTACCCTCG
CGGTCCGCCTGGGCGATGCGGGTGCTCGTAAGCTGTTCCTCGCGCTGATTTCCACGCCGTTCATCATGTCCATCTGCCTG
GCGTTTGTCGCCTGGCCAGCGCTGATCGCGATCATCATTTTCCCACTGGCGCTGAAAGCCGCAGGGCCGATCCGCAACAA
CGCCGCCGGCAAGGATCTCATCCCCGTCATCGGCTCAACAGGGCGCGCCATGGCGTTGTGGGCCGTGCTCACGGGCCTGG
CATTAGCGTTTAGCTAA

Upstream 100 bases:

>100_bases
TCTATTCATTTCACAATAGCGTTTCACACTCCCCCATAGCCTGCCGAACGTATTTCAAGCAATTGCGCGATCGAGTATGT
GATGGGGAAAGATAGAGGTT

Downstream 100 bases:

>100_bases
AACGCTTTTCGACGCTCCCCTCCCCTTTCCCCTCGCTTCCGCAAAGAACGAGGGGAATTTTTTAGCGGTCCGCCAGCTCG
CTTCGAACCCATTCCTTGTG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSHTEPQPNSVTLSDWIQGARPHTWANAFAPVIAGSGVAAFHDGFVWWKALLALVVAWALIIGVNYANDYSDGIRGTDED
RTGPLRLTGSGLAEPKKVKAAAFISFGIAGVAGTALSLLSAWWLILIGILCVLGAWFYTGGKNPYGYRGLGEIAVFIFFG
LVAVMGTQFTQTGSVSWAGLAAAVGVGSMSAGVNLANNIRDIPTDSKTGKITLAVRLGDAGARKLFLALISTPFIMSICL
AFVAWPALIAIIIFPLALKAAGPIRNNAAGKDLIPVIGSTGRAMALWAVLTGLALAFS

Sequences:

>Translated_298_residues
MSHTEPQPNSVTLSDWIQGARPHTWANAFAPVIAGSGVAAFHDGFVWWKALLALVVAWALIIGVNYANDYSDGIRGTDED
RTGPLRLTGSGLAEPKKVKAAAFISFGIAGVAGTALSLLSAWWLILIGILCVLGAWFYTGGKNPYGYRGLGEIAVFIFFG
LVAVMGTQFTQTGSVSWAGLAAAVGVGSMSAGVNLANNIRDIPTDSKTGKITLAVRLGDAGARKLFLALISTPFIMSICL
AFVAWPALIAIIIFPLALKAAGPIRNNAAGKDLIPVIGSTGRAMALWAVLTGLALAFS
>Mature_297_residues
SHTEPQPNSVTLSDWIQGARPHTWANAFAPVIAGSGVAAFHDGFVWWKALLALVVAWALIIGVNYANDYSDGIRGTDEDR
TGPLRLTGSGLAEPKKVKAAAFISFGIAGVAGTALSLLSAWWLILIGILCVLGAWFYTGGKNPYGYRGLGEIAVFIFFGL
VAVMGTQFTQTGSVSWAGLAAAVGVGSMSAGVNLANNIRDIPTDSKTGKITLAVRLGDAGARKLFLALISTPFIMSICLA
FVAWPALIAIIIFPLALKAAGPIRNNAAGKDLIPVIGSTGRAMALWAVLTGLALAFS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=278, Percent_Identity=25.1798561151079, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1790365, Length=246, Percent_Identity=36.5853658536585, Blast_Score=139, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17737429, Length=282, Percent_Identity=23.758865248227, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31060; Mature: 30928

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTEPQPNSVTLSDWIQGARPHTWANAFAPVIAGSGVAAFHDGFVWWKALLALVVAWAL
CCCCCCCCCCEEHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIGVNYANDYSDGIRGTDEDRTGPLRLTGSGLAEPKKVKAAAFISFGIAGVAGTALSLLS
HHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AWWLILIGILCVLGAWFYTGGKNPYGYRGLGEIAVFIFFGLVAVMGTQFTQTGSVSWAGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
AAAVGVGSMSAGVNLANNIRDIPTDSKTGKITLAVRLGDAGARKLFLALISTPFIMSICL
HHHHHCCCHHCCCCHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
AFVAWPALIAIIIFPLALKAAGPIRNNAAGKDLIPVIGSTGRAMALWAVLTGLALAFS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHTEPQPNSVTLSDWIQGARPHTWANAFAPVIAGSGVAAFHDGFVWWKALLALVVAWAL
CCCCCCCCCEEHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IIGVNYANDYSDGIRGTDEDRTGPLRLTGSGLAEPKKVKAAAFISFGIAGVAGTALSLLS
HHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AWWLILIGILCVLGAWFYTGGKNPYGYRGLGEIAVFIFFGLVAVMGTQFTQTGSVSWAGL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
AAAVGVGSMSAGVNLANNIRDIPTDSKTGKITLAVRLGDAGARKLFLALISTPFIMSICL
HHHHHCCCHHCCCCHHHCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
AFVAWPALIAIIIFPLALKAAGPIRNNAAGKDLIPVIGSTGRAMALWAVLTGLALAFS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]