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The map label for this gene is phoP [H]

Identifier: 145294164

GI number: 145294164

Start: 142272

End: 142994

Strand: Direct

Name: phoP [H]

Synonym: cgR_0122

Alternate gene names: 145294164

Gene position: 142272-142994 (Clockwise)

Preceding gene: 145294161

Following gene: 145294165

Centisome position: 4.29

GC content: 67.08

Gene sequence:

>723_bases
ATGGCTGACCGCACACCGACCACCGCCACGCCCCCGGGGCGGGTGCTGGTCGTCGATGATGAACAACCCCTGGCTCAGAT
GGTGGCCTCCTACCTCATCCGGGCCGGCTTCGATACCCGCCAGGCGCACACCGGCACCCAGGCCGTGGACGAGGCCCGTC
GCTTTTCCCCCGATGTTGTGGTGCTGGATCTGGGGCTGCCCGAACTCGACGGCCTGGAGGTGTGCCGACGGATCCGCACC
TTCTCGGACTGCTACATCCTCATGCTCACCGCGCGTGGCAGTGAGGACGACAAGATCAGCGGTTTGACCCTGGGGGCGGA
TGACTACATCACCAAACCTTTTAGCGTCCGGGAACTGGTGACCCGGGTGCATGCGGTGCTGCGCCGCCCGCGCACCAGCA
CCACCCCACCGCAGGTGACCACCCCCTTGATCGTTGGTGACCTCATCCTTGACCCCGTCGCCCATCAGGTGTGGGTGGGG
GAGACGACCGTGGAGCTCACCCGCACGGAGTTCGAGCTGCTGGTTGCCCTGGCCCTGCGCCCCGGCCAGGTGCTGACCCG
CCACGACCTGGTCACCGAGGTCTGGGACACCACCTGGGTCGGTGATGAACGCATCGTCGATGTCCACATCGGCAACTTGC
GTCGCAAGCTCGGCACCGACACCCGGGGCCGGGGGTTTATCGACACCGTGCGTGGCGTGGGCTACCGGGTGGGGCAGCCA
TGA

Upstream 100 bases:

>100_bases
CGGCGGTCGAAGGGTGATGTTTGAAGATTTGATGAAGGTTTCCCCGCCGGGCACTGAGCGAGGGTGGTATTCTCCCCTGG
CCGGAGCGATACTGGGGTCT

Downstream 100 bases:

>100_bases
ATCACGGACCCGGCCTGACCTTCCGCTTCCTGACCGCCCAGGTGTTGGTCGTGGTGATTAGCCTGCTGGTGGCCGCGGCC
GTGGCCACGATGGTGGGCCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MADRTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVVVLDLGLPELDGLEVCRRIRT
FSDCYILMLTARGSEDDKISGLTLGADDYITKPFSVRELVTRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVWVG
ETTVELTRTEFELLVALALRPGQVLTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRVGQP

Sequences:

>Translated_240_residues
MADRTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVVVLDLGLPELDGLEVCRRIRT
FSDCYILMLTARGSEDDKISGLTLGADDYITKPFSVRELVTRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVWVG
ETTVELTRTEFELLVALALRPGQVLTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRVGQP
>Mature_239_residues
ADRTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVVVLDLGLPELDGLEVCRRIRTF
SDCYILMLTARGSEDDKISGLTLGADDYITKPFSVRELVTRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVWVGE
TTVELTRTEFELLVALALRPGQVLTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRVGQP

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=41.3333333333333, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=40.7894736842105, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=39.9103139013453, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=39.2857142857143, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=38.2222222222222, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=38.0530973451327, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=35.0877192982456, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=34.2342342342342, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=37.219730941704, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=34.1991341991342, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32.8888888888889, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.8947368421053, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=32.8947368421053, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.9473684210526, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26621; Mature: 26490

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVV
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCEE
VLDLGLPELDGLEVCRRIRTFSDCYILMLTARGSEDDKISGLTLGADDYITKPFSVRELV
EEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCCHHHCCCHHHHHHH
TRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVWVGETTVELTRTEFELLVALALR
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHCC
PGQVLTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRVGQP
CCCHHHHHHHHHHHHHCEECCCCEEEEEEHHHHHHHHCCCCCCCCHHHHHHHCCEECCCC
>Mature Secondary Structure 
ADRTPTTATPPGRVLVVDDEQPLAQMVASYLIRAGFDTRQAHTGTQAVDEARRFSPDVV
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCEE
VLDLGLPELDGLEVCRRIRTFSDCYILMLTARGSEDDKISGLTLGADDYITKPFSVRELV
EEECCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCCHHHCCCHHHHHHH
TRVHAVLRRPRTSTTPPQVTTPLIVGDLILDPVAHQVWVGETTVELTRTEFELLVALALR
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHCC
PGQVLTRHDLVTEVWDTTWVGDERIVDVHIGNLRRKLGTDTRGRGFIDTVRGVGYRVGQP
CCCHHHHHHHHHHHHHCEECCCCEEEEEEHHHHHHHHCCCCCCCCHHHHHHHCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]