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The map label for this gene is fdh [H]

Identifier: 145294156

GI number: 145294156

Start: 132809

End: 133987

Strand: Reverse

Name: fdh [H]

Synonym: cgR_0114

Alternate gene names: 145294156

Gene position: 133987-132809 (Counterclockwise)

Preceding gene: 145294157

Following gene: 145294154

Centisome position: 4.04

GC content: 64.97

Gene sequence:

>1179_bases
ATGAAAGCGTTGACCTGGCAGGCGTCAAACACGGTGAATGTGGAGGAGGTCCCGGACCCACAGATCCAGGAACCCACCGA
TGCGGTCATCCGGGTCACCTCAACTGCCATCTGCGGATCTGACCTGCACCTCTATGAGGTGCTGACCCCGTTCATGGACA
AGGGCGACATCATCGGCCATGAGCCCATGGGCATCGTCGAGGAGATCGGCTCGGCCGTCACTCACATCAAGCCCGGGGAC
CGGGTGGTCATCCCCTTCAACATTTCCTGTGGCCACTGTTTCATGTGCCGCCAGGGCCTGCAGTCGCAGTGTGAAACCAC
CCAGGTCCGCGAATACGGCACCGGAGCCCAGTTCCTCGGTTACTCGCGGCTTTACGGCTCGGTGCCCGGCGGGCAGGCAG
AGTACCTGCGCGTGCCGCACGCGGACTACGGGGCAATCAAGGTTCCCAACGTCGGCGAAGACGAGCGCTACCTGTTTCTT
TCCGACGTCGTGCCCACCGCCTGGCAGGCCGTGGACTACGCGGCAGTCCCCGACGGCGGCACGCTGGCGGTGCTGGGTCT
GGGCCCCATCGGCCAGATGAGCGCCCGGATAGGCAAGCACCTGGGCTACCGGGTGATCGCGACGGATGCAGTGCCCGAGC
GTCGCGCCATGGCCGAGCGTTACGGCATTGAAACGCTGGATTCCTCCGAGGACGGCGTGGCGGAACAGCTCAAGGACCTG
ACTGACGGGCGTGGCCCGAACTCCGTGGTCGACGCCGTTGGCATGGAGGCGCACGGTTCGCCGGTGGCCAGCGCGGTGCA
GGCAGCCGTCGGCAAGCTGCCGTCGCCGCTGGACCGCAAGGCAATGGAGAGGGCCGGAGTGGACCGGATGAGTGCGTTGT
ACACCGCCATCGACTCCGTTCGCCGTGGCGGGACGATCTCAATCAGCGGCGTGTACGGCGGCATGAAGGACCCGATGCCG
ATGCTGACGATGTTCGACAAGCAGATCCAGCTGCGGATGGGCCAGTGCAACGTGCGCTCCTGGACCGAGACGCTGCTGCC
GCTGGTGGACGACCCGTCCGATCCGCTGGGCGTACTCGACCTCAAAACGCACACCGCGCCGTTGGAGGAGGCGCCAGCGA
TGTACGAGAAGTTCCAGAAGAAGCAGGACGGCTGCATCAAGGTGGTGCTCAAACCGTAA

Upstream 100 bases:

>100_bases
TATTGGTTACCCGCCTTCCGTGTTTTTAGAATAGTCGGTCACAACCAACCGAACAGTGGCGACGTTTCACCCGAGACGGC
CGCCCTGGCAAGGAGGACAC

Downstream 100 bases:

>100_bases
ATCCTGGACGTGTCGTCGGACCTTAGCCTTCACGCGAGGCTTGGGTCCGCCATCACTTAAAGACGGCCGCAATGCATGTT
CTATGCTGCCACTCGTAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKALTWQASNTVNVEEVPDPQIQEPTDAVIRVTSTAICGSDLHLYEVLTPFMDKGDIIGHEPMGIVEEIGSAVTHIKPGD
RVVIPFNISCGHCFMCRQGLQSQCETTQVREYGTGAQFLGYSRLYGSVPGGQAEYLRVPHADYGAIKVPNVGEDERYLFL
SDVVPTAWQAVDYAAVPDGGTLAVLGLGPIGQMSARIGKHLGYRVIATDAVPERRAMAERYGIETLDSSEDGVAEQLKDL
TDGRGPNSVVDAVGMEAHGSPVASAVQAAVGKLPSPLDRKAMERAGVDRMSALYTAIDSVRRGGTISISGVYGGMKDPMP
MLTMFDKQIQLRMGQCNVRSWTETLLPLVDDPSDPLGVLDLKTHTAPLEEAPAMYEKFQKKQDGCIKVVLKP

Sequences:

>Translated_392_residues
MKALTWQASNTVNVEEVPDPQIQEPTDAVIRVTSTAICGSDLHLYEVLTPFMDKGDIIGHEPMGIVEEIGSAVTHIKPGD
RVVIPFNISCGHCFMCRQGLQSQCETTQVREYGTGAQFLGYSRLYGSVPGGQAEYLRVPHADYGAIKVPNVGEDERYLFL
SDVVPTAWQAVDYAAVPDGGTLAVLGLGPIGQMSARIGKHLGYRVIATDAVPERRAMAERYGIETLDSSEDGVAEQLKDL
TDGRGPNSVVDAVGMEAHGSPVASAVQAAVGKLPSPLDRKAMERAGVDRMSALYTAIDSVRRGGTISISGVYGGMKDPMP
MLTMFDKQIQLRMGQCNVRSWTETLLPLVDDPSDPLGVLDLKTHTAPLEEAPAMYEKFQKKQDGCIKVVLKP
>Mature_392_residues
MKALTWQASNTVNVEEVPDPQIQEPTDAVIRVTSTAICGSDLHLYEVLTPFMDKGDIIGHEPMGIVEEIGSAVTHIKPGD
RVVIPFNISCGHCFMCRQGLQSQCETTQVREYGTGAQFLGYSRLYGSVPGGQAEYLRVPHADYGAIKVPNVGEDERYLFL
SDVVPTAWQAVDYAAVPDGGTLAVLGLGPIGQMSARIGKHLGYRVIATDAVPERRAMAERYGIETLDSSEDGVAEQLKDL
TDGRGPNSVVDAVGMEAHGSPVASAVQAAVGKLPSPLDRKAMERAGVDRMSALYTAIDSVRRGGTISISGVYGGMKDPMP
MLTMFDKQIQLRMGQCNVRSWTETLLPLVDDPSDPLGVLDLKTHTAPLEEAPAMYEKFQKKQDGCIKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=303, Percent_Identity=28.3828382838284, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4501939, Length=303, Percent_Identity=28.3828382838284, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI71565154, Length=256, Percent_Identity=28.515625, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71565152, Length=273, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786825, Length=407, Percent_Identity=41.2776412776413, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI87082125, Length=270, Percent_Identity=32.2222222222222, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790045, Length=271, Percent_Identity=33.9483394833948, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI226510992, Length=341, Percent_Identity=27.5659824046921, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787863, Length=274, Percent_Identity=28.1021897810219, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790718, Length=347, Percent_Identity=24.7838616714697, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788073, Length=247, Percent_Identity=31.1740890688259, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=242, Percent_Identity=30.5785123966942, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788407, Length=265, Percent_Identity=25.2830188679245, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=379, Percent_Identity=24.802110817942, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=257, Percent_Identity=26.4591439688716, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=234, Percent_Identity=27.3504273504274, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=32.0754716981132, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=310, Percent_Identity=27.741935483871, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=272, Percent_Identity=26.8382352941176, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=267, Percent_Identity=24.7191011235955, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=343, Percent_Identity=23.0320699708455, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=260, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550770, Length=239, Percent_Identity=26.7782426778243, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551930, Length=239, Percent_Identity=26.7782426778243, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221457811, Length=233, Percent_Identity=27.4678111587983, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137530, Length=397, Percent_Identity=24.9370277078086, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17737897, Length=397, Percent_Identity=24.4332493702771, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42320; Mature: 42320

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTWQASNTVNVEEVPDPQIQEPTDAVIRVTSTAICGSDLHLYEVLTPFMDKGDIIGH
CCCEEECCCCCCCHHCCCCCCCCCCCCHHEEEEHHEECCCCCHHHHHHHHHHCCCCCCCC
EPMGIVEEIGSAVTHIKPGDRVVIPFNISCGHCFMCRQGLQSQCETTQVREYGTGAQFLG
CCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
YSRLYGSVPGGQAEYLRVPHADYGAIKVPNVGEDERYLFLSDVVPTAWQAVDYAAVPDGG
HHHHHCCCCCCCCCEEECCCCCCCEEECCCCCCCCCEEEEHHCCHHHHHHHCEEECCCCC
TLAVLGLGPIGQMSARIGKHLGYRVIATDAVPERRAMAERYGIETLDSSEDGVAEQLKDL
EEEEEECCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
TDGRGPNSVVDAVGMEAHGSPVASAVQAAVGKLPSPLDRKAMERAGVDRMSALYTAIDSV
HCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHH
RRGGTISISGVYGGMKDPMPMLTMFDKQIQLRMGQCNVRSWTETLLPLVDDPSDPLGVLD
HCCCEEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCEEEE
LKTHTAPLEEAPAMYEKFQKKQDGCIKVVLKP
ECCCCCCHHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MKALTWQASNTVNVEEVPDPQIQEPTDAVIRVTSTAICGSDLHLYEVLTPFMDKGDIIGH
CCCEEECCCCCCCHHCCCCCCCCCCCCHHEEEEHHEECCCCCHHHHHHHHHHCCCCCCCC
EPMGIVEEIGSAVTHIKPGDRVVIPFNISCGHCFMCRQGLQSQCETTQVREYGTGAQFLG
CCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
YSRLYGSVPGGQAEYLRVPHADYGAIKVPNVGEDERYLFLSDVVPTAWQAVDYAAVPDGG
HHHHHCCCCCCCCCEEECCCCCCCEEECCCCCCCCCEEEEHHCCHHHHHHHCEEECCCCC
TLAVLGLGPIGQMSARIGKHLGYRVIATDAVPERRAMAERYGIETLDSSEDGVAEQLKDL
EEEEEECCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
TDGRGPNSVVDAVGMEAHGSPVASAVQAAVGKLPSPLDRKAMERAGVDRMSALYTAIDSV
HCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHH
RRGGTISISGVYGGMKDPMPMLTMFDKQIQLRMGQCNVRSWTETLLPLVDDPSDPLGVLD
HCCCEEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCEEEE
LKTHTAPLEEAPAMYEKFQKKQDGCIKVVLKP
ECCCCCCHHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]