Click here to switch to the map view.

The map label for this gene is panF [H]

Identifier: 138896343

GI number: 138896343

Start: 2816760

End: 2818223

Strand: Reverse

Name: panF [H]

Synonym: GTNG_2706

Alternate gene names: 138896343

Gene position: 2818223-2816760 (Counterclockwise)

Preceding gene: 138896344

Following gene: 138896342

Centisome position: 79.38

GC content: 36.82

Gene sequence:

>1464_bases
ATGGGATTATGGGTTGGCGTATTTACCACGGTTGCAACATGGGTCAGTGTAGCTTCGGTAATGGGAGTACCTGGTTATTT
ATATAGTAGTGGTGTGTCTGCTATTATTGGCTGGATAGCTGGATGGTTTTTAGCAACAGCATTTATCCCGATTGTTGCTT
ATAAAGTTAGAAGACCGAAAAACCCTCCAAGGACTTTTCCTGAGTTTATCCATCTTCGGTATGAACCTTTCCAAAAGAGA
AGTCCGCTTAGAGCCATTGTAGGATTATTGATGTCAATAGGCTACTTTATATTTGTACATTTACAAGTGGTTGGATTTGG
GATTGTTTTTTCAACGATTACGGGAATTCAATATGAAATAGCTTTATTTGGTTTCTTATTCTTTTTATTGTTTACAAGTA
TAGGAGGATTCTGGTCAGTTTCTGTTACGGACTCTGTTAATACCATAATCATTGTTTTAGGTGTTATACTTGGTGCTTTT
GCTGTATTATATTCAACTGGTGGATTTGGAAATATTTATGAAAACTTAGCTACTACAACTGCGCCTACGTTCGAAGGTGG
AGAAAGTCTTCCGAAAGGACTTTTATTATCACCTGTTGGCGGATTTGGATTTGGTGCACTTTGTTCCATTTTCCTATCGA
ATGCATTAGGTGCCATTGTGTCGCCACACTGGGTGACTAGAATGATGGCACCAAAGAATGTAAAAACTGCAATTTTACAA
ATGATGTTATCAGTTCTTATACTAACTTTAATATTTATTCCGTTAATCATTATTGGTTTAGGTGCAAAAATGCTAATACC
AAGTTTACCGGCTGGGCAAACAACTGATTATATTATGCCAACCGTTATTACAGAATTTGCTCACCCGATAGTTGGTGCAT
TTACACTAGTTGCATTATGTGCTGCAGCGATTTCTACTGCAAACTCAATGCTTTTACATGCAGGAACATCAATATACTAT
GATTTGTATCGAAATTTATTTCCCGATAAGGATTTTCATGATGAAAAGGGAAAAAAACAGCTTCGCTATTTAGTCTTAAC
CCTTGGGTTCTTAGCAGTGCTTAGTGCAATAAAACCACCAGTACTACTGGCTATGGGATTTACTTATGTATATGGGGCAT
TTGGTGCAGTATTCTTCTTTGTTGTGTTATTAGGATTATATACAAAACGTATGAATCGTCTTGCTGCTTACGCAAACATT
ATTGTGGGGCTTGTAGCTTTCATTATTGCACATATTGTTGGAGCCACAAATCCATTTTTAGTTTCTTTAGTTGTATCTTT
CATCGCAGTATTACTATCTATTATTATCGGGAAAAAGTCACCACTTGAAGCATACGAGCCGTATTTTGAGGTGGAAGTAA
GTCCGTCTACAGAAAAGGTATTAAATATTATTCGCAATGAAGGAGCAGATGGTTCTACAGACATACTAGCAAACGACTCA
ATAAATCACGAGATAAAGGCATAA

Upstream 100 bases:

>100_bases
TTTTGTTTTTGTATTATATACATTTTTTATAATTGTTTTGAACCTAAGAAGTCTTAAACAAGTCGAGACTTTTGCGGATT
TTACTACTGGCGGGCACAGA

Downstream 100 bases:

>100_bases
TTGTAAAATGACTATTATCTCAGTAAAGAAGCATAAATCATGATCCAGATCTTATAACATTTAATGATATAGTACGTGTA
ATTATTAGAATATTCTATCA

Product: Sodium/pantothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MGLWVGVFTTVATWVSVASVMGVPGYLYSSGVSAIIGWIAGWFLATAFIPIVAYKVRRPKNPPRTFPEFIHLRYEPFQKR
SPLRAIVGLLMSIGYFIFVHLQVVGFGIVFSTITGIQYEIALFGFLFFLLFTSIGGFWSVSVTDSVNTIIIVLGVILGAF
AVLYSTGGFGNIYENLATTTAPTFEGGESLPKGLLLSPVGGFGFGALCSIFLSNALGAIVSPHWVTRMMAPKNVKTAILQ
MMLSVLILTLIFIPLIIIGLGAKMLIPSLPAGQTTDYIMPTVITEFAHPIVGAFTLVALCAAAISTANSMLLHAGTSIYY
DLYRNLFPDKDFHDEKGKKQLRYLVLTLGFLAVLSAIKPPVLLAMGFTYVYGAFGAVFFFVVLLGLYTKRMNRLAAYANI
IVGLVAFIIAHIVGATNPFLVSLVVSFIAVLLSIIIGKKSPLEAYEPYFEVEVSPSTEKVLNIIRNEGADGSTDILANDS
INHEIKA

Sequences:

>Translated_487_residues
MGLWVGVFTTVATWVSVASVMGVPGYLYSSGVSAIIGWIAGWFLATAFIPIVAYKVRRPKNPPRTFPEFIHLRYEPFQKR
SPLRAIVGLLMSIGYFIFVHLQVVGFGIVFSTITGIQYEIALFGFLFFLLFTSIGGFWSVSVTDSVNTIIIVLGVILGAF
AVLYSTGGFGNIYENLATTTAPTFEGGESLPKGLLLSPVGGFGFGALCSIFLSNALGAIVSPHWVTRMMAPKNVKTAILQ
MMLSVLILTLIFIPLIIIGLGAKMLIPSLPAGQTTDYIMPTVITEFAHPIVGAFTLVALCAAAISTANSMLLHAGTSIYY
DLYRNLFPDKDFHDEKGKKQLRYLVLTLGFLAVLSAIKPPVLLAMGFTYVYGAFGAVFFFVVLLGLYTKRMNRLAAYANI
IVGLVAFIIAHIVGATNPFLVSLVVSFIAVLLSIIIGKKSPLEAYEPYFEVEVSPSTEKVLNIIRNEGADGSTDILANDS
INHEIKA
>Mature_486_residues
GLWVGVFTTVATWVSVASVMGVPGYLYSSGVSAIIGWIAGWFLATAFIPIVAYKVRRPKNPPRTFPEFIHLRYEPFQKRS
PLRAIVGLLMSIGYFIFVHLQVVGFGIVFSTITGIQYEIALFGFLFFLLFTSIGGFWSVSVTDSVNTIIIVLGVILGAFA
VLYSTGGFGNIYENLATTTAPTFEGGESLPKGLLLSPVGGFGFGALCSIFLSNALGAIVSPHWVTRMMAPKNVKTAILQM
MLSVLILTLIFIPLIIIGLGAKMLIPSLPAGQTTDYIMPTVITEFAHPIVGAFTLVALCAAAISTANSMLLHAGTSIYYD
LYRNLFPDKDFHDEKGKKQLRYLVLTLGFLAVLSAIKPPVLLAMGFTYVYGAFGAVFFFVVLLGLYTKRMNRLAAYANII
VGLVAFIIAHIVGATNPFLVSLVVSFIAVLLSIIIGKKSPLEAYEPYFEVEVSPSTEKVLNIIRNEGADGSTDILANDSI
NHEIKA

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=475, Percent_Identity=24.2105263157895, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87082237, Length=421, Percent_Identity=26.1282660332542, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787251, Length=405, Percent_Identity=27.1604938271605, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790503, Length=427, Percent_Identity=22.9508196721311, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790113, Length=478, Percent_Identity=25.5230125523013, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52720; Mature: 52589

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLWVGVFTTVATWVSVASVMGVPGYLYSSGVSAIIGWIAGWFLATAFIPIVAYKVRRPK
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPPRTFPEFIHLRYEPFQKRSPLRAIVGLLMSIGYFIFVHLQVVGFGIVFSTITGIQYEI
CCCCCCHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ALFGFLFFLLFTSIGGFWSVSVTDSVNTIIIVLGVILGAFAVLYSTGGFGNIYENLATTT
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
APTFEGGESLPKGLLLSPVGGFGFGALCSIFLSNALGAIVSPHWVTRMMAPKNVKTAILQ
CCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHH
MMLSVLILTLIFIPLIIIGLGAKMLIPSLPAGQTTDYIMPTVITEFAHPIVGAFTLVALC
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAAISTANSMLLHAGTSIYYDLYRNLFPDKDFHDEKGKKQLRYLVLTLGFLAVLSAIKPP
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
VLLAMGFTYVYGAFGAVFFFVVLLGLYTKRMNRLAAYANIIVGLVAFIIAHIVGATNPFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VSLVVSFIAVLLSIIIGKKSPLEAYEPYFEVEVSPSTEKVLNIIRNEGADGSTDILANDS
HHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEECCC
INHEIKA
CCCCCCC
>Mature Secondary Structure 
GLWVGVFTTVATWVSVASVMGVPGYLYSSGVSAIIGWIAGWFLATAFIPIVAYKVRRPK
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPPRTFPEFIHLRYEPFQKRSPLRAIVGLLMSIGYFIFVHLQVVGFGIVFSTITGIQYEI
CCCCCCHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ALFGFLFFLLFTSIGGFWSVSVTDSVNTIIIVLGVILGAFAVLYSTGGFGNIYENLATTT
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
APTFEGGESLPKGLLLSPVGGFGFGALCSIFLSNALGAIVSPHWVTRMMAPKNVKTAILQ
CCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHH
MMLSVLILTLIFIPLIIIGLGAKMLIPSLPAGQTTDYIMPTVITEFAHPIVGAFTLVALC
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAAISTANSMLLHAGTSIYYDLYRNLFPDKDFHDEKGKKQLRYLVLTLGFLAVLSAIKPP
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
VLLAMGFTYVYGAFGAVFFFVVLLGLYTKRMNRLAAYANIIVGLVAFIIAHIVGATNPFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VSLVVSFIAVLLSIIIGKKSPLEAYEPYFEVEVSPSTEKVLNIIRNEGADGSTDILANDS
HHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEECCC
INHEIKA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]