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The map label for this gene is iscS2 [H]

Identifier: 138896336

GI number: 138896336

Start: 2807609

End: 2808754

Strand: Reverse

Name: iscS2 [H]

Synonym: GTNG_2699

Alternate gene names: 138896336

Gene position: 2808754-2807609 (Counterclockwise)

Preceding gene: 138896337

Following gene: 138896335

Centisome position: 79.11

GC content: 56.46

Gene sequence:

>1146_bases
ATGATTTACCTTGATAACAGTGCGACGACCAAACCGTTTCCAGAAGTGATCGATTCGTTTGTCAAGGTCGCGACGGACTA
TTTTGCCAATCCGTCTTCGCTTCATGAACTGGGCATGAAGGCGGAGCGGCTGCTCGCGCAGGCGCGCGAACAAATCGCTG
CCATGCTGCGGGTCAAAGCGAACGAGGTCGTGTTCACGTCCGGTGGAACGGAAGCCAACAATTTCGCCATTAAAGGAGTG
GCTTGGCAATATCGGCGGCGCGGCCGGCATATTATTACGACGGAGATCGAGCATCCGTCCGTTGCTGAGCCGTGCCGTCA
GCTTGAGGAGCTCGGCTTTGAGGTGACGTATTTGCCGGTCGACCGCAACGGGAGAGTGTCGGCGGAGCAAGTCGAGCGCG
CGCTGCGCGATGATACGATTCTTGTTTCAATCATGCACGTCAATAACGAAGTCGGCACGGTGCAACCGATTGAGGAAATC
GGTGCGCTTCTTGCCCGCTACCCGAAGACGCTGTTTCATGTCGACCGGGTGCAAGGCATCAGCAAAGTGCCGCTTGATTT
GAAAAAGGCCGGCGTCGATTTAAGCACGATATCGGCTCATAAGTTTCACGGATTGCGCGGTGCCGGAGTGCTTTACGTCC
GCGAAGGTGTCCGCTTGACGTCGTTGATTGCCGGCGGCGGGCAGGAAATGCGGCTCCGGTCCGGAACGGAAAATGTGGCC
GCCATTGTCGCGATGGCGAAAGCGCTGCGCCTCGCTATGGAGAGATACGAGCGGGAGATCGACCGGCTCAAGGCGTTAAA
AGACGAGTGGCGAACCGCTCTTTCCGCCATTCCGGAGATTGAGATCAACACGCCGCGCGACGGTGCTGCGCCTCATATTA
TTAACTTTTCCTTAAAGCGCGGCATGAAGCCGGAAGTGTTCGTCCACGAACTGGCGAAAAGCGGCATTTACGTCTCGACA
ACATCGGCTTGTTCGTCGAAGAAAAAGGCGCCGAGCAAAACGCTGGTGGCGATGGGGCTTGGGGAAGACCGTGCTGAGCG
CGGCATCCGCGTCAGCTTATCGTTTGACAACACAAGCGAAGAAATCGCGCCGGCAGTGGCTGCCATGAAACAAGCGATCA
AAACGTTAAGCGAGGTAACGGGATAA

Upstream 100 bases:

>100_bases
TTTTTGGTGAATACTGTAAGTACGTGTGTGTTTTCAGCTCGGTTTTATGTTATTATACTATGTATGTACATTTGCCGATC
ATGAGCGGAGGATGGAAACA

Downstream 100 bases:

>100_bases
CATGGAAATGAAGTATGACCGCATTTTAATCCGTTATGGGGAAATGACGACAAAAGGAAAAAACCGCAATATTTTTGTTC
GACGGCTAAAAAACAACATC

Product: cysteine desulfhydrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIYLDNSATTKPFPEVIDSFVKVATDYFANPSSLHELGMKAERLLAQAREQIAAMLRVKANEVVFTSGGTEANNFAIKGV
AWQYRRRGRHIITTEIEHPSVAEPCRQLEELGFEVTYLPVDRNGRVSAEQVERALRDDTILVSIMHVNNEVGTVQPIEEI
GALLARYPKTLFHVDRVQGISKVPLDLKKAGVDLSTISAHKFHGLRGAGVLYVREGVRLTSLIAGGGQEMRLRSGTENVA
AIVAMAKALRLAMERYEREIDRLKALKDEWRTALSAIPEIEINTPRDGAAPHIINFSLKRGMKPEVFVHELAKSGIYVST
TSACSSKKKAPSKTLVAMGLGEDRAERGIRVSLSFDNTSEEIAPAVAAMKQAIKTLSEVTG

Sequences:

>Translated_381_residues
MIYLDNSATTKPFPEVIDSFVKVATDYFANPSSLHELGMKAERLLAQAREQIAAMLRVKANEVVFTSGGTEANNFAIKGV
AWQYRRRGRHIITTEIEHPSVAEPCRQLEELGFEVTYLPVDRNGRVSAEQVERALRDDTILVSIMHVNNEVGTVQPIEEI
GALLARYPKTLFHVDRVQGISKVPLDLKKAGVDLSTISAHKFHGLRGAGVLYVREGVRLTSLIAGGGQEMRLRSGTENVA
AIVAMAKALRLAMERYEREIDRLKALKDEWRTALSAIPEIEINTPRDGAAPHIINFSLKRGMKPEVFVHELAKSGIYVST
TSACSSKKKAPSKTLVAMGLGEDRAERGIRVSLSFDNTSEEIAPAVAAMKQAIKTLSEVTG
>Mature_381_residues
MIYLDNSATTKPFPEVIDSFVKVATDYFANPSSLHELGMKAERLLAQAREQIAAMLRVKANEVVFTSGGTEANNFAIKGV
AWQYRRRGRHIITTEIEHPSVAEPCRQLEELGFEVTYLPVDRNGRVSAEQVERALRDDTILVSIMHVNNEVGTVQPIEEI
GALLARYPKTLFHVDRVQGISKVPLDLKKAGVDLSTISAHKFHGLRGAGVLYVREGVRLTSLIAGGGQEMRLRSGTENVA
AIVAMAKALRLAMERYEREIDRLKALKDEWRTALSAIPEIEINTPRDGAAPHIINFSLKRGMKPEVFVHELAKSGIYVST
TSACSSKKKAPSKTLVAMGLGEDRAERGIRVSLSFDNTSEEIAPAVAAMKQAIKTLSEVTG

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=383, Percent_Identity=37.8590078328982, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI156713448, Length=414, Percent_Identity=33.0917874396135, Blast_Score=184, Evalue=9e-47,
Organism=Escherichia coli, GI48994898, Length=384, Percent_Identity=42.1875, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=24.317617866005, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789175, Length=272, Percent_Identity=25, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=366, Percent_Identity=40.4371584699454, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17533177, Length=334, Percent_Identity=31.437125748503, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=382, Percent_Identity=37.696335078534, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI20129463, Length=369, Percent_Identity=40.1084010840108, Blast_Score=248, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41874; Mature: 41874

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLDNSATTKPFPEVIDSFVKVATDYFANPSSLHELGMKAERLLAQAREQIAAMLRVKA
CEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NEVVFTSGGTEANNFAIKGVAWQYRRRGRHIITTEIEHPSVAEPCRQLEELGFEVTYLPV
CEEEEECCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEE
DRNGRVSAEQVERALRDDTILVSIMHVNNEVGTVQPIEEIGALLARYPKTLFHVDRVQGI
CCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SKVPLDLKKAGVDLSTISAHKFHGLRGAGVLYVREGVRLTSLIAGGGQEMRLRSGTENVA
CCCCCHHHHCCCCHHHCCHHHHCCCCCCCEEEEECCCEEEHHHHCCCCCEEECCCCHHHH
AIVAMAKALRLAMERYEREIDRLKALKDEWRTALSAIPEIEINTPRDGAAPHIINFSLKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEHHHHC
GMKPEVFVHELAKSGIYVSTTSACSSKKKAPSKTLVAMGLGEDRAERGIRVSLSFDNTSE
CCCHHHHHHHHHHCCEEEEECHHHHHCCCCCCCEEEEECCCCHHHCCCEEEEEEECCCHH
EIAPAVAAMKQAIKTLSEVTG
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYLDNSATTKPFPEVIDSFVKVATDYFANPSSLHELGMKAERLLAQAREQIAAMLRVKA
CEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NEVVFTSGGTEANNFAIKGVAWQYRRRGRHIITTEIEHPSVAEPCRQLEELGFEVTYLPV
CEEEEECCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEE
DRNGRVSAEQVERALRDDTILVSIMHVNNEVGTVQPIEEIGALLARYPKTLFHVDRVQGI
CCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SKVPLDLKKAGVDLSTISAHKFHGLRGAGVLYVREGVRLTSLIAGGGQEMRLRSGTENVA
CCCCCHHHHCCCCHHHCCHHHHCCCCCCCEEEEECCCEEEHHHHCCCCCEEECCCCHHHH
AIVAMAKALRLAMERYEREIDRLKALKDEWRTALSAIPEIEINTPRDGAAPHIINFSLKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEHHHHC
GMKPEVFVHELAKSGIYVSTTSACSSKKKAPSKTLVAMGLGEDRAERGIRVSLSFDNTSE
CCCHHHHHHHHHHCCEEEEECHHHHHCCCCCCCEEEEECCCCHHHCCCEEEEEEECCCHH
EIAPAVAAMKQAIKTLSEVTG
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]