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The map label for this gene is mutM [H]

Identifier: 138896290

GI number: 138896290

Start: 2759418

End: 2760242

Strand: Reverse

Name: mutM [H]

Synonym: GTNG_2653

Alternate gene names: 138896290

Gene position: 2760242-2759418 (Counterclockwise)

Preceding gene: 138896291

Following gene: 138896289

Centisome position: 77.75

GC content: 56.12

Gene sequence:

>825_bases
ATGCCAGAATTGCCGGAAGTGGAAACGATTCGCCGCACGTTGCTGCCGCTTATTGTTGGCAAAACGGTCGGGGATGTGCA
AATTTTTTGGCCGAACATCATTCGTCATCCACAAGATCCGGAGGCATTTGCCGCAAGGCTTGTTGGACAGACGGTGCGCG
GCATCGATCGGCGAGGGAAATTTTTGAAGTTTTTGTTTGACCAAGATATGCTTGTTTCCCATTTGCGCATGGAAGGGCGT
TACACCGTTGCTGATGCACACGAACCGCTTGACCCGCACACGCACGTCGTGTTCCGCTTCACTGACGATAGTGAACTCCG
TTATCGCGATGTGCGCAAGTTCGGAACGATGCATGTGTATGCCAAGGAGGAGGGAGACCGCCAGCCGCCGCTTGATCAAT
TGGGGCCGGAGCCGCTTTCCCCGGCGTTTTCTCCAGCCGTATTGGCGGAGCGGGCCGCGAAAACGAAACGGACTGTGAAA
GCGTTGCTGCTTGACCAAACCGTCGTCGCTGGATTTGGCAACATTTACGTCGATGAATCACTGTTTCGCGCTGGCATTCT
TCCCGAGCGGCAGGCCGCTTCACTGACAGACGAAGAAATCAAGCGGCTGCATGAACAGATGGTCGCCACCATCGGTGAGG
CCATCATGAAGGGGGGAAGCACGGTGCGAACGTACGTCAACACGCAAGGGGAAACGGGTACGTTCCAACATAGCTTGTTC
GTATATGGCCGCAAAGGGGAGCCGTGCAAACGGTGCGGAACCCCGATTGAAAAAACGGTCGTCGCCGGCCGCGGCACGCA
CTATTGCCCGCACTGTCAGCGGTAG

Upstream 100 bases:

>100_bases
GGGACGCCGGGTGAACGACAGGGAAGAAAAAGGCTCTCTGCCCGGCGAGCCTGCATTTTGTGATTGTACAGGCAAACGAG
CAAAGAAAGGAGGGAACGTG

Downstream 100 bases:

>100_bases
GCGACAAACGAAAAAGGAGAGAAATCAAATGGCAGTAACCATCGGGTTGACTGGGGGAATCGCGAGCGGGAAAAGTACGG
TCAGTGCCATGATGCGCGAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPELPEVETIRRTLLPLIVGKTVGDVQIFWPNIIRHPQDPEAFAARLVGQTVRGIDRRGKFLKFLFDQDMLVSHLRMEGR
YTVADAHEPLDPHTHVVFRFTDDSELRYRDVRKFGTMHVYAKEEGDRQPPLDQLGPEPLSPAFSPAVLAERAAKTKRTVK
ALLLDQTVVAGFGNIYVDESLFRAGILPERQAASLTDEEIKRLHEQMVATIGEAIMKGGSTVRTYVNTQGETGTFQHSLF
VYGRKGEPCKRCGTPIEKTVVAGRGTHYCPHCQR

Sequences:

>Translated_274_residues
MPELPEVETIRRTLLPLIVGKTVGDVQIFWPNIIRHPQDPEAFAARLVGQTVRGIDRRGKFLKFLFDQDMLVSHLRMEGR
YTVADAHEPLDPHTHVVFRFTDDSELRYRDVRKFGTMHVYAKEEGDRQPPLDQLGPEPLSPAFSPAVLAERAAKTKRTVK
ALLLDQTVVAGFGNIYVDESLFRAGILPERQAASLTDEEIKRLHEQMVATIGEAIMKGGSTVRTYVNTQGETGTFQHSLF
VYGRKGEPCKRCGTPIEKTVVAGRGTHYCPHCQR
>Mature_273_residues
PELPEVETIRRTLLPLIVGKTVGDVQIFWPNIIRHPQDPEAFAARLVGQTVRGIDRRGKFLKFLFDQDMLVSHLRMEGRY
TVADAHEPLDPHTHVVFRFTDDSELRYRDVRKFGTMHVYAKEEGDRQPPLDQLGPEPLSPAFSPAVLAERAAKTKRTVKA
LLLDQTVVAGFGNIYVDESLFRAGILPERQAASLTDEEIKRLHEQMVATIGEAIMKGGSTVRTYVNTQGETGTFQHSLFV
YGRKGEPCKRCGTPIEKTVVAGRGTHYCPHCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=274, Percent_Identity=40.1459854014599, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI1786932, Length=277, Percent_Identity=29.6028880866426, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30849; Mature: 30718

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETIRRTLLPLIVGKTVGDVQIFWPNIIRHPQDPEAFAARLVGQTVRGIDRRGK
CCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FLKFLFDQDMLVSHLRMEGRYTVADAHEPLDPHTHVVFRFTDDSELRYRDVRKFGTMHVY
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEE
AKEEGDRQPPLDQLGPEPLSPAFSPAVLAERAAKTKRTVKALLLDQTVVAGFGNIYVDES
ECCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHH
LFRAGILPERQAASLTDEEIKRLHEQMVATIGEAIMKGGSTVRTYVNTQGETGTFQHSLF
HHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEE
VYGRKGEPCKRCGTPIEKTVVAGRGTHYCPHCQR
EEECCCCCHHHHCCCHHHHEECCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETIRRTLLPLIVGKTVGDVQIFWPNIIRHPQDPEAFAARLVGQTVRGIDRRGK
CCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
FLKFLFDQDMLVSHLRMEGRYTVADAHEPLDPHTHVVFRFTDDSELRYRDVRKFGTMHVY
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEE
AKEEGDRQPPLDQLGPEPLSPAFSPAVLAERAAKTKRTVKALLLDQTVVAGFGNIYVDES
ECCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHH
LFRAGILPERQAASLTDEEIKRLHEQMVATIGEAIMKGGSTVRTYVNTQGETGTFQHSLF
HHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEE
VYGRKGEPCKRCGTPIEKTVVAGRGTHYCPHCQR
EEECCCCCHHHHCCCHHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA