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The map label for this gene is srrA [H]

Identifier: 138895944

GI number: 138895944

Start: 2424694

End: 2425368

Strand: Reverse

Name: srrA [H]

Synonym: GTNG_2303

Alternate gene names: 138895944

Gene position: 2425368-2424694 (Counterclockwise)

Preceding gene: 138895945

Following gene: 138895943

Centisome position: 68.31

GC content: 54.07

Gene sequence:

>675_bases
GTGAGTGAACGGACCGTTTTAATCGTGGATGACGAAGAGGAGATGCGGCTGTTAGTCAGCATGTATTTGGAAAACGCCGG
CTTTTGCTGTTTGGAAGCCGGAGACGGTGACGAAGCGTTGACGGTGTTGGCGCGTCGTTCGGTTGATGCGATTTTGCTTG
ATGTGATGATGCCAAACCAAGACGGCTTTTCCGTCTGTGCCCGCATTCGCGAGCAGTCGGATGTGCCGATTTTGTTTTTG
ACCGCCCTCGGCGAAGAGTGGGATAAAGTGAAAGGATTCAAGCTCGGCGGCGATGATTATATCGTCAAGCCGTTCAGCCC
GGGTGAGCTCATTGCCCGCCTTGAGGCGGTGCTGCGCCGGACGTGGCGCGGTCGCGAGCGCGATGGACAGCTACAATTTG
GCAACCTTGCGATCGATGAAAAAGGGCGGAAGGTGACCGTTGGGAGCGAGCCGGTGAGGTTGACGTTAAAAGAGTTTGAA
CTGTTGCTGTTTTTGGCCAAGCACCACGGTCAAGTGTTCAGCCGCGACGATTTGCTCGTCAACGTGTGGGGATATGATTA
CACAGGAAATGCCCGCACAGTCGATACGCATGTGAAGACGCTGCGCATGAAACTGAAAGACGCTGGCCGCTATATTCAAA
CGGTATGGGGCATCGGCTACAAATTTGAGGGATGA

Upstream 100 bases:

>100_bases
GCGATGAAATCATCGTGGTCGACGAGGCGACGTTGCGGCCGCTCGCTCGTTGGAAAACAGGGGATGGACCGCTGCAACTG
CTGATTCGGGAGGGACGAAC

Downstream 100 bases:

>100_bases
GTGATGAAACGGCTTCGTTTAGGGCAAAAAGTATGGCTGTCGATCGGAGCGGCGATCTTCGTGACGCTGGCGTTTTCATT
TTTGCTGTTAAATTACTTTT

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSERTVLIVDDEEEMRLLVSMYLENAGFCCLEAGDGDEALTVLARRSVDAILLDVMMPNQDGFSVCARIREQSDVPILFL
TALGEEWDKVKGFKLGGDDYIVKPFSPGELIARLEAVLRRTWRGRERDGQLQFGNLAIDEKGRKVTVGSEPVRLTLKEFE
LLLFLAKHHGQVFSRDDLLVNVWGYDYTGNARTVDTHVKTLRMKLKDAGRYIQTVWGIGYKFEG

Sequences:

>Translated_224_residues
MSERTVLIVDDEEEMRLLVSMYLENAGFCCLEAGDGDEALTVLARRSVDAILLDVMMPNQDGFSVCARIREQSDVPILFL
TALGEEWDKVKGFKLGGDDYIVKPFSPGELIARLEAVLRRTWRGRERDGQLQFGNLAIDEKGRKVTVGSEPVRLTLKEFE
LLLFLAKHHGQVFSRDDLLVNVWGYDYTGNARTVDTHVKTLRMKLKDAGRYIQTVWGIGYKFEG
>Mature_223_residues
SERTVLIVDDEEEMRLLVSMYLENAGFCCLEAGDGDEALTVLARRSVDAILLDVMMPNQDGFSVCARIREQSDVPILFLT
ALGEEWDKVKGFKLGGDDYIVKPFSPGELIARLEAVLRRTWRGRERDGQLQFGNLAIDEKGRKVTVGSEPVRLTLKEFEL
LLFLAKHHGQVFSRDDLLVNVWGYDYTGNARTVDTHVKTLRMKLKDAGRYIQTVWGIGYKFEG

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=41.0714285714286, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=37.6106194690265, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=39.1891891891892, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=37.10407239819, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=35.0877192982456, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=36.6071428571429, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=36.1990950226244, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=31.5068493150685, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=35.3448275862069, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=31.1965811965812, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=33.9449541284404, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=31.0810810810811, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=221, Percent_Identity=28.0542986425339, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=33.9622641509434, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=103, Percent_Identity=36.8932038834951, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25393; Mature: 25261

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERTVLIVDDEEEMRLLVSMYLENAGFCCLEAGDGDEALTVLARRSVDAILLDVMMPNQ
CCCCEEEEEECHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCC
DGFSVCARIREQSDVPILFLTALGEEWDKVKGFKLGGDDYIVKPFSPGELIARLEAVLRR
CHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCEEECCCCEEECCCCHHHHHHHHHHHHHH
TWRGRERDGQLQFGNLAIDEKGRKVTVGSEPVRLTLKEFELLLFLAKHHGQVFSRDDLLV
HHCCCCCCCCEEECCEEECCCCCEEEECCCCEEEEHHHHHHHHHHHHHCCCEEECCCEEE
NVWGYDYTGNARTVDTHVKTLRMKLKDAGRYIQTVWGIGYKFEG
EEECEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure 
SERTVLIVDDEEEMRLLVSMYLENAGFCCLEAGDGDEALTVLARRSVDAILLDVMMPNQ
CCCEEEEEECHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCC
DGFSVCARIREQSDVPILFLTALGEEWDKVKGFKLGGDDYIVKPFSPGELIARLEAVLRR
CHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCEEECCCCEEECCCCHHHHHHHHHHHHHH
TWRGRERDGQLQFGNLAIDEKGRKVTVGSEPVRLTLKEFELLLFLAKHHGQVFSRDDLLV
HHCCCCCCCCEEECCEEECCCCCEEEECCCCEEEEHHHHHHHHHHHHHCCCEEECCCEEE
NVWGYDYTGNARTVDTHVKTLRMKLKDAGRYIQTVWGIGYKFEG
EEECEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA