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The map label for this gene is yclK [H]

Identifier: 138895943

GI number: 138895943

Start: 2423284

End: 2424690

Strand: Reverse

Name: yclK [H]

Synonym: GTNG_2302

Alternate gene names: 138895943

Gene position: 2424690-2423284 (Counterclockwise)

Preceding gene: 138895944

Following gene: 138895942

Centisome position: 68.29

GC content: 55.44

Gene sequence:

>1407_bases
ATGAAACGGCTTCGTTTAGGGCAAAAAGTATGGCTGTCGATCGGAGCGGCGATCTTCGTGACGCTGGCGTTTTCATTTTT
GCTGTTAAATTACTTTTACCGAACGGTGTACGTGAAAGAAGTCGAACGAATGTTGATTGCTGAAGGGACAAGCCTAGCTC
ATGATTATCGAGGAGGGACGGTCACCGAGGCCTATCGGCGTCAAATCGAATGGTATGACGAAAAATCAACGGCAACGATC
TTGTTGATTGACAATCCGCGCGAATTGAGCGCTTGTTGGCCGTTTCCGGTCCATTATGACGCGTTAGTCAGCGGTCGCGA
TCGGGAAACGCTGCTGCACGGCAAGCCGGTGATCAAAACGGGGTATGAAAAGCGCTTCGACCGCCGTGTGATGGCGGTTG
TCGTCCCGCTTCTTGATGAGAAGCGACTTGAGGGAGCGATTTATTTGTATATGCCCCTCGCCGACGTTCAAGAAGCAACC
AAACGGGCAGCCGCCGCGTTTTGGCCGTTTGCTGCCTTGTTCGCTGCCGCGTTGTTGTTCGTTGGCAAGCGAATGGTGCG
CCAAATGACCGAGCCGCTCCAAGCGATGGAAAAAGCGGCTGGACGTATGGCGAAAGGGGATTATGGCGCAGCCATTTCAG
TGCGCACGGACGATGAGATCGGCCGTCTCGCTCAAGCGTTTAACCAAATGGCGGACGCCATCGCCAAAGAAGACGAGCGA
AAGCGTGAATTTTTAGCGAACGTCTCGCACGAATTACGCACGCCGTTAAGCTATATAAAAGGCTACAGTGAAGCGCTCCT
CTCCGGCCTGGCGAGAACGAAGGAAGAAGAACAGTCGCACCTTCGCCTCATCCACCGTGAAACGGAACGGATGGAGCGGC
TCGTCCGCGACTTGCTCGATTTGGCTCAACTTGAAGGGCAAAGCGTGCCGCTCGAGCGCGCTCCAGTGGCGTTCGCCCAA
GTGATCGAGGATGTCATGGACATGTATCGCCCAATCATAACCCAAAAACGGCTGACACTCACGTGCGACCTCGACTATGA
GCTTATCGTTGACGGCGATGCCGATCGGCTCGAACAAGTCGTGCGCAATTTACTCGACAACGCCATCCGCTACACCCCGG
AAGGCGGCGCGGTGACGGTGCGGCTTTCCCGTTTTTCAGACACAGAAGGCGAACTCGTGATCCGAGATACGGGCAAAGGC
ATCCCGAAAGACCAGCTTCCGCTTCTCGGCCAGCGCTTTTTCCGCGTCGACCGCGCCCGCACCCGCAAAGAAGGAGGCAC
TGGCTTAGGGCTTGCCATCGTCAAACAAATTGTCGCCCTTCATGGCGGTGCGATTCAGTTCGACAGCGACCTCGGCCAAG
GAACGACCGTATCTGTCCGCCTGCCGCTCGTTCAAGAAGAGGAATAA

Upstream 100 bases:

>100_bases
AGTCGATACGCATGTGAAGACGCTGCGCATGAAACTGAAAGACGCTGGCCGCTATATTCAAACGGTATGGGGCATCGGCT
ACAAATTTGAGGGATGAGTG

Downstream 100 bases:

>100_bases
GGGTTCTAAACGTGGAAGTTTCAATGTGTCTCATCCATGACCTGGCGGATCAAGTAGTGGAAGTTGATTTATGTGAGAAA
ATAGAGGGCGTTGGAGTTTT

Product: two component system histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKRLRLGQKVWLSIGAAIFVTLAFSFLLLNYFYRTVYVKEVERMLIAEGTSLAHDYRGGTVTEAYRRQIEWYDEKSTATI
LLIDNPRELSACWPFPVHYDALVSGRDRETLLHGKPVIKTGYEKRFDRRVMAVVVPLLDEKRLEGAIYLYMPLADVQEAT
KRAAAAFWPFAALFAAALLFVGKRMVRQMTEPLQAMEKAAGRMAKGDYGAAISVRTDDEIGRLAQAFNQMADAIAKEDER
KREFLANVSHELRTPLSYIKGYSEALLSGLARTKEEEQSHLRLIHRETERMERLVRDLLDLAQLEGQSVPLERAPVAFAQ
VIEDVMDMYRPIITQKRLTLTCDLDYELIVDGDADRLEQVVRNLLDNAIRYTPEGGAVTVRLSRFSDTEGELVIRDTGKG
IPKDQLPLLGQRFFRVDRARTRKEGGTGLGLAIVKQIVALHGGAIQFDSDLGQGTTVSVRLPLVQEEE

Sequences:

>Translated_468_residues
MKRLRLGQKVWLSIGAAIFVTLAFSFLLLNYFYRTVYVKEVERMLIAEGTSLAHDYRGGTVTEAYRRQIEWYDEKSTATI
LLIDNPRELSACWPFPVHYDALVSGRDRETLLHGKPVIKTGYEKRFDRRVMAVVVPLLDEKRLEGAIYLYMPLADVQEAT
KRAAAAFWPFAALFAAALLFVGKRMVRQMTEPLQAMEKAAGRMAKGDYGAAISVRTDDEIGRLAQAFNQMADAIAKEDER
KREFLANVSHELRTPLSYIKGYSEALLSGLARTKEEEQSHLRLIHRETERMERLVRDLLDLAQLEGQSVPLERAPVAFAQ
VIEDVMDMYRPIITQKRLTLTCDLDYELIVDGDADRLEQVVRNLLDNAIRYTPEGGAVTVRLSRFSDTEGELVIRDTGKG
IPKDQLPLLGQRFFRVDRARTRKEGGTGLGLAIVKQIVALHGGAIQFDSDLGQGTTVSVRLPLVQEEE
>Mature_468_residues
MKRLRLGQKVWLSIGAAIFVTLAFSFLLLNYFYRTVYVKEVERMLIAEGTSLAHDYRGGTVTEAYRRQIEWYDEKSTATI
LLIDNPRELSACWPFPVHYDALVSGRDRETLLHGKPVIKTGYEKRFDRRVMAVVVPLLDEKRLEGAIYLYMPLADVQEAT
KRAAAAFWPFAALFAAALLFVGKRMVRQMTEPLQAMEKAAGRMAKGDYGAAISVRTDDEIGRLAQAFNQMADAIAKEDER
KREFLANVSHELRTPLSYIKGYSEALLSGLARTKEEEQSHLRLIHRETERMERLVRDLLDLAQLEGQSVPLERAPVAFAQ
VIEDVMDMYRPIITQKRLTLTCDLDYELIVDGDADRLEQVVRNLLDNAIRYTPEGGAVTVRLSRFSDTEGELVIRDTGKG
IPKDQLPLLGQRFFRVDRARTRKEGGTGLGLAIVKQIVALHGGAIQFDSDLGQGTTVSVRLPLVQEEE

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=33.9350180505415, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=39.6551724137931, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1789149, Length=439, Percent_Identity=27.5626423690205, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=33.1983805668016, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786783, Length=293, Percent_Identity=30.3754266211604, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=32.520325203252, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=29.3859649122807, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI87081816, Length=357, Percent_Identity=29.1316526610644, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790861, Length=355, Percent_Identity=29.8591549295775, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788279, Length=244, Percent_Identity=29.5081967213115, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790551, Length=289, Percent_Identity=31.8339100346021, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1787894, Length=300, Percent_Identity=28.6666666666667, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=32.2033898305085, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=28.158844765343, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788549, Length=261, Percent_Identity=26.4367816091954, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789808, Length=482, Percent_Identity=26.3485477178423, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789403, Length=233, Percent_Identity=31.7596566523605, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=31.4893617021277, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=308, Percent_Identity=23.0519480519481, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790300, Length=253, Percent_Identity=30.0395256916996, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787374, Length=254, Percent_Identity=23.2283464566929, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=204, Percent_Identity=28.4313725490196, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52896; Mature: 52896

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLRLGQKVWLSIGAAIFVTLAFSFLLLNYFYRTVYVKEVERMLIAEGTSLAHDYRGGT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
VTEAYRRQIEWYDEKSTATILLIDNPRELSACWPFPVHYDALVSGRDRETLLHGKPVIKT
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHHCCCCHHHC
GYEKRFDRRVMAVVVPLLDEKRLEGAIYLYMPLADVQEATKRAAAAFWPFAALFAAALLF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGKRMVRQMTEPLQAMEKAAGRMAKGDYGAAISVRTDDEIGRLAQAFNQMADAIAKEDER
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHH
KREFLANVSHELRTPLSYIKGYSEALLSGLARTKEEEQSHLRLIHRETERMERLVRDLLD
HHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQLEGQSVPLERAPVAFAQVIEDVMDMYRPIITQKRLTLTCDLDYELIVDGDADRLEQV
HHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHH
VRNLLDNAIRYTPEGGAVTVRLSRFSDTEGELVIRDTGKGIPKDQLPLLGQRFFRVDRAR
HHHHHHHHHEECCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
TRKEGGTGLGLAIVKQIVALHGGAIQFDSDLGQGTTVSVRLPLVQEEE
HHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKRLRLGQKVWLSIGAAIFVTLAFSFLLLNYFYRTVYVKEVERMLIAEGTSLAHDYRGGT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
VTEAYRRQIEWYDEKSTATILLIDNPRELSACWPFPVHYDALVSGRDRETLLHGKPVIKT
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCHHHHCCCCHHHC
GYEKRFDRRVMAVVVPLLDEKRLEGAIYLYMPLADVQEATKRAAAAFWPFAALFAAALLF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGKRMVRQMTEPLQAMEKAAGRMAKGDYGAAISVRTDDEIGRLAQAFNQMADAIAKEDER
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHH
KREFLANVSHELRTPLSYIKGYSEALLSGLARTKEEEQSHLRLIHRETERMERLVRDLLD
HHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQLEGQSVPLERAPVAFAQVIEDVMDMYRPIITQKRLTLTCDLDYELIVDGDADRLEQV
HHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHH
VRNLLDNAIRYTPEGGAVTVRLSRFSDTEGELVIRDTGKGIPKDQLPLLGQRFFRVDRAR
HHHHHHHHHEECCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
TRKEGGTGLGLAIVKQIVALHGGAIQFDSDLGQGTTVSVRLPLVQEEE
HHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]