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The map label for this gene is mutA [H]

Identifier: 138895941

GI number: 138895941

Start: 2420476

End: 2422524

Strand: Reverse

Name: mutA [H]

Synonym: GTNG_2300

Alternate gene names: 138895941

Gene position: 2422524-2420476 (Counterclockwise)

Preceding gene: 138895942

Following gene: 138895940

Centisome position: 68.23

GC content: 56.71

Gene sequence:

>2049_bases
ATGAGTGATGTCGCGAAGATGAAGGAAGCGGCGTTTTCAGCTCCGACGGTTGAGGAGTGGGAGCGGGAAGCGGAAAGATC
GCTGAAAGGAAAGCCGCTCGAGCGGCTTCATTCGATGACGTACGAAAACATAGCGGTCAAGCCGCTTTATACACGCCGAG
ATGTAGAGGCGCTCGGCTCGCTTGAGCAGTACCCGGGCTTTGGCCAGTACGTGCGCGGGACGCGGCCGGAAGGATATCGA
AGCAAGCCATGGAAGGTGAGCCAGGAAATTTCGGCAATGAGCCCCTCTGAATGGAACGAGGCGGTCAAGCACGACTTGCA
AAAGGGACAGACGGAAATCCATCTTTCCCTTGAACGGCTGCCGTTTGCTGTTCAGTCGGTCGATGATGTGGCTGCAATGT
TTGCTGGCGTGTCGCTCGATCGCTATTCGCTCCGTGTGGACGCGGGGGCGCAGTCGCTTCCGTTTTTAGCGTTGCTGGCT
GCGTATTTGCAAGAACAAGGAATATCACTCTCAGTCGTGCGCGGCGCGATCGGTATGGATCCGCTTGGAGTGTGGGCAGA
AGGCGGGGCGCTGCCGAGGTCGCTCGATGGGTTGTATGATGAAATGGCGGAAGCGGTGAAGTGGGCGAAGGAACAAATGC
CTTCCGTTCGCACGATTTTCGTGCGTGGAGAGCCGTATCATAACGGCGGAGCGAACGCTGTGCAGGAGCTCGCGTTTTCG
TTGGCGACGGCGGTCGAGTACATCCGTGCAGGGCTGGATCGTGGTCTGACTATCGATGACATCGCTACGCGGATGCAAGT
GTCGTTGTCGGTCGGAGCTGACTTTTTCATGGAAATTGCCAAGTTGCGGGCAGCGCGGCGGTTGTTTGCGCAAGTGATCG
GAGCGTTTGGCGGCGGTGAATCAGCAAGACGGATCGAACTGCATGTGCGCACATCGCGCTTTACCAAAACCGTGTACGAC
CCGTATGTGAACATGCTTCGCGCGGGAGCAGAAGCGTTTGCGGCCGTTGTTGGCGGTGCTGATGGCGTGCATGTGTCACC
GTTTGACGAAGCGATCGGACTCGCTGATGAGTTTTCACGGCGCATCGCTCGCAACACGCAGCTTATTTTGCTTGAAGAGG
CACATCTCGCCCATGTCATCGATCCGGCGGGCGGCTCGTATTATGTTGAGACATTGACGGCTAAACTCGCTGAAGAAGCA
TGGAAGCTGTTCCAACAAGTTGAAGAAAAAGGCGGTATGAAACAAGCGCTTCAAGACGGCTTCGTGCAGGCAGAAGTAGC
GACAGTGGCCGAGCAGCGGCTTGAGCGCGTCAAACAGCGGAAAGAAAAAATCGTCGGCACGAATGTGTATGCGAACTTGG
CGGAAACGCCGATTCAAAAGCCGGAACAAGCTGAAGTGAATGAGGTGCTCCCGGTAGAGGAAACGCGGGTGTCGGATCTT
CACGCTACGCTTGCGAATGGAAAATGGATGGAAGCGATGATTCGTGCGGCTCGTTGTCGAGCAACCGCTCGGGAAATGGT
GGCAGCGCTCGCAGATGGAAAGGCACCTGTACGCATTACGCCCATTTCGCCATGGCGTTTAGCCGAGCCGTTTGAGCAGT
TGCGACAGGCGGCGGAAAAGCATGCGGAACGCACCGGAGAGAAGCTCACCGTTCATTTGATTGCGCTCGGACCGCTTGTT
CGCCATCAGGCGCGTACCGATTTCATTGCCGGGCTGTTTGCAGCCGGTGGGGTGACGGCCGAGCGGAGCAACGGCTTCGC
ATCGGTTGAGGAAGTGGTCGAATGGGTGCGGAACACGAACGGGACGCATTACGTCATCTGCGGCGCCGACGCTGATTATC
CATCGTTCGTTCCCGCGTTGGCCGAGGCGTTTAAGCAGGCAAAGCCGAATGCGAAGCTGTATCTTGCTGGAAAACCGCCG
GAAGAGCTCGAAAAAACGTATGCTGCTGCTGGCGTAGATGGGTCGATTCATCTCGGTTCGAACGCTTACGATGTCATTGT
GGCGTTTCTCACGGAAAGAGGGGTGGCGTTTGATGGCGAAGTACGTTGA

Upstream 100 bases:

>100_bases
TGAGACATCTCCGGACGTTGACGGCTTCAGGTGGGTAAAAGGCGGCGAAAAACGAAAGCGGTTTCTTTTTTTGGAGAAAG
ACGCGAAAGGGGATGGGGAA

Downstream 100 bases:

>100_bases
CTTTACAAATATGACGCTCTCCACGGCAGCGGCCGATGTGGATGAGAAACAGTGGAGAGACGCGGTGGAGCGGCGCGTGC
AAGCGTCGATCGATGAACTG

Product: methylmalonyl-CoA mutase subunit beta

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 682; Mature: 681

Protein sequence:

>682_residues
MSDVAKMKEAAFSAPTVEEWEREAERSLKGKPLERLHSMTYENIAVKPLYTRRDVEALGSLEQYPGFGQYVRGTRPEGYR
SKPWKVSQEISAMSPSEWNEAVKHDLQKGQTEIHLSLERLPFAVQSVDDVAAMFAGVSLDRYSLRVDAGAQSLPFLALLA
AYLQEQGISLSVVRGAIGMDPLGVWAEGGALPRSLDGLYDEMAEAVKWAKEQMPSVRTIFVRGEPYHNGGANAVQELAFS
LATAVEYIRAGLDRGLTIDDIATRMQVSLSVGADFFMEIAKLRAARRLFAQVIGAFGGGESARRIELHVRTSRFTKTVYD
PYVNMLRAGAEAFAAVVGGADGVHVSPFDEAIGLADEFSRRIARNTQLILLEEAHLAHVIDPAGGSYYVETLTAKLAEEA
WKLFQQVEEKGGMKQALQDGFVQAEVATVAEQRLERVKQRKEKIVGTNVYANLAETPIQKPEQAEVNEVLPVEETRVSDL
HATLANGKWMEAMIRAARCRATAREMVAALADGKAPVRITPISPWRLAEPFEQLRQAAEKHAERTGEKLTVHLIALGPLV
RHQARTDFIAGLFAAGGVTAERSNGFASVEEVVEWVRNTNGTHYVICGADADYPSFVPALAEAFKQAKPNAKLYLAGKPP
EELEKTYAAAGVDGSIHLGSNAYDVIVAFLTERGVAFDGEVR

Sequences:

>Translated_682_residues
MSDVAKMKEAAFSAPTVEEWEREAERSLKGKPLERLHSMTYENIAVKPLYTRRDVEALGSLEQYPGFGQYVRGTRPEGYR
SKPWKVSQEISAMSPSEWNEAVKHDLQKGQTEIHLSLERLPFAVQSVDDVAAMFAGVSLDRYSLRVDAGAQSLPFLALLA
AYLQEQGISLSVVRGAIGMDPLGVWAEGGALPRSLDGLYDEMAEAVKWAKEQMPSVRTIFVRGEPYHNGGANAVQELAFS
LATAVEYIRAGLDRGLTIDDIATRMQVSLSVGADFFMEIAKLRAARRLFAQVIGAFGGGESARRIELHVRTSRFTKTVYD
PYVNMLRAGAEAFAAVVGGADGVHVSPFDEAIGLADEFSRRIARNTQLILLEEAHLAHVIDPAGGSYYVETLTAKLAEEA
WKLFQQVEEKGGMKQALQDGFVQAEVATVAEQRLERVKQRKEKIVGTNVYANLAETPIQKPEQAEVNEVLPVEETRVSDL
HATLANGKWMEAMIRAARCRATAREMVAALADGKAPVRITPISPWRLAEPFEQLRQAAEKHAERTGEKLTVHLIALGPLV
RHQARTDFIAGLFAAGGVTAERSNGFASVEEVVEWVRNTNGTHYVICGADADYPSFVPALAEAFKQAKPNAKLYLAGKPP
EELEKTYAAAGVDGSIHLGSNAYDVIVAFLTERGVAFDGEVR
>Mature_681_residues
SDVAKMKEAAFSAPTVEEWEREAERSLKGKPLERLHSMTYENIAVKPLYTRRDVEALGSLEQYPGFGQYVRGTRPEGYRS
KPWKVSQEISAMSPSEWNEAVKHDLQKGQTEIHLSLERLPFAVQSVDDVAAMFAGVSLDRYSLRVDAGAQSLPFLALLAA
YLQEQGISLSVVRGAIGMDPLGVWAEGGALPRSLDGLYDEMAEAVKWAKEQMPSVRTIFVRGEPYHNGGANAVQELAFSL
ATAVEYIRAGLDRGLTIDDIATRMQVSLSVGADFFMEIAKLRAARRLFAQVIGAFGGGESARRIELHVRTSRFTKTVYDP
YVNMLRAGAEAFAAVVGGADGVHVSPFDEAIGLADEFSRRIARNTQLILLEEAHLAHVIDPAGGSYYVETLTAKLAEEAW
KLFQQVEEKGGMKQALQDGFVQAEVATVAEQRLERVKQRKEKIVGTNVYANLAETPIQKPEQAEVNEVLPVEETRVSDLH
ATLANGKWMEAMIRAARCRATAREMVAALADGKAPVRITPISPWRLAEPFEQLRQAAEKHAERTGEKLTVHLIALGPLVR
HQARTDFIAGLFAAGGVTAERSNGFASVEEVVEWVRNTNGTHYVICGADADYPSFVPALAEAFKQAKPNAKLYLAGKPPE
ELEKTYAAAGVDGSIHLGSNAYDVIVAFLTERGVAFDGEVR

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=524, Percent_Identity=32.4427480916031, Blast_Score=263, Evalue=5e-70,
Organism=Escherichia coli, GI1789284, Length=461, Percent_Identity=34.70715835141, Blast_Score=275, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI25144500, Length=536, Percent_Identity=30.5970149253731, Blast_Score=262, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 74700; Mature: 74568

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVAKMKEAAFSAPTVEEWEREAERSLKGKPLERLHSMTYENIAVKPLYTRRDVEALGS
CCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCEEECCCCCHHHHHHHCC
LEQYPGFGQYVRGTRPEGYRSKPWKVSQEISAMSPSEWNEAVKHDLQKGQTEIHLSLERL
HHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEHHHC
PFAVQSVDDVAAMFAGVSLDRYSLRVDAGAQSLPFLALLAAYLQEQGISLSVVRGAIGMD
CHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEHHHHCCCC
PLGVWAEGGALPRSLDGLYDEMAEAVKWAKEQMPSVRTIFVRGEPYHNGGANAVQELAFS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHH
LATAVEYIRAGLDRGLTIDDIATRMQVSLSVGADFFMEIAKLRAARRLFAQVIGAFGGGE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SARRIELHVRTSRFTKTVYDPYVNMLRAGAEAFAAVVGGADGVHVSPFDEAIGLADEFSR
CCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHH
RIARNTQLILLEEAHLAHVIDPAGGSYYVETLTAKLAEEAWKLFQQVEEKGGMKQALQDG
HHHCCCCEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
FVQAEVATVAEQRLERVKQRKEKIVGTNVYANLAETPIQKPEQAEVNEVLPVEETRVSDL
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHH
HATLANGKWMEAMIRAARCRATAREMVAALADGKAPVRITPISPWRLAEPFEQLRQAAEK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHH
HAERTGEKLTVHLIALGPLVRHQARTDFIAGLFAAGGVTAERSNGFASVEEVVEWVRNTN
HHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
GTHYVICGADADYPSFVPALAEAFKQAKPNAKLYLAGKPPEELEKTYAAAGVDGSIHLGS
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEECC
NAYDVIVAFLTERGVAFDGEVR
CHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SDVAKMKEAAFSAPTVEEWEREAERSLKGKPLERLHSMTYENIAVKPLYTRRDVEALGS
CHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCEEECCCCCHHHHHHHCC
LEQYPGFGQYVRGTRPEGYRSKPWKVSQEISAMSPSEWNEAVKHDLQKGQTEIHLSLERL
HHHCCCCCHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEHHHC
PFAVQSVDDVAAMFAGVSLDRYSLRVDAGAQSLPFLALLAAYLQEQGISLSVVRGAIGMD
CHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEHHHHCCCC
PLGVWAEGGALPRSLDGLYDEMAEAVKWAKEQMPSVRTIFVRGEPYHNGGANAVQELAFS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHH
LATAVEYIRAGLDRGLTIDDIATRMQVSLSVGADFFMEIAKLRAARRLFAQVIGAFGGGE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SARRIELHVRTSRFTKTVYDPYVNMLRAGAEAFAAVVGGADGVHVSPFDEAIGLADEFSR
CCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHH
RIARNTQLILLEEAHLAHVIDPAGGSYYVETLTAKLAEEAWKLFQQVEEKGGMKQALQDG
HHHCCCCEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
FVQAEVATVAEQRLERVKQRKEKIVGTNVYANLAETPIQKPEQAEVNEVLPVEETRVSDL
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHH
HATLANGKWMEAMIRAARCRATAREMVAALADGKAPVRITPISPWRLAEPFEQLRQAAEK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHH
HAERTGEKLTVHLIALGPLVRHQARTDFIAGLFAAGGVTAERSNGFASVEEVVEWVRNTN
HHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCC
GTHYVICGADADYPSFVPALAEAFKQAKPNAKLYLAGKPPEELEKTYAAAGVDGSIHLGS
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEECC
NAYDVIVAFLTERGVAFDGEVR
CHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]