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The map label for this gene is mutB [H]

Identifier: 138895940

GI number: 138895940

Start: 2418297

End: 2420465

Strand: Reverse

Name: mutB [H]

Synonym: GTNG_2299

Alternate gene names: 138895940

Gene position: 2420465-2418297 (Counterclockwise)

Preceding gene: 138895941

Following gene: 138895939

Centisome position: 68.18

GC content: 53.8

Gene sequence:

>2169_bases
ATGACGCTCTCCACGGCAGCGGCCGATGTGGATGAGAAACAGTGGAGAGACGCGGTGGAGCGGCGCGTGCAAGCGTCGAT
CGATGAACTGTTGTTCCAGACGAATGAGCACATTGCGGTGAAGCCGCTTTATACAAAGAAAGACATCGATGGGCTCGATT
TCCTTGATTATATGCCCGGCTTGCCGCCGTATTTGCGCGGGCCGTATCCGACGATGTATGTCGCACGGCCGTGGACGATC
CGCCAATACGCCGGCTTTTCGACGGCTGAGGAAAGCAATGCATTTTATCGGCGCAATTTGGCGATGGGGCAAAAAGGGCT
GTCGGTCGCTTTTGACCTTGCCACCCATCGTGGCTATGACTCCGACCATCCACGCGTCGTCGGCGATGTCGGCAAAGCAG
GGGTCGCCATTGATTCGGTGCTCGATATGAAAATTTTGTTTGACGGCATTCCGCTCGATCAAATGTCGGTGTCGATGACG
ATGAACGGAGCGGTGCTCCCGATCATGGCGTTTTACATCGTCACTGCTGAAGAACAAGGAGTGACGCAAGACAAGCTGTC
GGGAACGATTCAAAACGATATTTTGAAAGAATACATGGTGCGTAACACGTACATTTATCCGCCGGAAATGTCCATGCGCA
TCATTGCTGATATTTTCGCCTATACGGCCAAATACATGCCGAAATTCAACAGCATCAGCATTTCTGGCTATCATATGCAG
GAAGCTGGGGCGCCGGCCGACTTGGAGCTGGCATACACGCTTGCCGATGGGCTCGAATATGTGCGCACCGGTCTGAAAGC
GGGGATTGACATCGATTCATTCGCTCCAAGGCTGTCGTTTTTCTGGGCGATCGGCATGAACTATTTTATGGAAGTGGCGA
AAATGCGGGCGGCGCGTCTCATGTGGGCGAAAATGATGAAAACGTTCAATCCGAAAAATCCGAAATCGCTCGCATTAAGG
ACGCATTCGCAAACATCGGGATGGAGTTTGACCGAGCAAGATCCGTTCAACAATGTTGTGCGTACGCTCATTGAAGCGCA
TGCGGCAGCGATGGGGCATACGCAGTCGCTTCATACGAACGCCCTTGACGAAGCGATTGCCTTGCCGACCGACTTCTCGG
CACGCATCGCCCGTAATACGCAGCTGTACTTGCAGGAAGAGACGGGCATTTGTCGGACGATCGACCCGTGGGCCGGCTCG
TATTACGTCGAGACGTTGACAAACGAATTGATGAAGCGGGCGTGGGCGCATATTGAAGAAATCGAAAGCTTAGGTGGAAT
GGCGAAAGCGATCGAAACTGGCATTCCGAAAATGCGTATCGAAGAAGCGGCAGCTCGGCGTCAAGCGCGCATCGATTCAG
GAGCAGAAACGATTATTGGTGTCAATCAATACCGTCCGGAAAAAGAAGAGCCAATCGACATTTTGGAAGTTGACAACACT
GCTGTGCGCGAGCGGCAAATCGAACGACTGAACGAGCTAAAGGCGACGCGCGATAACGAGCAAGTCGAAGCAGCACTTGC
TGCGATTACGAAAGCGGCGGAAACGGGCGAAGGAAATTTGCTTGAGCTCGCCGTCCAAGCAGCGCGCGTTCGTGCAACAC
TCGGGGAAATTTCGTACGCCATTGAAAAAGTGGCGAAGCGTCATCGCGCTACGATTCGTTCGATCAGCGGCGTTTACAGC
TCGGAGTATAAAAATGAAGCGCAGCTTGAACGGGTGAAAGCGAAAGTGGCGCAGTTCGCGGAACTAGAAGGGCGGCGTCC
GCGCCTGTTGGTCGCAAAAATGGGACAGGATGGCCATGACCGTGGGGCGAAAGTGATCGCCACCGCGTTTGCTGATTTAG
GGTTTGACGTTGATATCGGACCGCTGTTTCAAACACCGGAAGAAACAGCGCGCCAAGCGGTCGAAAACGATGTACACGCC
GTCGGCATCAGTTCGCTCGCCGGTGGACATAAGACGCTCGTGCCCCAGCTCGTTGCGGAGCTCGAAAAACTTGGCCGCGA
CGATATTTTAGTTATCGTCGGCGGCGTCATTCCGCCGCAAGATTACGCGTTTTTATATGAGCACGGAGCCGCTGCCGTCT
TCGGGCCGGGCACGGTGATTCCGGAAGCGGCAGAAACCGTATTAGACGAAATTTATGCTCGACTCGGCTATGAGGAAGTG
AGCGAATGA

Upstream 100 bases:

>100_bases
GGGTCGATTCATCTCGGTTCGAACGCTTACGATGTCATTGTGGCGTTTCTCACGGAAAGAGGGGTGGCGTTTGATGGCGA
AGTACGTTGACTTTACAAAT

Downstream 100 bases:

>100_bases
ACGGTGAAGAGAAACAACAAGAACGAGCAGGCGGCGAAGGTGCGGTAGACGGTCAAGGGAAGCGTCCCGAATGGGCGGAC
GGCGAGAGCGCGTCATCGTA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MTLSTAAADVDEKQWRDAVERRVQASIDELLFQTNEHIAVKPLYTKKDIDGLDFLDYMPGLPPYLRGPYPTMYVARPWTI
RQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVLDMKILFDGIPLDQMSVSMT
MNGAVLPIMAFYIVTAEEQGVTQDKLSGTIQNDILKEYMVRNTYIYPPEMSMRIIADIFAYTAKYMPKFNSISISGYHMQ
EAGAPADLELAYTLADGLEYVRTGLKAGIDIDSFAPRLSFFWAIGMNYFMEVAKMRAARLMWAKMMKTFNPKNPKSLALR
THSQTSGWSLTEQDPFNNVVRTLIEAHAAAMGHTQSLHTNALDEAIALPTDFSARIARNTQLYLQEETGICRTIDPWAGS
YYVETLTNELMKRAWAHIEEIESLGGMAKAIETGIPKMRIEEAAARRQARIDSGAETIIGVNQYRPEKEEPIDILEVDNT
AVRERQIERLNELKATRDNEQVEAALAAITKAAETGEGNLLELAVQAARVRATLGEISYAIEKVAKRHRATIRSISGVYS
SEYKNEAQLERVKAKVAQFAELEGRRPRLLVAKMGQDGHDRGAKVIATAFADLGFDVDIGPLFQTPEETARQAVENDVHA
VGISSLAGGHKTLVPQLVAELEKLGRDDILVIVGGVIPPQDYAFLYEHGAAAVFGPGTVIPEAAETVLDEIYARLGYEEV
SE

Sequences:

>Translated_722_residues
MTLSTAAADVDEKQWRDAVERRVQASIDELLFQTNEHIAVKPLYTKKDIDGLDFLDYMPGLPPYLRGPYPTMYVARPWTI
RQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVLDMKILFDGIPLDQMSVSMT
MNGAVLPIMAFYIVTAEEQGVTQDKLSGTIQNDILKEYMVRNTYIYPPEMSMRIIADIFAYTAKYMPKFNSISISGYHMQ
EAGAPADLELAYTLADGLEYVRTGLKAGIDIDSFAPRLSFFWAIGMNYFMEVAKMRAARLMWAKMMKTFNPKNPKSLALR
THSQTSGWSLTEQDPFNNVVRTLIEAHAAAMGHTQSLHTNALDEAIALPTDFSARIARNTQLYLQEETGICRTIDPWAGS
YYVETLTNELMKRAWAHIEEIESLGGMAKAIETGIPKMRIEEAAARRQARIDSGAETIIGVNQYRPEKEEPIDILEVDNT
AVRERQIERLNELKATRDNEQVEAALAAITKAAETGEGNLLELAVQAARVRATLGEISYAIEKVAKRHRATIRSISGVYS
SEYKNEAQLERVKAKVAQFAELEGRRPRLLVAKMGQDGHDRGAKVIATAFADLGFDVDIGPLFQTPEETARQAVENDVHA
VGISSLAGGHKTLVPQLVAELEKLGRDDILVIVGGVIPPQDYAFLYEHGAAAVFGPGTVIPEAAETVLDEIYARLGYEEV
SE
>Mature_721_residues
TLSTAAADVDEKQWRDAVERRVQASIDELLFQTNEHIAVKPLYTKKDIDGLDFLDYMPGLPPYLRGPYPTMYVARPWTIR
QYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSVLDMKILFDGIPLDQMSVSMTM
NGAVLPIMAFYIVTAEEQGVTQDKLSGTIQNDILKEYMVRNTYIYPPEMSMRIIADIFAYTAKYMPKFNSISISGYHMQE
AGAPADLELAYTLADGLEYVRTGLKAGIDIDSFAPRLSFFWAIGMNYFMEVAKMRAARLMWAKMMKTFNPKNPKSLALRT
HSQTSGWSLTEQDPFNNVVRTLIEAHAAAMGHTQSLHTNALDEAIALPTDFSARIARNTQLYLQEETGICRTIDPWAGSY
YVETLTNELMKRAWAHIEEIESLGGMAKAIETGIPKMRIEEAAARRQARIDSGAETIIGVNQYRPEKEEPIDILEVDNTA
VRERQIERLNELKATRDNEQVEAALAAITKAAETGEGNLLELAVQAARVRATLGEISYAIEKVAKRHRATIRSISGVYSS
EYKNEAQLERVKAKVAQFAELEGRRPRLLVAKMGQDGHDRGAKVIATAFADLGFDVDIGPLFQTPEETARQAVENDVHAV
GISSLAGGHKTLVPQLVAELEKLGRDDILVIVGGVIPPQDYAFLYEHGAAAVFGPGTVIPEAAETVLDEIYARLGYEEVS
E

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=685, Percent_Identity=67.5912408759124, Blast_Score=977, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=706, Percent_Identity=63.4560906515581, Blast_Score=914, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=691, Percent_Identity=64.10998552822, Blast_Score=944, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 80010; Mature: 79879

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSTAAADVDEKQWRDAVERRVQASIDELLFQTNEHIAVKPLYTKKDIDGLDFLDYMPG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCC
LPPYLRGPYPTMYVARPWTIRQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYD
CCHHHCCCCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHHCCCCCCEEEEHHHHCCCC
SDHPRVVGDVGKAGVAIDSVLDMKILFDGIPLDQMSVSMTMNGAVLPIMAFYIVTAEEQG
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCC
VTQDKLSGTIQNDILKEYMVRNTYIYPPEMSMRIIADIFAYTAKYMPKFNSISISGYHMQ
CCHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEHH
EAGAPADLELAYTLADGLEYVRTGLKAGIDIDSFAPRLSFFWAIGMNYFMEVAKMRAARL
CCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWAKMMKTFNPKNPKSLALRTHSQTSGWSLTEQDPFNNVVRTLIEAHAAAMGHTQSLHTN
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
ALDEAIALPTDFSARIARNTQLYLQEETGICRTIDPWAGSYYVETLTNELMKRAWAHIEE
HHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
IESLGGMAKAIETGIPKMRIEEAAARRQARIDSGAETIIGVNQYRPEKEEPIDILEVDNT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCCCCCEEECCCH
AVRERQIERLNELKATRDNEQVEAALAAITKAAETGEGNLLELAVQAARVRATLGEISYA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
IEKVAKRHRATIRSISGVYSSEYKNEAQLERVKAKVAQFAELEGRRPRLLVAKMGQDGHD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
RGAKVIATAFADLGFDVDIGPLFQTPEETARQAVENDVHAVGISSLAGGHKTLVPQLVAE
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHEEHHHHCCCHHHHHHHHHHH
LEKLGRDDILVIVGGVIPPQDYAFLYEHGAAAVFGPGTVIPEAAETVLDEIYARLGYEEV
HHHCCCCCEEEEECCCCCCCCCCHHEECCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHH
SE
CC
>Mature Secondary Structure 
TLSTAAADVDEKQWRDAVERRVQASIDELLFQTNEHIAVKPLYTKKDIDGLDFLDYMPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHCCC
LPPYLRGPYPTMYVARPWTIRQYAGFSTAEESNAFYRRNLAMGQKGLSVAFDLATHRGYD
CCHHHCCCCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHHCCCCCCEEEEHHHHCCCC
SDHPRVVGDVGKAGVAIDSVLDMKILFDGIPLDQMSVSMTMNGAVLPIMAFYIVTAEEQG
CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCC
VTQDKLSGTIQNDILKEYMVRNTYIYPPEMSMRIIADIFAYTAKYMPKFNSISISGYHMQ
CCHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEHH
EAGAPADLELAYTLADGLEYVRTGLKAGIDIDSFAPRLSFFWAIGMNYFMEVAKMRAARL
CCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MWAKMMKTFNPKNPKSLALRTHSQTSGWSLTEQDPFNNVVRTLIEAHAAAMGHTQSLHTN
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
ALDEAIALPTDFSARIARNTQLYLQEETGICRTIDPWAGSYYVETLTNELMKRAWAHIEE
HHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
IESLGGMAKAIETGIPKMRIEEAAARRQARIDSGAETIIGVNQYRPEKEEPIDILEVDNT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCCCCCCCEEECCCH
AVRERQIERLNELKATRDNEQVEAALAAITKAAETGEGNLLELAVQAARVRATLGEISYA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
IEKVAKRHRATIRSISGVYSSEYKNEAQLERVKAKVAQFAELEGRRPRLLVAKMGQDGHD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
RGAKVIATAFADLGFDVDIGPLFQTPEETARQAVENDVHAVGISSLAGGHKTLVPQLVAE
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHEEHHHHCCCHHHHHHHHHHH
LEKLGRDDILVIVGGVIPPQDYAFLYEHGAAAVFGPGTVIPEAAETVLDEIYARLGYEEV
HHHCCCCCEEEEECCCCCCCCCCHHEECCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHH
SE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]