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The map label for this gene is rnz [H]

Identifier: 138895904

GI number: 138895904

Start: 2377196

End: 2378122

Strand: Reverse

Name: rnz [H]

Synonym: GTNG_2263

Alternate gene names: 138895904

Gene position: 2378122-2377196 (Counterclockwise)

Preceding gene: 138895907

Following gene: 138895901

Centisome position: 66.98

GC content: 57.71

Gene sequence:

>927_bases
ATGAGCTTGGAATTGTTGTTTTTAGGCACCGGCGCCGGCGTGCCGGCGAAAGAGCGCAACGTGTCATCCATCGCTTTGCA
GCTGCTCGAAGAACGGGGGGCGACATGGCTGTTTGACTGCGGCGAAGCGACGCAGCACCAAATTTTGCATACCGCCATTC
GCCCGCGCCGCATCGAGCATATTTTCATTACTCATTTGCACGGTGATCATTTATTTGGATTGCCCGGCCTGCTCGGCAGC
CGCTCGTTTCAAAGTGGTGAGACGCCGCTGACCGTCTTCGGTCCAAAGGGCATCCGCCAGTTTGTCGAAACCGCGCTCAC
CGTCAGCGGGACAAGGCTTCGGTATGAATTGAACATCGCTGAGATCGACGAAGGTGTCATCTTTGACGATGAACGGTTTT
CCGTGACCGCGAAGCGGCTCGACCACGGCATGCCGTCATACGGATTTCGCGTCGCAGAAAAAGATTTGCCCGGGCCGCTT
CTTGTCGACCGGTTAAAGGCGCTCGGCGTCCGCCCGGGCCCGATTTACCAACAAATTAAGCAAGGCAAAACGGTCGTACT
TGAGGACGGCACCGTGCTTGACGGGCGCGAGTTTGTCGGCCCGCCGCAAAAAGGAAGGATCGTTGCCGTTTTAGGTGACA
CCCGCTTTTGCGAAGCGGCAATCGAACTGGCGCATGAGGCCGATGTCGTCATCCACGAGGCGACGTTTGCCGCGGCGGAA
CAGCGGCTTGCCCGCGATTATTTCCATTCAACGACTACGGACGCGGCCGAAGTGGCGAAACGAGCCGGAGCGAAGCGGCT
CATTTTAACTCACATCAGCTCGCGCTACCAAGGTGAAGCGGCGCTCAAGTTATTGGAGGAGGCGCGCCGCGTGTTTCCGA
ACACCGAGCTCGCCGCCGATTTTGCTTCATTTTCGATTCCGCGTTAA

Upstream 100 bases:

>100_bases
CGCAAACATTTTACCGCTTCTTTGTGTAAAAGAAAGTTGAAAAGCGCTCGGCAAACATTGTACGCTAACAACAGGCAATG
ATGACCGAGACAAGGAGTGA

Downstream 100 bases:

>100_bases
AATCGCCAGCCGCGCTCGTATTGCACCGGTGCTTCAATTTTTACGCCAAGTTCTTTAGCGGCAGCATACGGCCAATACGG
GTTGCGCAGCAGTTCACGTC

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSLELLFLGTGAGVPAKERNVSSIALQLLEERGATWLFDCGEATQHQILHTAIRPRRIEHIFITHLHGDHLFGLPGLLGS
RSFQSGETPLTVFGPKGIRQFVETALTVSGTRLRYELNIAEIDEGVIFDDERFSVTAKRLDHGMPSYGFRVAEKDLPGPL
LVDRLKALGVRPGPIYQQIKQGKTVVLEDGTVLDGREFVGPPQKGRIVAVLGDTRFCEAAIELAHEADVVIHEATFAAAE
QRLARDYFHSTTTDAAEVAKRAGAKRLILTHISSRYQGEAALKLLEEARRVFPNTELAADFASFSIPR

Sequences:

>Translated_308_residues
MSLELLFLGTGAGVPAKERNVSSIALQLLEERGATWLFDCGEATQHQILHTAIRPRRIEHIFITHLHGDHLFGLPGLLGS
RSFQSGETPLTVFGPKGIRQFVETALTVSGTRLRYELNIAEIDEGVIFDDERFSVTAKRLDHGMPSYGFRVAEKDLPGPL
LVDRLKALGVRPGPIYQQIKQGKTVVLEDGTVLDGREFVGPPQKGRIVAVLGDTRFCEAAIELAHEADVVIHEATFAAAE
QRLARDYFHSTTTDAAEVAKRAGAKRLILTHISSRYQGEAALKLLEEARRVFPNTELAADFASFSIPR
>Mature_307_residues
SLELLFLGTGAGVPAKERNVSSIALQLLEERGATWLFDCGEATQHQILHTAIRPRRIEHIFITHLHGDHLFGLPGLLGSR
SFQSGETPLTVFGPKGIRQFVETALTVSGTRLRYELNIAEIDEGVIFDDERFSVTAKRLDHGMPSYGFRVAEKDLPGPLL
VDRLKALGVRPGPIYQQIKQGKTVVLEDGTVLDGREFVGPPQKGRIVAVLGDTRFCEAAIELAHEADVVIHEATFAAAEQ
RLARDYFHSTTTDAAEVAKRAGAKRLILTHISSRYQGEAALKLLEEARRVFPNTELAADFASFSIPR

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=363, Percent_Identity=38.0165289256198, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI87082078, Length=305, Percent_Identity=50.8196721311475, Blast_Score=317, Evalue=9e-88,
Organism=Caenorhabditis elegans, GI71985808, Length=283, Percent_Identity=30.0353356890459, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71985814, Length=283, Percent_Identity=30.0353356890459, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652403, Length=107, Percent_Identity=37.3831775700935, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 33916; Mature: 33785

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLELLFLGTGAGVPAKERNVSSIALQLLEERGATWLFDCGEATQHQILHTAIRPRRIEH
CCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEE
IFITHLHGDHLFGLPGLLGSRSFQSGETPLTVFGPKGIRQFVETALTVSGTRLRYELNIA
EEEEEECCCCEECCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCEEEEEEEEHE
EIDEGVIFDDERFSVTAKRLDHGMPSYGFRVAEKDLPGPLLVDRLKALGVRPGPIYQQIK
ECCCCEEECCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
QGKTVVLEDGTVLDGREFVGPPQKGRIVAVLGDTRFCEAAIELAHEADVVIHEATFAAAE
CCCEEEEECCCEECCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEHHHHHHHH
QRLARDYFHSTTTDAAEVAKRAGAKRLILTHISSRYQGEAALKLLEEARRVFPNTELAAD
HHHHHHHHHCCCCHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHH
FASFSIPR
HHHCCCCC
>Mature Secondary Structure 
SLELLFLGTGAGVPAKERNVSSIALQLLEERGATWLFDCGEATQHQILHTAIRPRRIEH
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEE
IFITHLHGDHLFGLPGLLGSRSFQSGETPLTVFGPKGIRQFVETALTVSGTRLRYELNIA
EEEEEECCCCEECCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCEEEEEEEEHE
EIDEGVIFDDERFSVTAKRLDHGMPSYGFRVAEKDLPGPLLVDRLKALGVRPGPIYQQIK
ECCCCEEECCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
QGKTVVLEDGTVLDGREFVGPPQKGRIVAVLGDTRFCEAAIELAHEADVVIHEATFAAAE
CCCEEEEECCCEECCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEHHHHHHHH
QRLARDYFHSTTTDAAEVAKRAGAKRLILTHISSRYQGEAALKLLEEARRVFPNTELAAD
HHHHHHHHHCCCCHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHH
FASFSIPR
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA